The invention discloses a method based on an automatic radioactive particle loading machine. The designed and produced automatic radioactive particle loading machine is composed of a feed port, a sequencer, a guider, a cutter, a discharge port and a touch screen, and the whole loading machine is covered and wrapped by a lead anti-radiation material to prevent radioactive leakage. The invention relates to the technical field of medical clinic. According to the method based on the radioactive particle automatic loading machine, the problems of storage, implantation, spacing, leakage and the like existing in a previous particle operation can be completely solved, radioactive contamination caused by particle exposure is avoided, the preoperative preparation time and the intraoperative particle implantation time are greatly shortened, the operation difficulty is reduced, the number of doctors needing to be allocated for operation is reduced, the distance between the particles completely meets the requirement of a preoperative treatment plan, therefore, the treatment effect is improved, and the pressure of storing, transporting and distributing the particles in a particle production plant is relieved.