Systems and methods for combined ultrasound and electrical stimulation for treating a subject

A subject, electrical stimulation technology, applied in the direction of ultrasound therapy, treatment, electrotherapy, etc., can solve the complex problems of the vagus nerve

Pending Publication Date: 2021-12-31
RGT UNIV OF MINNESOTA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While vagus nerve stimulation holds promise, applying electrical stimulation to the vagus nerve is complicated by the fact that electrical current can flow through the tissue in an uncontrollable manner and that the vagus nerve is involved in many functions of the body, even life-sustaining functions such as heart rate

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  • Systems and methods for combined ultrasound and electrical stimulation for treating a subject
  • Systems and methods for combined ultrasound and electrical stimulation for treating a subject
  • Systems and methods for combined ultrasound and electrical stimulation for treating a subject

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Embodiment Construction

[0029]Systems and methods for coordinated non-invasive neuromodulation are provided. Ultrasound stimulation can be: applied to the spleen and / or joints, extremities, or other areas experiencing pain with localized swelling; combined with electrical stimulation of the neck, face, or other body areas in an appropriately timed pattern to drive targeting of autoimmune Diseases and inflammatory diseases such as rheumatoid arthritis. Coordinated or combined methods of ultrasound stimulation and electrical stimulation harness natural body functions for healing where these different pathways and localized areas are activated in a coordinated manner. The systems and methods of the present disclosure mimic these more natural processes to provide more enhanced healing than can be provided by non-coordinated stimulation or either stimulation alone. Since the different components of the body do not naturally work in isolation but in connection with each other and need to be co-activated i...

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Abstract

Systems and methods are provided for combined ultrasound and electrical stimulation for treating inflammation, autoimmune disorders, rheumatoid arthritis, and the like. Noninvasive ultrasound stimulation may be applied to the spleen, joints, limbs, or a region experiencing pain that has local swelling, and electrical stimulation may be applied to the face, neck, or other body region to access a peripheral nerve, vagus nerve, trigeminal nerve, or other nerves in appropriately-timed patterns to drive therapeutic effects. Stimulation timings or delay timings may be optimized based upon a desired clinical effect or treatment. Multiple targets may be stimulated in a coordinated fashion to better mimic natural physiology. A wearable ultrasound phased array device may be used to beam form energy to target the spleen while also having imaging capabilities to track the motion of the spleen to maintain localized stimulation of target regions.

Description

[0001] Cross References to Related Applications [0002] This application claims the U.S. patent application titled "Systems and Methods for Combined Ultrasound and Electrical Stimulation for Treating A Subject," filed March 11, 2019. The benefit of Provisional Patent Application Serial No. 62 / 816,857, which is incorporated herein by reference in its entirety. [0003] Statement Regarding Federally Funded Research [0004] Not applicable Background technique [0005] Rheumatoid arthritis (RA) and other inflammatory disorders are often treated with disease-modifying antirheumatic drugs (DMARDs) or anti-tumor necrosis factor drugs (anti-TNF). Although effective for many patients, such treatment regimens can cause serious side effects and remain ineffective for a large number of patients—it is estimated that as many as one-third of RA patients respond to their primary antibody- TNF drug did not respond. Patients who do not respond are often prescribed nonsteroidal anti-inflam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61H23/00A61N1/18A61N1/36
CPCA61N1/36014A61N1/36021A61N7/00A61N2007/0026A61N2007/0095A61N1/36031A61N1/36034A61N1/0492
Inventor 赫伯特·利姆丹尼尔·扎克斯克莱尔·凯泽
Owner RGT UNIV OF MINNESOTA
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