Catalyst, method for preparing 3-aminopropanol through catalyst, and adopted system

A technology of aminopropanol and heterogeneous catalysts, which is applied in the direction of catalyst activation/preparation, chemical instruments and methods, and preparation of organic compounds. It can solve problems such as low activity, poor catalyst stability, and harsh reaction conditions, and achieve process operation. Simple, wide response pressure range, and improved stability

Active Publication Date: 2019-05-28
ZHEJIANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problems currently existing are one or more problems such as harsh reaction conditions, poor catalyst stability, and low activity.

Method used

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  • Catalyst, method for preparing 3-aminopropanol through catalyst, and adopted system

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Experimental program
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preparation example Construction

[0035] Preparation of 3-aminopropanol:

[0036] The product obtained in the present invention is analyzed using Agilent7890B, DB-35 capillary chromatographic column, and FID detector.

Embodiment 1

[0038] Weigh the above 20Ni-3Re / SiO 2 Catalyst 2.6g (approximately 5ml) is loaded into a fixed-bed reactor. Before use, the catalyst is activated by hydrogenation treatment. The activation conditions are: temperature T=390°C; pressure P is 0.3MPa, gas volume space velocity GHSV=1500h -1 , The reduction time is 6 hours. When the temperature in the reactor naturally drops to 100°C, the pressure is increased to 8MPa, and the system is stabilized. Mix liquid ammonia and 3-hydroxypropionitrile with a molar ratio of 5:1, then put the mixed liquid into the mixer 10 through the high-pressure pump 12 after the fixed bed reaction system is stable, and adjust the liquid of 3-hydroxypropionitrile The mass space velocity is 1.0 3-hydroxypropionitrile g / catalyst g h, the mol ratio of hydrogen and 3-hydroxypropionitrile in the reaction system is 2.0:1, reacts, and the reaction time is 48 hours, sampled by collection tank 17 Analysis by gas chromatography. 3-Hydroxypropionitrile hydrogena...

Embodiment 2

[0040] Weigh the above 20Ni-3Re / SiO 2 Catalyst 2.6g (approximately 5ml) is loaded into a fixed-bed reactor. Before use, the catalyst is activated by hydrogenation treatment. The activation conditions are: temperature T=390°C; pressure P is 0.3MPa, gas volume space velocity GHSV=1500h -1 , The reduction time is 6 hours. When the temperature in the reactor naturally drops to 100°C, the pressure is increased to 8MPa, and the system is stabilized. Mix liquid ammonia and 3-hydroxypropionitrile with a molar ratio of 5:1, then put the mixed liquid into the mixer 10 through the high-pressure pump 12 after the fixed bed reaction system is stable, and adjust the liquid of 3-hydroxypropionitrile Mass space velocity is 1.0 3-hydroxypropionitrile g / catalyst g h, the mol ratio of hydrogen and 3-hydroxypropionitrile in the reaction system is 2.2:1, reacts, and the reaction time is 48 hours, is sampled by collection tank 17 Analysis by gas chromatography. 3-Hydroxypropionitrile is subject...

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Abstract

The invention discloses a loaded heterogeneous catalyst. The loaded heterogeneous catalyst is prepared from main active components, an assistant and a carrier or prepared from main active components and a carrier, wherein the assistant is prepared from one or two or more of elementary substances or oxides of Fe, Cu, Ru, Re, K, Zn and B, the carrier is prepared from one or two or more of graphite,activated carbon, a carbon nano tube, graphene, silicon dioxide, aluminum oxide, a molecular sieve, titanium dioxide and zirconium dioxide, and the loaded heterogeneous catalyst is prepared through anultrasonic loading method. By adopting the loaded heterogeneous catalyst for preparing 3-aminopropanol, (1) the mass space-time yield of the 3-aminopropanol is increased; (2) selectivity of the 3-aminopropanol is improved; (3) a reaction can be implemented under the low reaction pressure; (4) stability of a catalytic system is improved; and (5) process operation is easy, convenient and feasible,the one-time investment and production costs of production and subsequent separating devices are lowered, and large-scale continuous industrial production is easy to achieve.

Description

technical field [0001] The invention relates to a catalyst, a method for preparing 3-aminopropanol by using the catalyst, and system equipment used, belonging to the technical field of chemical synthesis. Background technique [0002] 3-Aminopropanol is an important pharmaceutical intermediate, which is widely used in medicine, pesticides, dyes, etc., and is used to synthesize cyclophosphamide, propanol and other drugs. In addition, it is a synthetic vitamin B (DL - panthenol) raw material. In recent years, with the improvement of social development level, the application of panthenol in daily chemical products has been continuously improved, especially in cosmetics and shampoo products, which has greatly driven the market demand for 3-aminopropanol . [0003] Chinese patent application 201110289735.7 reports a method that uses 1,4-butyrolactone as a raw material, opens the ring under the action of hydrazine hydrate, adds sodium nitrite aqueous solution to generate acyl az...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J23/889B01J37/34C07C213/02C07C215/08
Inventor 陈兴坤丁云杰陈芳黄传奇
Owner ZHEJIANG NORMAL UNIVERSITY
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