Methods of controlling proliferation and differentiation of stem and progenitor cells

a progenitor cell and stem cell technology, applied in the direction of plant growth regulators, biochemical apparatus and processes, biocide, etc., can solve the problems of halting cell division, limiting the differentiation process, severe cases of shwanchman syndrome, etc., to increase ra-induced differentiation, increase copper content per protein content, and increase the effect of copper uptak
US20020114789A1Inactive Publication Date: 2002-08-22PELED TONY +2
0 Cites 20 Cited by

Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
PELED TONY
Publication Date
2002-08-22
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

A method of expanding a population of cells, while at the same time inhibiting differentiation of the cells, the method includes the step of providing the cells with conditions for cell proliferation and, at the same time, for reducing a capacity of the cells in utilizing copper. The method can be executed both in-vivo and ex-vivo. A method of inducing differentiation in a population of cells, the method includes the step of providing the cells with a transition metal chelator which binds copper and which is effective in inducing cell differentiation.
Need to check novelty before this filing date? Find Prior Art

Description

[0001] This is a continuation of PCT / IL99 / 00444, filed Aug. 17, 1999, which claims priority from U.S. patent application Ser. No. 09 / 161,659, filed Sep. 29, 1998, which is a continuation in part of U.S. patent application Ser. No. 09 / 130,367, filed Aug. 7, 1998, which is a continuation in part of U.S. patent application Ser. No. 09 / 024,195, filed Feb. 17, 1998. In addition, PCT / IL99 / 00444 claims priority from PCT / US99 / 02664, filed Feb. 8, 1999, which claims priority from U.S. patent application Ser. Nos. 09 / 024,195 and 09 / 30,367.FIELD AND BACKGROUND OF THE INVENTION

[0002] The present invention relates to methods of controlling proliferation and differentiation of stem and progenitor cells. In one aspect, the present invention relates to a method of imposing proliferation yet restricting differentiation of stem and progenitor cells by treating the cells with chelators of transitional metals, resulting in reduction if transitional metals availability. In another aspect, the present in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More