Preparation method of fucosan sulphate oligosaccharide

A technology of fucoidan sulfate and oligosaccharides, applied in the direction of oligosaccharides, etc., can solve problems such as unsuitable for industrial production, severe reaction conditions, complex desalination steps, etc., to achieve easy operation, increase activity, and reduce content Effect

Inactive Publication Date: 2004-08-04
OCEAN UNIV OF CHINA
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Problems solved by technology

The reaction conditions of this method are severe, difficult to operate, and require complicated desalination steps, so it is not suitable for industrial production

Method used

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Examples

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Embodiment Construction

[0006] The present invention is illustrated by the following examples.

[0007] Dissolve 50 g of crude fucoidan sulfate extracted from kelp in 2000 mL of water, add 250 ml of 30% (weight percent concentration) hydrogen peroxide solution to the obtained polysaccharide aqueous solution, and stir evenly. The resulting mixed solution was reacted at 60°C for 6h. Impurities were removed by centrifugation, the obtained supernatant was passed through an ultrafiltration membrane with a molecular weight of 3000, and the ultrafiltration liquid was concentrated in a vacuum and then freeze-dried to obtain 32 g of fucoidan sulfate oligosaccharide products.

[0008] The oxidant hydrogen peroxide used in this embodiment can be replaced by hypochlorous acid or nitrous acid or their salts, and the weight ratio of the fucoidan sulfate ester to the oxidant is 1:1-3. The heating temperature is 60-120°C.

[0009] The fucoidan sulfate used in the present invention can be extracted from brown algae...

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Abstract

A process for preparing the oligose of fucosan sulfate includes such steps as preparing the aqueous solution of fucosan sulfate, adding oxidant chosen from hydrogen peroxide, hypochlorous acid, nitrous acid, or their salts, heating, membrane ultrafilter, vacuum concentrating and freeze drying. Its advantages are high medical effect to protect liver and take care of health, and low cost.

Description

technical field [0001] The invention relates to a preparation method of fucoidan sulfate ester oligosaccharides with liver-protecting functions. technical background [0002] Fucoidan sulfate (Fucoidan) is a kind of water-soluble sulfated polysaccharide in brown algae, which is mainly composed of fucose and organic sulfate. A large number of studies have shown that fucoidan sulfate has anti-coagulant, immunity-enhancing, anti-tumor, anti-virus, hypoglycemic, anti-inflammatory, anti-radiation, and inhibition of ascites cancer activities, but in the traditional processing and utilization of brown algae, fucoidan As an important active ingredient in brown algae, sugar sulfate has not been fully utilized. Fucoidan sulfate oligosaccharides are rarely reported, and the reports mention that it has antiviral, anticoagulant and other functions. The preparation method of fucoidan sulfate oligosaccharides is also limited to the acid degradation method. The reaction conditions of thi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/06
Inventor 薛长湖蔡跃飘李兆杰许加超徐杰欧昌荣赵雪
Owner OCEAN UNIV OF CHINA
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