24 results about "Hydroxyacetone" patented technology

The present disclosure relates to a process of preparation of 2-amino alcohol of formula I comprising: i) reacting 2-hydroxyketone or 2-hydroxyaldehyde of formula II in presence of an aminating agent and a solvent under condition to obtain imine intermediate; and ii) processing by hydrogenation the imine intermediate in presence of a metal catalyst and H2 under condition to obtain 2-amino alcohol of Formula I.

The present invention discloses a melt-alkalized attapulgite / platinum-based transition bimetallic catalyst and its preparation method and application. The catalyst includes a carrier and an active component supported on the carrier, the carrier being melt-alkalized attapulgite, the active component being platinum and a transition metal, and the transition metal being selected from iron, cobalt, nickel and copper. The catalyst of the present invention can be applied to glycerol aqueous phase reforming hydrogen production and value-added products in the absence of an additional hydrogen source. Its stronger acid site is conducive to the dehydration of glycerol to form hydroxyacetone, and further hydrogenation on the acid site generates value-added products such as 1,2-propylene glycol and 1,3-propylene glycol, showing good prospects for industrial application.

The present invention relates to a novel method for preparing a benzyl α-hydroxyketone derivative by mono-α-arylating O-protected hydroxyacetone with a palladium catalyst, followed by deprotection.

The present invention relates to a novel process for the preparation of benzyl alpha-hydroxyketone derivatives by mono alpha-arylation of O-protected hydroxyacetone under palladium catalysis and subsequent deprotection.

The application provides a method for efficiently reducing imines to synthesize alpha-amino acid compounds and application thereof, and belongs to the technical field of chemical synthesis. The method comprises the following steps: using hydroxyacetone as a reducing agent, and reducing imines under the catalysis of aza-cycloalkyl carbine catalysts to obtain alpha-amino acid compounds. The method uses hydroxyacetone as a reducing agent, and adopts aza-cycloalkyl carbine catalysts to realize the reduction of imines under mild conditions. The method is simple in operation, low in cost, green and pollution-free, suitable for industrial production, and solves the problems of non-cleanness caused by the use of metal catalysts in the existing imine reduction method, use of dangerous and unstable reducing agents, harsh reaction conditions and high production cost.

This invention belongs to the field of catalysis technology, and specifically relates to a method for the liquid-phase catalytic oxidation of 1,2-propanediol to prepare hydroxyacetone. The catalyst is an M-Zr-UiO-66 catalyst, where the metal M is selected from Fe, Cr, Cu, and Co, and the ligand is terephthalic acid. The catalyst preparation and catalytic reaction process of this invention are simple, the catalyst is reusable, and it is environmentally friendly. Using the catalyst and corresponding catalytic conditions of this invention, a good yield of hydroxyacetone can be obtained under relatively mild conditions. The main product is hydroxyacetone, and the byproduct is acetone. The selectivity of the main product can reach over 80%, and the conversion rate of 1,2-propanediol can reach over 14%.

The present application discloses a mutant Asaia bogorensis strain (Deposition number DSM 34962) as well as compositions, cell cultures and kits comprising said strain. The present application also discloses the use of said Asaia bogorensis strain, compositions, cell cultures or kits in methods of producing dihydroxyacetone (DHA).

The invention relates to a dihydroxyacetone phosphate transaminase CJ1361 mutant with improved stability, and a gene recombinant bacterium containing the dihydroxyacetone phosphate transaminase CJ1361 mutant and an enzyme liquid of the gene recombinant bacterium as biocatalysts, which are used for synthesizing serinol by a microbial fermentation method. Compared with the wild type dihydroxyacetone phosphate transaminase CJ1361, the yield of serinol produced by the dihydroxyacetone phosphate transaminase CJ1361 mutant provided by the invention is remarkably improved.

A method for preparing hydroxyacetone by catalytic conversion of Enteromorpha and its derivatives rhamnose, glucose, and xylose. First, a Pd-based catalyst supported on different supports (γ-Al2O3, MgO, hydrotalcite, TiO2, and ZrO2) was designed and prepared using an impregnation-freeze-drying method. Hydroxyacetone was prepared in an autoclave under a hydrogen atmosphere using Enteromorpha and its derivatives rhamnose, glucose, and xylose as raw materials and water as the reaction solvent. The Pd / γ-Al2O3 catalyst exhibited the best catalytic activity. Under the optimal reaction conditions, the carbon molar yields of hydroxyacetone obtained using Enteromorpha and rhamnose as raw materials were 45.9% and 62.2%, respectively.

The invention discloses a method for high-yield synthesis of an iopromide EP impurity F. The method comprises the following steps: dissolving iopromide with an organic solvent, and adding hydroxyacetone; after uniformly stirring, adding a catalytic amount of acid, carrying out nitrogen displacement, heating to 75-95 DEG C in an oil bath, and carrying out a reaction; after the reaction is finished, pouring reaction liquid into water, extracting twice with ethyl acetate, and extracting twice with dichloromethane; discarding an organic phase, and carrying out vacuum spin-drying on a water phase; adding a certain amount of water into residues, and then adding activated carbon for decoloration; filtering, and spin-drying filtrate again; and adding the residue into absolute ethyl alcohol, refluxing for 2-4 hours, naturally cooling to room temperature, crystallizing, filtering, adding ethyl alcohol into a filter cake again, repeatedly crystallizing for more than three times, and freeze-drying the obtained filter cake to obtain the iopromide impurity F with the purity of more than 98%. The method for synthesizing the iopromide EP impurity F has the advantages of simple operation, short preparation period, low cost and environmental protection, and the purity is high.

The invention provides a property-changed dihydroxyacetone kinase mutant and application thereof, and relates to the technical field of enzyme engineering. Through rational design and molecular modification, wild dihydroxyacetone kinase is subjected to single-point mutation and combined mutation, a series of enzyme mutants with enhanced thermal stability are obtained, and the catalytic activity of the mutants under the high-temperature condition is remarkably superior to that of wild enzymes. The invention further provides a multienzyme coupling reaction system containing the dihydroxyacetone kinase mutant, and the multienzyme coupling reaction system is used for efficiently catalyzing the process of synthesizing lactic acid by taking dihydroxyacetone as a substrate. The thermostable dihydroxyacetone kinase mutant provided by the invention solves the key bottleneck that a wild enzyme is easy to thermally inactivate under industrial application conditions, and has important industrial application prospects.

The present invention provides a method for synthesizing poly(3-hydroxybutyrate) from crude glycerol by using Escherichia coli, which includes a glycerol assimilation step and a strain genetic modification step. The glycerol assimilation step is to pass the crude glycerol through the extracellular membrane of Escherichia coli, so that the crude glycerol can enter the cells of Escherichia coli through uptake of a glycerol facilitator and is transformed into dihydroxyacetone phosphate through anaerobic and aerobic pathways. The strain genetic modification step includes a PHB-8 strain synthetic pathway, so that a λPL promoter is constructed to control a phaCAB genome, and then a PHB-8 strain producing poly(3-hydroxybutyrate) is produced. Thereby, the metabolic pathway of Escherichia coli is reprogramed to convert the crude glycerol into acetyl-CoA and NADPH, and in turn increase the yield of poly(3-hydroxybutyrate).

Provided is a method for producing 1,2-propanediol, comprising a) reacting a substrate containing an α-1,4-glycosidic bond with a mixture I comprising α-1,4-glucan lyase, 1,5-anhydro-D-fructose reductase, and reduced-form nicotinamide adenine dinucleotide (NADH) or reduced-form nicotinamide adenine dinucleotide phosphate (NADPH); or reacting a culture solution of cells capable of expressing and secreting α-1,4-glucan lyase and / or 1,5-anhydro-D-fructose reductase, with NADH or NADPH and the substrate containing the α-1,4-glycosidic bond; and b) the reaction product obtained in step a) undergoing a reaction with a mixture II comprising a sugar kinase, a 1,5-anhydro-sugar alcohol-6-phosphate isomerase, a free radical enzyme-activating enzyme, an aldolase and a hydroxyacetone reductase, or undergoing co-culture with cells capable of expressing the 1,5-anhydro-sugar alcohol-6-phosphate isomerase, the free radical enzyme-activating enzyme, the aldolase, the hydroxyacetone reductase and the transport complex, so as to obtain 1,2-propanediol.

The present invention relates to a binder composition comprising component A comprising polymer(s) A1 and optionally component B comprising component B1 which is selected from the group consisting of a mono-saccharides, disaccharides, hydroxyacetone, glycolaldehyde and mixtures thereof, wherein polymer(s) A1 comprises at least 70 wt.-% poly(amino acid)s based on the total weight of the polymers) A1 and has (have) a total weight average molecular weight Mw, total of 800 g / mol to 10.000 g / mol, wherein the binder composition comprises 60 to 100 wt.-% polymer(s) A1, and 0 to 40 wt.-% component B1, based on the total weight of the sum of polymer(s) A1 and component B1, wherein the weight amounts of the polymer(s) A1 and component B1 are selected such that the total weight of the sum of polymer(s) A1 and component B1 is 100 wt.-%.

The disclosure relates to a process for producing hydroxyacetone, by catalytic dehydration of glycerol in the presence of a copper catalyst slurry comprising a copper catalyst and a polymeric material or an ionic liquid.

The present invention relates to a process for preparing bisphenol A in the presence of at least two impurities being selected from the group consisting of 2-methylbenzofurane, hydroxyacetone, alpha-methylstyrene, acetophenone, benzene and / or cumene without poisoning the catalyst system comprising an ion exchange resin catalyst and a sulfur containing cocatalyst, wherein at least part of the sulfur containing cocatalyst is not chemically bound to the ion exchange resin catalyst. Moreover, the present invention provides a process for preparing polycarbonate.

The invention discloses a method for identifying aroma active components of bamboo chips, which comprises the following steps of: extracting aroma activity from the bamboo chips by using a supercritical carbon dioxide (SC-CO2) technology, and detecting and analyzing the aroma extracting solution of the bamboo chips by using a high-resolution mass spectrum system and a gas mass-smelling instrument combined system. The combination of the extraction and identification methods can comprehensively and accurately identify (+)-vaccinium asiaticum resinol 9 '-O-glucoside (lignan aroma), arbutin (plant aroma), gamma-terpinene (wood lemon flavor), 4-methylvalerophenone (with special aroma), 2-methylpyrazine (with nut flavor), 2-methylpyrazine (with special aroma), and the like in the bamboo chips. Nine characteristic aroma substances such as aroma (baking aroma), hydroxyacetone (caramel aroma), 3-furfural (special smell and almond flavor similar to benzaldehyde), tetrahydrofurfuryl alcohol propionate (tropical fruit flavor) and benzaldehyde (almond flavor) are adopted.

The application provides a shaped hydroxypropanone catalyst which is prepared from a hydroxypropanone catalyst powder, a binder, a pore-forming agent and a dilute acid solution. The hydroxypropanone catalyst provided by the application has a catalyst reaction life of not less than 600 hours in a reaction of preparing hydroxypropanone by dehydrating glycerol.

The application discloses a Yarrowia lipolytica gene engineering bacterium for producing erythritol by glycerol, and the Yarrowia lipolytica gene engineering bacterium is obtained by random insertion mutation mediated by non-homologous end connection, and strains with high cell growth and high erythritol yield are screened. Further, the gene engineering bacterium overexpresses glycerol dehydrogenase gene GCY3 or ARA1 and dihydroxyacetone kinase gene DAK2 of a glycerol metabolism dihydroxyacetone pathway. Further, the gene engineering bacterium overexpresses transketolase gene TKL1 and transaldolase gene TAL1 of a non-oxidative pentose phosphate pathway. The application further discloses a construction method and application of the gene engineering bacterium. The superior gene engineering bacterium obtained by constructing a mutant library has the characteristics of tolerating high-concentration glycerol, and the substrate conversion rate and glycerol utilization rate are significantly higher than those of a starting strain.

Selective hydrogenation processes are disclosed that can upgrade impure feeds, such as those obtained from biomass and containing a number of small (e.g., 2-6 carbon atom) molecules having aldehyde and / or ketone carbon atoms. For example, whereas glycolaldehyde and its methylated derivative, hydroxyacetone (acetol) are both high value intermediates for certain downstream processing reactions, they are normally recovered in a condensate from pyrolysis of carbohydrates (e.g., aldose-containing sugars) together with glyoxal and its methylated derivative, pyruvaldehyde. The selective hydrogenation of these compounds bearing two carbonyl carbon atoms, without over-hydrogenation to ethylene glycol and propylene glycol, can increase the concentration of the desired intermediates. These beneficial effects of selective hydrogenation may be achieved through the use of a hydrogenation catalyst comprising noble metals such as Ru and Pt.

The disclosure relates to a process for producing hydroxyacetone, by catalytic dehydration of glycerol in the presence of a copper catalyst slurry comprising a copper catalyst and a polymeric material or an ionic liquid.

The present invention relates to [1] a dispersion of metal fine particles containing hydroxyacetone and propylene glycol, in which a cumulant average particle size of the metal fine particles is not less than 0.01 μm and not more than 0.1 μm, and [2] an ink containing the dispersion of metal fine particles as described in the above [1].

The invention discloses a preparation method of a gadotetrol isomer. The method comprises the following steps: by taking cycleanine as an initial raw material, firstly reacting with tert-butyl bromoacetate to obtain a trisubstituted intermediate; then in the presence of a reducing agent, carrying out reductive amination reaction with hydroxyacetone, and directionally introducing a 1-hydroxy-propyl-2-yl side chain; and removing a protecting group through alkaline hydrolysis, carrying out chelation reaction with a gadolinium source, and purifying to obtain the gadotetrol isomer. The method adopts a reductive amination strategy to solve the problem of regioselectivity, is combined with an alkaline hydrolysis process, has the advantages of short synthesis route, high total yield, mild reaction conditions, simplicity and convenience in operation and the like, effectively avoids the use of high-pressure hydrogenation and highly toxic reagents, and is suitable for industrial preparation.

The present invention relates to a synthesis process of propranolol, belonging to the technical field of pharmaceutical synthesis. A synthesis process of propranolol is provided. The method includes reacting 1-naphthol with 1-bromo-3-hydroxyacetone in an organic solvent to form Compound 3, 1-hydroxy-3-(1-naphthyloxy)-2-propanone; reacting Compound 3 with isopropylamine in an organic solvent to form Compound 2, 1-isopropylamino-3-(1-naphthyloxy)-2-propanone; and subjecting Compound 2 to a reduction reaction under the action of a catalyst to form Compound 1, 1-isopropylamino-3-(1-naphthyloxy)-2-propanol. Overall, the present invention has the advantages of less generation of by-products and impurities, high product yield, high product purity, and simple post-treatment.