The invention relates to the technical field of food processing, and in particular relates to health wine and a preparation method thereof, the health wine mainly comprises grapes, cherries, passion fruit, watermelon, plant concentrate juice, a sweetener, tragacanth, adenylate, citric acid, an enzyme preparation, microorganisms and other raw materials; wherein the plant concentrate juice extract is mainly made of paulownia leaves, basil, hyssop, Rangoon creeper, gemma agrimoninae, lithospermum, Gynura divaricata, dandelion, corn stigma and other raw materials; and the plant juice concentrate extract, the sweetener and fruit juice are first prepared, then all mixed, clarified, homogenized, fermented, blended, mixed and aged to obtain the health wine. The health wine is clear in liquid, non-sedimentation, rich in wine and fruity fragrance, sweet and mellow, high in soluble solid content, high in nutritional value, and low in alcohol content and sugar content, reduces too-high alcohol content and sugar content to benefit human health, has prolonged shelf life, and has the functions such as clearing away heat and detoxifying, promoting fluid, stimulating thirst, dispelling the effectsof alcohol, beautifying, nourishing face, killing insects and lowering blood sugar.