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Degradable biological hybrid high-strength hydrogel stent as well as preparation method and application thereof

A bio-hybrid and hydrogel technology, used in tissue regeneration, medical science, prosthesis, etc., can solve the problems of inability to fully degrade, difficult to carry tissue engineering scaffolds, and inability to fully meet requirements, and achieve the effect of promoting tissue regeneration.

Inactive Publication Date: 2020-12-22
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, both physically cross-linked Gelatin hydrogels and chemically cross-linked methacrylated gelatin (GelMA) hydrogels exhibit "weak and brittle" mechanical properties, making it difficult to be used alone to construct load-bearing tissues. Engineering support
In order to solve the above problems, people have introduced supramolecular host-guest interaction and double synergistic physical cross-linking into the gelatin network, and successfully constructed a series of high-strength gelatin-based hydrogels. However, due to the existence of stable cross-linking, These systems usually cannot be completely degraded, and still cannot fully meet the requirements for scaffold materials for tissue engineering scaffolds

Method used

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  • Degradable biological hybrid high-strength hydrogel stent as well as preparation method and application thereof
  • Degradable biological hybrid high-strength hydrogel stent as well as preparation method and application thereof
  • Degradable biological hybrid high-strength hydrogel stent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of bioactive glass (BG): solid-phase 1393-1.5B6Sr bioglass was prepared by melting method, and its molar composition was as follows: 6Na 2 O.8K 2 O.8MgO.16CaO.6SrO.27SiO 2 .27B 2 o 3 .2P 2 o 5 (mol%), the carbonates, phosphates, boric acids, etc. corresponding to the alkali metals and alkaline earth metals are fully mixed according to the proportioning ratio, and then the platinum crucible with the mixed raw materials is placed in a silicon-molybdenum furnace at 1100 ° C, melted After 2-4 hours, the melt is quenched to obtain bulk glass, and the glass block is ground and sieved to obtain a powder with a particle size of less than 40 μm, namely to obtain bioactive glass (BG).

[0024] Taking methacrylylated gelatin (GelMA) with a mass fraction of 7%, N-acryloylglycine (ACG) with a mass fraction of 35%, and bioactive glass (BG) with a concentration of 3% of the total mass of the monomers as an example, in constructing a gradient scaffold The subchondral ...

Embodiment 2

[0028] Preparation of bioactive glass (BG): solid-phase 1393-1.5B6Sr bioglass was prepared by melting method, and its molar composition was as follows: 6Na 2 O.8K 2 O.8MgO.16CaO.6SrO.27SiO 2 .27B 2 o 3 .2P 2 o 5 (mol%), the carbonates, phosphates, boric acids, etc. corresponding to the alkali metals and alkaline earth metals are fully mixed according to the proportioning ratio, and then the platinum crucible with the mixed raw materials is placed in a silicon-molybdenum furnace at 1100 ° C, melted After 2-4 hours, the melt is quenched to obtain bulk glass, and the glass block is ground and sieved to obtain a powder with a particle size of less than 40 μm, namely to obtain bioactive glass (BG).

[0029] Taking methacrylylated gelatin (GelMA) with a mass fraction of 7%, N-acryloylglycine (ACG) with a mass fraction of 35%, and bioactive glass (BG) with a concentration of 5% of the total monomer mass as an example, the gradient scaffold was constructed The subchondral bone l...

Embodiment 3

[0033] Preparation of bioactive glass (BG): solid-phase 1393-1.5B6Sr bioglass was prepared by melting method, and its molar composition was as follows: 6Na 2 O.8K 2 O.8MgO.16CaO.6SrO.27SiO 2 .27B 2 o 3 .2P 2 o 5 (mol%), the carbonates, phosphates, boric acids, etc. corresponding to the alkali metals and alkaline earth metals are fully mixed according to the proportioning ratio, and then the platinum crucible with the mixed raw materials is placed in a silicon-molybdenum furnace at 1100 ° C, melted After 2-4 hours, the melt is quenched to obtain bulk glass, and the glass block is ground and sieved to obtain a powder with a particle size of less than 40 μm, namely to obtain bioactive glass (BG).

[0034] Taking methacrylylated gelatin (GelMA) with a mass fraction of 7%, N-acryloylglycine (ACG) with a mass fraction of 35%, and bioactive glass (BG) with a concentration of 1% of the total monomer mass as an example, the gradient scaffold was constructed The subchondral bone l...

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Abstract

The invention provides a degradable biological hybrid high-strength hydrogel stent as well as a preparation method and application thereof. The hydrogel stent is constructed by taking methacrylated gelatin loaded with manganese ions or bioactive glass and an aqueous solution of an N-acryloylglycine monomer precursor as biological ink by a method of firstly performing 3D printing molding and then performing free radical polymerization. The stent is integrally formed, the formula is simple, the components are safe, the preparation conditions are mild, the problem of interface bonding of cartilage and subchondral bone layers is solved, and the hydrogel stent has two properties of high strength and degradability, can play a role in bearing at the initial stage of implantation of a defect part,and can be gradually degraded along with the extension of implantation time. Space is provided for growth of new tissues, and an osteochondral integrated repair effect is achieved.

Description

technical field [0001] The invention relates to the technical field of high-strength hydrogel and 3D printing hydrogel, and more specifically relates to a degradable biohybrid high-strength hydrogel scaffold and its preparation method and application. Background technique [0002] Articular cartilage damage and its complications (such as subchondral bone degeneration and osteoarthritis, etc.) are a common clinical problem. These diseases can cause loss of knee joint function, severe pain, and even disability, seriously affecting people's lives quality. Unfortunately, due to the lack of blood vessels and nerves in the articular cartilage, once the injury is caused, it is difficult to heal spontaneously. Autologous chondrocyte transplantation techniques, etc.) have problems such as insufficient donors and poor shape matching. Therefore, people began to seek ways to construct tissue engineering scaffolds to achieve integrated osteochondral repair. [0003] Scaffold materials...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/22A61L27/10A61L27/02A61L27/16A61L27/50A61L27/52A61L27/58B33Y10/00B33Y70/10B33Y80/00C08F120/34
CPCA61L27/222A61L27/10A61L27/025A61L27/16A61L27/50A61L27/52A61L27/58B33Y10/00B33Y70/00B33Y80/00C08F120/34A61L2300/412A61L2430/02A61L2430/06
Inventor 刘文广徐子扬高飞
Owner TIANJIN UNIV
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