Tenofovir and preparation technology thereof

Abstract

The invention discloses tenofovir and a preparation technology thereof, and relates to the technical field of the tenofovir. The tenofovir comprises a capsule wall material and a capsule core, whereinthe capsule core is prepared from, by weight, 23-25 parts of R-methyl lactate, 7-9 parts of adenine, 13-15 parts of diisopropyl-p-tosyloxymethylphosphonate and 3-5 parts of sodium borohydride; the capsule wall material is prepared from, by weight, 17-19 parts of choline glycerophosphate, 17-19 parts of palmitic acid, 2-3 parts of sodium hydroxide, 4-6 parts of ethyldiisopropylamine, 6-9 parts ofparaformaldehyde, 4-7 parts of acetic acid, 7-9 parts of polyacrylic resin, 12-19 parts of deionized water, 8-12 parts of absolute ethyl alcohol, 3-7 parts of a surface active agent, 4-6 parts of a water-soluble dispersing agent and 5-10 parts of a solvent. The tenofovir prepared by using the technology is composed of the capsule core and the capsule wall material, the physical properties of the tenofovir are improved, the tenofovir is easily absorbed by the human body, and therefore, the pharmaceutical effect of the tenofovir is improved.

Description

technical field

[0001] The invention relates to the technical field of tenofovir, in particular to a tenofovir and a preparation process thereof. Background technique

[0002] Tenofovir, chemical name (R)-{[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}phosphonic acid, or (R)-9 -(2-phosphonomethoxypropyl) adenine, tenofovir disoproxil fumarate is a first-line antiviral drug for the treatment of HIV, HBV, tenofovir is the preparation of tenofovir fumarate Key intermediates of esters. Oral administration and rectal administration are two common administration methods. The drug is absorbed by the stomach or rectal mucosa and enters the blood, and is transported to the whole body through blood circulation, so as to achieve the purpose of treating diseases. The existing tenofovir is not easy to Absorbed by the gastrointestinal tract, the purpose of optimal absorption and utilization by the human body cannot be achieved. Contents of the invention

[0003] The technical prob...