42 results about "Bound copper" patented technology

Though copper is elevated in the tumor tissue and plasma of patients with various malignancies, the molecular targets for copper binding agents in angiogenesis and tumor progression remain poorly understood. It is disclosed that one anti-angiogenic target for the copper binding agent tetrathiomolybdate is intracellular CuZn-superoxide dismutase (SOD1). A second generation tetrathiomolybdate analog, ATN-224, inhibits endothelial cell (EC) proliferation in vitro, binds to SOD1 and inhibits its activity without displacing bound copper ATN-224 can accumulate in ECs and inhibit CuZnSOD activity with an IC₅₀ similar to the IC₅₀ for EC proliferation, resulting in increased generation of intracellular reactive oxygen species. Inhibition of EC proliferation by ATN-224 in vitro is substantially reversed by a synthetic porphyrin SOD mimetic. Similar results were observed in vivo, where inhibition of angiogenesis by ATN-224 in a Matrigel plug model was also reversed by MnTBAP. Thus, a distinct molecular target for copper depletion therapy has been identified and SOD1 is now validated as a target for anti-angiogenesis. Methods for screening, or designing, such SOD1 inhibitors for use as angiogenesis inhibitors and anti-cancer agents are disclosed.

The invention belongs to the field of wastewater treatment and specially, relates to a system for treatment of acid mine drainage and resource recovery of iron, aluminum, copper and zinc in drainage. The system is characterized in that the system is composed of an iron removal system, an aluminum removal system, a copper removal system, a zinc removal system, a sedimentation basin 1 and a sedimentation basin 2 by sequential connection. Based on differences of precipitation performances of a metal ion under pH conditions and differences of solubility products (Ksp) of a reaction between copperand a sulfur-containing organic chelating agent and a reaction between zinc and the sulfur-containing organic chelating agent, through a fractional precipitation method, iron, aluminum, copper, zinc and the like are separated effectively; resource recovery and utilization is realized; hidden troubles of secondary pollution caused by waste residues are eliminated; and treated drainage reaches a reuse standard and can is fed directly into mineral processing pool for reuse. The system has the advantages of simple process, good effect of drainage treatment, stable operation, low costs of treatment, capital construction investment, energy consumption and operation, and wide application prospect.

A method of expanding a population of cells, while at the same time inhibiting differentiation of the cells, the method includes the step of providing the cells with conditions for cell proliferation and, at the same time, for reducing a capacity of the cells in utilizing copper. The method can be executed both in-vivo and ex-vivo. A method of inducing differentiation in a population of cells, the method includes the step of providing the cells with a transition metal chelator which binds copper and which is effective in inducing cell differentiation.

The invention relates to a furnace-through fixture for reflow soldering. The furnace-through fixture is used for bearing printed circuit boards (PCB), direct bounding coppers (DBC) and a lead frame array during the reflow soldering process. The furnace-through fixture comprises: a carrier board which is provided with a plurality of clamp holes for positioning and fixing the PCBs and the DBCs and a clamp groove for positioning and fixing the lead frame array, besides, a plurality of magnetic contacts are arranged on the parts of the carrier board that are beyond the clamp holes and that are covered by the lead frame array; and magnetic covers which are for exerting pressure on the lead frame array that is between the magnetic covers and the carrier board to fasten the lead frame array when the magnetic covers are adsorbed on the magnetic contacts.

The invention provides a macromolecule bridging flotation method for a combined copper disseminated body, and aims to the combined copper disseminated body which can not be recycled through a conventional flotation manner. The method comprises the following steps of: adopting macromolecule bridging agent, copper ion bridging ion and xanthate bridging collecting agent; adsorbing polyatom on the surface of the combined copper disseminated body through macromolecule bridging agent ion; re-adsorbing copper ion on bridging agent, wherein the bridging agent is adsorbed on the surface; adsorbing a collecting agent xanthate negative ion on bridging copper ion; and dewatering the surface of the combined copper disseminated body, thus achieving the effective flotation. In the method, the macromolecule bridging agent is of polyatom adsorption ability, therefore, adsorption strength of the bridging agent on the surface of the combined copper disseminated body can be greatly improved, the copper ion is utilized as bridging ion, and mineral, bridging agent molecule and collecting agent xanthate molecule are connected together, so that collecting agent xanthate can be indirectly adsorbed on the surface of the combined copper disseminated body, and flotation recycling of the combined copper disseminated body which can not be floated and recycled can be achieved.

A thermometal compound flat wire is manufactured by the compounding of core layer metal of modified aluminium alloy and coating layer metal of copper, and is characterized in that interfaces of the core layer metal of the modified aluminium alloy and the coating layer metal of the copper are in metallurgical bonding; the purity of the copper is 99.95%-99.99%; the proportional range of the cross-sectional area of the coating layer metal of the copper is 15%-30%; the width of the copper-coated rare earth aluminum alloy flat wire is 30-200 mm, and the width-to-thickness ratio is 30:1. According to the flat wire, the interfaces of the copper and the aluminium reach the metallurgical bonding; the technological process is short, the production efficiency is high, and the product cost is low; the flat wire is suitable for large-scale and normalized industrial production; the length ratio of the flat wire to a pure copper wire is 2.5:1, namely, 1.58 ton pure copper can be saved when 1 ton copper-coated modified aluminium alloy compound conductor material is produced, so that the copper resource is effectively saved; the cost of downstream industry product is lowered.

Provided is a fixing method for a ceramic tile suitable for the range of inclination angles from 20 degrees to 45 degrees of a slope roof. The construction process follows the sequence of a pre-embedded steel bar in a structure layer, a water-proof layer, a heat-preserving layer, a leveling layer, a tile-laying layer, fixation of the ceramic tile and cleaning. The construction process comprises the following steps: a, laying the structure layer; b, laying the water-proof layer; c, laying the heat-preserving layer; d, laying the leveling layer; e, laying the tile-laying layer; f, fixing the ceramic tile; g, cleaning waste and foreign matter on the surface of a surface of the ceramic tile in order to keep the surface of the ceramic tile clean and bright. The fixing method for the ceramic tile has a fixing structure of the ceramic tile. The structure is simple and the ceramic tile is convenient to manufacture. A pre-embedded steel bar head is combined with a binding copper wire in order to fix the ceramic tile. The project quality is safe and reliable. The construction speed is high. The construction is simple and convenient. In addition, the ceramic tile is firmly fixed with a basiclayer in order to prevent the tile from falling down. The fixing method is advantaged by being excellent in waterproofness and helps reduce project cost.

Disclosed are shelf stable nutritional liquids including metal amino acid chelates. Metal amino acid chelates, such as copper amino acid chelates and iron amino acid chelates, limit the capacity of incompletely bound copper and iron to catalyze the oxidation of sensitive nutrients such as vitamins, particularly vitamin A, vitamin B12 and vitamin C, thereby imparting both nutritional benefits and sensory benefits to the nutritional liquids.

The invention belongs to a thinning tool, and particularly relates to a grinding wheel for roughing and thinning mobile phone backboard glass and a preparation method of the grinding wheel. Diamond, epoxy resin and copper-tin-titanium alloy powder are mixed, and diamond particles wrapped with the alloy powder are obtained; then mixing the diamond particles wrapped with the alloy powder with the ball-milled metal matrix to obtain a material; and the material is subjected to cold pressing and sintering, and the grinding wheel for roughing and thinning the mobile phone backboard glass is obtained. According to the grinding wheel for roughing and thinning the mobile phone backboard glass, the diamond is subjected to surface brazing pretreatment, the holding performance of a binding agent on the diamond is improved, meanwhile, cobalt is added to be combined with copper and tin for modification, good sharpness and deformation resistance are achieved, and the service life of the grinding wheel for roughing and thinning the mobile phone backboard glass can be greatly prolonged in the aspect of practical application.

The present invention provides agents capable of binding copper and forming a three-component complex with proteins, and the use of these agents in the prevention and treatment of diseases involving vascular components, such as solid tumors. Compositions and methods for the combination therapy of these diseases, including cancer, are also provided, as well as therapeutic kits.

The invention relates to graphene lubricating oil, in particular to modified anti-friction graphene lubricating oil, which is prepared from the following materials in parts by mass: 0.01 to 0.05 partof modified graphene, 8 to 16 parts of boric acid ester, 80 to 90 parts of mineral base oil, 2 to 4 parts of dispersing agent and 1 to 4 parts of anti-foaming agent. According to the modified anti-friction graphene lubricating oil provided by the invention, the graphene is modified and is combined with the copper nanoparticles to form a compound, so that the agglomeration and anti-friction and wear-resistant effects of the graphene are effectively improved.

A fabrication method of semiconductor packaging and the packaging element is disclosed. A layer of copper is formed on a thick heat-resistant tape and the surface of the copper layer is coated with a light sensitive photoresist. A light source passes through a pre-fabricated circuit negative being performed on the copper layer such that the photoresist is retained on the surface of the copper layer. An etching step is performed so as to obtain a copper wire with circuit diagram. After that, a wire bonding or a flip chip method is used to bind copper wire circuit with the chip. An appropriate packaging method is performed, a packaging element is obtained after the heat-resistant tape is removed.

The invention discloses an enhanced leaching method for copper ore, and relates to the field of hydrometallurgy. In the leaching process of complex copper ore containing sulfur, arsenic and combined copper, a composite catalytic oxidizing agent and an activating agent with super-strong oxidizing capacity are added, and the copper ore is leached in cooperation with acid leaching agent dilute sulphuric acid or alkaline leaching agent ammonia water, ammonium salt and the like. Due to the enhanced oxidation effect of the catalytic oxidizing agent and the activating agent, arsenic-sulfur minerals can be subjected to an oxidation reaction at high temperature and high pressure under normal temperature and normal pressure, so that the refractory copper ore is oxidized and leached. Therefore, the leaching rate is improved, and better economic benefits are obtained.

The invention discloses a production process of an industrial frequency transformer. The production process comprises the following steps of: preparing required raw materials and equipment tools; starting to wind wires; binding copper wires; welding the copper wires to transformer pins; and assembling an iron core finished semi-finished product. According to the industrial frequency transformer manufactured through the process, the process is effectively simplified, meanwhile, the product quality is improved, the number of defective products is reduced, the service life of the transformer is prolonged, and the production efficiency is improved.

The invention discloses an electrolytic cell for an over-oxidation potential water generator. The electrolytic cell comprises an electrolytic cell main body. A plurality of alternately arranged anodeand cathode electrode plates are arranged in the electrolytic cell main body. A gap is formed between the anode and cathode electrode plates. The anode and cathode electrode plates are rounded. Two ends of each one of the anode electrode plates are connected to anode binding posts. Two ends of each one of the cathode electrode plates are connected to cathode binding posts. The anode binding postsand the cathode binding posts are arranged on a binding copper bar. The binding copper bar is connected to an external electrolysis power supply through a port. The electrolytic cell is provided witha water inlet and a water outlet. The electrolytic cell has a simple structure, is easy to assemble, has a strong electrolytic capacity, realizes a low preparation cost, repeatedly utilizes main components, is free of a cleaning agent in the electrolysis process and satisfies environmental protection requirements.

The invention relates to a comprehensive utilization method of reverse flotation products of calcium and magnesium carbonates in mixed copper ores. The comprehensive utilization method comprises the following steps of: against the copper-containing products obtained by performing reverse flotation on the calcium and magnesium carbonates in the mixed copper ores, sequentially pressing to form pellets, calcining in a rotary kiln, grinding the ores and performing ammonia leaching to recover copper in the copper-containing products to obtain copper concentrate, and using the leached residue as ansubstitute for cement for filling ingredients in an underground goaf. According to the method disclosed by the invention, combined copper resources which can not be recovered by flotation, acid leaching and ammonia leaching can be effectively recovered, and the calcium and magnesium carbonates, silicates and aluminosilicates can be simultaneously transformed to the cement substitutes which can beused locally, so that the comprehensive utilization of the resources is realized, the filling cost in the goaf is lowered and the economic benefits are significant.

The invention belongs to the technical field of packaging mechanical equipment, and particularly relates to a high-speed end sealing wiring structure, one end of an external power line is fixed on a copper screw, the other end of the external power line enters an end sealing shaft through an inclined hole and then is connected with a collector ring, a carbon brush extends out under the action of elastic force and is attached to a copper plate, the external power line is connected with a heating pipe through the collector ring, the end sealing shaft, the copper screw, the copper plate, the carbon brush, a hollow copper stud and a copper block to achieve electric heating, in the operation process of equipment, only the carbon brush and the copper plate of a conductive part rub relatively, and the heating pipe, the external power line and a sealer do not move relatively, the external power line cannot leak electricity due to repeated bending, so that the problem of line breakage is solved; the structure is simple, active disconnecting is carried out at the position where the external power line easily generates relative motion, the carbon brush is connected with the copper plate, so that the carbon brush is always tightly combined with the copper plate when sliding on the copper plate, the external power line on one side of the copper plate is relatively static, and the external power line on one side of the carbon brush is also relatively static.

The invention discloses an anti-corrosion treatment process for an anti-corrosion alloy pipe. The anti-corrosion treatment process comprises the following specific machining processes that the surface of the alloy pipe is polished by adopting abrasive paper, then ultrasonic treatment is sequentially carrying out on the pipe for 5-6 minutes by using an acetone solution and absolute ethyl alcohol, then the pipe is soaked for 3-4 minutes by using a 1mol/L hydrochloric acid solution, the pipe is washed by using deionized water, and the pipe is dried for later use; the pipe is added into a surface treating agent solution with the concentration being 15% to be soaked for 5-6 min at the normal temperature, and the pipe is taken out and aired; and then a layer of epoxy resin anticorrosive paint is sprayed on the surface of the pipe. According to the anti-corrosion treatment process for the anti-corrosion alloy pipe, a metal surface is pretreated through a surface treating agent, then a coating is compounded, the surface treating agent is of a hyperbranched structure, the end group of the surface treating agent contains a large amount of oxysilane, sulfydryl and amino, silicon hydroxyl generated through hydrolysis of oxysilane bonds can be combined with hydroxyl on the surface of iron or aluminum metal in metal, and copper can be bonded with the sulfydryl, so that the binding capacity can be improved.