93 results about "Urine glucose" patented technology

Provided is a novel C-phenyl glycitol compound that may serve as a prophylactic or therapeutic agent for diabetes by inhibiting both SGLT1 activity and SGLT2 activity, thereby exhibiting a glucose absorption suppression action and a urine glucose excretion action. A C-phenyl glycitol compound represented by a formula (I) below (as figure 1) or a pharmaceutically acceptable salt thereof or a hydrate thereof wherein R1 and R2 are the same or different and represent a hydrogen atom, a hydroxyl group, a C1-6 alkyl group, a C1-6 alkoxy group or a halogen atom, R3 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or a halogen atom, Y is a C1-6 alkylene group, -O-(CH2)n- (n is an integer of 1 to 4) or a C2-6 alkenylene group, provided that when Z is NHC(= NH)NH2 or -NHCON(R)RC, n is not 1, Z is -CONHRA, -NHC(=NH)NH2 or -NHCON(R)RC, (as figure 2).

The invention provides a glucose detection method. The glucose detection method comprises the following steps: (1) preparing: preparing an in-vitro biological synthetic system; (2) adding: adding a sample into the synthetic system in step (1); (3) synthesizing: starting the in-vitro biological synthetic reaction of a target object; (4) detecting: detecting a signal intensity of the synthesized target object in the synthetic system; and (5) calculating: calculating a glucose concentration or content of a to-be-detected sample according to a signal intensity-glucose concentration relation curve.The invention also provides a glucose detection kit adopting the detection method stated in a first aspect and an application of the glucose detection kit in detecting blood glucose and urine glucose. Compared with a glucose oxidase electrode method in the prior art, the glucose detection method has the advantages of high specificity, high sensitivity, less external interference, ease in high-flux and big data measurement and the like.

A C-phenyl 1-thioglucitol compound represented by the formula (I), a pharmaceutically acceptable salt thereof, or a hydrate of the compound or the pharmaceutically acceptable salt. (I) wherein X represents a hydrogen atom or a C1-6 alkyl group; Y represents a C1-6 alkylene group or -O-(CH2)n- (n represents an integer ranging from 1 to 5); and Z represents -CONHR or -NHCONHR (provided that, when Z represents -NHCONHR, n is not 1), where R represents a C1-6 alkyl group substituted by 1 to 3 groups independently selected from a hydroxyl group and -CONH2; and R represents a hydrogen atom or a C1-6 alkyl group substituted by 1 to 3 groups independently selected from a hydroxyl group and -CONH2. The compound, the salt or the solvate can inhibit the SGLT1 activity to prevent the absorption of glucose or the like, or can inhibit both the SGLT1 activity and the SGLT2 activity to prevent the absorption of glucose or the like and excrete a urine sugar, and is therefore useful as a prophylactic or therapeutic agent for diabetes.

The invention provides a photon crystal gel material for detecting glucose, which comprises polyacrylamide-acrylic acid gel and a photon crystal embedded in the gel, wherein the gel is directly or indirectly chemically grafted with phenylboronic acid groups, and the photon crystal is two-dimensional photon crystal or three-dimensional photon crystal. The invention also provides a glucose detection method based on the photon crystal gel material, and the color information displayed after the photon crystal gel material detects a glucose solution is converted into glucose concentration information. The glucose detection method provided by the invention can qualitatively or quantitatively detect glucose concentration with high selectivity, sensitivity, convenience and visualization, and provide a novel non-invasive detection method for urine glucose monitoring of diabetics.

The invention aims to provide a urine glucose testing method through which the urea conductivity is tested at high precision and high reliability and full and accurate correction can be performed as well as a biosensor used in the method. The biosensor is easy in manufacturing process, low in cost and convenient to use. The method comprises the following steps: a, performing oxidation reduction on glucose in urea in the presence of an amboceptor by utilizing an oxidation-reduction enzyme; b, detecting the generated oxidation current or reduction current at the moment through an electrode system, and calculating the glucose concentration based on the current value; and c, testing the conductivity in the urea, and correcting the glucose concentration in the urea by utilizing the conductivity. The biosensor comprises an insulating substrate, an electrode system positioned on the insulating substrate, an electric insulating layer and a reaction layer which is positioned in an electrochemical electrode reaction region.

The invention relates to a functional food and particularly relates to a composition capable of reducing blood glucose. The composition capable of reducing blood glucose comprises 95-98 parts of water-soluble dietary fibers (resistance dextrin), 1.5-3 parts of L-arabinose and 0.5-2 parts of jade plant powder. Compared with the prior art, the composition has the advantages that the water-soluble dietary fibers (resistance dextrin) can relieve or eliminate the sense of hunger for diabetics, can improve the physical energy and is significant in blood glucose and urine glucose reduction effect, simultaneously, the L-arabinose and the jade plant powder in the composition are also significant in blood glucose reduction effect, the blood glucose can be reduced further, the postprandial blood glucose rising can be restrained significantly after the composition is taken, and the composition can achieve a unique prophylaxis and treatment effect for complications caused by diabetes mellitus.

The invention belongs to the field of urine analysis and detection, relates to urine glucose test paper capable of resisting ascorbic acid interference and a preparation method thereof and solves thetechnical problem of existence of ascorbic acid interference in the detection of urine glucose in an existing dry chemistry test paper. The urine glucose test paper capable of resisting ascorbic acidinterference is formed by a substrate and filter paper fixedly arranged on the substrate. The test paper is obtained by being immersed into immersion liquid consisting of a buffer solution, glucose oxidase, peroxidase, potassium iodide, ascorbic acid oxidase, anti-interference substance xanthan gum, a surfactant, an enzyme stabilizer and a blue dye substance, so that anti-VC interference capability of the glucose test paper with potassium iodide as the substrate can be significantly improved, and sensitivity and accuracy of the detection result are enhanced; and the glucose detection result isnot influenced when the content of the VC in the sample does not exceed 3.5mmol/L. The preparation method of the urine glucose test paper capable of resisting ascorbic acid interference is simple andeasy to operate, stable in performance and accurate in test result.

The invention discloses a urine glucose detection device for an endocrinology department as well as an application method. The urine glucose detection device comprises a rectangular box, a water tankand a water pump are respectively fixedly arranged on the inner wall of the bottom of the rectangular box, a liquid inlet of the water pump is connected with a water inlet pipe by virtue of a screw thread, one end of the water inlet pipe penetrates the water tank and extends into the water tank, and a liquid outlet of the water pump is connected with a water outlet pipe by virtue of a screw thread. The urine glucose detection device disclosed by the invention is simple in structure, urine glucose test paper is firmly clamped on a detection kit, urine is poured into the detection kit, if the urine glucose test paper is not obviously changed, a valve is opened, the urine can flow into a transparent box, and a piston rod of an injector is pushed to inject a fixed quantity of chemical materials into the transparent box, so that prediction can be performed firstly by using the urine glucose test paper, then glucose content in the urine is accurately detected by virtue of chemical reagents,and waste of plenty of medicines is avoided; and the water pump can clean the detection kit and the transparent box, a detection result the next time is prevented from being influenced, and use convenience is realized.

The invention discloses powders, a decoction, and pills used for treating diabetes mellitus. Through syndrome differentiation, licorice root, gypsum, skunk bugbane rhizome, lobed kudzuvine root, and snakegourd root are adopted in a powder; common jujube, licorice root, ginseng, cochinchinese asparagus root tuber, creeping liriope, ternate pinellia are adopted in a powder; rhubarb, ligusticum, incised notopterygium rhizome and root, Chinese ephedra herb, cochinchinese asparagus root tuber, and peach seed are adopted in the pills; and licorice root, largehead atractylodes rhizome, dried ginger, ginseng, snakegourd root, and prepared rehmannia rhizome are adopted in the decoction. Therefore, diabetes mellitus can be cured or relieved, and urine glucose can be reduced.

The invention discloses an all-in-one machine with double-lifting caring handrails and seat of a toilet and urine glucose detection data uploading through a network. According to the machine, fast lifting is conducted which satisfies a user who has difficulty in crouching and sitting, operation is simple, and the machine is practical. The technical scheme is characterized in that the all-in-one machine with double-lifting caring handrails and seat of the toilet and urine glucose detection data uploading through the network comprises a toilet body, a support, a holding plate bracket and the handrails, the support is vertically arranged on the back side of the toilet body in an inverted-U shape, sliding rails are vertically arranged correspondingly on both sides of the support respectively, a feces flushing box is arranged between the sliding rails, two sliding blocks are correspondingly arranged on both sides of the feces flushing box in a matched mode respectively, a driving device is arranged on the bottoms of the sliding blocks and used for driving the sliding blocks to vertically move back and forth along the sliding rails, the holding plate bracket and the handrails are transversely and fixedly arranged on the sliding blocks, the two handrails are located above the holding plate bracket and matched with the holding plate bracket to form a seat-type structure, and the holding plate bracket and the handrails are provided with antibacterial coatings. The machine is widely applied to the field of safe use of toilets.

The invention relates to a three-dimensional inverse opal polymer photonic crystal material and a preparation method and application thereof, and belongs to the technical field of chemical and clinical analysis detection of glucose. According to the three-dimensional inverse opal polymer photonic crystal material, a polymer of an inverse opal structure is mainly prepared through a polymerization reaction of a functional polymerization monomer and a crosslinking agent, and the functional polymerization monomer is 3-acrylamidophenylboronic acid. The three-dimensional inverse opal photonic crystal material has good optical performance, and the material is a photonic crystal gel material which generates reversible change with external stimulation, has excellent expansion and recovery properties, and has fast response; and the content of glucose can be detected with high selectivity sensitively and quickly in real time, and the three-dimensional inverse opal polymer photonic crystal material is especially suitable for convenient detection of the level of human urine sugar, and excellent recyclability is achieved.

The present invention provides a urine test device incorporating a urinary catheter attachment device. This urine test device may be used in an ER environment or the like to simultaneously test a catheterized (or uncatheterized) patient for pregnancy, alcohol, a variety of illicit and legal drugs, blood in the urine, urine glucose, disease, point of care concerns, and/or the like. The urine test device is selectively attached to a patient's urinary catheter (or the associated urinary bag or tubing) to conveniently extract a urine sample for testing on site. Alternatively, a urine sample can be introduced into the urine test device via a more conventional approach, such as voluntarily by the patient, or by syringe by a medical professional. Appropriate attachments are provided for these purposes.

The invention provides hydrogel and application of an ampholytic hydrogel shaped body prepared from the hydrogel in medicine for detecting glucose content in urine. The ampholytic hydrogel shaped body comprises a monomer with telescopic performance and a monometer having response with glucose, a surface active agent and magnetic-induction particles are wrapped in copolymer of the two monomers, a moving route of the ampholytic hydrogel shaped body can be controlled by a magnetic field, and the moving distance and the glucose concentration of ampholytic hydrogel in the same period are calculated and analyzed to obtain a curve chart. The ampholytic hydrogel shaped body has the advantages of being low in detection limit in urine glucose detection and capable of visually and accurately detecting the glucose concentration in the urine.

The invention relates to the technical field of medical equipment, and discloses a urine glucose sugar detection device for nurses in the endocrinology department; the urine glucose sugar detection device comprises a clamping mechanism; the clamping mechanism comprises an outer cylinder; the bottom of the outer cylinder is in limited connection with a sleeving shaft, the top end of the sleeving shaft is fixedly connected with an inner cylinder, the bottom end of the inner cylinder is elastically connected with a first spring, and an insert slot is formed in the inner cylinder. According to the urine glucose sugar detection device for the nurses in the endocrinology department, a urine test tube is grabbed and inserted into the insert slot, the inner cylinder drives a rack section to move downwards, a first gear is matched for transmission, a wedge-shaped rotating block rotates oppositely to approach the test tube, and based on the elasticity difference of second springs on the upper side and the lower side of the wedge-shaped rotating block, the top of a clamping block presses the outer wall of the test tube with increased force, and friction between the clamping block and the outer wall of the test tube is increased; and an eccentric wheel rotates to jack up, a stirring block enables a test paper belt to move up and down to be mixed with urine, the stirring block is lifted up to be separated from the test tube after wetting is finished, and the effect that the test paper is moved and wetted at any time in the rotating and shaking-up process is achieved.

The invention discloses a diabetes rapid detection device for an endocrinology department. The diabetes rapid detection device for the endocrinology department comprises a shell body, wherein a urineanalyzer and a water suction pump are sequentially arranged at the bottom of an inner cavity of the shell body; and a liquid outlet at the bottom of the side face of the urine analyzer is connected with a liquid inlet of the water suction pump through a connecting pipe, and a urine inlet of the side face of the urine analyzer is connected to one end of a urine inlet pipe. According to the diabetesrapid detection device for the endocrinology department, pathogenetic conditions of patients can be subjected to multiple kinds of detection from aspects such as the acetone concentration content, and the concentration of blood glucose and urine glucose comprehensively, rapidly and conveniently, and data of multiple times of detection can be subjected to comparative analysis; and an acetone detecting instrument can detect the acetone concentration content in exhaled air of the patients rapidly, the blood glucose of the patients can be detected by a blood glucose detecting instrument, the urine glucose of the patients can be detected by a urine glucose detecting instrument, and the detected data can be visually seen through a display screen of a PLC.

The invention relates to an antidiabetic traditional Chinese medicine preparation. The antidiabetic traditional Chinese medicine preparation is mainly prepared from the following raw medicines in parts by weight: 10 to 15 parts of dandelion, 5 to 10 parts of radix saposhnikoviae, 5 to 15 parts of salvia miltiorrhiza, 3 to 10 parts of safflower carthamus, 9 to 20 parts of myrrh. 10 to 15 parts of cassia twig, 4 to 10 parts of radices lithospermi, 5 to 9 parts of peach kernel, 4 to 9 parts of cowherb seed, 10 to 20 parts of lodestone, 10 to 15 parts of jujube kernel, 3 to 5 parts of juncus roemerianus, 10 to 15 parts of cape jasmine fruit, 2 to 5 parts of buthus martensi kirsch, 10 to 20 parts of jumble beads, 10 to 20 parts of pearl barley, 6 to 9 parts of poria cocos, 10 to 20 parts of lotus seed, and 20 to 30 parts of lily. According to the formula, all raw medicines of the antidiabetic traditional Chinese medicine preparation are coordinated to realize the effects of tonifying Qi and eliminating evil, nourishing liver and kidney, and promoting blood circulation to remove meridian obstruction; the functions of nourishing Yin, tonifying spleen, benefiting Qi and promoting blood circulation are ingeniously combined to enable blood glucose and urine glucose to be stably kept within a normal range for a long term, and the effective rate is up to 97.1%.

The diabetes treating medicine prepared with over ten kinds of Chinese medicinal materials, including trichosanthes root, pseudostellaria root, Chinese yam, dogwood, wolfberry fruit, etc. can be prepared to medicine powder, capsule or pills. It can reduce blood sugar and urine glucose of diabetics and prevent complication, and has no side effect.

The invention discloses a composition for curing II-type diabetes mellitus, comprising the following components in parts by weight (in dry weight): 3-6 parts of balsam pear or roots and stems of the balsam pear, 3-6 parts of animal pancreas, 3-6 parts of lotus root starch, 10-20 parts of pumpkin powder and 3-5 parts of ginseng. The invention also discloses a preparation method of the composition. The composition makes the pancreas functions of patients return to normal by adopting the combination of pure plants and animal pancreas with a scientific and standard application method to fundamentally cure the II-type diabetes mellitus. The fasting blood-glucose values of the patients can be reduced to the normal level in general after the composition is taken 5-10 months, fasting urine glucose is in light blue, which is a negative and no-urine glucose standard, and no recidivation condition exists after drug withdrawal. The preparation method of the composition has the advantages of simple operation and easy enforcement.

This is a biochemistry detection liquid of urine glucose comprising 9.8-17.3w/v percents citric acid trisodium (sodium citrate) 5.3-100w/v percents anhydrous sodium carbonate, 1.3-1.73w/v percents blue copperas and distilled water. This invention offers biochemistry detection liquid and self-checking method of urine glucose for the mass scoutting and checking dynamically. Through the recording curve diagram in accordance with series detecting color result one can self-judge something: 1, warning signal of health and pathogenic factor; 2. forepart detectable rate of diabetes mellitus; 3, the synchronous tracking monitoring of curative effect during the treating course. The above liquid offers the likelihood of carrying out all this function.

The invention discloses a treatment formula for diabetes and complications thereof. The treatment formula consists of the following components in parts by mass: 8-12 parts of sun-dried ginseng, 8-12 parts of raw milkvetch root, 8-12 parts of raw Chinese yam, 8-12 parts of dwarf lilyturf tuber, 12-18 parts of common anemarrhena rhizome, 14-20 parts of pollen, 4-8 parts of kudzuvine root, 16-22 parts of Chinese magnoliavine fruit, 14-20 parts of chicken's gizzard-membrane, 6-12 parts of danshen root, 10-14 parts of Chinese angelica and 16-20 parts of earthworm. The treatment formula disclosed by the invention abides by a formula principle of 'monarch, minister, assistant and guide' of traditional Chinese medicine, and all the components are medicines recorded by the Chinese Pharmacopeia and are compatible to achieve the effects of supplementing qi, nourishing yin and invigorating spleen and kidney, so that the formula is particularly suitable for diabetics, can achieve the effects of clearing heat, promoting fluid production and reducing blood sugar, and after being taken, the blood sugar and urine glucose are effectively controlled, the functions of energy, physical power and the like are recovered very satisfactorily, the glycated serum protein is obviously reduced, and the formula can be used for preventing and treating kidney, heart and blood vessel complications caused by diabetes effectively.

A squatting pan capable of monitoring urine glucose comprises a water tank, a water supply pipe and a urinal, wherein the water supply pipe between the water tank and the urinal is communicated with aurinary, a urinal hole is formed in one side of the urinary, a baffle is slidably arranged on the urinal hole, and the urinal hole is opened and closed by the baffle; the other side of the urinary isprovided with a urine detection device, and one end of the urine detection device extends into the urinary freely. The squatting pan capable of monitoring the urine glucose can be used for people tomonitor the urine glucose condition at home by themselves.

The present invention relates to a C-aryl glucoside derivative of Formula (I) below, a preparation method therefor and a use thereof, wherein X, R¹, R², R³, R⁴, m and n are as defined in specification. The derivative of the present invention is a sodium-glucose co-transporter 2 (SGLT-2) inhibitor associated with glucose reabsorption of bowel or kidney, and has a good urine glucose excreting effect, thus being useful as a therapeutic agent for treating diabetes and related diseases.