45 results about "Copper binding" patented technology

Though copper is elevated in the tumor tissue and plasma of patients with various malignancies, the molecular targets for copper binding agents in angiogenesis and tumor progression remain poorly understood. It is disclosed that one anti-angiogenic target for the copper binding agent tetrathiomolybdate is intracellular CuZn-superoxide dismutase (SOD1). A second generation tetrathiomolybdate analog, ATN-224, inhibits endothelial cell (EC) proliferation in vitro, binds to SOD1 and inhibits its activity without displacing bound copper ATN-224 can accumulate in ECs and inhibit CuZnSOD activity with an IC₅₀ similar to the IC₅₀ for EC proliferation, resulting in increased generation of intracellular reactive oxygen species. Inhibition of EC proliferation by ATN-224 in vitro is substantially reversed by a synthetic porphyrin SOD mimetic. Similar results were observed in vivo, where inhibition of angiogenesis by ATN-224 in a Matrigel plug model was also reversed by MnTBAP. Thus, a distinct molecular target for copper depletion therapy has been identified and SOD1 is now validated as a target for anti-angiogenesis. Methods for screening, or designing, such SOD1 inhibitors for use as angiogenesis inhibitors and anti-cancer agents are disclosed.

The present invention is an electronic circuit experiment board, which is composed of an insulated base plate, copper binding posts and a bracket and so on. The base plate is divided into an upper plate and a lower plate, which have binding post inserting holes and circlips. The binding posts can be inserted into the binding post inserting holes and then be fastened by the circlips. There are a binding hole and a screw hole on the ends of the binding posts respectively. The binding post also includes a screw lever cooperated with the screw hole, a positioning groove and a positioning ring. The experiment board has the advantages of good contact performance, convenient to use, high experimental efficiency, long service life and strong ability of splicing and dilatancy, arranging elements in double sides, and multilayer wiring in electronic circuit.

The invention discloses a ceramic casting mold applied to metal casting under electric field treatment and a method for casting titanium aluminum-based alloy by using the same. The invention relates to a ceramic casting mold and a method for casting alloy by using the same, and solves the problems of a small electric field service area, current density maldistribution and molten metal polluted by electrodes in the electrode connection method of the prior metal casting method under electric field treatment, and gross column crystal tissues and uncontrolled orientation of a solid phase precipitation layer in the directional solidified titanium aluminum-based alloy. Two homogenous composite electrodes which respectively consist of a copper sheet, an alloy sheet and a copper binding post and have the same shape with the side of a casting mold cavity are arranged on the opposite sides of the ceramic casting mold cavity. The casting method comprises the following steps of: placing the ceramic casting mold into a vacuum induction melting furnace, and connecting the binding posts with the positive and negative poles; weighing raw alloy material, and starting the melting furnace after vacuum pumping to obtain molten mass; and injecting the molten mass into the ceramic casting mold, and cooling down after electric field treatment. The homogenous composite electrodes have the advantages of enlarged service area of the electric field, uniform distribution of current density and obvious grain refinement effects for the titanium aluminum-based alloy.

The invention provides a copper binding wire tension tester with the good fixing effect. The tester comprises a longitudinal installation frame, a Velcro buckle, an adjustable movable fixing frame structure, a copper binding wire clamping fastening seat structure, a lead screw, a longitudinal U-shaped sliding groove, a sliding block, a connection frame with an internal thread, a tension sensor, atransverse fixing plate, a longitudinal positioning pipe, a manual rotary frame structure, a ball bearing, a displaying screen and a miniature PLC, wherein the Velcro buckle is transversely adhered tothe outer sides of the lower parts of the longitudinal installation frame and the transverse fixing plate. Arrangement of a reinforcing limiting block and a jacking spacer block is beneficial for utilizing a jacking bolt to jack a copper binding wire between the jacking spacer block and the reinforcing limiting block, and accordingly the clamping and fixing degree of the copper binding wire can be improved; and arrangement of the transverse connection rod, the transverse positioning pipe and a rocking handle is beneficial for adjusting the length of the left end or the right end of the transverse connection rod conveniently, and accordingly the labor intensity of rotating the rocking handle can be saved when the length of the left side is increased.

The invention discloses a micro-etching solution capable of preventing a circular hole from turning white, and relates to the field of production of circuit boards. By adoption of the micro-etching solution, the problems that in the prior art, after a pore ring is electroplated, copper lattices are changed, and the circular hole turns white before pre-treatment micro-etching is conducted are solved. The micro-etching solution is technically characterized in that the micro-etching solution comprises 10-20g/L of hydrogen peroxide, 90-110g/L of sulfuric acid, 5-15g/L of a copper binding inhibitor, 0.5-2g/L of a copper binding accelerator, 1.5-3g/L of a hydrogen peroxide stabilizer, 0.2-0.3g/L of a low-foaming surfactant, and 1L of deionized water. According to the micro-etching solution capable of preventing the circular hole from turning white, relevant functional additives are added, so that a stable micro-etching rate is achieved, and the micro-etching process is mild and controllable;hydrogen peroxide decomposition is restrained, a copper surface can be uniformly coarsened; oxidization of the copper surface is unlikely to be caused, and changes of the copper lattices and whitening of the circular hole are effectively restrained; and residues on the plate surface can be removed easily, and pollution is small.

The invention discloses a large-current electromagnetic relay. According to the large-current electromagnetic relay, a sampling assembly is fixedly inserted into steps at two sides of an energy-saving type large-current electromagnetic relay, an electronic sensor circuit board is installed on one lateral inner wall of the sampling assembly, two temperature sampling connection rings connected with two copper binding posts respectively and a current sampling magnetism-conductive ring are arranged on the circuit board, a temperature control circuit, a current control circuit, an alarm circuit and a disconnection execution circuit are arranged on the circuit board, a power supply positive pole connector N, a power supply negative pole connector E, a relay coil positive pole connector M and a signal amplification output connector K are installed on a plug at the outer side of the assembly in sequence, and the plug is provided with a connector socket with a lead led out from the lower portion. After being additionally provided with an overload and overheating sensor based on the prior art, the large-current electromagnetic relay has the advantages of being high in voltage resisting grade, small in size, low in energy consumption and long in service life, is safer to use, and can timely give an alarm and cut off an external overload power supply circuit.

The invention discloses a polar fast electron measurement probe system suitable for magnetic confinement plasma. The polar fast electron measurement probe system comprises an insulating shell, fast electron probe assemblies, a Langmuir probe assembly, a ceramic base and a graphite shell. The insulating shell is made of high-temperature-resistant boron nitride, and the ceramic base is made of machinable ceramic. The probe assembly comprises a graphite probe, a copper binding post, a wire and other components, the graphite probe is in threaded connection with the copper binding post, and the copper binding post is in tin soldering connection with the wire or is in press connection with the wire through crimping pliers. The fast electron probes are uniformly and symmetrically distributed in the polar direction, and fast electron components from different directions can be measured. The graphite probes of the fast electron probes are located in the small holes and are applied with positivebias voltage. The radius of the electron Larmor in the magnetic confinement plasma is far less than that of ions, the ions can be effectively repelled by setting the diameter and the depth of the small hole so as to collect electrons. The system can work in the high-temperature environment in the magnetic confinement fusion device, and is stable in mechanical performance, reliable in signal, highin spatial resolution and small in occupied space.

The invention discloses a powerful high-speed electromagnetic valve. The powerful high-speed electromagnetic valve is characterized in that an electromagnetic coil in an electromagnet comprises two or more mutually independent windings; the coil windings are wound on a polymer skeleton in certain sequence; after being connected in parallel, terminals of the windings are connected with a control electrode through copper binding posts; wire diameters and number of turns of the windings in the coil can be the same and can be different; transverse sections of the windings can be circular, oval, square, rectangular, triangular, polygonal, and the like; longitudinal sections of the windings are rectangular, trapezoidal, outside-convex inside-concave circular arc-shaped and crescent-shaped; and relative positions of the windings in the coil can be arbitrarily arranged and are not limited. The high-speed electromagnetic valve has the characteristics that the impedance is low, the inductance is low, the electromagnetic force is high, the structure is compact, the dynamic response speed of an armature valve rod motion component is high, and the like, and the high quality requirement of different working conditions and different load conditions of an internal combustion engine on fuel injection principle and injection form can be met.

This invention relates to compounds which have the ability to act as agonists for the binding of divalent copper ions to amyloid precursor protein (APP) and to methods of identifying such compounds by using the three-dimensional structure of the copper-binding domain of APP.

The invention provides a resistance tester with a good antiskd effect and for a copper binding wire. The resistance tester comprises a resistance tester body, a control switch, an anode terminal, a cathode terminal, clamping protruded sheets, an anti-skid fixed stand structure, a fixable test wire containing box structure, a rotationally foldable dust shield structure, a portable handle, an anti-skid sleeve, a lead, an anode clamp, a cathode clamp, a clasp and a recorder pen; and the resistance tester body is fixed to the inner upper side of the anti-skid fixed stand structure. Due to arrangement of a U-shaped stand, threaded through holes, puller bolts and an anti-skid fixed sucker, anti-skid is realized by adsorption fixation, and stability of the resistance tester is ensured; due to arrangement of a winding wheel, a rotating shaft and a hand-operated winding handle, the lead of the resistance tester can be accommodated, and taken up and paid off conveniently during use; and due to arrangement of the clasp and recorder pen, the data recording pen can be carried at any time, and detection data can be recorded conveniently.

Disclosed are copper-binding compounds with improved properties and methods of using such compounds in the prevention and treatment of angiogenic diseases, such as cancer. Advantages of the invention include the enhanced stability of the compounds, which is achieved without reduction in efficacy. Pharmaceutical compositions, therapeutic kits and combination treatment methods and uses are also provided.

The invention discloses a method for making a plug-pull high voltage terminal. The method comprises the following steps of: peeling an outer sheath of a cable to expose a copper shield with the length of 210 millimeters; cutting a cable core, and insulating the cut core; fixing a grounding copper braided strap on the copper shield by using a copper binding wire and welding firmly; wrapping a step by using a semi-conductive strap at a position of 96 millimeters far away from the insulated end of the core; covering a thermal shrinkage protective sleeve on the cable, and covering an aluminum shell on the cable; covering a plastic guide sleeve on the core, and forcibly covering the terminal on the cable till a stress cone step of the terminal is in well contact with the semi-conductive strap on the cable; sequentially covering a bearing ring, a compression cone and a contact ring on the cable core; covering a tensioning sleeve on the contact ring; and pressing the contact ring on the compression cone by using a conductor pressing device. By the method, the weakness of a semiconductor in the cable and a peeled section of a copper shielding layer is well eliminated, insulation breakdown is effectively prevented, equipment runs safely and reliably, and economic loss caused by short circuit of the high voltage terminal is effectively prevented.

The invention discloses a rod secure socket used for charging a high-power autonomous robot. The rod secure socket comprises an insulating support rod, a square copper binding post, a movable spring insulation sleeve, symmetrical ring-shaped copper electrodes, symmetrical electrode insulating covers, symmetrical insulating end covers and a spring, wherein the square copper binding post is arranged in the insulating support rod; the middle section of the insulating support rod is tightly sleeved with the spring insulation sleeve; the insulating support rod is tightly sleeved with the ring-shaped copper electrodes which are arranged outside the spring insulation sleeve; the upper and lower sections of the insulating support rod and the ring-shaped copper electrodes are tightly sleeved with the electrode insulating covers which are arranged outside the spring insulation sleeve; the two ends of the insulating support rod are tightly sleeved with the insulating end covers respectively; the insulating support rod is sleeved with the spring which is arranged in the spring insulation sleeve; the insulating end covers, the electrode insulating covers and the spring insulation sleeve are tightly connected in sequence. The rod secure socket has the beneficial effects that the rod secure socket has a large electrode contact surface; the electrode contract force is determined by the elastic force of the spring; whether electrodes of plugs are clamped in the socket or not, the electrodes are not exposed; the novel socket which is simple and convenient to operate, is good in contact and is secure and reliable is provided for charging the high-power autonomous robot.

The present invention shows the crystal structure of protein C inactivated factor Va (A1-A3-C1-C2) that depicts a novel domain arrangement. The newly disclosed orientation has implications for binding to membranes essential for function. A high-affinity calcium binding site and a copper binding site have been identified, neither of which show a direct involvement in chain association. This structure represents the largest physiologically relevant fragment of factor Va solved to date and provides a new scaffold for generation of models of coagulation factors.

The invention is suitable for the technical field of power semiconductor module packaging, and provides a power module internal binding wire connection process, which comprises the following steps ofconnecting a copper binding wire to a metal plate in a bonding mode, and then connecting the copper binding wire to a chip and an electrode of a power module in a welding or sintering mode. Compared with an existing mode that a chip and DBC are connected directly through an aluminum binding wire, the method of the invention has the advantages that the thermal expansion coefficient of a metal plateis close to that of a semiconductor chip, so that the power cycle life is greatly prolonged; compared with an existing mode that a chip and DBC are connected directly through a copper binding wire, the method of the invention has the advantages that the surface of a chip does not need to be connected with a thick copper foil layer, so that the process is simple, and the cost is low; and comparedwith the two modes, the method of the invention has the advantages that the contact area with the surface of the chip is increased, most of the circuit passes through a thick metal plate, the on-resistance is greatly reduced, and the parasitic inductance is also reduced.

The invention discloses a waste copper binding post pressing block recycling device. The waste copper binding post pressing block recycling device comprises a base table provided with a tabletop. Thewaste copper binding post pressing block recycling device further comprises a feeding device, a pressing block tool, a hydraulic machine and a mechanical arm. The pressing block tool comprises a sliding base, a bottom plate, springs, a pressing die, a vibration motor, a first drive mechanism, a second drive mechanism and a third drive mechanism. The sliding base is arranged on the tabletop and isin sliding connection with the base table in the first direction. The bottom plate is arranged above the sliding base and is elastically supported through the springs. The pressing die is arranged onthe bottom plate and provided with a die cavity. The bottom plate is provided with a through hole communicating with the die cavity. The vibration motor is arranged on the bottom plate. The first drive mechanism is provided with a supporting table and a plug. The second drive mechanism is provided with a movable end, and the movable end is connected to the sliding base and can drive the sliding base to reciprocate in the first direction. The third drive mechanism is provided with an ejection head, and the ejection head can move in the second direction and stretch into the through hole. The waste copper binding post pressing block recycling device has the beneficial effect that waste copper materials can be automatically and rapidly pressed into blocks.

The invention belongs to the technical field of rivet type electrical contact processing and manufacturing, and particularly relates to a high-reliability rivet type electrical contact, forming equipment and a forming method. According to the high-reliability rivet-type electrical contact, the groove is formed in the surface of the silver alloy layer and serves as a foreign matter collecting groove, the surface area of the contact working face is increased, a containing space is provided for high-resistance substances such as foreign matter and alloy generated after contact of part of the electrical contact, and the phenomenon that the substances are subjected to fusion welding and sticking on the combination face is reduced. According to the high-reliability rivet-type electrical contact provided by the invention, the contact surface of the silver alloy layer and the copper-based layer is concave-convex, so that the area of the contact surface of the silver alloy layer and the copper-based layer is increased, the silver-copper binding force can be improved, and the service life of the composite electrical contact is prolonged.

The invention discloses a graphene modified electrically antibacterial membrane element, and an electrically antibacterial treatment system. The graphene modified electrically antibacterial membrane element comprises a membrane shell, a membrane element, a raw water inlet, a raw water outlet, end sockets, double-clip type quick joints, and seal washers; the internal side of each double-clip type quick joint is provided with graphene modified conductive hollow membrane wires; the gaps between the graphene modified conductive hollow membrane wires, and the graphene modified conductive hollow membrane wires and the membrane shell are filled with a graphene modified conductive pouring sealant; each of the four contact surfaces of the graphene modified conductive hollow membrane wires with the membrane shell is provided with a conductive copper ring; the conductive copper rings on the upper parts are connected with copper binding posts; the bottom parts of the membrane shell close to the internal sides of the graphene modified conductive hollow membrane wires are provided with produced water outlet pipes. The graphene modified electrically antibacterial membrane element is capable of killing and inhibiting bacteria, and solving problems such as operation pressure difference is large, and membrane element flux is reduced because of microbial pollution, and avoiding operation cost increasing and membrane wire aging caused by frequent adding of oxidizing bactericides.

The invention discloses a Z-shaped rope positioning system for an abat vent pull rod. The Z-shaped rope positioning system includes jackscrews, copper binding posts, locking rope springs, positioningblocks and nylon ropes in four plastic slotting angles, wherein the nylon ropes are arranged at the horizontal parts of the plastic slotting angles in the horizontal direction; the copper binding posts are sleeved with the head ends of the nylon ropes; the horizontal tail ends of the nylon ropes at the plastic slotting angles are sleeved with the fixed positioning blocks; the nylon ropes between the positioning blocks and the copper binding posts are sleeved with the locking rope springs; the two nylon ropes respectively connected with the opposite plastic slotting angles penetrate through a horizontal pull rod from the two sides simultaneously. According to the positioning system, the nylon ropes penetrate through the pull rod simultaneously, the pull rod can stay at any position throughfriction; the locking rope springs are mounted at all the ends of the nylon ropes for buffering, so as to guarantee that the pull rod beginning to start cannot be clamped when bearing too big tension,and the entire process is smooth; maintenance and adjustment are convenient, the outer dimension of a hatch is reduced, and the appearance is more beautiful and ingenious.