Preparation method of D-panthenol

A technology of panthenol and aminopropanol, which is applied in the field of D-panthenol preparation, can solve the problems of poor quality of D-panthenol, high reaction requirements, and high quality requirements, etc., and achieve less impurities, high purity, and high purity. Effect

Pending Publication Date: 2021-01-05
安徽泰格生物科技有限公司
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Problems solved by technology

[0004] At present, for the synthesis method of D-panthenol, it is reported that D-pantolactone and 3-aminopropanol are heated and reacted in the reactor under the condition of ethanol as the solvent, and then vacuum concentrated in the reactor to obtain D-panthenol. -panthenol, because D-panthenol is a viscous liquid in this preparation method, the reaction solvent ethanol cannot be completely removed by vacuum concentration, and if concentrated at high temperature for a long time, the quality of the product will deteriorate under high temperature conditions, and the optical rotation value will be low; In addition, CN101851171A discloses a preparation method of D-panthenol, which reacts D-pantolactone with 3-aminopropanol under solvent-free conditions to obtain D-panthenol, although the solvent is omitted The step of vacuum concentration and solvent removal, but the reaction requirements are high, and the quality requirements for the raw materials D-pantolactone and 3-aminopropanol are too high; and because D-panthenol is relatively thick, without solvent Reaction, along with the generation material of D-panthenol can be thicker and thicker, cause part 3-aminopropanol and D-pantoacidolactone to be inaccessible and react insufficiently, the quality of D-panthenol obtained is poor, The residue of raw materials is high, and the products obtained above cannot meet the application requirements for the purity of D-panthenol

Method used

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Examples

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Effect test

Embodiment 1

[0032] A kind of preparation method of D-panthenol is as follows:

[0033] (1) 1310 kg of D-pantoolactone was dissolved in 1500L of methanol, 750 kg of 3-aminopropanol was added to the reaction kettle, the temperature was raised to 28° C. for acylation reaction for 6 hours, and a mixed solution containing D-panthenol was obtained;

[0034] (2) The mixed solution is filtered through a resin column (filled with adsorption ester resin FB-02), and the filtered solution enters a water-bath scraper concentrator to recover methanol under reduced pressure. The temperature of the water bath is 65° C. to obtain D-panthenol.

Embodiment 2-3

[0036] The difference from Example 1 is that in this example, the molar ratios of D-pantolactone and 3-aminopropanol are 1.01:1 (Example 2) and 1.05:1 (Example 3).

Embodiment 4

[0038] A kind of preparation method of D-panthenol is as follows:

[0039] (1) 1306 kg of D-pantoolactone was dissolved in 1500L of methanol, 750 kg of 3-aminopropanol was added to the reaction kettle, the temperature was raised to 25° C. for acylation reaction for 8 hours, and a mixed solution containing D-panthenol was obtained;

[0040] (2) The mixed solution is filtered through a resin column, and the filtrate enters a water-bath scraper concentrator for methanol recovery. The temperature of the water bath is 68° C., and the methanol is recovered under reduced pressure to obtain D-panthenol.

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Abstract

The invention provides a preparation method of dianhydrol. The preparation method comprises the following steps: carrying out acylation reaction on D-pantoic acid lactone and 3-aminopropanol in a solvent to obtain a mixed solution containing D-panthenol, wherein the reaction temperature of the acylation reaction is 10-35 DEG C. The yield of the D-panthenol obtained by the preparation method is high, and the purity is high; meanwhile, the recovered solvent can be continuously used, and is safe and environment-friendly.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis and relates to a preparation method of D-panthenol. Background technique [0002] Panthenol also known as provitamin B 5 , can be divided into 3 forms of DL-type, D-type and L-type, of which only the D-type has biological activity, and the L-type has no biological activity; D-panthenol is an optically active stereoisomer of ubiquinol body. [0003] D-panthenol is the equivalent of D-pantothenic acid, which is widely used in medicine, food, feed and cosmetic industries. In the food industry, it is used as a nutritional supplement and fortifier to promote the metabolism of human protein, fat, and sugar, maintain skin and mucous membranes, improve hair luster, improve immunity, and prevent the occurrence of diseases; in the cosmetics industry, on the skin The care function of the hair is manifested as a deeply penetrating moisturizer, which stimulates the growth of epithelial cells, pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/02C07C231/24C07C235/08
CPCC07C231/02C07C231/24C07C235/08
Inventor 陈修段小瑞王浩黄飞飞汪洪湖
Owner 安徽泰格生物科技有限公司
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