The invention discloses a production method of health-care baijiu. The production method comprises the following steps of mixing sorghum, corns, wheat, buckwheat, polished round-grained rice and jujubes, soaking a mixture with water, mixing the soaked mixture with rice husks and bran, adding a urease-producing bacterium solution for material moisture treatment, performing retort filling for steaming, and performing discharging from the retort to obtain cooked grains; cooling the cooked grains, adding distiller's yeast for uniform stirring, adding the urease-producing bacterium solution to obtain a mixed fermented feed, performing stacking fermentation on the mixed fermented feed, and putting the mixed fermented feed after stacking fermentation into a pool for fermentation to obtain fermented grains; removing kernels of pawpaw, peaches and avocados, mixing the pawpaw, the peaches and the avocados after kernel removal with grapes, apples, fructus lycii, rhizoma dioscoreae, blueberries, olives, lotus seeds and spirulina, and performing pulping to obtain a slurry; mixing flos chrysanthemi indici, fiveleaf gynostemma herb, bulbus lilii, folium mori, folium isatidis with folium apocyni veneti, and performing extraction and concentration to obtain a leaching solution; mixing the fermented grains, the slurry and the leaching solution, and adding a fermenting enzyme for fermentation toobtain a brut; distilling the brut to obtain a base liquor; and adding activated carbon into the base liquor for adsorption, and performing freeze filtering, storage and blending to obtain the health-care baijiu.