62 results about "Dihydrogen Peroxide" patented technology

A multifunctional membrane is provided. The multifunctional membrane is suitable for use in an analyte sensor. In a particular application, the multifunctional membrane may be used in connection with an amperometric biosensor, such as a transcutaneous amperometric biosensor. Some functions of the membrane are associated with properties of membrane itself, which is comprised of crosslinked polymers containing heterocyclic nitrogen groups. For example, the membrane, by virtue of its polymeric composition, may regulate the flux of an analyte to a sensor. Such regulation generally improves the kinetic performance of the sensor over a broad range of analyte concentration. Other functions of the membrane are associated with functional components, such as a superoxide-dismutating/catalase catalyst, either in the form of an enzyme or an enzyme mimic, that can be bound to the scaffold provided by the membrane. The effect of any such enzyme or enzyme mimic is to lower the concentration of a metabolite, such as superoxide and/or hydrogen peroxide, in the immediate vicinity of the sensing layer of the biosensor. Lowering the concentrations of such metabolites, which are generally deleterious to the function of the sensor, generally protects or enhances biosensor integrity and performance. The membrane is thus an important tool for use in connection with analyte sensors, amperometric sensors, biosensors, and particularly, transcutaneous biosensors. A membrane-covered sensor and a method for making same are also provided.

A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.

The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.

The invention relates to a sludge dewatering agent which is formed by a filter aid, a flocculant and a superoxide, the specific resistance of sludge can be effectively reduced, the sludge dewatering agent can be taken as an accessory for further aerobic composting treatment of the dewatered sludge, the accessory consumption of the composting stage is reduced, the turning times can be reduced due to high porosity, the composting power consumption is reduced, and the sludge dewatering agent has multiple purposes; substances of lime and the like which influence follow-up resource utilization are not contained; ferric chloride is not contained, corrosion to the steel structure is not produced, the colloid structure of the sludge is changed by the superoxide, and the addition of the filter aid is reduced greatly. The invention further relates to a use method of the sludge dewatering agent, the method comprises the following steps that firstly thickened sludge is heated to 40 DEG C to 50 DEG C, then the superoxide is added, the flocculant and the filter aid are added, the treated sludge is subjected to mechanical filter pressing, and the moisture content is reduced to 70% or below.

The invention provides a method for extracting and removing a sulfur compound in crude oil. The method for extracting and desulfurating comprises the following steps that (1) liquid or solid superoxide serves as an oxidizing agent to conduct pre-oxidation treatment on the sulfur compound in crude oil; (2) an eutectic solvent serves as an extraction agent to extract sulfide from the pre-oxidized crude oil obtained in the step (1), and a raffinate oil phase on the upper layer, an extract phase on the middle layer and a solid oxidizing agent phase on the bottom layer are obtained after centrifugalization is conducted; (3) crude oil with the content of sulfide being low is obtained after the raffinate oil phase in the step (2) is separated; and (4) the sulfide in the extract phase in the step(2) is removed after the extraction phase is dissolved by adding water and is filtered, and the regenerated eutectic solvent is obtained after distillation and dehydration are conducted. According tothe method, on the basis that the polarity of the sulfur compound in the crude oil is improved by assistance of oxidation, the eutectic solvent serves as the extraction agent to conduct liquid-liquidextraction and removal on the sulfur compound in the crude oil, operation is easy and convenient, the condition is mild, the desulfurization degree is high, and the content of sulfide in the crude oilcan be effectively lowered.

The invention relates to preparation of a superoxide anion sensor based on a noble metal alloy/carbon composite material. The preparation specifically comprises the steps of loading the noble metal alloy material on the surface of a carbon material serving as a carrier through a chemical reaction so as to form a noble metal alloy/carbon material compound with high catalysis performance; and modifying the noble metal alloy/carbon material compound on the surface of an electrode to form an electrochemical interface with high biocompatibility, and then fixing superoxide dismutase on the surface of the electrode, thus obtaining the superoxide anion sensor. According to the preparation, the noble metal alloy is loaded on the carbon material, and then the SOD (superoxide dismutase) is fixed; the carbon material supplies a friendly fixing environment to superoxide dismutase; due to the noble metal alloy, the catalysis performance of the sensor is improved, and electronic transmission between superoxide dismutase and the electrode is improved; the constructed biosensor has the characteristics of wide linear range, high sensitivity, short response time, high stability and high repetitiveness, and can accurately and conveniently perform qualitative and quantitative detection on O2<-1>.

This invention relates to compositions which enhance a mammal's immune response to a cytokine by administering therapeutic amounts of catalysts for the dismutation of superoxide which include superoxide dismutase enzyme (SOD) and small molecular weight organic ligand mimics of that enzyme (SOD mimetics or SODms), alone or in combination with a cytokine. These compositions may be used in methods for enhancing a mammal's immune response to a virus such as the hepatitis C virus or the human immunodeficiency virus (HIV) or to a tumor thereby inhibiting the proliferation of the tumor. Relatedly, these compositions may be used in methods of treating mammals infected with HIV or mammals suffering from Hepatitis C or AIDS. This invention also relates to methods of enhancing cancer therapy and methods of preventing and treating hypotension in a mammal resulting from the administration of cytokines by the administration of therapeutic amounts of catalysts for the dismutation of superoxide in combination with a cytokine and catecholamine pressor agents. Also provided are pharmaceutical compositions comprising catalysts for the dismutation of superoxide alone or in combination with cytokines and catecholamine pressor agents for use in the above methods.

A method of treating cancer through the application of a compound that causes the intra-mitochondrial generation of reactive oxygen species in tumor cells by a mechanism that is independent of the peripheral benzodiazepine receptor.

The invention discloses a method for fast screening a xanthine oxidase inhibitor or a superoxide anion scavenging agent by utilizing a coupling technique of thin-layer chromatography and bioautography. According to the method, the thin-layer chromatography is combined with biological activity assay, a superoxide anion free radical (O2<.->) generated by an enzymatic reaction reacts with nitroblue tetrazolium (NBT) to generate formazan which is a bluish violet insoluble substance, and substances capable of inhibiting xanthine oxidase or scavenging superoxide anion inhibit the reaction so yellow and/or white spots under a purple background show on a thin layer plate. The method is suitable for analyzing the in-vitro inhibition activity to the the xanthine oxidase or the scavenging activity to the superoxide anion of natural drugs and/or traditional Chinese medicine extracts or monomeric compounds.

The invention discloses a polymer injection block oil-water well production and injection increase technology. The technology comprises the steps of washing a well using clean water in large discharge capacity through an inverse well-flushing method, and flushing grit, dirt and polymers around a shaft and a blasthole out of the ground from a well bottom; connecting pipelines in a positive circulation mode, opening the gates of an oil tube and a casing, and putting a newly prepared blockage relieving agent at the bottom of the well until the upper bound of an oil layer; closing the gate of the casing, and squeezing the surplus blockage relieving agent into the oil tube; squeezing the clean water into the casing, and squeezing the blockage relieving agent in a tube column into a stratum; then closing the well for reaction for 48 hours; squeezing hydrochloric acid with the hydrogen chloride content of 12% and hydrofluoric acid with the hydrogen fluoride content of 2% into the casing in sequence after the well is opened; squeezing the clean water into the casing to push the blockage relieving agent to the far-end of the stratum and make the blockage relieving agent react with deep polymers; finally conducting normal production after a 48-hour closing-well reaction. The polymer injection block oil-water well production and injection increase technology effectively removes blocking stuffs of immediate vicinity of wellbore of the polymer injection block oil-water well, recovers the yield, greatly increases the treating radius of the blockage relieving agent, is safe and reliable, and avoids the safety loophole of producing oxygen, chlorine and the like by superoxide .

A reactive oxygen species measuring device according to the present invention comprises a reactive oxygen species sensor provided with an electrode assembly capable of detecting the presence of reactive oxygen species or the like in terms of an electric current, a power source means for applying a measuring voltage to the reactive oxygen species sensor, and a reactive oxygen species concentration measuring means for measuring a concentration of the reactive oxygen species or the like from the current detected by the reactive oxygen species sensor. According to the present invention, a concentration of reactive oxygen species or the like such as in vivo or in vitro superoxide anion radical (O₂⁻.) can be measured reliably, and the entire device can be formed in a smaller size and always mounted to a living body. In addition, the measured data can be transmitted to a remote place or location, and further, the health condition of a living body or the like determined in the remote place can be returned to a measuring place and informed, and thus, the health condition of the living body can be monitored by measuring and monitoring reactive oxygen species.

The invention belongs to the field of biotechnology, and particularly relates to adipose tissue cryopreservation liquid, a cryopreservation method and application of the adipose tissue cryopreservation liquid. The adipose tissue cryopreservation liquid is prepared from a DMEM culture medium, sucrose, propylene glycol, proline, tetrahydromethyl pyrimidine, dismutase superoxide, glutathione peroxidase, and tocopherol. No serum is added into the prepared cryopreservation liquid, pathogenic microorganism pollution and rejection reaction are avoided, no DMSO with strong toxicity is added, and thustoxic adipose tissue iss are prevented from being cultured. The cryopreservation liquid has a good cryopreservation effect on the adipose tissues, the adipose tissue iss are high in cell activity andlow in apoptosis rate, a preparation method is simple and easy to operate, and new ideas can be provided for research and development of the field.

The disinfectant containing chlorine dioxide component consists of: sodium chlorite 1-20 wt%, citric acid 70-98 wt%, and anhydrous calcium chloride 0-15 wt%. The disinfectant is safe and non-toxic and may be used widely in disinfection in agriculture, culture, medicine, environment and drinking water.

The invention provides a heat accumulation type waste liquid combustor, and belongs to the technical field of environment protection. The heat accumulation type waste liquid combustor comprises a shell, a waste liquid atomization nozzle, a combustion supporting nozzle, a heat accumulation gasification cover and an igniter used for igniting waste liquid. The heat accumulation gasification cover is arranged in the shell and prevents heat generated during combustion from diffusing, the waste liquid sprayed out of the atomization nozzle can be rapidly gasified at the high temperature, sufficient combustion of the waste liquid is promoted, and the waste liquid can be treated more thoroughly; and more superoxide cannot be generated even when high-temperature oxygen-excess combustion happens, more environment protection treatment cost is saved, and the environment is protected.

The device for diagnosing tissue injury of the invention has a catheter insertable into the body and a radical sensor provided in the catheter, and is characterized in that the radical sensor has a sensor electrode capable of measuring superoxide anion radicals provided at a tip end of the catheter, a lead wire connector for a sensor provided at a basal portion of the catheter, and a lead wire for a sensor for connecting the sensor electrode portion to the lead wire connector for a sensor. With the device, in vivo free radicals typified by superoxide anions in systemic organ or tissue injury caused by cerebral ischemia reperfusion injury, severe infection or sepsis can be promptly and quantitatively monitored, and whether the in vivo tissue conditions are good or not can be accurately diagnosed.

Multifonctional ACE inhibitor compounds are provided, that combine ACE-inhibiting activity with capability to scavenge superoxide and other reactive oxygen species, and that may further function as nitric oxide donors. The compounds are useful for preventing or treating various disorders, including cardiovascular, and diabetes associated disorders.

The present invention provides an in vitro method for quantifying exposure to psychological stress which relies on measuring the retained ability of neutrophils, preferably neutrophils in a whole blood sample, to exhibit challenge-induced superoxide anion production. Using such methodology, coping capacity of individuals for particular psychological stressors may be assessed.