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Protein markers assisting diagnosis of severe secondary pulmonary tuberculosis

A technology for auxiliary diagnosis and pulmonary tuberculosis, applied in biological testing, material inspection products, etc., can solve problems such as aggravating protein markers, aggravating pathophysiological mechanisms, and lack of progression of pulmonary tuberculosis lesions

Active Publication Date: 2017-06-30
BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although great progress has been made in research on the pathogenesis of tuberculosis in recent years, the pathophysiological mechanism of further aggravation, factors or mechanisms affecting its occurrence, development and prognosis are still unclear
There is currently a lack of protein markers for early warning of the progression and exacerbation of secondary pulmonary tuberculosis

Method used

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  • Protein markers assisting diagnosis of severe secondary pulmonary tuberculosis
  • Protein markers assisting diagnosis of severe secondary pulmonary tuberculosis
  • Protein markers assisting diagnosis of severe secondary pulmonary tuberculosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Example 1, Screening of protein markers

[0078] 1. Research object

[0079] The peripheral blood plasma samples of 6 patients diagnosed with secondary pulmonary tuberculosis from March 2015 to December 2015 in Beijing Chest Hospital Affiliated to Capital Medical University were collected. Among them, there were 3 cases of severe secondary pulmonary tuberculosis, 2 males and 1 female, with an average age of 51.33±16.66 years. There were 3 cases of mild secondary pulmonary tuberculosis, 2 males and 1 female, with an average age of 52.67±22.82 years. The informed consent protocol and research procedures were approved by the ethics committee, and all patients and healthy volunteers who agreed to participate in this study signed an informed consent form.

[0080] 2. Screening protein markers

[0081] The peripheral blood plasma samples of the research subjects were taken, proteins were extracted, and the differentially expressed proteins were screened for the severe seco...

Embodiment 2

[0086] Embodiment 2, establishment and verification of diagnostic model

[0087] 1. Selection and grouping of research objects

[0088] Collected peripheral blood plasma samples from 143 cases of patients diagnosed with secondary pulmonary tuberculosis in Beijing Chest Hospital Affiliated to Capital Medical University from March 2015 to December 2015. The patients were divided into severe secondary pulmonary tuberculosis group with 72 cases and mild secondary There were 71 cases in the pulmonary tuberculosis group. The informed consent protocol and research procedures were approved by the ethics committee, and all patients and healthy volunteers who agreed to participate in this study signed an informed consent form.

[0089] 2. Elisa detection

[0090] The peripheral blood plasma samples collected in step 1 were taken, and the concentrations of SOD1, S100A9, ORM2, and IL1F6 in plasma were detected using SOD1 Elisa kit, S100A9 Elisa kit, ORM2 Elisa kit, and IL1F6 Elisa kit, ...

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Abstract

The invention discloses protein markers assisting diagnosis of severe secondary pulmonary tuberculosis. The invention provides applications of a product for detecting SOD1 protein, a product for detecting S100A9 protein, a product for detecting ORM2 protein and a product for detecting IL1F6 protein in preparation of a kit used for assisting diagnosis of severe secondary pulmonary tuberculosis. The four protein markers (S100A9, ORM2, IL1F6 and SOD1) assisting diagnosis of the severe secondary pulmonary tuberculosis are found, and a model for assisting diagnosis of the severe secondary pulmonary tuberculosis by utilizing the four protein markers is built. The protein markers provide basis for further explanation of developing and aggravating mechanisms of the secondary pulmonary tuberculosis, provide a novel method and novel indexes for disease development, aggravation early warning, and forecast evaluation, lays a foundation for reasonable treatment and cure of the severe secondary pulmonary tuberculosis, and provides technical supports for reducing the death rate of pulmonary tuberculosis.

Description

technical field [0001] The invention relates to a protein marker for auxiliary diagnosis of severe secondary pulmonary tuberculosis. Background technique [0002] Tuberculosis is still one of the deadly infectious diseases of worldwide concern. If it develops into severe secondary pulmonary tuberculosis, the hospitalization time will be long, the hospitalization fee will be high, the mortality rate will increase, and a lot of medical resources will be consumed. The mechanism of disease progression, aggravation, and death in patients with secondary pulmonary tuberculosis is complex, involving multiple mechanisms such as etiology, molecular biology, immune regulation, therapeutic drugs, underlying diseases, nutritional status, and socioeconomics. Although the research on the pathogenesis of tuberculosis has made great progress in recent years, the pathophysiological mechanism of its further aggravation, the factors or mechanisms affecting its occurrence, development and progn...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/68
Inventor 刘秋月张宗德李琦潘丽萍骆宝建韩芬
Owner BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV
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