85 results about "Use insulin" patented technology

The invention provides a method for preparing a multi-layer bio-based vesica capable of releasing insulin, and belongs to the field of functional materials. The method uses a bio-based macro-molecule as a main raw material, and comprises the following steps: respectively modifying sodium alginate (Alg) and chitosan oligosaccharide (CS) by function monomer 3-aminobenzeneboronic acid (APBA) and 3-carboxyphenylboronic acid (CPBA) to synthesize Alg-g-CPBA grafted copolymer and CS-g-CPBA grafted copolymer; preparing a multi-layer bio-based macromolecular microsphere by using insulin pre-embedded silicon dioxide nano-particles as a template by virtue of layer-by-layer self-assembly; adding CaCl2 to enable the Alg layer to perform physical crosslinking so as to improve the microsphere stability; and finally, removing the template to prepare the multi-layer bio-based vesica capable of releasing insulin. The prepared vesica has high stability, unique hollow structure and excellent biocompatibility, and has a covering amount on insulin being 60 percent; and controllable release of insulin can be realized under the stimulating action of glucose with different concentrations, and the release capacity is 80 percent. The vesica has a potential application value in the field of drug loading, controllable release and the like.

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in cancer.