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41results about How to "Amenable" patented technology
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Methods for detection of genetic disorders
InactiveUS20070178478A1Minimize disruptionMaximize efficiencyMicrobiological testing/measurementFermentationGeneticsAllele
The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.
Owner:RAVGEN INC
Methods for detection of genetic disorders
ActiveUS20060121452A1Minimize disruptionMaximize efficiencySugar derivativesMicrobiological testing/measurementNon invasiveChromosomal Abnormality
The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.
Owner:RAVGEN INC
Encapsulation compositions and processes for preparing the same
Matrix compositions which contain a mixture of two different food polymers are useful for encapsulating encapsulates, such as flavoring agents.
Owner:MCCORMICK & CO INC
Methods for detection of genetic disorders
InactiveUS20060160105A1Minimize disruptionMaximize efficiencySugar derivativesMicrobiological testing/measurementGeneticsAllele
Owner:RAVGEN INC
Sample preparation method and apparatus for nucleic acid sequencing
InactiveUS20070128610A1Reduce lossesAmenableBioreactor/fermenter combinationsBiological substance pretreatmentsNucleic acid sequencingNucleic acid sequence
Owner:FLUIDIGM CORP
Method for screening inhibitors of ras
ActiveUS20170131278A1Robust and high throughput interrogationInhibit Ras functionCompound screeningApoptosis detectionBiochemistryPharmacology
Provided herein are compositions, reactions mixtures, mutant Ras proteins, kits, substrates, and systems for selecting a Ras antagonist, as well as methods of using the same.
Owner:ARAXES PHARMA LLC
Physiogenomic method for predicting response to diet
InactiveUS20070196841A1Reduce weightReduce morbiditySugar derivativesMicrobiological testing/measurementGenomicsPersonalization
The present invention relates to the use of genetic variants of associated marker genes to predict an individual's response to diet. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for developing personalized diet regimens to optimize physiological response, including changes in body mass index (BMI) and blood lipid and triglyceride levels.
Owner:GENOMAS
Method for screening inhibitors of Ras
ActiveUS9810690B2Robust and high throughput interrogationInhibit Ras functionCompound screeningApoptosis detectionBiochemistryMutant protein
Provided herein are compositions, reactions mixtures, mutant Ras proteins, kits, substrates, and systems for selecting a Ras antagonist, as well as methods of using the same.
Owner:ARAXES PHARMA LLC
Manual odor removal structure
InactiveUS20100042113A1Increase surface areaHigh appearance requirementsSurgeryDetergent mixture composition preparationPunch pressOrganic matter
A volumetric stainless steel structure is provided by punch pressing a single blank and results in a volumetric presentation of alternating bands of stainless steel material. The spacing of the bands is sufficient to provide (1) an interruption in the surface to surface contact which might entrap organic species and (2) a space which allows the epidermis to be scrubbed, manipulated and massaged by the rounded edge of the bands as the hands manipulate it in a way similar the manipulation of soap. Further, the alternating bands provide internal surface area, in the form of the inside of the bands which are protruding, for additional adsorptive area.
Owner:DAKA RESEARCH INC
Microfluidic Embryo and Gamete Culture Systems
InactiveUS20110250690A1Eliminate needProlongs timeBioreactor/fermenter combinationsBiological substance pretreatmentsPhysicsOocyte
A robotic microfluidic incubator system has a thin transparent sidewall and close proximity of the embryo / oocyte / cultured cells to the sidewall allow close approach of a side view microscope with adequate focal length for mid to high power. This arrangement permits microscopic examination of multiple culture wells when arranged in rows (linear or along the circumference of a carousel). Manual or automated side to side movement of the linear well row, or rotation of the carousel, allows rapid inspection of the contents each well. Automated systems with video capability also allow remote inspection of wells by video connection or Internet connection, and automated video systems can record oft-hours inspections or time lapse development in culture (i.e. embryo cell division progression, or axon growth in neuron cell cultures).
Owner:CRAIG H RANDALL
Biological materials and uses thereof
InactiveUS20090053247A1Reduce managementHighly preventive effectAntibacterial agentsSenses disorderCoupling ratioSolvent
FR1 1 2 3H1-H2Locus123456789012345678901234567890VH11-31-02QVQLVQSGAEVKKPGASVKVSCKASGYTFT1-31-03QVQLVQSGAEVKKPGASVKVSCKASGYTFT1-31-08QVQLVQSGAEVKKPGASVKVSCKASGYTFT1-21-18QVQLVQSGAEVKKPGASVKVSCKASGYTFT1-U1-24QVQLVQSGAEVKKPGASVKVSCKVSGYTLT1-31-45QMQLVQSGAEVKKTGSSVKVSCKASGYTFT1-31-46QVQLVQSGAEVKKPGASVKVSCKASGYTFT1-31-58QMQLVQSGPEVKKPGTSVKVSCKASGFTFT1-21-69QVQLVQSGAEVKKPGSSVKVSCKASGGTFS1-21-eQVQLVQSGAEVKKPGSSVKVSCKASGGTFS1-21-fEVQLVQSGAEVKKPGATVKISCKVSGYTFTVH23-1 / 2-12-05QITLKESGPTLVKPTQTLTLTCTFSGFSLS3-12-26QVTLKESGPVLVKPTETLTLTCTVSGFSLS3-12-70QVTLKESGPALVKPTQTLTLTCTFSCFSLSVH31-33-07EVQLVESGGGLVQPGGSLRLSCAASGFTFS1-33-09EVQLVESGGGLVQPGRSLRLSCAASGFTFD1-33-11QVQLVESGGGLVKPGGSLRLSCAASGFTFS1-13-13EVQLVESGGSLVQPGGSLRLSCAASGFTFS1-U3-15EVQLVESGGGLVKPGGSLRLSCAASGFTFS1-33-20EVQLVFSGGSVVRPGGSLRLSCAASGFTFD1-33-21EVQLVESGGGLVKPGGSLRLSCAASGFTFS1-33-23EVQLLESGGGLVQPGGSLRLSCAASGFTFS1-33-30QVQLVESSGGVVQPGRSLRLSCAASGFTFS1-33-30.3QVQLVESGGGVVQPGRSLRLSCAASGFTFS1-33-30.5QVQLVESGGGVVQPGRSLRLSCAASGFTFSFR2CDR1 4H1-H2Locus1ab234567890123456789VH11-31-02G--YYMHWVRQAPGQGLEWMG1-31-03S--YAMHWVRQAPGQRLEWMG1-31-08S--YDINWVRQATGQGLEWMG1-21-18S--YGISWVRQAPGQGLEWMG1-U1-24E--LSMHWVRQAPGKGLEWMG1-31-45Y--RYLHWVRQAPGQALEWMG1-31-46S--YYMHWVRQAPGQGLEWMG1-31-58S--SAVQWVRQARGQRLEWIG1-21-69S--YAISWVRQAPGQGLEWMG1-21-eS--YAISWVRQAPGQGLEWMG1-21-fD--YYMHWVQQAPGKGLEWMGVH23-1 / 2-12-05TSGVGVGWIRQPPGKALEWLA3-12-26NARMGVSWIRQPPGKALEWLA3-12-70TSGMRVSWIRQPPGKALEWLAVH31-33-07S--YWMSWVRQAPGKGLEWVA1-33-09D--YAMHWVRQAPGKGLEWVS1-33-11D--YYMSWIRQAPGKGLEWVS1-13-13S--YDMHWVRQATGKGLEWVS1-U3-15N--AWMSWVRQAPGKGLEWVG1-33-20D--YGMSWVRQAPGKGLEWVS1-33-21S--YSMNWVRQAPGKGLEWVS1-33-23S--YAMSWVRQAPGKGLEWVS1-33-30S--YGMHWVRQAPGKGLEWVA1-33-30.3S--YAMHWVRQAPGKGLEWVA1-33-30.5S--YGMHWVRQAPGKGLEWVAThe invention provides a compound comprising a photosensitising agent coupled to a carrier molecule with a minimum coupling ratio of 3:1 wherein the carrier molecule has a binding specificity for a target cell. There is also provided a process of conjugation comprising the use of a first and second aprotic solvent and uses of the conjugated compounds.
Owner:PHOTOBIOTICS
Physiogenomic method for predicting statin injury to muscle and muscle side effects
InactiveUS20070202518A1Reduce generationPrevent and reduce muscular side effectBioreactor/fermenter combinationsBiological substance pretreatmentsSide effectMedicine
The present invention relates to the use of genetic variants of associated marker genes to predict an individual's susceptibility to muscular injury and muscular side effects in response to statin therapy. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for personalized medical treatment, drug safety, statin compliance, and prophylaxis of muscle side effect.
Owner:GENOMAS
Enhancement of reverberant speech by binary mask estimation
ActiveUS20150124987A1Enhancing reverberant speech recognition performanceImproving reverberant speech identificationSpeech analysisLine-transmissionEstimation methodsSpeech identification
The invention is directed to a single channel mask estimation method capable of improving reverberant speech identification for CI users. The method is based on the energy of the reverberant signal and the residual signal computed from linear prediction (LP) analysis. The mask is estimated by comparing the energy ratio of the two signals at different frequency bins with an adaptive threshold. As the threshold is updated for each frame of speech based on the energy ratios of the reverberant and LP residual signals computed from previous frames, it is amenable for real-time implementation. It can thus be used as a specialized (for reverberant environments) sound coding strategy used for cochlear implant applications.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Methods and construction and screening of libraries of chemokine variants
The present invention provides a method for the design and / or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and / or curing viral diseases, as well as clues for preventing and / or curing inflammatory or malignant diseases.
Owner:UNIV PIERRE & MARIE CURIE +1
Hematopoietic cell phenotyping using free circulating cellular markers
The present invention provides methods of identifying cluster of differentiation (CD) marker phenotype for hematopoietic cells using multiple soluble CD markers circulating in bodily fluid. In particular aspects, the CD marker phenotype can be used to classify the tumor type of a patient having a proliferative disorder. In other aspects, treatment and disease progression can be monitored by measuring the levels of CD markers in bodily fluids of a patient over time.
Owner:QUEST DIAGNOSTICS INVESTMENTS INC
Noise reduction of imaging data
ActiveUS20120093376A1Reduce computing costAccurate modelingImage enhancementMedical imagingDiagnostic Radiology ModalityDescent algorithm
The present invention relates to systems and methods for reducing noise in image data. Preferred embodiments relate to methods for analyzing two-photon in vivo imaging of biological systems. With neuronal population imaging with subcellular resolution, this modality offers an approach for gaining a fundamental understanding of brain anatomy and physiology. Analysis of calcium imaging data requires denoising, that is separating the signal from complex physiological noise. To analyze two-photon brain imaging data, for example, harmonic regression plus colored noise model and an efficient cyclic descent algorithm for parameter estimation. This approach reliably separates stimulus-evoked fluorescence response from background activity and noise, assesses goodness of fit, and estimates confidence intervals and signal-to-noise ratio.
Owner:MASSACHUSETTS INST OF TECH
Enhancement of reverberant speech by binary mask estimation
ActiveUS9538297B2Enhancing reverberant speech recognition performanceImproving reverberant speech identificationSpeech analysisLine-transmissionEstimation methodsSpeech identification
The invention is directed to a single channel mask estimation method capable of improving reverberant speech identification for CI users. The method is based on the energy of the reverberant signal and the residual signal computed from linear prediction (LP) analysis. The mask is estimated by comparing the energy ratio of the two signals at different frequency bins with an adaptive threshold. As the threshold is updated for each frame of speech based on the energy ratios of the reverberant and LP residual signals computed from previous frames, it is amenable for real-time implementation. It can thus be used as a specialized (for reverberant environments) sound coding strategy used for cochlear implant applications.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Microfluidic Embryo and Gamete Culture Systems
InactiveUS20130172667A1Easily benefitEfficient and effectiveFlow mixersRotary stirring mixersThe InternetMicroscopic exam
A robotic microfluidic incubator system has a thin transparent sidewall and close proximity of the embryo / oocyte / cultured cells to the sidewall allow close approach of a side view microscope with adequate focal length for mid to high power. This arrangement permits microscopic examination of multiple culture wells when arranged in rows (linear or along the circumference of a carousel). Manual or automated side to side movement of the linear well row, or rotation of the carousel, allows rapid inspection of the contents each well. Automated systems with video capability also allow remote inspection of wells by video connection or Internet connection, and automated video systems can record oft-hours inspections or time lapse development in culture (i.e. embryo cell division progression, or axon growth in neuron cell cultures).
Owner:CRAIG H RANDALL
Fluid pulse generator for cleaning passageways
InactiveUS9233404B1Easy to adjustPrecise maintenanceTransportation and packagingMixing methodsLine tubingEngineering
The apparatus for producing a pulsing flow of fluids to a fluid line including a housing having first, second and third passages. The first passage communicates with a source of compressed gas and a first conduit, communicating with a solvent liquid source, and passes through the housing. A narrowed transverse dimension between the conduit and the inner chamber of the housing creates a pulsing delivery of fluids from the gas and liquid sources.
Owner:MUNOZ ROBERT J +2
Topical preparations for use in treatment of anorectal disease
InactiveUS20050074510A1Amenable to preparationImprove securityBiocideUnknown materialsDiseaseTherapeutic effect
The invention herein describes an improved approach to managing hemorrhoids by combining current approaches of topical anesthetics, vasoconstrictors, ant-inflammatories, protectants, anti-pruretics, astringents, keratolytics, anticholinergics, cicatrizants, and antimicrobials with Croton species material. The botanical extracts are concentrated biologically active materials and thus provide enhanced therapeutic benefit. The Croton species components add a breadth and immediacy to the termination of neurogenic responses that mediate, sustain, and prolong the symptoms and underlying pathology.
Owner:RAINFOREST NUTRITIONALS
Olefin-based thermoplastic alloy, process for making the same and molded parts containing the same
InactiveUS6870005B1Unique characteristic of resistance to abrasion and scratchSuitable impact modificationSynthetic resin layered productsThin material handlingThermoplasticPolyolefin
A polymeric composition and process for making the same suitable for injection molding processes and procedures containing an olefinic polymer component selected from at least one a group which includes polyalkylenes, copolymers of polyalkylenes and a non-olefinic thermoplastic. The non-olefinic and olefinic polymeric components are present in random orientable locations in the initial polymeric composition. When injection molded against a temperature gradient, the resulting workpiece composed of the composition has distinctive regions of elevated non-olefinic concentration proximate the outwardly oriented surface and distinctive regions of elevated olefinic polymeric concentration proximate to interior regions of the workpiece. The non-olefinic thermoplastic may be at least one of thermoplastic polyamides, thermoplastic polyolefins and thermoplastic polycarbonates.
Owner:ACI TECH
Microfluidic embryo and gamete culture systems
InactiveUS20160278366A1Easily benefitEfficient and effectiveFlow mixersTransportation and packagingThe InternetEmbryo
A robotic microfluidic incubator system has a thin transparent sidewall and close proximity of the embryo / oocyte / cultured cells to the sidewall allow close approach of a side view microscope with adequate focal length for mid to high power. This arrangement permits microscopic examination of multiple culture wells when arranged in rows (linear or along the circumference of a carousel). Manual or automated side to side movement of the linear well row, or rotation of the carousel, allows rapid inspection of the contents each well. Automated systems with video capability also allow remote inspection of wells by video connection or Internet connection, and automated video systems can record oft-hours inspections or time lapse development in culture (i.e. embryo cell division progression, or axon growth in neuron cell cultures).
Owner:CRAIG H RANDALL
Method of amplifying nucleic acid
InactiveUS20100297633A1Simple and inexpensive methodLow costElectrolysis componentsMicrobiological testing/measurementBiologyNucleic acid
The present invention provides a method for detecting a polymorphism or mutation in nucleic acid comprising a first phase to amplify or enrich for a sequence comprising a polymorphism or mutation and a second phase for detecting the polymorphism or mutation, wherein both phases are performed in the same reaction vessel.
Owner:MOLECULAR PLANT BREEDING NOMINEES
Noise reduction of imaging data
ActiveUS8903192B2Reduce computing costAccurate modelingImage enhancementMedical imagingDiagnostic Radiology ModalityDescent algorithm
The present invention relates to systems and methods for reducing noise in image data. Preferred embodiments relate to methods for analyzing two-photon in vivo imaging of biological systems. With neuronal population imaging with subcellular resolution, this modality offers an approach for gaining a fundamental understanding of brain anatomy and physiology. Analysis of calcium imaging data requires denoising, that is separating the signal from complex physiological noise. To analyze two-photon brain imaging data, for example, harmonic regression plus colored noise model and an efficient cyclic descent algorithm for parameter estimation. This approach reliably separates stimulus-evoked fluorescence response from background activity and noise, assesses goodness of fit, and estimates confidence intervals and signal-to-noise ratio.
Owner:MASSACHUSETTS INST OF TECH
Modified proteins, isolated novel peptides,and uses thereof
InactiveUS20040091964A1AmenableModulate transporter activityAntibacterial agentsFungiPolarized cellChemo therapy
The present invention provides several modified ABC transporter polypeptides that exhibit novel localization in the plasma membrane of polarized and non-polarized cells. The modified ABC transporter of the invention comprises the amino acid sequence of a native apically targeted ABC transporter, in particular cMOAT, MDR3 or MRP4, wherein the terminal tripeptide T-K-F motif of said native ABC transporter is mutated. The isolated modified ABC transporter polypeptide of the invention, and the nucleotide sequence encoding said polypeptide, have utility in the following applications: First, they are used to induce a drug resistant phenotype in a cell. Second, they are used to protect non-polarized cells during chemotherapy and other therapeutic applications. Third, they are used to produce novel cell lines that are used to screen for novel agonists or antagonists of the corresponding native ABC transporter polypeptides.
Owner:BOARD PHILLIP +1
Physiogenomic Method for Predicting Statin Injury to Muscle and Muscle Side Effects
InactiveUS20090233299A1Reduce generationAmenableMicrobiological testing/measurementSide effectMedicine
Owner:GENOMAS
Affinity based drug release formulations
ActiveUS10576061B2Good water solubilityQuick releaseOrganic active ingredientsPeptide/protein ingredientsCombinatorial chemistryPharmaceutical Substances
The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.
Owner:MCMASTER UNIV
Manufacturing and engineering of DNASE enzymes for therapy
ActiveUS10988746B2AmenableDelay EliminationHydrolasesPeptide/protein ingredientsExtracellular proteinsGranulocytic cells
The present disclosure provides engineered human extracellular DNASE proteins (e.g., variants of DNASE1 (D1), DNASE1-LIKE 1 (D1L1), DNASE1-LIKE 2 (D1L2), DNASE1-LIKE 3 Isoform 1 (D1L3), DNASE1-LIKE 3 Isoform 2 (D1L3-2), DNASE2A (D2A), and DNASE2B (D2B)) that are useful for treating conditions characterized by neutrophil extracellular trap (NET) accumulation and / or release. In accordance with the invention, the DNase variant has advantages for therapy and / or large-scale manufacturing.
Owner:NEUTROLIS INC
High through-put cloning of protooncogenes
InactiveUS7083913B2Improve throughputOvercome limitationsVirusesMicrobiological testing/measurementRetroviral provirusProto-Oncogenes
The present invention provides a process of identifying protooncogenes using high-throughput provirus tagging (HPT), e.g., by recovering host / virus junction sequences from chimeric transcripts containing both host and virus sequences.
Owner:RGT UNIV OF CALIFORNIA
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