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N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists

Inactive Publication Date: 2005-01-27
MERCK SHARP & DOHME CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases a

Problems solved by technology

Anti-inflammatory agents such as NSAIDs act principally by blocking the effect or secretion of these mediators but do nothing to modify the immunologic basis of the disease.
Though they are effective in delaying or suppressing transplant rejection, Cyclosporin A and FK-506 are known to cause several undesirable side effects including nephrotoxicity, neurotoxicity, and gastrointestinal discomfort.

Method used

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  • N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists
  • N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists
  • N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists

Examples

Experimental program
Comparison scheme
Effect test

example 1

N-((4-Decyloxy)benzyl)-3-aminopropylphosphonic acid

3-Aminopropylphosphonic acid (0.064 g, 0.457 mmol) and tetrabutylammonium hydroxide (1.0M in methanol, 0.46 mL, 0.46 mmol) in methanol (3 mL) were heated at 50° C. for 1 h to dissolve all solids. 4-(Decyloxy)benzaldehyde (0.100 g, 0.381 mmol) and sodium cyanoborohydride (0.025 g, 0.40 mmol) were added and stirring was continued for 1 h at 50° C. The reaction mixture was made acidic (pH˜5) by the addition of concentrated HCl then directly purified by LC-3 to give the title compound (0.055 g): 1H NMR (500 MHz , CD3OD) δ 7.39 (d, J=8.7 Hz, 2H), 6.98 (d, J=8.7 Hz, 2H), 4.12 (s, 2H), 3.99 (t, J=6.4 Hz, 2H), 3.12 (t, J=7.7 Hz, 2H), 2.0 (m, 2H), 1.64-1.84 (m, 4H), 1.47 (m, 2H1), 1.24-1.40 (m, 12H), 0.90 (t, J=6.9 Hz, 3H); MS m / e 386.4 (M+H).

examples 2-107

The following Examples (2-112) were prepared using a procedure analogous to that described in EXAMPLE 1 substituting A for 4-(decyloxy)benzaldehyde and B for 3-aminopropylphosphonic acid.

EXAMPLEABESI-MS2358.21H NMR (500 MHz, CD3OD) δ 7.35-7.41 (m, 2H), 6.94-7.01 (m, 2H), 4.08-4.13 (m,2H), 3.96-4.02 (m, 2H), 3.08-3.14 (m, 2H), 1.93-2.04 (m, 2H), 1.73-1.82 (m, 4H),1.43-1.51 (m, 2H), 1.26-1.41 (m, 8H), 0.87-0.94 (m, 3H).3372.21H NMR (500 MHz, CD3OD) δ 7.38 (d, 2H), 6.98 (d, 2H), 4.86 (s, 19H), 4.12 (s,2H), 3.98 (t, 2H), 3.12 (t, 2H), 1.94-2.04 (m, 2H), 1.72-1.84 (m, 4H), 1.42-1.52 (m,2H), 1.24-1.41 (m, 8H), 0.90 (t, 3H).4400.21H NMR (500 MHz, CD3OD) δ 7.36-7.40 (m, 2H), 6.95-7.01 (m, 2H), 4.12 (s, 2H),3.95-4.02 (m, 2H), 3.09-3.15 (m, 2H), 1.94-2.04 (m, 2H), 1.72-1.84 (m, 4H), 1.42-1.52(m, 2H), 1.24-1.42 (m, 8H), 0.87-0.94 (m, 3H).5336.21H NMR (500 MHz, CD3OD) δ 7.33-7.44 (m, 5H), 7.27-7.33 (m, 2H), 7.03-7.09 (m,2H), 5.11 (s, 2H), 4.11 (s, 2H), 3.07-3.15 (m, 2H), 1.92-2.04 (m, 2H), 1...

example 108

(R / S)-3-(N-(4-Nonylbenzyl)amino-1-hydroxypropylphosphonic acid

Step A: (R / S)-Diethyl 3-benzyloxycarbonylamino-1-hydroxypropylphosphonate

To a solution of potassium bis(trimethylsilyl)amide (1.13g, 5.66 mmol) in tetrahydrofuran (10 mL) at 0° C. was added diethyl phosphite (0.73 g, 5.66 mmol). After 10 min, 3-(benzyloxycarbonylamino)propanal (0.78 g, 3.77 mmol) was added as a solution in tetrahydrofuran (5 mL). After 30 min, the reaction was quenched by the addition of 2N hydrochloric acid (25 mL) and extracted with ethyl acetate (50 mL). The organic layer was washed with sat'd sodium chloride (50 mL), dried over magnesium sulfate and concentrated in vacuo. Silica gel chromatography eluting with hexane / acetone (1:1) gave a colorless oil (0.36 g): ESI-MS 346.1 (M+H).

Step B: (R / S)-Diethyl 3-amino-1-hydroxypropylphosphonate

(R / S)-Diethyl 3-benzyloxycarbonylamino-1-hydroxypropylphosphonate (0.36 g, 1.04 mmol, from Step A) and palladium on carbon (10%, 0.10 g) were stirred together in m...

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Abstract

The present invention encompasses compounds of Formula (I) as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

Description

BACKGROUND OF THE INVENTION The present invention is related to compounds that are S1P1 / Edg1receptor agonists and thus have immunosuppressive activities by producing lymphocyte sequestration in secondary lymphoid tissues. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention. Immunosuppressive agents have been shown to be useful in a wide variety of autoimmune and chronic inflammatory diseases, including systemic lupus erythematosis, chronic rheumatoid arthritis, type I diabetes mellitus, inflammatory bowel disease, biliary cirrhosis, uveitis, multiple sclerosis and other disorders such as Crohn's disease, ulcerative colitis, bullous pemphigoid, sarcoidosis, psoriasis, autoimmune myositis, Wegener's granulomatosis, ichthyosis, Graves ophthalmopathy, atopic dermatitis and asthma. They have also proved useful as part of chemotherapeutic regimens for the treatment of cancers, lymphomas and leukemias. Although t...

Claims

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Application Information

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IPC IPC(8): A61K31/197A61K31/41A61K31/4245A61K31/662A61P1/04A61P1/18A61P3/10A61P11/06A61P17/06A61P21/00A61P27/02A61P29/00A61P35/00A61P35/02A61P37/02A61P37/06C07C229/10C07C229/14C07C229/20C07C229/22C07D257/04C07D333/16C07D413/04C07F9/30C07F9/38C07F9/48C07F9/59C07F9/6553C07F9/6558
CPCC07C229/14C07C229/20C07C229/22C07D333/16C07D413/04C07F9/65586C07F9/307C07F9/3808C07F9/4816C07F9/591C07F9/655345C07F9/301C07F9/59A61P1/04A61P1/18A61P11/06A61P17/06A61P21/00A61P27/02A61P29/00A61P35/00A61P35/02A61P37/02A61P37/06A61P3/10
Inventor DOHERTY, GEORGE A.LI, ZHENHALE, JEFFREY J.MILLS, SANDER G.
Owner MERCK SHARP & DOHME CORP
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