The invention relates to the technical field of wine making, in particular to wax gourd wine and a preparation method thereof. The wax gourd wine mainly comprises the following raw materials in parts by weight: 70-80 parts of wax gourds, 40-50 parts of pumpkins, 15-20 parts of hawthorns, 10-15 parts of celeries, 20-25 parts of sugarcanes, 17-20 parts of radix notoginseng, 15-17 parts of lithospermum, 15-17 parts of madders, 15-17 parts of liquorice, 13-15 parts of shizandra berries, 0.2-0.4 part of a de-acidification agent, 1-2 parts of zymocyte and the like, and is prepared by the steps of raw material treatment, pulping, enzymatic hydrolysis, fermentation, de-acidification, clarification, aging, super-high pressure sterilization and the like. The wax gourd wine provided by the invention is thick in wine fragrance, sour, sweet and tasty, and rich in nutrition and has the effects of detoxifying, inducing diuresis, dissolving phlegm, relieving restlessness, quenching thirst, eliminating dampness, relieving summer-heat, beautifying, nourishing skin and the like; the preparation method is simple and convenient for practical operation.