46results about How to "Novel synthetic route" patented technology

The invention discloses a preparation method and an application of salts of dialkylphosphinic acid, the salts of dialkylphosphinic acid has a structure shown in a formula (I). The preparation method of the salts of dialkylphosphinic acid comprises the following steps: hypophosphorous acid or hypophosphites are reacted with aldehyde in an aqueous solution to obtain di(alpha-hydroxy)alkyl hypophosphorous acid, hydroxy is reduced through HI / P to obtain an dialkylphosphinic acid solution, and the dialkylphosphinic acid solution and metal salt are reacted to obtain the corresponding salts of dialkylphosphinic acid. The preparation method of salts of dialkylphosphinic acid has the advantages of high yield, simple synthesis process and convenient operation, and substantially reduces production cost, simplifies production equipment and enhances the security of production process.

The invention discloses a method for preparing octafluoro-2-butene, comprising Cu + Under the action of a procatalyst and a cocatalyst including an organic amine, 2,2‑dichloro1,1,1,2‑tetrafluoroethane reacts with copper to give 1,1,1,2,3,4,4,4 ‑Octafluoro‑2‑butene. The preparation method provided by the invention has the advantages of novel synthetic route, readily available raw materials, low cost and suitable for industrial production.

The invention relates to a preparation method of 2,4-dichloro-5-methoxypyrimidine, and belongs to the technical field of the preparation of intermediates of pesticides. According to the method, first, ethyl formate and methyl methoxyacetate are used as raw materials, and 2-thiol-4-hydroxyl-5-methoxypyrimidine is made through condensation and cyclization; afterwards, chlorination is carried out by using chlorine and phosphorus oxychloride successively, so as to obtain the 2,4-dichloro-5-methoxypyrimidine. All raw materials for the preparation method of the 2,4-dichloro-5-methoxypyrimidine are easily obtained; a synthetic route is novel; the yield of a ring formation step is high; the use level of a chlorinating agent is low; the preparation method of the 2,4-dichloro-5-methoxypyrimidine is suitable for industrialized production.

The invention discloses asymmetric cyclobutane derivatives (synthetic derivatives G of rabdosia scoparia lactones), which are named as scopariusicide derivatives, a pharmaceutical composition taking the asymmetric cyclobutane derivatives as the active component, a preparation method of asymmetric cyclobutane derivatives, and an application of asymmetric cyclobutane derivatives in preparation of immuno-suppressive drugs. According to the preparation, scopariusicides, which is derived from pharmaceutical plants, is taken as the template; a precursor compound ent-clerodane diterpene A is taken as the initial raw material, a series of artificial analogues are obtained through six steps of chemical synthesis; the basic structure of the derivatives has a characteristic that ent-clerodane hetero-diterpene has an asymmetric cyclobutane segment, the side chain and aromatic ring of the derivatives may have different substituents, and thus there are many kinds of derivatives. The compounds are synthesized for the first time, the synthesis route is novel, and the derivatives have potential bioactivity, can be used as the lead compounds of immuno-suppressive drugs, and have a very important research value and application prospect.

The invention discloses a method for preparing 2-chloro-3,3,3-trifluoropropene from trichloropropene. First, 1,1,3-trichloropropene and / or 3,3,3-trichloropropene, HCl and O 2 The gas phase mixture of the mixture is used as a raw material, reacted under the action of an oxychlorination catalyst, and then passed through anhydrous HF under the action of a fluorination catalyst for further reaction to obtain 2-chloro-3,3,3-trifluoropropene. The 2-chloro-3,3,3-trifluoropropene prepared by the invention can be used to synthesize 2,3,3,3-tetrafluoropropene.

The invention discloses a preparation method of a pharmaceutical intermediate, whose chemical name is: (S)-1-[(4S,5R)-4-(2,2-dimethyl-5 E ‑propenyl‑1,3 dioxolane]‑1‑octanol, which belongs to the field of chemical and pharmaceutical intermediates. The present invention starts from the chiral raw material (R)-epichlorohydrin, and the preparation process needs to go through reduction reaction, prins cyclization reaction, asymmetric dihydroxylation reaction, elimination reaction participated by zinc powder and double bond isomerization catalyzed by rhodium Reaction and so on 8-step reaction. The invention has the advantages of simple operation, cheap and easy-to-obtain raw materials, novel synthesis route, high-efficiency construction of multiple chiral centers, and the like.

A cyclic aminopyrimidine derivative and its activity and application for inhibiting kinase The derivative can inhibit the activity of kinases, is a variety of kinase inhibitors, can be more widely used in the treatment of cancer, and has great clinical application prospects. General formula (I).