Ginkgo biloba leaf extract injection quality control method based on quantitative analysis of multi-components by single marker and fingerprint spectrum

A measurement method and injection technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., to achieve the effect of fast measurement method, high precision and good stability
CN107064397AInactive Publication Date: 2017-08-18HEILONGJIANG ZBD PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEILONGJIANG ZBD PHARMA
Publication Date
2017-08-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relate to a ginkgo biloba leaf extract injection quality control method based on quantitative analysis of multi-components by a single marker and a fingerprint spectrum. The method comprises the steps that rutin is adopted as a reference sample, flavonols kaempferol-3-O-rutinoside, isorhamnetin-3-O-rutinoside, kaempferol-3-O-rhamnose-2-glucoside, quercetin-3-O-rhamnose-2-O-(6-O-p-hydroxy cinnamoyl) glucosyl and kaempferol-3-O-rhamnose-9-O-6-O-(p-hydroxy cinnamoyl) glucosyl are quantified through quantitative analysis of multi-components by a single marker, and the ginkgo biloba leaf extract injection batched quality stability is controlled through the fingerprint spectrum. The problem that ginkgo biloba leaf extract injection multi-component quantification and multi-index quality control lack reference samples is solved, and the quality of the ginkgo biloba leaf extract injection is ensured while the product batched quality stability is controlled through the fingerprint spectrum.
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Description

technical field

[0001] The invention relates to a method for controlling the quality of Shuxuening injection based on a one-measurement-multiple-assessment method and a fingerprint. Background technique

[0002] Shuxuening Injection dilates blood vessels and improves microcirculation. For ischemic cardiovascular and cerebrovascular diseases, coronary heart disease, angina pectoris, cerebral embolism, cerebral vasospasm, etc. The raw material is Ginkgo biloba, and the excipients are glucose and ethanol. Every 2 mL of Shuxuening injection contains 7.0 mg of Ginkgo biloba extract, which contains 1.68 mg of total flavonol glycosides and 0.28 mg of ginkgo biloba lactone.

[0003] The fingerprint of traditional Chinese medicine refers to the chromatogram or spectrum of a certain type or several types of components that are common in certain Chinese medicinal materials or Chinese patent medicines. At the present stage, when most of the active ingredients of traditional Chinese me...

Claims

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