40results about How to "Amenable" patented technology

The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.

The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.

The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.

The invention provides methods and apparatus for preparation and sequencing of nucleic acids.

The present invention relates to the use of genetic variants of associated marker genes to predict an individual's response to diet. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for developing personalized diet regimens to optimize physiological response, including changes in body mass index (BMI) and blood lipid and triglyceride levels.

The present invention is directed to blends of ABS copolymer and aliphatic polymers, such as polyolefins, which blends include a compatibilizer. Such blends exhibit improved impact resistance over blends lacking the compatibilizer.

A volumetric stainless steel structure is provided by punch pressing a single blank and results in a volumetric presentation of alternating bands of stainless steel material. The spacing of the bands is sufficient to provide (1) an interruption in the surface to surface contact which might entrap organic species and (2) a space which allows the epidermis to be scrubbed, manipulated and massaged by the rounded edge of the bands as the hands manipulate it in a way similar the manipulation of soap. Further, the alternating bands provide internal surface area, in the form of the inside of the bands which are protruding, for additional adsorptive area.

A robotic microfluidic incubator system has a thin transparent sidewall and close proximity of the embryo/oocyte/cultured cells to the sidewall allow close approach of a side view microscope with adequate focal length for mid to high power. This arrangement permits microscopic examination of multiple culture wells when arranged in rows (linear or along the circumference of a carousel). Manual or automated side to side movement of the linear well row, or rotation of the carousel, allows rapid inspection of the contents each well. Automated systems with video capability also allow remote inspection of wells by video connection or Internet connection, and automated video systems can record oft-hours inspections or time lapse development in culture (i.e. embryo cell division progression, or axon growth in neuron cell cultures).

The invention provides a compound comprising a photosensitising agent coupled to a carrier molecule with a minimum coupling ratio of 3:1 wherein the carrier molecule has a binding specificity for a target cell. There is also provided a process of conjugation comprising the use of a first and second aprotic solvent and uses of the conjugated compounds.

The present invention relates to the use of genetic variants of associated marker genes to predict an individual's susceptibility to muscular injury and muscular side effects in response to statin therapy. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for personalized medical treatment, drug safety, statin compliance, and prophylaxis of muscle side effect.

The invention is directed to a single channel mask estimation method capable of improving reverberant speech identification for CI users. The method is based on the energy of the reverberant signal and the residual signal computed from linear prediction (LP) analysis. The mask is estimated by comparing the energy ratio of the two signals at different frequency bins with an adaptive threshold. As the threshold is updated for each frame of speech based on the energy ratios of the reverberant and LP residual signals computed from previous frames, it is amenable for real-time implementation. It can thus be used as a specialized (for reverberant environments) sound coding strategy used for cochlear implant applications.

The present invention provides methods of identifying cluster of differentiation (CD) marker phenotype for hematopoietic cells using multiple soluble CD markers circulating in bodily fluid. In particular aspects, the CD marker phenotype can be used to classify the tumor type of a patient having a proliferative disorder. In other aspects, treatment and disease progression can be monitored by measuring the levels of CD markers in bodily fluids of a patient over time.

The apparatus for producing a pulsing flow of fluids to a fluid line including a housing having first, second and third passages. The first passage communicates with a source of compressed gas and a first conduit, communicating with a solvent liquid source, and passes through the housing. A narrowed transverse dimension between the conduit and the inner chamber of the housing creates a pulsing delivery of fluids from the gas and liquid sources.

The invention herein describes an improved approach to managing hemorrhoids by combining current approaches of topical anesthetics, vasoconstrictors, ant-inflammatories, protectants, anti-pruretics, astringents, keratolytics, anticholinergics, cicatrizants, and antimicrobials with Croton species material. The botanical extracts are concentrated biologically active materials and thus provide enhanced therapeutic benefit. The Croton species components add a breadth and immediacy to the termination of neurogenic responses that mediate, sustain, and prolong the symptoms and underlying pathology.

The present invention provides a method for detecting a polymorphism or mutation in nucleic acid comprising a first phase to amplify or enrich for a sequence comprising a polymorphism or mutation and a second phase for detecting the polymorphism or mutation, wherein both phases are performed in the same reaction vessel.

The present invention provides several modified ABC transporter polypeptides that exhibit novel localization in the plasma membrane of polarized and non-polarized cells. The modified ABC transporter of the invention comprises the amino acid sequence of a native apically targeted ABC transporter, in particular cMOAT, MDR3 or MRP4, wherein the terminal tripeptide T-K-F motif of said native ABC transporter is mutated. The isolated modified ABC transporter polypeptide of the invention, and the nucleotide sequence encoding said polypeptide, have utility in the following applications: First, they are used to induce a drug resistant phenotype in a cell. Second, they are used to protect non-polarized cells during chemotherapy and other therapeutic applications. Third, they are used to produce novel cell lines that are used to screen for novel agonists or antagonists of the corresponding native ABC transporter polypeptides.

The present invention provides a process of identifying protooncogenes using high-throughput provirus tagging (HPT), e.g., by recovering host/virus junction sequences from chimeric transcripts containing both host and virus sequences.