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Ultrafine high-performance microcrystalline cellulose product and preparation method thereof

A technology of microcrystalline cellulose and equipment, applied in the field of ultra-fine high-performance microcrystalline cellulose products and their preparation, can solve the problems of poor product fluidity and limited application, and achieve high bulk density, wide application fields, and enhanced flow. sexual effect

Active Publication Date: 2020-06-26
MUDANJIANG LINRUN PHARM EXCIPIENTS LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commercially available microcrystalline cellulose products with small particle size generally have an average particle size D50 of about 15-30 μm, and a bulk density of 0.2-0.3 g / ml. Therefore, there is a problem that the smaller the particle size, the worse the fluidity of the product. Greatly limit its application in industry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take the wood pulp cellulose pulp on the market, and hydrolyze it with high-temperature acid (hydrolysis temperature 115-170°C, acid concentration 0.03-0.35mol / L) for 1-2 hours to obtain hydrolyzed microcrystalline cellulose, filter and wash to pH to 4-5, and increase the solid content of the filter cake to 40%. The filter cake with this solid content is extruded 3 times through a high-shear extruder (a continuous extruder with a high-shear paddle), and the torque of the extruder is controlled between 50-150 N.m. In between, in the interlayer of the extruder, cooling water is passed into it for cooling. The extruded material is diluted with water, stirred, neutralized to a pH of 5-8, and then spray-dried to obtain the microcrystalline cellulose product of the present invention.

[0035] Through the measurement of particle size and density, the microcrystalline cellulose particles prepared above have a loose density of 0.670 g / ml, a tap density of 0.807 g / ml, and a part...

Embodiment 2

[0037] Get commercially available Vivapur PH102 microcrystalline cellulose powder, its limiting degree of polymerization is 225, through particle size and density measurement, loose density is 0.32g / ml, and tap density is 0.44g / ml, and particle size distribution D10 is 29.623 μ m , D50 is 104.997 μm, and D90 is 227.668 μm.

[0038] Take by weighing Vivapur PH102 microcrystalline cellulose powder 500g, add water 500g and mix evenly to material solid content after being 50%, the filter cake of this solid content is extruded 3 times by high-shear extruding device, and control extruding device The torque is between 50-150 Nm. In the interlayer of the extruder, cooling water is passed through. The extruded material is diluted with water and stirred, then neutralized to a pH of 5-8, and then spray-dried to obtain the microcrystalline cellulose product of the present invention.

[0039] Through the measurement of particle size and density, the microcrystalline cellulose product obta...

Embodiment 3

[0041] Take the cellulose pulp made from bamboo on the market, and hydrolyze it with high temperature acid (hydrolysis temperature 115-170°C, acid concentration 0.03-0.35mol / L) for 1-2 hours to obtain hydrolyzed microcrystalline cellulose, filter and wash with water When the pH reaches 4-5, the filter cake is diluted with water, neutralized to a pH of 5-8, and then spray-dried to obtain a traditional microcrystalline cellulose product. After measurement, the bulk density of the microcrystalline cellulose powder is It is 0.440g / ml, the tap density is 0.575g / ml, and the particle size distribution D50 is 39.01μm.

[0042] Get the bamboo pulp microcrystalline cellulose filter cake that above-mentioned makes, solid content is controlled at 40%, extrude 3 times by high-shear extruding device, and the torque of controlling extruding device is between 50-150 Newton.meter , In the interlayer of the extruder, cooling water is passed into it for cooling. The extruded material is diluted...

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Abstract

The invention provides an ultrafine high-performance microcrystalline cellulose product and a preparation method thereof. In particular, the average particle size D50 of the microcrystalline celluloseproduct is 1-25 microns, the bulk density is 0.50-0.80g / ml, and the ultrafine high-performance microcrystalline cellulose product is prepared from common microcrystalline cellulose through high-shear-force equipment under the mechanical action of high shear force. The product disclosed by the invention has low particle size and high density, so that the product has the properties of good flowability, strong compressibility and the like, and can be widely applied to various fields of food, medicine, chemical engineering and the like.

Description

technical field [0001] The invention relates to the field of microcrystalline cellulose, in particular to an ultrafine high-performance microcrystalline cellulose product and a preparation method thereof. Background technique [0002] Microcrystalline cellulose is a free-flowing fine powder granule obtained from natural cellulose by dilute acid hydrolysis to the limiting degree of polymerization (LODP). Its color is white or nearly white, odorless and tasteless, and the limiting degree of polymerization (LODP) is usually 100-350; it is insoluble in water, dilute acid, organic solvent and grease, and partially dissolves and swells in dilute alkali solution. Microcrystalline cellulose is stable in high temperature, high humidity, and strong light conditions, and is widely used in various industries such as medicine, food, daily chemicals, and light industry. [0003] Microcrystalline cellulose is widely used in the pharmaceutical industry as a pharmaceutical excipient. It is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08B15/02C08L1/04A23L33/24
CPCC08J3/122C08B15/02A23L33/24C08J2301/04A23V2002/00A23V2200/3202C08L1/04A23L29/262C08J3/12
Inventor 尹丽敏
Owner MUDANJIANG LINRUN PHARM EXCIPIENTS LLC
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