46results about How to "Novel synthetic route" patented technology

The invention discloses a 4-aroyl-1,8-naphthalimide compound and a preparation method and use thereof, wherein the 4-aroyl-1,8-naphthalimide compound has a structural formula as shown in the specification, R1 is C1-C10 straight chain or branched chain alkyl; and R2 is phenyl, naphthyl, biphenylyl, substituted phenyl, quinary or senary heteroaryl or benzo quinary or senary heteroaryl. The preparation method is as follows: a 4 bromo-1,8-naphthalimide compound is used as a raw material to react with substituted phenylacetonitrile or aromatic ring acetonitrile in an organic solvent in the presence of an alkali catalyst to obtain a 4-aryl acetonitrile-1,8-naphthalimide compound, and then the 4-aroyl-1,8-naphthalimide compound is obtained in the effects of fluoride ions or cyanide ions. The 4-aryl acetonitrile-1, 8-naphthalimide compound is used as a color or fluorescence sensor for detection of the fluoride ions or cyanide ions, and has high sensitivity and high selectivity during identifying of the cyanide ions in a mixed solvent.

The invention discloses a synthesis method of 3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid. The synthesis method takes furfuryl alcohol as a starting raw material and four-step reaction including rearrangement, addition, hydroxyl protection and oxidization is carried out; the total mol yield of a synthesis route is greater than 32 percent; the synthesis method has the characteristics of relatively moderate reaction conditions and the like, and the yield and purity of the 3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid are remarkably improved; meanwhile, the synthesis method has the advantagesof detailed technological operation steps, specific parameters, controllable conditions and stable technology, and can realize industrial large-batch production.

The invention discloses a hydroquinone synthetic method. The method comprises the steps that sodium phenate is reacted with ozone on the condition that catalyst hydroxyapatite exists, and benzene quinone is obtained after reaction liquid water steam is distilled; hydroquinone is obtained after hydrogen is added into the benzene quinone on the condition that catalyst raney nickel exists. The hydroquinone synthetic method is simple in synthetic route, novel, simple in technology, high in yield and purity of products, incapable of influencing the environment, and suitable for industrial production. Moreover, catalyst is cheap and can be obtained easily.

The invention discloses asymmetric cyclobutane derivatives (synthetic derivatives G of rabdosia scoparia lactones), which are named as scopariusicide derivatives, a pharmaceutical composition taking the asymmetric cyclobutane derivatives as the active component, a preparation method of asymmetric cyclobutane derivatives, and an application of asymmetric cyclobutane derivatives in preparation of immuno-suppressive drugs. According to the preparation, scopariusicides, which is derived from pharmaceutical plants, is taken as the template; a precursor compound ent-clerodane diterpene A is taken as the initial raw material, a series of artificial analogues are obtained through six steps of chemical synthesis; the basic structure of the derivatives has a characteristic that ent-clerodane hetero-diterpene has an asymmetric cyclobutane segment, the side chain and aromatic ring of the derivatives may have different substituents, and thus there are many kinds of derivatives. The compounds are synthesized for the first time, the synthesis route is novel, and the derivatives have potential bioactivity, can be used as the lead compounds of immuno-suppressive drugs, and have a very important research value and application prospect.

The invention relates to the technical field of enzyme engineering and particularly relates to a biosynthesis method of a atomoxetine intermediate and carbonyl reductase, the carbonyl reductase producing strain is Escherichia coli TM1908, and the preservation number of the strain is CCTCC NO: M2019714. In the presence of a coenzyme, a coenzyme circulating enzyme, a cosolvent and a buffer solution,the carbonyl reductase is catalyzed and converted into a atomoxetine intermediate compound I. The invention further discloses a preparation method of the atomoxetine intermediate compound I. The synthesis method provided by the invention solves a problem of chemical catalysis of low-chirality products in the prior art, reduces production cost and reduces pollution. Meanwhile, the invention provides a new catalytic substrate for the preparation of the important chiral intermediate of the atomoxetine.

The invention discloses a preparation method of a sofosbuvir intermediate of (2R)-2-deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid-g-lactone 3,5-dibenzoate. The intermediate structure corresponds toa formula I shown as the description. The method comprises the step that the sofosbuvir intermediate shown as the formula I is finally obtained by using (D2) (S)-(+)-4-phenyl-2-oxazolidinone of a compound shown as a formula II as a raw material through six-step reaction of condensation, fluorination, Adol addition, oxidation cyclization, isomerization and benzoylation. The preparation method hasthe advantages that the raw materials are cheap and can be easily obtained; the reaction conditions are mild; the route is short; the yield is high; three wastes are few; the pollution is little; thepreparation method is suitable for industrial production.

The invention discloses a preparation method for 3-O-alkyl ascorbic acid. The preparation method comprises the steps that under protection of nitrogen, 2-keto-L-gulonic acid ester reacts with sulfuric acid diester at the presence of catalyst molecular sieves, and an obtained intermediate under the action of sodium bicarbonate and calcium fluoride generates the 3-O-alkyl ascorbic acid. According to the preparation method, a synthetic route is simple, a synthetic method is novel, a process is easy and convenient to achieve, postprocessing is simple, the yield and purity of products are high, catalysts are low in price and easy to obtain, the environment is not affected, and the preparation method is suitable for industrial production.

The invention relates to the technical field of chemical industry synthesis, and particularly discloses a 4-phenoxybenzoic acid synthesis method, which comprises: carrying out a mixing heating reaction on phenol as a raw material, sodium hydroxide and water to obtain a sodium phenolate solution; slowly adding the sodium phenolate solution into a mixture of tetrahydronaphthalene and p-chlorobenzoicacid in a dropwise manner while heating, and carrying out a thermal insulation reaction; after completing the reaction, cooling the reaction liquid, filtering, washing the obtained solid, filtering,mixing by adding clear water, adjusting the pH value, and filtering to obtain crude and wet 4-phenoxybenzoic acid; and dissolving the crude and wet 4-phenoxybenzoic acid in ethanol, adsorbing with active carbon, filtering, cooling, and filtering to obtain the product. According to the present invention, the process route is simple and easy to operate, the reaction can be completed in one step, thestarting raw material is simple and cheap, and is easy to obtain, the generated waste water is less, and the method is suitable for industrial production, and is a completely-new synthesis route.

The invention discloses a method for synthesizing weight loss drug orlistat key intermediate. According to the method disclosed by the invention, n-dodecanal is utilized as a beginning raw material, orlistat intermediate compound (9) is prepared through multiple steps of reaction, and finally, orlistat can be prepared through two steps of known reaction of chiral hydroxyl deprotection reaction andmistsunobu reaction. A synthesizing strategy of the method disclosed by the invention is a typical linear strategy, a route design is simple and reasonable, an operation technology is convenient, reaction conditions are moderate, steps are few, a product yield is high, production cost is remarkably reduced, and the method is suitable for industrial preparation.

The invention provides a pentachlorocyclopropane preparation method. Pentachlorocyclopropane is generated through chlorinating 3,3,3-trichloropropylene which is a raw material by chlorine at 0-100DEG C. The pentachlorocyclopropane preparation method has the advantages of novel synthetic route, high product yield, simple operation, easy industrialized amplification and the like. The synthesized pentachlorocyclopropane can be used for synthesizing other fluorine-containing compounds.

The invention discloses a preparation method of photocurable hyperbranched polyurethane-epoxy acrylate, which comprises the following steps: firstly synthesizing hyperbranched polyisocyanate, then reacting with glycidyl to obtain hyperbranched polyurethane-epoxy resin, and finally performing ring-opening reaction with acrylic acid or methacrylic acid to obtain the photocurable hyperbranched polyurethane-epoxy acrylate. And the photocurable hyperbranched polyurethane-epoxy acrylate is obtained. The method is simple and easy to implement and high in feasibility, the prepared photocurable hyperbranched polyurethane-epoxy acrylate is high in curing speed, and a cured film is high in hardness, good in flexibility and good in wear resistance.

The invention provides a 2-chloro-3,3,3-trifluoropropylene preparation method. 2-chloro-3,3,3-trifluoropropylene is prepared through reacting halogenated cyclopropane which is a raw material and has a formula of C3HClXmYn with HF under the action of a fluorination catalyst, X and Y in the C3HClXmYn are independently selected from F, Cl, Br and I, m and n are integers in a range of 0-4, and the m+n value is 4. The method has the advantages of novel synthetic route, easily available raw material, high selectivity, high conversion rate and the like. The synthesized 2-chloro-3,3,3-trifluoropropylene can be used for preparing 2,3,3,3-tetrafluoropropylene.

The invention discloses eriocalyxin A and B and a preparation method thereof, and belongs to the technical field of organic synthesis of natural products and the technical field of medicines. The invention provides a novel pentacyclic enantiomer-kaurane diterpenoid compound (eriocalyxin A and eriocalyxin B) and a preparation method of the novel pentacyclic enantiomer-kaurane diterpenoid compound (eriocalyxin A and eriocalyxin B). The compound is synthesized for the first time, the synthesis route is novel, the synthesis method can provide an effective means for structure optimization based on oridonin, and the compound has important research value and application prospects.