Polylactic acid preparation method

A technology of polylactic acid and amino polylactic acid, applied in the field of polylactic acid preparation, can solve the problems of polymer pollution, low reactivity, insufficient reaction of terminal hydroxyl groups, etc., and achieve the effects of high end capping rate, high amino group and simple preparation process.

Inactive Publication Date: 2016-05-04
SHAANXI YUHANG ELECTRONICS
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main chain of the PLLA molecule does not contain reactive side groups, and the terminal group is a hydroxyl group with very low reactivity. It can only react with other substances under severe conditions. How to solve this problem has always been the focus of exploration.
However, later research confirmed that due to the agglomeration effect of macromolecular chains, the reaction of terminal hydroxyl groups in PLLA was not sufficient, and at least 30% of the terminal hydroxyl groups in the PLLA system did not undergo condensation reactions.
Synthesis of PLLA-NH by Ring-opening Polymerization of L-Lactide Initiated by Initiator with Amino Group 2 , but the naphthalene used in the polymerization process has certain toxicity and pollutes the polymer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment

[0013] Specific embodiments: the preparation process of the present invention includes three steps of synthesis of tert-butoxycarbonyl aminopropanol, synthesis of amino-terminated polylactic acid and synthesis of polylactic acid-polylysine;

[0014] The synthetic step of described tert-butoxycarbonyl aminopropanol (Boc-aminopropanol) is, get 22mmol tert-butoxycarbonyl carbonic anhydride (Boc) 2 O was dissolved in 40mL of chloroform, slowly added dropwise into 40mL of chloroform solution containing 20mmol aminopropanol at 0°C, slowly raised to room temperature, continued to stir for 24h, and then mixed with KHSO with W=0.05 4 Wash with deionized water, dry the organic layer, and remove the solvent to obtain a colorless viscous liquid, which is Boc-aminopropanol;

[0015] The amino-terminated polylactic acid (PLLA-NH 2 ) The synthetic steps include:

[0016] tert-butoxycarbonyl amino-terminated polylactic acid (BocNH-PLLA) synthesis: under the protection of dry nitrogen, weigh...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a polylactic acid preparation method, belongs to the field of preparation of polylactic acid, and concretely provides an aminopolylactic acid preparation method with simple preparation process and high amino termination rate. The aminopolylactic acid preparation method comprises the following steps: reacting tert-butoxycarbonyl carbonic anhydride with aminopropanol to synthesize tert-butyloxycarbonyl aminopropanol, initiating ring-opening polymerization of L-lactide with tert-butyloxycarbonyl aminopropanol as an initiator under the catalysis of stannous octoate to synthesize tert-butyloxycarbonylamino-terminated polylactic acid, carrying out trifluoroacetic acid treatment to remove a tert-butyloxycarbonyl group to obtain amino-terminated polylactic acid, and initiating ring-opening polymerization of w-benzyloxycarbonyl-L-lysine-N-carboxylic anhydride with aminopolylactic acid as a macromolecular initiator to synthesize polylactic acid-polylysine. The method has a simple preparation process, and the polylactic acid-polylysine prepared in the invention has a high amino termination rate.

Description

technical field [0001] The invention belongs to the field of polylactic acid preparation. Background technique [0002] Polylactic acid (PLLA) is known as the most promising degradable polymer material because of its excellent biocompatibility. However, the main chain of the PLLA molecule does not contain reactive side groups, and the terminal group is a hydroxyl group with very low reactivity. It can only react with other substances under severe conditions. How to solve this problem has always been the focus of exploration. At present, a better solution is to modify the terminal hydroxyl groups of PLLA. The most commonly used method for modification of terminal hydroxyl groups is to convert them into amino groups. For example, the terminal amination of polyethylene glycol can greatly improve the reactivity of the terminal groups. The amino-terminated polylactic acid (PLLA-NH 2 ). However, later studies confirmed that due to the agglomeration effect of macromolecular chai...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/44
CPCC08G69/44
Inventor 郝青
Owner SHAANXI YUHANG ELECTRONICS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap