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Catalyst, method for preparing 3-aminopropanol using the catalyst, and system used

A technology of aminopropanol and heterogeneous catalysts, which is applied in the direction of catalyst activation/preparation, chemical instruments and methods, and preparation of organic compounds. It can solve the problems of harsh reaction conditions, low activity, and poor catalyst stability, and achieve reaction pressure. Large range, simple process operation, and improved stability

Active Publication Date: 2021-12-24
ZHEJIANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main problems currently existing are one or more problems such as harsh reaction conditions, poor catalyst stability, and low activity.

Method used

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  • Catalyst, method for preparing 3-aminopropanol using the catalyst, and system used

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preparation example Construction

[0035] Preparation of 3-aminopropanol:

[0036] The product obtained in the present invention is analyzed using Agilent7890B, DB-35 capillary chromatographic column, and FID detector.

Embodiment 1

[0038] Weigh the above 20Ni-3Re / SiO 2 Catalyst 2.6g (approximately 5ml) is loaded into a fixed-bed reactor. Before use, the catalyst is activated by hydrogenation treatment. The activation conditions are: temperature T=390°C; pressure P is 0.3MPa, gas volume space velocity GHSV=1500h -1 , The reduction time is 6 hours. When the temperature in the reactor naturally drops to 100°C, the pressure is increased to 8MPa, and the system is stabilized. Mix liquid ammonia and 3-hydroxypropionitrile with a molar ratio of 5:1, then put the mixed liquid into the mixer 10 through the high-pressure pump 12 after the fixed bed reaction system is stable, and adjust the liquid of 3-hydroxypropionitrile The mass space velocity is 1.0 3-hydroxypropionitrile g / catalyst g h, the mol ratio of hydrogen and 3-hydroxypropionitrile in the reaction system is 2.0:1, reacts, and the reaction time is 48 hours, sampled by collection tank 17 Analysis by gas chromatography. 3-Hydroxypropionitrile hydrogena...

Embodiment 2

[0040] Weigh the above 20Ni-3Re / SiO 2 Catalyst 2.6g (approximately 5ml) is loaded into a fixed-bed reactor. Before use, the catalyst is activated by hydrogenation treatment. The activation conditions are: temperature T=390°C; pressure P is 0.3MPa, gas volume space velocity GHSV=1500h -1 , The reduction time is 6 hours. When the temperature in the reactor naturally drops to 100°C, the pressure is increased to 8MPa, and the system is stabilized. Mix liquid ammonia and 3-hydroxypropionitrile with a molar ratio of 5:1, then put the mixed liquid into the mixer 10 through the high-pressure pump 12 after the fixed bed reaction system is stable, and adjust the liquid of 3-hydroxypropionitrile Mass space velocity is 1.0 3-hydroxypropionitrile g / catalyst g h, the mol ratio of hydrogen and 3-hydroxypropionitrile in the reaction system is 2.2:1, reacts, and the reaction time is 48 hours, is sampled by collection tank 17 Analysis by gas chromatography. 3-Hydroxypropionitrile is subject...

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Abstract

The invention discloses a supported heterogeneous catalyst, which comprises a main active component, an auxiliary agent and a support, or comprises a main active component and a support, and the auxiliary agent is Fe, Cu, Ru, Re, K, Zn or B One or two or more elemental substances or their oxides; the carrier is one or more of graphite, activated carbon, carbon nanotubes, graphene, silicon dioxide, aluminum oxide, molecular sieve, titanium dioxide, and zirconium dioxide , the supported heterogeneous catalyst is prepared by ultrasonic loading method. Utilize catalyst of the present invention to prepare 3 aminopropanol, (1) improve the quality space-time yield of 3aminopropanol, (2) improve the selectivity of 3aminopropanol, (3) make reaction can be in lower Realized under reaction pressure, (4) improves the stability of the catalytic system, (5) the process operation is simple, convenient and feasible, reduces the one-time investment and production cost of production and subsequent separation devices, and is easy to realize large-scale continuous industrial production.

Description

technical field [0001] The invention relates to a catalyst, a method for preparing 3-aminopropanol by using the catalyst, and system equipment used, belonging to the technical field of chemical synthesis. Background technique [0002] 3-Aminopropanol is an important pharmaceutical intermediate, which is widely used in medicine, pesticides, dyes, etc., and is used to synthesize cyclophosphamide, propanol and other drugs. In addition, it is a synthetic vitamin B (DL - panthenol) raw material. In recent years, with the improvement of social development level, the application of panthenol in daily chemical products has been continuously improved, especially in cosmetics and shampoo products, which has greatly driven the market demand for 3-aminopropanol . [0003] Chinese patent application 201110289735.7 reports a method that uses 1,4-butyrolactone as a raw material, opens the ring under the action of hydrazine hydrate, adds sodium nitrite aqueous solution to generate acyl az...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J23/889B01J37/34C07C213/02C07C215/08
Inventor 陈兴坤丁云杰陈芳黄传奇
Owner ZHEJIANG NORMAL UNIVERSITY
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