282 results about "Phosphinidene" patented technology

The present invention encompasses compounds of Formula (I) as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

The invention provides methods and medicaments for improving attentiveness in humans, including subjects diagnosed with attention disorders. In one aspect, a GABA_B receptor antagonist, such as 3-aminopropyl-(n-butyl)-phosphinic acid (ABPA), is used to improve attention.

The invention relates to an antistatic, halogen-free, and fire-retardant enhanced master batch dedicated for polyamide and a preparation method thereof. The fire-retardant master batch is composed of following components in parts by weight: 25 to 50 parts of PA, 15 to 30 parts of alkyl phosphinate fire-retardant, 15 to 30 parts of melamine polyphosphate fire retardant, 8 to 15 parts of zinc borate fire retardant, 4 to 6 parts of CTI improver, 1 to 1.5 parts of antistatic agent, 3 to 8 parts of flexibilizer, 0.5 to 1 part of coupling agent, 0.7 to 1.5 parts of lubricant, and 0.3 to 1 part of anti-oxidant. The sum of the weight ratio of components mentioned above is 100 wt%. The fire-retardant master batch is used to produce fire-retardant enhanced and modified nylon, meets standards of the United States underwriters laboratories (UL)-941.6mm and a higher V-0 grade, simultaneously achieves that glowing wire temperature (GWIT) is equal to or larger than 750 DEG C and the CTI value is equal to or larger than 600 V, also has a antistatic performance, meets European Union RoHS, International Electrotechnical Commission (IEC) halogen-free and Reach rule requirements, is easy to use and excellent in comprehensive performance, and does not affect color matching.

The present invention relates to a thermoplastic flame retardant composition comprising a specific flame retardant system based on phosphinates and melamine derivatives. Such compositions are especially useful in the preparation of articles for use in the field of electrical or electronic connectors.

The invention discloses monoalkyl/dialkyl phosphinate and a preparation method thereof. The method comprises the steps that: organic solvent-water is adopted as a reaction medium; under the effect of an initiator I, hypophosphite is subjected to a reaction with alkene I under a temperature of 70-90 DEG C, such that monoalkyl phosphinate is obtained; the temperature is increased to 90-110 DEG C by heating; the obtained monoalkyl phosphinate is subjected to a reaction with alkene II under the effect of an initiator II, such that dialkyl phosphinate is obtained; Or, organic solvent-water is adopted as a reaction medium; under the effect of an initiator III, hypophosphite is subjected to a reaction with alkene III under a temperature of 70-120 DEG C, such that dialkyl phosphinate is obtained. The hypophosphite is hypophosphorous acid salt of Mg, Ca, Al, Sb, Sn, Ge, Ti, Zn, Fe, Zr, or Sr. According to the invention, the reaction period is short, obtained monoalkyl/dialkyl phosphinate can be precisely controlled, a total yield is high, and product purity is high. When the product is salified, the contents of other salts are low. The product is easy to wash.

The invention discloses a preparation method and application of dialkyl phosphinate with high density and large diameter. The method comprises steps of: a) adding an alkali compound aqueous solution into a dialkyl phosphinic acid and / or dialkyl phosphinic acid alkali metal salt aqueous solution, and adjusting the solution to an alkaline state to obtain a dialkyl phosphinate aqueous solution under alkaline conditions; b) reacting the metal compound aqueous solution with the dialkyl phosphinate aqueous solution under alkaline conditions; and c) neutralizing the solution with acid to obtain the dialkyl phosphinate shown such as a formula (I). R1, R2 are the same or different, and represent methyl, ethyl, butyl, pentyl, cyclopentyl, cyclohexyl or octyl; M represents Mg, Ca, Al, Fe, Zn, Sb, Sn, Ge, Ti, Zr or Sr; and m is 2-4. The prepared dialkyl phosphinate has large diameter and high bulk density; the method has simple process, convenient operation and easy product packaging, and can greatly reduce dust pollution during the production process; and the product can be used as an environment-friendly, efficient, halogen-free flame retardant in polymer materials.

There is provided a flame-retardant resin composition which is excellent in flame retardancy and excellent in low water-absorbing property and exhibits a small dimensional change and a small decrease in insulating properties. A flame-retardant resin composition containing: (A) an aliphatic polyamide resin; (B) an aromatic polyamide resin; (C) a flame retardant containing (c1) a phosphinic acid salt represented by the following formula (I) and/or (c2) a diphosphinic acid salt represented by the following formula (II) and/or a polymer containing at least one of these (c1) and (c2) as a component C1 and containing (c3) a melamine condensation product and/or (c4) a reaction product of melamine with phosphoric acid and/or (c5) a reaction product of a melamine condensation product with phosphoric acid and/or a mixture containing at least two of these (c3) to (c5) as a component C2; and (D) an inorganic filler.

The invention discloses a preparation method of a dialkylphosphinate metal salt. The preparation method comprises the following steps: a) adding a coupling agent into a water solution of dialkyl phosphinic acid and/or a dialkylphosphinate alkali metal salt to get the water solution of dialkyl phosphinic acid and/or the dialkylphosphinate alkali metal salt containing the coupling agent; and b) adding the coupling agent or not adding the coupling agent into a mixture of a metal compound and water, and further reacting with the water solution of dialkyl phosphinic acid and/or the dialkylphosphinate alkali metal salt containing the coupling agent to generate the dialkylphosphinate metal salt. The dialkylphosphinate metal salt obtained by the preparation method disclosed by the invention has small particle size and good flowability; and furthermore, when the particle size is less than 90 mu m, in particular to 40 mu m, the tap density can still above 600g/L, and the problems that such flame retardants are easy to raise dust during the feeding process and less prone to uniformly mixing with resin can be well solved. The preparation method disclosed by the invention has the advantages of simple process and convenience in operation, and the coupling agent is low in price and easy to obtain; and simultaneously, production equipment is simplified and production cost is reduced.

The invention discloses monoalkyl/dialkyl phosphinate and a preparation method thereof. The method comprises the steps that: water is adopted as a reaction medium; under the effect of an initiator I, hypophosphite is subjected to a reaction with alkene I under a temperature of 70-90 DEG C, such that monoalkyl phosphinate is obtained; the temperature is increased to 90-110 DEG C by heating; the obtained monoalkyl phosphinate is subjected to a reaction with alkene II under the effect of an initiator II, such that dialkyl phosphinate is obtained; Or, water is adopted as a reaction medium; under the effect of an initiator III, hypophosphite is subjected to a reaction with alkene III under a temperature of 70-120 DEG C, such that dialkyl phosphinate is obtained. The hypophosphite is hypophosphorous acid salt of Mg, Ca, Al, Sb, Sn, Ge, Ti, Zn, Fe, Zr, or Sr. According to the invention, hypophosphite is directly adopted as a raw material, and the monoalkyl/dialkyl phosphinate is obtained with a one-step method. The reaction period is short, a total yield is high, product purity is high, process flow is simple, no organic solvent or other solvent is adopted, and no subsequent processing is needed. When the product is salified, the contents of other salts are low. The product is easy to wash.

A composition comprising: polybutylene terephthalate; a nitrogen-containing flame retardant selected from the group consisting of triazine, guanidine, cyanurate, isocyanurate and the nitrogen-containing flame retardant comprising the above-mentioned a mixture of at least one of; a phosphinate or a diphosphinate; and a carbonized polymer.

The invention relates to an alkyl phosphinate polymer and a preparation method and application thereof. The method comprises the following steps of: filling a mixture of hypophosphorous acid or phosphinate and water or acetic acid into a pressure reactor with a jacket; when the mixture is heated to between 70 and 110 DEG C, adding alkyne into the pressure reactor through a pressure-reducing valvetill the mixture in the pressure reactor is saturated; uniformly adding aqueous solution of free radical initiator into the obtained mixture with continuous stirring till reaching the required alkynequantity, and then switching the alkyne into olefin; adding the olefin into the pressure reactor through the pressure-reducing valve till the mixture in the pressure reactor is saturated, uniformly adding a catalyst into the mixture, reacting the mixture for 8 to 12 hours, reducing the pressure of the pressure reactor, and cooling the mixture to 80 DEG C; and adding a metal compound into the pressure reactor to perform reaction, centrifuging the obtained solid, washing the solid by using water, and drying the solid in vacuum to obtain the alkyl phosphinate polymer. The invention also relates to the application of the alkyl phosphinate polymer serving as a flame retardant, a flame retardant composition and a flame-retardant polymer molding composition.

The invention relates to flame-retardant nylon 6 and a preparation method thereof. The flame-retardant nylon 6 is prepared by performing polymerization on a nylon polymerization monomer namely caprolactam, aminomethyl phenyl phosphinic acid and a polymer catalyst. The preparation method comprises the following steps: performing heating reaction on hydroxymethyl phenyl phosphinic acid, sulfoxide chloride and ether in a reaction kettle according to a certain mole ratio, putting the prepared chloromethyl phenyl phosphinic acid into a sodium hydroxide solution, and introducing ammonia gas into the sodium hydroxide solution to perform ammoniation reaction so as to prepare aminomethyl phenyl phosphinic acid; and performing polymerization on the nylon polymerization monomer namely caprolactam, aminomethyl phenyl phosphinic acid and the polymer catalyst to obtain the flame-retardant nylon 6. According to the flame-retardant nylon 6 provided by the invention, the aminomethyl phenyl phosphinic acid is added into a polymerization system of the flame-retardant nylon 6 to ensure that a flame retardant is perfectly combined with nylon 6, and the flame retardant cannot generate negative influence on the mechanical properties of the nylon 6, and can ensure that the nylon 6 has a very good flame retardant effect under the condition that very little flame retardant is added.

The invention discloses a preparation method of a monohydroxy dialkyl phosphinic acid metal salt fire retardant. The preparation method comprises the following steps: 1) performing reaction on alkyl phosphonium dichloride and alcohol to obtain monoalkyl phosphonate; 2) in the presence of acid and water, performing reaction on monoalkyl phosphonate obtained from the former step and aldehyde to obtain monohydroxy alkyl phosphinic acid solution; 3) performing reaction on monohydroxy alkyl phosphinic acid solution obtained from the former step and lewis acid in water, generating the monohydroxy dialkyl phosphinic acid metal salt fire retardant solid, separating out solid, washing and drying the solid to obtain the product. According to the preparation method, monosubstituted phosphonium dichloride is taken as a starting material, so that the synthetic route is novel. The risk of using gaseous state raw material such as olefin is avoided. According to the invention, the reaction conditions are mild (normal pressure, and temperature not higher than 100 DEG C); the synthetic steps are few; separate purification is needless; the technology is simple; the production equipment is simplified; the safety of the production process is improved.

In a process for the production of dialkylphosphinic acids, especially branched, dialkylphosphinic acids in high purity via the reaction of an alpha olefin with a hypophosphorous acid or a salt thereof, the improvement comprising conducting the reaction in the presence of a stoichiometric excess of the olefin and isolating and purifying the desired dialkylphosphinic acid product by neutralizing the monoalkylphosphinic acid by-product with an aqueous base; removing the aqueous phase in which the neutralized monoalkylphosphinic acid is preferentially solubilized; acidifying the dialkyl product in the organic phase; and isolating the purified product.

The invention discloses monoalkyl/dialkyl phosphinate and a preparation method thereof. The method comprises the steps that: an organic solvent is adopted as a reaction medium; under the effect of an initiator I, hypophosphite is subjected to a reaction with alkene I under a temperature of 70-90 DEG C, such that monoalkyl phosphinate is obtained; the temperature is increased to 90-110 DEG C by heating; the obtained monoalkyl phosphinate is subjected to a reaction with alkene II under the effect of an initiator II, such that dialkyl phosphinate is obtained; Or, an organic solvent is adopted as a reaction medium; under the effect of an initiator III, hypophosphite is subjected to a reaction with alkene III under a temperature of 70-120 DEG C, such that dialkyl phosphinate is obtained. The hypophosphite is hypophosphorous acid salt of Mg, Ca, Al, Sb, Sn, Ge, Ti, Zn, Fe, Zr, or Sr. According to the invention, hypophosphite is directly adopted as a raw material, and the monoalkyl/dialkyl phosphinate is obtained with a one-step method. The reaction period is short, obtained monoalkyl/dialkyl phosphinate can be precisely controlled, a total yield is high, and process floe is simple. When the product is salified, the contents of other salts are low. The product is easy to wash.

The invention discloses an irradiating crosslinking halogen-free flame-retardant material with a non-foaming pipe wall in heating shrinkage. The irradiating crosslinking halogen-free flame-retardant material comprises the following raw materials in parts by weight: 10-100 parts of ethylene-vinyl acetate copolymer, 0.5-10 parts of organosilicon polymer, 0.1-10 parts of antioxidant, 0.1-50 parts of coated red phosphorus flame retardant, 1-150 parts of aluminium hydroxide and/or magnesium hydrate and/or modified aluminium hydroxide and/or modified magnesium hydrate, 0-50 parts of high molecular weight ammonium polyphosphate (APP) and/or 0-50 parts of phosphate flame retardant and/or 0-50 parts of melamine cyanurate (MCA) and/or 0-50 parts of phosphinates, 0.1-100 parts of carbonate and/or phosphate and/or phosphide and/or calcined clay and/or kaoline and/or clay. The irradiating crosslinking halogen-free flame-retardant material can be applied to a heating shrinkage sleeve and the like, the flame retardant grade achieves the American UL224VW-1 standard, and no halogen is contained.

Polyamide moulding composition in particular for railway applications consisting of:

• (A) from 50 to 90% by weight of a polyamide matrix consisting of (A1) polyamide 12 and optionally (A2) up to 85% by weight of polyamide elastomer based on polyamide 12;
• (B) from 7 to 28% by weight of flame retardant consisting of (B1) at least one metal phosphinate, and also optionally (B2) up to 40% of a nitrogen-containing synergist and/or at least one nitrogen- and phosphorus-containing flame retardant;
• (C) from 3 to 15% by weight of plasticizer;
• (D) from 0 to 15% by weight polyolefin;
• (E) from 0 to 10% by weight of additives and/or particulate fillers, with exclusion of fibrous reinforcing materials;

where the entirety of (C) and (D) is from 3 to 20% by weight, based on the entire moulding composition, and where the entirety of (A) to (E) provides 100% by weight.

The invention relates to a high-glow-wire halogen-free flame-retardant polyamide compound, wherein the high-glow-wire halogen-free flame-retardant polyamide compound comprises the following componentsin percentage by weight: 40-90% of polyamide resin, 2% -25% of an organic phosphinate flame retardant, 1% -40% of a melamine flame retardant, 1% -10% of a phosphate flame retardant, 0-45% of a reinforcing agent and 0.1-3% of other additives, wherein the total weight of the components is 100%. The invention aims to provide the halogen-free environmentally- friendly polyamide compound with high-glow-wire performance and high flame retardancy, the glow-wire performance and the flame retardancy of the polyamide compound are remarkably improved by adding the phosphate flame retardant.

The invention discloses a particle size control method of a dialkylphosphinate salt. The particle size control method comprises the following steps: a) adding a strong electrolyte into a water solution of dialkyl phosphinic acid and/or a dialkylphosphinate alkali metal salt to get a strong electrolyte water solution of dialkyl phosphinic acid and/or the dialkylphosphinate alkali metal salt; and b) enabling a mixture of a metal compound and water to react with the strong electrolyte water solution of dialkyl phosphinic acid and/or the dialkylphosphinate alkali metal salt to get the dialkylphosphinate salt as shown in formula (I), wherein R<1> and R<2> are identical or different and represent straight chain or branched chain C1-C6 alkyl; M is Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr or Mn; m is 2-4; and the strong electrolyte is a metal salt compound. According to the particle size control method disclosed by the invention, by changing the adding quantity of the strong electrolyte, products with a very small particle size range can be obtained; the method is simple in process and convenient to operate, and production equipment is simplified; and the obtained dialkylphosphinate salt can be applied to production of flame retardants.

The invention discloses a preparation method of dialkyl phosphinic acid and salts thereof. The method comprises the following steps: reacting hypophosphorous acid with high concentration with olefin under the effect of an initiator to obtain dialkyl phosphinic acid; and then diluting the dialkyl phosphinic acid with water and neutralizing with an aqueous solution of an alkaline compound to obtain a dialkyl phosphinic acid alkali metal salt aqueous solution; and reacting the dialkyl phosphinic acid alkali metal salt aqueous solution with a metal compound aqueous solution to obtain the dialkyl phosphinic acid salt. The concentration of the hypophosphorous acid with high concentration is 80-100%; and the metal compound is compound of Mg, Ca, Al, Sb, Sn, Ge, Ti, Zn, Fe, Zr and Sr. The invention employs hypophosphorous acid with high concentration as a raw material, which is added with no solvent; a bulk free radical reaction has a quite short reaction cycle requiring only 3-5 h to complete a high pressure synthesis process, and has high total yield; the synthesized dialkyl phosphinic acid product has high concentration and high purity; the process is simple, does not use organic solvent or other solvent; and the salified product does not contain other harmful substance or need any post-treatment.