Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
a technology of epithelial growth factor and antiher2 is applied in the field of combined therapy with antiher2 and antiher2 antibodies, which can solve the problems of poor prognosis and survival, her2 over-expression, etc., and achieve the effects of reducing metastasis, reducing metastasis, and reducing metastasis
Inactive Publication Date: 2007-09-27
F HOFFMANN LA ROCHE & CO AG
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[0013]The invention further comprises a method for increasing the duration of survival of a patient having breast cancer disease who has failed prior therapy with an anti-VEGF antibody, comprising administering to the patient effective amounts of an anti-VEGF antibody and an anti-HER2 antibody, whereby the co-administration of the anti-VEGF antibody and the anti-HER2 antibody effectively increases the duration of survival.
[0014]The invention further comprises a method for increasing the progression free survival of a patient having breast cancer disease who has failed prior therapy with an anti-VEGF antibody, comprising administering to the patient effective amounts of an anti-VEGF antibody and an anti-HER2 antibody, whereby the co-administration of the anti-VEGF antibody and the anti-HER2 antibody effectively increases the duration of progression free survival.
[0015]The invention further comprises a method for treating a group of patients, having breast cancer disease and having failed prior therapy with an anti-VEGF antibody, comprising administering to the patient effective amounts of an anti-VEGF antibody and an anti-HER2 antibody, whereby the co-administration of the anti-VEGF antibody and the anti-HER2 antibody effectively increases the response rate in the group of patients.
[0016]The invention further comprises a method for increasing the duration of response of a patient having breast cancer disease who has failed prior therapy with an anti-VEGF antibody, comprising administering to the patient effective amounts of an anti-VEGF antibody and an anti-HER2 antibody, whereby the co-administration of the anti-VEGF antibody and the anti-HER2 antibody effectively increases the duration of response.
[0018]This invention further comprises a method for reducing metastasis in a patient having breast cancer disease who has failed prior therapy with an anti-VEGF antibody, comprising administering to the patient effective amounts of an anti-VEGF antibody and an anti-HER2 antibody, whereby the co-administration of the anti-VEGF antibody and the anti-HER2 antibody effectively reduces metastasis.
[0019]The invention further comprises a method for treating a group of patients, having breast cancer disease and having failed prior therapy, with an anti-VEGF antibody, comprising administering to the patient effective amounts of an anti-VEGF antibody and an anti-HER2 antibody, whereby the co-administration of the anti-VEGF antibody and the anti-HER2 antibody effectively reduces metastasis in the group of patients.
Problems solved by technology
HER2 is over-expressed in tumor cells and is correlated with poor prognosis and survival.
Method used
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[0024]Al references cited herein are hereby incorporated by reference in their entirety.
Definitions
[0025]The term “VEGF” according to the invention refers to the vascular endothelial cell growth factor (Swiss-Prot No. P 15692), alternative splicing forms (see e.g. Leung, D. W., et al., Science, 246 (1989) 1306-1309; and Houck, K. A., et al., Mol. Endocrin. 5 (1991) 1806-1814) and active fragments, preferably N-terminal fragments thereof.
[0026]The term “anti-VEGF antibody” according to the invention is an antibody that binds specifically to VEGF. The preferred humanized anti-VEGF antibody or variant anti-VEGF antibody herein binds human VEGF with a Kd value of no more than about 1×10−8M and preferably no more than about 5×10−9M. Preferably the anti-VEGF antibody is a monoclonal antibody that binds to the same epitope as recombinant humanized anti-VEGF monoclonal antibody generated according to Presta, L. G., et al., Cancer Res. 57 (1997) 4593-4599. A preferred antibody is bevacizumab...
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Abstract
The present invention provides a method of treating a breast cancer disease in a patient who has failed prior treatment with an anti-VEGF antibody, comprising administering to the patient a therapeutically effective amount of an anti-HER2 antibody while continuing said anti-VEGF antibody therapy. The invention also provides corresponding pharmaceutical kits and pharmaceutical compositions.
Description
PRIORITY TO RELATED APPLICATIONS[0001]This application claims the benefit of European Application No. EP06111523.4, filed Mar. 22, 2006 and EP06021815.3, filed Oct. 18, 2006, which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]The present invention is directed to combined therapy with anti-HER2 and anti-VEGF antibodies. In particular, the invention concerns the use of such antibodies to treat breast cancer disease in a patient who has failed prior breast cancer treatment with an anti-VEGF antibody.BACKGROUND OF THE INVENTION[0003]Angiogenesis is implicated in the pathogenesis of a variety of disorders which include solid tumors, intraocular neovascular syndromes such as proliferative retinopathies or age-related macular degeneration (AMD), rheumatoid arthritis, and psoriasis (Folkman, J., et al., J. Biol. Chem. 267 (1992) 10931-10934; Klagsbrun, M., et al., Annu. Rev. Physiol. 53 (1991) 217-239; and Garner, A, Vascular diseases, In: Pathobiology of ...
Claims
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IPC IPC(8): A61K39/395
CPCA61K2039/507C07K16/32C07K16/3015C07K16/22A61P35/00A61P35/02A61P35/04A61K39/395C07K16/00A61K39/3955A61K39/39558C07K2317/24
Inventor FRIESS, THOMASHASMANN, MAXSCHEUER, WERNER
Owner F HOFFMANN LA ROCHE & CO AG
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