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Method for preparing aminopropanol by electrolysis

A technology of aminopropanol and aminopropionic acid, which is applied in the direction of electrolysis process, electrolysis components, electrolysis organic production, etc., can solve the problems that aminopropanol has not been publicly reported, and achieve the effect of mild reaction conditions and cost reduction

Inactive Publication Date: 2010-03-03
淮北煤炭师范学院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no public report on the method of preparing aminopropanol by electrolytic reduction of water-soluble amino acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] In this embodiment, the electrolytic cell is made of plexiglass, and a cathode chamber and an anode chamber are separated by a cation exchange membrane. The anode and the cathode adopt platinum sheets or molybdenum sheets as electrodes, and the effective area of ​​the cathode and the anode is 14 cm. 2 , the distance between cathode and anode is 1.5cm.

[0029] Prepare 100mL of 0.5mol / L L-alanine solution with distilled water, add 2mL of concentrated sulfuric acid and 2g of sodium sulfate, add 0.1g of palladium carbon catalyst to obtain catholyte; 2 Under the condition of electrolysis for 7 hours, the conversion rate of raw materials was analyzed by high performance liquid chromatography to be 46.7%. The 2.0KPa fraction obtained L-aminopropanol with a yield of 41.3%.

Embodiment 2

[0031] The initial composition of the electrolytic cell and electrolyte of this embodiment is the same as that of Example 1. The catalyst uses 0.1 gram of ruthenium carbon, a constant voltage of 14V, and electrolysis for 9 hours. The conversion rate of raw materials analyzed by high performance liquid chromatography is 67.8%, and the catholyte is filtered and filtrated. Neutralize to neutral with sodium carbonate, then filter and distill to obtain L-aminopropanol with a yield of 64.7%.

Embodiment 3

[0033] The starting amino acid of this embodiment uses DL-alanine, the catalyst is 0.1 grams of Raney nickel, others are the same as Example 1, and the current density is controlled at 20A / dm 2 , Electrolyzed for 12 hours, and analyzed by high performance liquid chromatography, the conversion rate of raw materials was 38.6%, and the catholyte was filtered, neutralized, refiltered, and distilled to obtain DL-aminopropanol with a yield of 35.4%.

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Abstract

A method for preparing aminopropanol by electrolysis comprises two steps, namely preparation of aminopropanol by electrolysis reduction of an amino acid cathode and purification; the method for preparing aminopropanol by electrolysis is characterized in that an ion exchange membrane is adopted to divide an electrolyzer into a negative chamber and a positive chamber; the concentration of the aminopropanol in catholyte is 0.3mol / L to 2.0mol / L; the pH of the catholyte is 1 to 4; the anolyte is sulfuric acid with mass percentage concentration of 2 percent to 20 percent; the temperature of the electrolyte is controlled to be from 30 DEG C to 60 DEG C; the current density is 200 A / m<2> to 2000 A / m<2>; and when electrolyte balance is reached, the aminopropanol is obtained after the catholyte experiences filtration, neutralization, re-filtration and distillation. The method for preparing aminopropanol by electrolysis has low production cost and no pollution in the production process.

Description

technical field [0001] The invention relates to a method for preparing aminopropanol, more precisely a method for preparing aminopropanol by electrolytically reducing water-soluble amino acids. Background technique [0002] Aminopropanol has a broad market prospect. In 2002, in the fine chemical and pharmaceutical industries in the world chemical market, its sales volume reached 7 billion and 159 billion US dollars respectively. L-aminopropanol is an important intermediate for the synthesis of the third-generation quinolone broad-spectrum antibacterial drug levofloxacin. Its optical purity and price directly affect the quality and price of levofloxacin. The important raw materials, intermediates and chiral auxiliaries in the industry are widely used as chiral sources and chiral modifiers in asymmetric synthesis. Its preparation is mainly based on the reduction method, such as patents: 01127017.9; 200710190457.3; discloses the method of preparing aminopropanol with L-alanine...

Claims

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Application Information

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IPC IPC(8): C25B3/04C07C215/08C25B3/25
Inventor 王永秋赵慧何晓玲吴金城
Owner 淮北煤炭师范学院
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