29 results about "Anion radicals" patented technology

The invention discloses a method for preparing antioxidant active polypeptide based on tyrosinase modified collagen, silk fibroin and mussel protein, and belongs to the technical field of bioengineering. According to the invention, high-activity tyrosinase protein is screened and prepared, and the prepared tyrosinase is used for dopa modification of antioxidant protein. The dopa modification degree of the antioxidant protein prepared by the method disclosed by the invention is remarkably improved, and the DPPH free radical scavenging power and superoxide anion free radical scavenging power of the antioxidant protein are enhanced. The method is suitable for various proteins such as collagen, silk fibroin and mussel protein, can be used in the fields of functional food, cosmetics, biological materials and the like, and has good adaptability and wide application prospects.

The invention discloses a water-soluble stable anion free radical compound and a preparation method and application thereof, the anion free radical compound comprises an electron donor and an electron acceptor, the electron donor is an alkali metal compound, and anions of the alkali metal compound are halide ions; moreover, electrons of halide ions are delocalized from an electron donor to an electron acceptor to form an anion free radical compound. An electron donor and an electron acceptor form a charge transfer compound, and the charge transfer compound is self-assembled to form a stable anion free radical compound. The free radical compound takes alkali metal halide salt as an electron donor, on one hand, integer charge transfer between halogen anions and an electron acceptor can be met, and F4TCNQ.-anion free radicals are rapidly generated; on the other hand, coordination bonds with moderate strength are formed between alkali metal cations and F4TCNQ.-. Therefore, the composition has excellent water solubility and stability.

The invention discloses a preparation method of a photocatalytic silicon-containing 1.1-diaryl compound, which realizes that olefin simultaneously reacts with aromatic cyanide and a silicon-boron compound to generate a silicon arylation product of olefin in the presence of photocatalysis and alkali. And reducing the aromatic cyanogen compound through a photocatalyst to generate aromatic cyanogen anion free radicals and an oxidation state. Then the alkali-silicon-boron complex is subjected to photocatalytic oxidation in an oxidation state, catalytic regeneration and cation free radicals of the alkali-silicon-boron complex are achieved, then silicon-boron bonds in the cation free radicals of the alkali-silicon-boron complex are broken to generate silicon free radicals, and the silicon free radicals and olefin are subjected to addition to generate alkyl free radicals; and finally, coupling the generated alkyl free radical with the aromatic cyanide anion free radical to generate the target olefin silicon arylation product. According to the invention, the aryl group and the silicon free radical are introduced into olefin at the same time, and are used for post-modification application of natural products and drug derivatives, and the method has the value of developing functional compounds which can be used for industrial synthesis and contain silicon groups and aryl groups.

The present application belongs to the field of organic photo-functional materials and biomedical materials, and particularly relates to a phenanthraquinone-based covalent organic framework material, a nano-preparation containing the same, a preparation method thereof and biomedical applications. In the present application, a Schiff base condensation reaction is carried out between a bis(formylphenyl) monomer with a phenanthraquinone group or an aza-phenanthraquinone group and N,N,N',N'-tetra(p-aminophenyl)-p-phenylenediamine, and through reversible covalent connection of aldehyde groups and amino groups, the phenanthraquinone-based covalent organic framework material is prepared, and it is found that the phenanthraquinone-based covalent organic framework material can efficiently generate superoxide anion radicals under 808 nm near-infrared light irradiation, thereby destroying the intracellular redox homeostasis, selectively accelerating NADPH consumption, promoting excessive formation of disulfide bonds, and leading to induction of tumor cells to undergo disulfide death. The phenanthraquinone-based covalent organic framework material of the present application provides a new strategy for solving the problem of drug resistance in tumor treatment, and has a broad application prospect.

The present application belongs to the technical field of application of fungal polysaccharides, and particularly relates to a Boletus edulis fruiting body polysaccharide as well as a preparation method and application thereof. Polysaccharides in Boletus edulis fruiting bodies are extracted, and the chemical structure of BDP-F is characterized by ultraviolet-visible light, Fourier transform infrared spectroscopy, one-dimensional nuclear magnetic resonance and two-dimensional nuclear magnetic resonance. The research results show that BDP-F is mainly composed of mannose, glucose, galactose and fucose. Methylation and nuclear magnetic resonance analysis show that the glycosidic bond of BDP-F is (1→6)-alpha-d-galactose, the main chain is composed of ->6)-alpha-d-galp-(1→ residues, and the O-2 position is branched by alpha-L-Fucp-(1→ and alpha-D-Manp-(1→ residues. Through DPPH free radical, hydroxyl radical and superoxide anion radical scavenging experiments, it is shown that BDP-F has the ability to serve as a natural antioxidant, and BDP-F can also reduce alcohol-induced GES-1 cell damage through antioxidant and anti-inflammatory effects within the experimental concentration range.

The invention provides photocatalyst nanoparticles for air sterilization and a preparation method of the photocatalyst nanoparticles. The preparation method of the photocatalyst nano-particles for air sterilization comprises the steps of preparing nitrogen-doped titanium dioxide precursor sol, preparing nitrogen-doped titanium dioxide nano-particles, preparing a second mixed system and preparing Ag / Cu bimetallic loaded nitrogen-doped titanium dioxide nano-particles. According to the preparation method, the nitrogen doping amount, the calcining temperature and the heat preservation time are synergistically optimized, so that the obtained nitrogen-doped TiO2 nanoparticles have relatively high crystallinity and relatively large specific surface area while keeping stable existence of an anatase phase, thereby improving the separation efficiency of photo-induced electron-hole pairs and the number of surface active sites; under the irradiation of visible light, more hydroxyl free radicals, superoxide anion free radicals and peroxides can be generated, and bacteria, viruses and volatile organic compounds in the air can be efficiently oxidized, decomposed and inactivated. The invention also provides an air filtration nanofiber membrane.

The invention belongs to the technical field of nano-catalyst antibiosis, and particularly relates to a zinc-based nitrogen-doped carbon-loaded metal palladium nano-enzyme as well as a preparation method and application thereof. The ZnNC-loaded metal palladium nano-enzyme is prepared by adopting a deposition-precipitation method which is simple to operate, taking ZnNC as a carrier and taking metal palladium nano-particles as an active center. The nano-enzyme has excellent oxidase-like activity, can catalyze O2 to generate hydroxyl free radicals (. OH), singlet oxygen (< 1 > O2) and superoxide anion free radicals (O2 <->) so as to kill bacteria and achieve an antibacterial effect, and has a remarkable antibacterial effect on escherichia coli under an acidic condition.

This invention belongs to the field of fluorescent probe technology, specifically relating to a nitroreductase fluorescent probe, its preparation method, and its application. To develop an NTR fluorescent probe with high selectivity, high sensitivity, short response time, and long excitation and emission wavelengths, this invention utilizes pentamethine cyanine dye and a "ester group → carboxyl group" conversion strategy at the central site of this dye to develop a nitroreductase fluorescent probe, Cy5-NTR. In the presence of NADPH, the nitro group of the probe is first catalyzed by the overexpression of NTR by cancer cells, resulting in a single-electron transfer and the generation of a nitro anion radical. This radical is then further reduced to an amino group, followed by a 1,6-rearrangement and elimination reaction, releasing the strongly fluorescent centrally carboxyl-substituted pentamethine cyanine dye Cy5-COO. This probe can not only distinguish cancer cells / tissues from normal cells / tissues with high contrast under hypoxic conditions, but also provide in situ real-time imaging of tumors in tumor-bearing mice.

The present application provides a kind of fluorine boron compound, the fluorine boron compound contains anthraquinone group, can generate strong oxidizing anion radical after photoexcitation efficiently, thus has lower half inhibitory concentration, stronger inhibitory effect, has stronger phototoxicity, can kill cancer cells in shorter time;Meanwhile, the superoxide anion radical generated can specifically oxidize FADH2 coenzyme in mitochondrial electron transport chain, by oxidizing its isoalloxazine ring structure to cause coenzyme inactivation, then mitochondrial electron transport process, and inhibit cancer cell energy metabolism, so as to effectively inhibit the proliferation activity of cancer cells.

This invention belongs to the technical field of organometallic luminescent materials and photosensitizers, specifically relating to a triphenylamine-containing heteropolymer luminescent iridium(III) complex capable of generating reactive oxygen species, its preparation method, and its applications. The iridium(III) complex has the structure shown in formula (I), [Ir(L1)2(L2)]PF6, where L1 is 1-(4-(diphenylamino)phenyl)isoquinoline and L2 is 2-[3-methyl-1-(4-(diphenylamino)phenyl)-1H-1,2,4-triazol-5-yl]pyridine. The complex can be prepared by first preparing a chlorobridged iridium dimer intermediate, then coordinating it with an auxiliary ligand and followed by anion exchange. This complex exhibits luminescent properties in both dilute solutions and solid states, and displays certain solvent-dependent luminescence behavior. Under LED white light irradiation, the complex can effectively generate reactive oxygen species (ROS). Detection using DCFH-DA, HPF, and DHR123 probes indicates that it possesses the ability to generate total ROS, hydroxyl radicals, and superoxide anion radicals. The complex can be used to prepare luminescent materials, ROS-generating materials, and photodynamic photosensitive materials.

The invention belongs to the technical field of microbial fermentation, and particularly relates to saccharomycetes SY and application thereof in preparation of a codonopsis pilosula fermentation product which is high in in-vivo and in-vitro bioavailability and capable of improving gastrointestinal motility. The codonopsis pilosula fermented product is prepared by fermenting codonopsis pilosula with saccharomycetes SY. The content of lobetyolin in the pilose asiabell root leavening prepared by fermenting pilose asiabell root through the saccharomycetes SY is high, in-vitro digestion experiments prove that the removal rate of lobetyolin, total flavonoids and superoxide anion free radicals and the bioaccessibility of the total reducing capacity are remarkably improved, and rat experiments find that the pilose asiabell root leavening can promote gastrointestinal motility and improve the bioavailability of the pilose asiabell root. Intestinal mucosa regeneration and barrier repair are promoted; the content of effective components such as luteolin 7-glucosid-3 '-xyloside capable of enhancing immune cell activity, regulating inflammatory factor balance, protecting cells from oxidative stress injury and improving gastrointestinal digestion and absorption functions and energy metabolism in serum is increased, and absorption of the effective components in blood is promoted.

The application discloses a hybrid synergistic electrochemiluminescence quencher, a preparation method and application thereof. Dopamine, zinc ions and 2-methyl imidazole are used as raw materials to synthesize polydopamine and a hybrid material of a zeolitic imidazolate framework by one-pot synthesis under alkaline conditions. The introduction of the electropositive zeolitic imidazolate framework can greatly eliminate the strong electronegativity of the polydopamine and simultaneously endow the quencher with good porosity. The quencher prepared by the application is nanospheres, has a large specific surface area and weak electronegativity, and exhibits good scavenging capacity for free radicals, especially electrogenerated anionic radicals, and has a high quenching efficiency on electrochemiluminescence. After the quencher is labeled with an antibody, the quencher is used for constructing an electrochemiluminescence immunosensor for ochratoxin A. The electrochemiluminescence immunosensor prepared by the application has a wide detection range, a low detection limit and good stability in the detection of ochratoxin A, and has a wide application prospect in the fields of electrochemiluminescence technology and the like.

The application provides an antioxidant and anti-aging composition, a preparation and application thereof. The composition is formed by reasonable compounding of NADH, sheep placenta polypeptide, ginseng polysaccharide, oligopeptide and coenzyme Q10. In the scheme, the bioavailability of NADH is significantly increased by compounding NADH with sheep placenta polypeptide, ginseng polysaccharide, oligopeptide and coenzyme Q10, and the compounding combination can significantly play a synergistic effect. The superoxide anion radical clearance rate can reach 98%, the ABTS radical clearance rate can reach 98%, the DPPH radical clearance rate can reach 96%, and the free radical clearance effect is significantly improved. The composition of the application realizes the synergistic effect of each component in the aspects of antioxidant and anti-aging, effectively improves the bioavailability of the antioxidant active component, the raw materials are reasonably matched, there is no side effect, and the composition is suitable for internal and external use, and has good application value in the development of antioxidant and anti-aging medical, health care and cosmetic products.

The present application discloses a two-dimensional paramagnetic conductive metal-organic framework material enhanced by anionic free radicals, its preparation method and application, and relates to the technical field of paramagnetic conductive materials. The preparation method comprises: dissolving nickel nitrate hexahydrate in a dispersion 1 of degassed dimethyl sulfoxide containing ammonia water and mixing hexaminobenzene hydrochloride in a dispersion 2 of degassed dimethyl sulfoxide and heating the mixture to obtain a two-dimensional metal-organic framework with semiconductor characteristics, and dispersing the mixture in an N, N-dimethylformamide solution containing tetrachlorobenzoquinone for reaction to obtain a two-dimensional paramagnetic conductive metal-organic framework material enhanced by anionic free radicals. In the present application, it was observed that the distance between Ni1-Ni4 in each pore of Ni3(HIB)2 was 1.35nm, and the distance between Cl1-Cl3 where tetrachlorobenzoquinone was in the para position was 0.61nm, which indicates that the pores of Ni3(HIB)2 can better accommodate tetrachlorobenzoquinone guests to form Ni3(HIB)2-CHL charge transfer complexes. By accommodating tetrachlorobenzoquinone in the pores of Ni3(HIB)2, conductivity and paramagnetism can be adjusted.

The invention discloses a near-infrared light response nano heterojunction with antibacterial and anti-inflammatory functions and a preparation method of the nano heterojunction. The nano heterojunction takes Prussian blue nanoparticles as a core, and a manganese phthalocyanine shell layer is polymerized on the surface to obtain the Prussian blue poly-manganese phthalocyanine. The nanometer heterojunction obtained by the invention has excellent singlet oxygen generation capability and photothermal effect under the irradiation of 808nm near-infrared light, so that bacteria can be effectively killed; under the condition of stopping near-infrared light irradiation, the nano heterojunction has excellent active oxygen scavenging capacity, can effectively scavenge hydrogen peroxide, superoxide anion free radicals and hydroxyl free radicals, and shows a good anti-inflammatory effect. The preparation method is simple, the material source is wide, and the obtained near-infrared light response nano heterojunction with the antibacterial and anti-inflammatory functions shows excellent stability and biocompatibility and has a good application prospect.

The application relates to an earth magnetic field sewage treatment equipment and a water body treatment method thereof, the water body treatment method comprising the following steps: immersing the box into water and electrifying, the electron of H atom in water molecules is subjected to transition, the water molecules are ionized and decomposed, atomic H and atomic O are generated; a functional film layer made of low-dimensional carbon nanomaterials absorbs ultraviolet energy in sunlight, when the ultraviolet energy is greater than the forbidden band width of the functional film layer, intrinsic excitation is generated, an electron-hole pair is generated, the electron and the hole both enter water, and a photochemical reaction occurs to generate superoxide anion radical O2-, hydroxyl radical.OH, monatomic H and monatomic O; the water body is purified through the superoxide anion radical O2-, the hydroxyl radical.OH, the monatomic H and the monatomic O. Different pollutions can be effectively removed to cope with different pollution conditions.

The invention belongs to the technical field of microbial fermentation, and particularly relates to a microbial preparation and application of the microbial preparation in preparation of an astragalus mongholicus fermented product with the effects of reducing blood sugar and blood fat and high bioaccessibility. The microbial preparation is prepared from lactobacillus mucus fermentation FJ701 and leuconostoc mesenteroides XD054. The preparation method comprises the following steps: performing enzymolysis on astragalus membranaceus, inoculating a microbial preparation and fermenting to obtain an astragalus membranaceus fermented product; the Astragalus mongholicus fermented product has high content of total polyphenol, total saponin and polysaccharide, and can inhibit pancreatic lipase activity and alpha-glucosidase activity, and in vitro digestion tests find that the scavenging rates of formononin, total polyphenol, total saponin and superoxide anion free radicals are high in bioaccessibility; rat experiments find that the concentration of calycosin-7-glucoside in blood in the astragalus membranaceus fermentation product is high, various active ingredients such as syringin 3-robiniobioside in serum are increased, and the anti-inflammatory and antioxidant capacities are improved.

The application discloses a method for preparing a deuterated compound through a boron-type reduction reaction under a transition metal-free condition and the deuterated compound obtained through the method. The method comprises the following steps: under the protection of an inert atmosphere and under normal temperature and pressure, de-aromatic deuterization is performed on (hetero)arene through an electro-optical catalysis method in the presence of a deuterated reagent, so that the deuterated compound is obtained. The method directly reduces an organic photocatalyst which is independent of a transition metal into a corresponding anion radical through an electro-optical catalysis synthesis technology, and the anion radical has strong reduction capacity after being excited by light, so that boron-type reduction deuterization of inert (hetero)arene is realized. The method is more moderate, has fewer side reactions, and has high yield of a target product.

The invention relates to the technical field of water treatment, in particular to a method for removing organic pollutants in wastewater by using a micromolecular organic carboxylic acid and / or a salt enhanced oxidation system thereof. O-O bonds in persulfate ions (S2O8 < 2->) are broken under the irradiation of ultraviolet light to form sulfate free radicals, and TiO2 can generate electrons and holes under the irradiation of ultraviolet light, so that hydroxyl free radicals are generated through excitation. In a UV / PDS and UV / TiO2 system, sulfate free radicals and hydroxyl free radicals further react with carboxylate radicals generated by micromolecular organic carboxylic acid and / or salts thereof to generate carbon dioxide anion free radicals, and the carbon dioxide anion free radicals have strong reducibility and show very strong reaction activity on refractory pollutants with relatively high ionization potential; the catalyst is easy to react with an organic compound rich in electrons, and finally efficient removal of nondegradable organic pollutants such as nitrobenzene, carbamazepine, metronidazole and tetracycline is achieved.

The invention provides a superoxide anion free radical activated indometacin-transretinoic acid prodrug, a preparation method of an albumin compound of the superoxide anion free radical activated indometacin-transretinoic acid prodrug and application of a composition prepared from the compound and an antitumor drug. The prodrug compound and an anti-tumor drug are prepared into the composition, the prodrug is activated by superoxide anion free radicals overexpressed in a tumor microenvironment, prototype drugs of indometacin and transretinoic acid are released, the damage effect of the transretinoic acid on a Golgi apparatus structure of a tumor cell is remarkably enhanced, and excellent broad-spectrum applicability is shown; and the device can be adapted to various drug delivery systems and disease models.

The application belongs to the technical field of biological medicine, and particularly relates to a coumarin hydrazone derivative with antioxidant activity and application thereof. The chemical structural formula of the coumarin derivative is shown as formula (I), wherein R is an aromatic ring containing different substituents. The in vitro antioxidant experiment results show that most of the derivatives exhibit certain scavenging capacity on DPPH, ABTS, superoxide anion and hydroxyl radicals, and have certain reducing capacity. Notably, the derivatives 5a-5d, 5i-5k, 5m and 5n have better scavenging effect on superoxide anion radicals than or equivalent to vitamin C. The method for preparing the coumarin hydrazone derivative has the advantages of simple operation, convenient post-treatment, high product separation yield and the like. The coumarin compound can be used for preparing an antioxidant.

This invention belongs to the field of antitumor drug technology, specifically disclosing a method for preparing and applying an AIE-type photosensitizer primarily for type I photodynamic therapy. The chemical structure of the AIE-type photosensitizer of this invention is shown in formula (Ⅰ). Due to the heavy atom effect of the sulfur atom, the photosensitizer of this invention can increase the coupling constant, which is beneficial for intersystem crossing of excitons, increasing the yield of reactive oxygen species generated by the photosensitizer™, resulting in good photodynamic therapy effects. The photosensitizer™ skeleton contains an R1-substituted tetraphenylethylene unit, exhibiting significant aggregation-induced emission (AIE) properties. The AIE-type photosensitizer can rapidly generate cytotoxic superoxide anion radicals (·O2) through electron transfer. ‑ This invention kills tumor cells, achieving the therapeutic goal of inhibiting tumor growth. The photosensitizer prepared using readily available raw materials, with mild synthesis conditions, a simple preparation method, convenient purification, and is easy to implement, showing great application potential.

This invention discloses a method for preparing pear peel polyphenols based on thiols and their antioxidant applications, belonging to the field of natural product extraction and functional foods. The preparation of pear peel polyphenols according to this invention includes the following steps: adding acidified methanol solution and toluene-α-thiol solution to pear peel powder, and ultrasonically extracting at 40-45℃ for 20-30 min. After extraction, the supernatant is collected and concentrated by rotary evaporation to obtain a pear peel polyphenol extract. This pear peel polyphenol extract is rich in chlorogenic acid, cryptochlorogenic acid, arbutin, and other phenolic components; it exhibits significant scavenging ability against hydroxyl radicals, superoxide anion radicals, DPPH radicals, and ABTS radicals, demonstrating good antioxidant activity; it can be used as a natural antioxidant to replace synthetic antioxidants in food systems; effectively realizing the high-value utilization of pear processing by-products (pear peel).

The invention belongs to the crossing field of organic optical functional materials and biomedical materials, and particularly relates to a phenanthrenequinone-based covalent organic framework material, a nano preparation containing the phenanthrenequinone-based covalent organic framework material as well as a preparation method and biomedical application of the phenanthrenequinone-based covalent organic framework material. The phenanthrenequinone-based covalent organic framework material is prepared by carrying out Schiff base condensation reaction on a phenanthrenequinone-based or aza-phenanthrenequinone-based bis (formyl phenyl) monomer and N, N, N ', N'-tetra (p-aminophenyl) p-phenylenediamine and carrying out reversible covalent connection on an aldehyde group and an amino group. And it is found that superoxide anion free radicals can be efficiently generated under irradiation of 808 nm near-infrared light, so that the redox steady state in cells is destroyed, NADPH consumption is selectively accelerated, disulfide bond excessive formation is promoted, and tumor cells are induced to generate disulfide death. The phenanthrenequinone-based covalent organic framework material provides a new strategy for solving the problem of drug resistance in tumor treatment, and has a wide application prospect.

This invention discloses a non-heavy atom near-infrared two-photon photosensitive dye, TMBDP, its preparation method, and its applications. This TMBDP photosensitive dye contains no heavy atoms, possesses a fluoroboron dipyrrole dimer structure and two-photon absorption properties, and can simultaneously generate singlet oxygen and superoxide anion radicals through a spin vibrational coupling mechanism. The non-heavy atom two-photon photosensitive dye TMBDP is prepared from triphenylamine fluoroboron dipyrrole dimer and 1-(2-morpholinoethyl)-1H-indole-3-carboxaldehyde via a multi-step tandem reaction. Under near-infrared laser excitation, the non-heavy atom two-photon photosensitive dye TMBDP effectively releases reactive oxygen species through two-photon absorption, promoting tumor cell apoptosis through oxidative damage. As a high-performance near-infrared non-heavy atom two-photon photosensitive dye, it has wide applications in two-photon photodynamic therapy, two-photon fluorescence imaging, and two-photon fluorescence labeling.

The present application provides a kind of NIR-II fluorescent emission and I type photodynamic activity of nitrogen hetero fluorine boron fluorescent molecule and its preparation method, nitrogen hetero fluorine boron fluorescent molecule has good light absorption in near infrared (NIR) region, and its emission peak is extended to near infrared two (NIR-II) and exhibits 13% of super high NIR-II fluorescence quantum yield.Meanwhile, the photosensitizer prepared by using nitrogen hetero fluorine boron fluorescent molecule can also effectively produce I type active oxygen species-super oxide anion radical under 808nm laser excitation.Based on this, the NIR-II fluorescence of nitrogen hetero fluorine boron fluorescent photosensitizer can realize high-resolution tumor fluorescence imaging, for deep tumor tissue precise, efficient NIR-II fluorescence imaging mediated I type photodynamic therapy.

This invention discloses a photosensitizing lipid nanoparticle based on a multi-resonance core framework, its preparation method, and its antibacterial application, belonging to the field of biomedical materials technology. The photosensitizer structure in this invention is characterized by a multi-resonance fused-ring boron nitrogen as the molecular core framework, with a cleverly introduced triazine electron-withdrawing group on the periphery. This enhances the stretching vibration of the molecule, increases its collision probability with oxygen molecules, accelerates the electron transfer process, and thus promotes the generation of type I reactive oxygen species (ROS). The lipid nanoparticles BN-TRZ@NPs prepared by ultrasound have an absorption wavelength in the range of 550-680 nm. Under white light irradiation, BN-TRZ@NPs can efficiently generate type I ROS (superoxide anion radicals) and exhibit excellent sterilization effects against methicillin-resistant Staphylococcus aureus (MRSA). This invention is the first to apply a photosensitizer based on a multi-resonance structure to biomedical research in the field of antibacterial applications, providing a new approach for the biomedical application of next-generation biotherapeutic photosensitizer molecules.

The invention relates to the technical field of hydrogel, in particular to a conductive hydrogel material, a preparation method and application. The conductive hydrogel provided by the invention takes a free radical nano material as a conductive medium; wherein the free radical nano-material comprises ZIF-8-TCNQ NPs anion free radical nano-particles, ZIF-8-TCNQ NPs can form a stable aqueous solution in water, after the ZIF-8-TCNQ NPs aqueous solution is mixed with a hydrogel precursor solution, due to the fact that a photo-crosslinking agent is added into the hydrogel precursor solution, the hydrogel precursor solution is crosslinked and cured under the irradiation of ultraviolet light, and the ZIF-8-TCNQ NPs anion free radical nano-particles are formed. The conductive hydrogel material disclosed by the invention can be obtained. The method is simple and practical, and the prepared conductive hydrogel material has good tissue adhesiveness, flexibility and conductivity and has wide application prospects in the fields of flexible devices, electronic skin and the like.

This invention discloses a method for deep treatment of pharmaceutical wastewater based on peroxide removal mediated by interfacial electron migration of immobilized materials. Using porous, highly stable, and mechanically strong SiC foam as a carrier, highly active components such as CuBi₂O₄, CuCo₂O₄, Cu / MnO₂, and Fe / C₃N₄ are loaded in situ and with high dispersion at the interface. This effectively solves the problems of easy agglomeration, difficulty in separation, and low recovery efficiency of powdered active ingredients. By adding hydroxylamine hydrochloride and ascorbic acid to enhance interfacial electron transfer of active ingredients, the method addresses the issues of slow reduction rates of high-valence metal ions and difficulty in regenerating free electrons. This achieves efficient activation of hydrogen peroxide, monopersulfate, persulfate, and ozone, mediating the generation of highly oxidizing hydroxyl radicals, sulfate radicals, superoxide anion radicals, and singlet oxygen, thus realizing the efficient oxidation of recalcitrant organic matter in drinking water and wastewater.