226 results about "Porphyrin structure" patented technology

Metallotetrapyrrolic compounds having photherapeutic properties useful in photodetection and phototherapy of target issues, particularly porphyrins and azaporphyrins that including gallium in the central pyrrolic core. Also disclosed are methods of using metallotetrapyrrolic compounds for the treatment or detection of cardiovascular disease.

The acne treatment devices use an array of LEDs, which emit monochromatic light substantially at a wavelength of 405 nanometers, which is coincident with the peak absorbance of light by acne porphyrins. The emitted light is directed from the light source to an acne area of the skin. The device can either be hand-held, with the LEDs mounted on a handle portion, or an LED can be mounted on a patch-like mounting element, which is adapted to be secured to the skin for longer exposure at less intensity.

An oxygen sensitive probe comprises a monofunctional derivative of an oxygen-sensitive photoluminescent dye covalently attached to a water soluble and / or hydrophilic macromolecular carrier. The probe may be a chemical conjugate of a monofunctional phosphorescent porphyrin dye and a poly(ethyleneglycol), polypeptide or polysaccharide.

Methods of mitigating acne include exposing an expanse of skin to light; terminating the exposure of the skin to the light; and applying a benefit agent to the expanse of skin after a delay following the termination. The light exposure may be for a period of less than about one hour, and the light may be suitable for either (a) exciting porphyrins associated with the expanse of skin into an energetic state suitable for destroying acne-causing micro-organisms, or (b) for heating lipids present in sebaceous glands within the expanse of skin in order to modulate the flow of sebum in said sebaceous glands, or (c) for reducing inflammation. The benefit agent is suitable for either (a) providing anti-microbial action that is complementary to either said modulating of said sebum by said band of light, or complementary to said reduction of inflammation by said light or (b) providing sebum-modulating action that is complementary to either said destruction of said acne-causing microorganisms or complementary to said reduction of inflammation by said light; or (c) providing anti-inflammation that is complementary to either said modulating of said sebum by said band of light, or complementary to said destruction of said acne-causing microorganisms. These treatments may be repeated, as necessary.

This invention provides a new procedure for attaching molecules to semiconductor surfaces, in particular silicon. The molecules, which include, but are not limited to porphyrins and ferrocenes, have been previously shown to be attractive candidates for molecular-based information storage. The new attachment procedure is simple, can be completed in short times, requires minimal amounts of material, is compatible with diverse molecular functional groups, and in some instances affords unprecedented attachment motifs. These features greatly enhance the integration of the molecular materials into the processing steps that are needed to create hybrid molecular / semiconductor information storage devices.

This invention relates to photosensitizer dyes for dye-sensitized solar cells. The photosensitizer dyes are porphyrin-based zinc complexes represented by the following general formulae (100) and (200).wherein A is represented by one of the following formulae (111)˜(118),wherein Z1˜Z10 independently represent a hydrogen atom (H), lithium (Li), sodium (Na), or tetra-alkyl ammonium group (as represented by the following general formula (120)),wherein X1˜X4 independently represent CmH2m+1 (m=1˜6), and B, C, D, and E independently represent one of the following formulae (131)˜(140),wherein Ra˜Rz are independently selected from the group consisting of H, CmH2m+1 (m=1˜15), OCpH2p+1 (p=1˜15), CH2[OC2H4]nOCH3 (n=1˜30), and [OC2H4]qOCH3 (q=1˜30).

There is provided a field effect transistor having an organic semiconductor layer, including: an organic semiconductor layer containing at least porphyrin; and a layer composed of at least a polysiloxane compound, the layer being laminated on the organic semiconductor layer so as to be in intimate contact with the organic semiconductor layer. As a result, there can be provided a field effect transistor which enables an organic semiconductor layer having high crystallinity and high orientation to be formed and which exhibits a high mobility.

A long wavelength absorbing porphyrin / metalloporphyrin molecule is provided, made up of a porphyrin macrocycle and an anchor group for attachment to a substrate. A molecular linking element is interposed between the porphyrin macrocycle and the anchor group. The porphyrin / metalloporphyrin molecule also includes an (aminophenyl)amine group, either N,N-(4-aminophenyl)amine or N-phenyl-N-(4-aminophenyl)amine, where an amino moiety of the 4-aminophenyl group is derivatized by an element such as hydrogen, haloalkanes, aromatic hydrocarbons, halogenated aromatic hydrocarbons, heteroarenes, halogenated heteroarenes, or combinations of the above-mentioned elements.

The present invention involves an artificial nose having an array comprising at least a first dye and a second dye in combination and having a distinct spectral response to an analyte. In one embodiment, the first and second dyes are from the group comprising chemoresponsive dyes, and the second dye is distinct from the first dye. In one embodiment, the first dye is selected from the group consisting of porphyrin, chlorin, chlorophyll, phthalocyanine, and salen, or their metal complexes. In another embodiment, the second dye is selected from the group of dyes consisting of acid-base indicator dyes and solvatochromic dyes. The present invention is particularly useful in detecting metal ligating vapors. Further, the array of the present invention can be connected to a visual display device.

Compositions and methods of using thereof for the prevention of sexually transmitted diseases resulting from infection with one or more of viral pathogens have been developed. The compositions contain one or more porphyrins, tetrapyrrole macrocycle compounds with bridges of one carbon joining the pyrroles. In a preferred embodiment, the compositions are administered in a formulation suitable for administration to a mucosal surface.

This invention provides a procedure for growing oligomers via a stepwise process. The oligomers can include porphyrins, which have been previously shown to be attractive candidates for molecular-based information storage. The stepwise synthesis procedure requires no protecting groups, thus eliminating protection / deprotection reactions that add complexity to the process.

The invention provides a method for fast detecting pesticide residue, which relates to a fluoroscopic detection method of organic phosphor pesticide. The invention utilizes a fluorescence spectrophotometer with program, uses porphyrin compounds as fluorescence indicating agents and developers, and detects the organic phosphor pesticide in the liquid state porphyrin detection solution through preparing a porphyrin solution, an organic phosphor pesticide solution and a liquid state detection solution. The invention has the characteristics of high detection sensitivity, low detection limitation, high accuracy, simple and convenient operation, convenient and fast in-site detection, high economical efficiency, convenient popularization and application and the like. The invention can be widely used for the trace amount detection of foodgrain, food and the like which easily contain the organic phosphor pesticide residue, and can also be used in the security assessment of food such as vegetables, fruit and the like and the environment detection.

This invention provides a new procedure for attaching molecules to semiconductor surfaces, in particular silicon. The molecules, which include, but are not limited to porphyrins and ferrocenes, have been previously shown to be attractive candidates for molecular-based information storage. The new attachment procedure is simple, can be completed in short times, requires minimal amounts of material, is compatible with diverse molecular functional groups, and in some instances affords unprecedented attachment motifs. These features greatly enhance the integration of the molecular materials into the processing steps that are needed to create hybrid molecular / semiconductor information storage devices.

The present invention relates to a dye-sensitized type photoelectric conversion device for generating electric power by using solar light. The dye-sensitized type photoelectric conversion device includes a semiconductor layer on which a sensitizing dye having an acidic group-containing porphyrin polymer expressed by a below-described general formula (1) is carried and an electrolyte layer. (Here, in the above-described general formula (1), R1 to R18 indicate substituents such as hydrogen atoms, halogen atoms and at least one of R1 to R18 is an acidic substituent such as 4-carboxyphenyl group.)

A pharmaceutical liposomal formulation for photodynamic therapy comprising a non-polar porphyrin photosensitizer and one or more phospholipids, which are stable in storage without requiring freeze-drying is described. The liposomal formulation provides therapeutically effective amounts of the photosensitizer for intravenous administration. The phospholipids may be modified by pegylation, i.e. they contain poly ethylene glycol as an integral part of the phospholipids. The formed liposomes contain the non-polar photosensitizer within the membrane and are useful for the combined targeting of a non-polar photosensitizer and a second polar substance. When a formulation includes the presence of monosaccharides or polyalcohols, it can be efficiently freeze-dried preserving the size of the liposomal vehicles and the content of a therapeutically effective amount of the photosensitizing agent. The invention also relates to the liposome composition formed upon reconstitution with an aqueous vehicle. The freeze-dried formulation upon reconstitution with a suitable aqueous vehicle forms liposomes that are also useful for intravenous administration.

The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction due to surgery, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, or to prolong the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of a Pyridyl-Substituted Porphyrin Compound.

The invention provides a portable device for diagnosis of lung cancer, which comprises a balloon, a gas pump, a buffer gas chamber, a reaction gas chamber, an image collection and processing system and a control system; the balloon collects exhaled gas of a patient with suspected lung cancer to carry out the reaction with a pre-designed porphyrin sensor array (the sensor array for detecting lung cancer markers, if the lung cancer markers exist, the color of the sensor array is changed before and after the reaction) in the reaction gas chamber, the collection of images before and after the reaction is realized by controlling the image collection and processing system through the control system, the images are compared, the collected images are carried out with the pretreatment to obtain the differential images before and after the reaction, the differential images are further compared with data in an expert lesion database to obtain the detection result, and the detection result is finally displayed through a liquid crystal screen or a micro-printer, thereby judging whether the patient suffers from the lung cancer or not.

Though copper is elevated in the tumor tissue and plasma of patients with various malignancies, the molecular targets for copper binding agents in angiogenesis and tumor progression remain poorly understood. It is disclosed that one anti-angiogenic target for the copper binding agent tetrathiomolybdate is intracellular CuZn-superoxide dismutase (SOD1). A second generation tetrathiomolybdate analog, ATN-224, inhibits endothelial cell (EC) proliferation in vitro, binds to SOD1 and inhibits its activity without displacing bound copper ATN-224 can accumulate in ECs and inhibit CuZnSOD activity with an IC50 similar to the IC50 for EC proliferation, resulting in increased generation of intracellular reactive oxygen species. Inhibition of EC proliferation by ATN-224 in vitro is substantially reversed by a synthetic porphyrin SOD mimetic. Similar results were observed in vivo, where inhibition of angiogenesis by ATN-224 in a Matrigel plug model was also reversed by MnTBAP. Thus, a distinct molecular target for copper depletion therapy has been identified and SOD1 is now validated as a target for anti-angiogenesis. Methods for screening, or designing, such SOD1 inhibitors for use as angiogenesis inhibitors and anti-cancer agents are disclosed.

The invention is directed to an improved drug delivery system that includes a micelle, comprising polyethylene glycol and a lipid component, and a pharmaceutical agent dispersed in the lipid component. The delivery system may also include a targeting ligand. The micelle delivery system of the invention is capable of stabilizing, inter alia, poorly soluble pharmaceutical agents and increasing their delivery efficacy. Appropriate pharmaceutical agents useful in the system of the invention include anti-inflammatory agents, agents for photodynamic therapy, anti-tumor agents, anti-neoplastic agents, anti-metastatic agents, and imaging agents, as well as hydrophobized derivatives thereof. Specifically, the pharmaceutical agent can be porphyrin, chlorine-6-trimethyl ester, tamoxifen, paclitaxel, 1,3-bis(2-chloroethyl)-1-nitrosourea, camptothecin, ellipticine, rhodamine, dequalinium, diphenylhexatriene, vitamin K3, diethylene triamine pentaacetic acid, or a functional derivative thereof. The micelles in the system of the invention have low critical micellar concentration and high kinetic stability, which provides great advantages in biodistribution, for example, accumulation at the site of a tumor.

The invention discloses a lithium ion battery negative electrode MOF material. The MOF material disclosed by the invention is prepared by reacting porphyrin or porphyrin derivative of the porphyrin with transition metal or a transition metal cluster through a solvent thermal or wet chemistry method. When the MOF material is utilized as a lithium ion battery negative electrode material, the MOF material has a series of advantages of high specific capacity, long cycle life, outstanding rate capability and the like. Theoretical calculation proves that an active site of the action between the MOFmaterial disclosed by the invention and metal lithium has excellent performance, and the MOF material can be applied to developing high energy density lithium ion batteries.

Provided is a field effect transistor having an organic semiconductor layer, in which the organic semiconductor layer contains at least a tetrabenzo copper porphyrin crystal and has peaks at two or more of Bragg angles (2θ) in CuKα X-ray diffraction of 8.4°±0.2°, 10.2°±0.2°, 11.80°±0.20°, and 16.90°±0.20°, and the tetrabenzo copper porphyrin crystal comprises a compound represented by the following general formula (1): (Wherein R2's each represent a hydrogen atom, a halogen atom, a hydroxyl group, or an alkyl group, oxyalkyl group, thioalkyl group, or alkylester group having 1 to 12 carbon atoms, and R3's each represent a hydrogen atom or an aryl group.)

Porphyrin compounds having a surface attachment group coupled thereto at the 5 position are described. The surface attachment group has the formula: wherein R is —CHCH2 or —CCH and Ar is an aromatic group. Methods and intermediates useful for making such compounds are also described.

The invention discloses a method for manufacturing an all-solid visualized taste sense sensor array, and belongs to the technical field of sensor array manufacturing methods. The method comprises the steps of selecting hydrophobic porphyrin compounds or phthalocyanine compounds with color response to microchemical substances in a liquid sample as visualized sensitive materials; selecting a hydrophilic mixed cellulose ester microporous membrane, a hydrophobic acrylonitrile-butadiene-styrene (ABS) plastic sheet and waterproof double-faced adhesive tape as substrate manufacturing materials, taking 0.1-10 microliters of visualized sensitive material solutions through a micro-sampling device, and fixing the visualized sensitive material solutions to the mixed cellulose ester microporous membrane in pores of a substrate, wherein one visualized sensitive material is fixed in one pore; drying chloroform to obtain the visualized taste sense sensor array. The all-solid visualized taste sense sensor array has the advantages of being low in cost, high in detection precision, wide in detection range, long in service life, high in batch uniformity and the like.

The present invention is a tinted, optical adhesive for use in making plasma display filters comprising a substantially acid free, pressure-sensitive adhesive (PSA) containing a narrow-band, visible spectrum dye (e.g. less than 30 nm bandwidth) and a broader-band, near infra-red spectrum dye (e.g. greater than 200 nm), the second dye providing enhanced thermal stability as well as near infra-red (NIR) blocking. Further, acid-free adhesives offer improved stability of light control dyes. In the present invention, porphyrin-based dyes combined with acrylate-based, pressure-sensitive optical adhesives are preferred. Invention offers reduced number of functional layers in an optical filter structure as well as reduced number of manufacturing (lamination) steps in the optical filter / plasma display assembly process.

The invention discloses a preparation method of a photosensitive antibacterial fabric. The method comprises the steps of soaking the fabric in dopamine aqueous solution to generate a fabric with a polydopamine layer on the surface, taking out the fabric, sequentially washing the fabric by utilizing the deionized water and absolute ethyl alcohol, and drying the fabric in the air to obtain the fabric with the polydopamine layer on the surface; soaking the fabric with the polydopamine layer on the surface in an ethanol and water mixed solution of BAPDPP compound, taking out the fabric after reacting for 6 to 24 hours, washing the fabric by sequentially utilizing the deionized water and absolute ethyl alcohol, vacuum drying the fabric for 5 to 10 hours at the temperature of 40 DEG C, and obtaining the photosensitive antibacterial fabric which is chemically bonded with a porphyrin compound by adopting the polydopamine as a bridging base. The photosensitive antibacterial fabric is good in soap washing resistance and high-efficient and lasting in antibacterial property, the sterilizing rate still can reach 95 to 100 percent after the fabric is washed for 20 times, the variety of the fabric is diversified, and the application range is wide; moreover, the preparation process is simple, environmentally friendly, low in cost and applicable to mass production.

A method for treating helminthic infections in a mammal or plant which entails administering one or more compounds which are metal-ligand chelate compounds containing a metal and a tetrapyrrole compound or a porphyrin compound, to mammal or plant in need thereof.

The invention discloses a slightly decayed fruit quick identification method based on smell spectral imaging technology, which includes the steps of (1) according to the smell characters of fruits, screening m porphyrin or metal porphyrin color-sensitive materials to produce a sensor array, determining a balance time responding to the smell of the fruits, and obtaining sensor arrays before and after a reaction; (2) by means of a hyperspectral imaging system, collecting a hyperspectral image of the sensor array, performing pivot element dimension reduction, and preferably selecting n characteristic wave lengths; (3) designing a multispectral system in a multiple wave filter sheet type, obtaining n characteristic wave length images, and calculating the difference value image before and after the equilibrium reaction; and (4) extracting m*n characteristic variables on m color-sensitive points from the difference value image, constructing a determination model through mode identification, and performing quick detection to decayed fruit. Compared with a wide frequency spectrum color image obtained through CCD or a scanning instrument in the prior art, the multispectral image allows the spectral difference of unique smell molecules after effect with the color-sensitive materials, thereby increasing precision and sensitivity of detection.

A metal porphyrin lange mull bulogit film optical fiber gas sensor relates to a sensor for checking harmful gas device in industrial condition. The inventive sensor comprises a dual-arm optical fiber, a reaction chamber, and a metal porphyrin LB film array board. The invention is characterized in low check limit, high sensitivity, repeat application, and wide check air range, and the invention can be used to check various volatile harmful gas, more particularly check the discharge and leaked harmful gas as NO2, SO2, NO, CO, H2S and carbonyl chloride.

The invention discloses an acylhydrazone zinc protoporphyrin and a zinc and cobalt complex thereof, belonging to the field of chemical synthesis. In the acylhydrazone zinc protoporphyrin, an acylhydrazone structure and a porphyrin structure form a large conjugated system which can absorb a wider range of sunlight as compared with most of porphyrin dyes; and in the zinc and cobalt complex of the acylhydrazone zinc protoporphyrin, acylhydrazone zinc protoporphyrin molecules are connected to form a chain structure or high-dimensional structure, thereby improving the electron transfer efficiency and consequently improving the photoelectric conversion efficiency. Thus, the zinc and cobalt complex can be used as a dye sensitizer for the preparation of fuel-sensitive solar cells. Photoelectric property test results show that the fuel-sensitive solar cells prepared by the invention are capable of outputting a certain current to an external load and have different degrees of photoelectric conversion efficiency under the irradiation of standard light; and for the photocell using the zinc complex of the zinc protoporphyrin acylhydrazone as the dye, the maximum IPCE (Incident Photon to Current Efficiency) value is 13.4%.

An metalloporphyrin-complex-embedded liposome, comprising a cationic metalloporphyrin complex and a lipid having liposome forming ability is disclosed. As metalloporphyrin-complex-embedded liposomes according to the present invention act on superoxide anion radicals (O2−), and can surely lower their concentration, they can exhibit superb effects for the treatment of cancers and have excellent characteristics as antioxidants.