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Closed-loop electroencephalogram regulation and control method and system

A control system and EEG technology, applied in medical science, sensors, diagnostic recording/measurement, etc., can solve problems such as θ rhythm without consideration, achieve the effect of ensuring the accuracy of stimulation and improving learning and memory

Pending Publication Date: 2022-04-19
YANSHAN UNIV
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  • Application Information

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Problems solved by technology

However, none of the existing closed-loop EEG regulation methods consider theta rhythm

Method used

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  • Closed-loop electroencephalogram regulation and control method and system
  • Closed-loop electroencephalogram regulation and control method and system
  • Closed-loop electroencephalogram regulation and control method and system

Examples

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Embodiment 1

[0052] Please refer to figure 1 , the present embodiment provides a closed-loop EEG control system, the system includes an acquisition module, a processing module, a control module and an ultrasonic stimulation module.

[0053] The collection module is connected to the experiment object and is used to collect the EEG signal of the experiment object in real time; wherein, the experiment object is set to a small black mouse commonly used when carrying out experiments in the laboratory; the collection module includes EEG electrodes and nerve signals Processor; the EEG electrodes include three circuits, wherein one tungsten microelectrode is inserted into the CA1 region of the hippocampus under the skull of the subject to record the EEG of this brain region, and the other two electrodes are inserted on the nasal bone of the subject as reference electrodes and a ground electrode; the neural signal processor is connected with the EEG electrode, configured to convert the EEG signal i...

Embodiment 2

[0076] This embodiment provides a closed-loop EEG regulation method using the closed-loop EEG regulation system described in Embodiment 1, figure 2 It is a flowchart of the method, and the method includes the steps of:

[0077] S1. Receive the EEG signal of the subject.

[0078] In this embodiment, the experimental subjects are small black mice commonly used in laboratory experiments.

[0079] S2. Preprocessing the EEG signal to obtain a preprocessed EEG signal.

[0080] This step specifically includes: performing down-sampling, 50 Hz notch wave denoising and 4-200 Hz filter processing on the EEG signal to obtain a preprocessed EEG signal.

[0081] S3. Calculate and process the preprocessed EEG signal to obtain the θ rhythm EEG signal and EEG feature value.

[0082] Such as image 3 As shown, this step specifically includes:

[0083] S31. Perform 4-8 Hz filtering on the preprocessed EEG signal to obtain theta rhythm EEG signal;

[0084] S32. Calculate and process the pr...

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Abstract

The invention provides a closed-loop electroencephalogram regulation and control method and system. The method comprises the following steps: receiving an electroencephalogram signal of an experimental subject; preprocessing the electroencephalogram signal to obtain a preprocessed electroencephalogram signal; calculating and processing the preprocessed electroencephalogram signal to obtain a theta rhythm electroencephalogram signal and an electroencephalogram characteristic value; processing the theta rhythm electroencephalogram signal and the electroencephalogram characteristic value to obtain an ultrasonic stimulation parameter and a theta rhythm set stimulation phase; and according to the ultrasonic stimulation parameters and the theta rhythm, setting a stimulation phase, and sending ultrasonic stimulation to the experimental subject to perform electroencephalogram regulation and control. By collecting and analyzing the electroencephalogram signals of the experimental subject in real time and using the closed-loop ultrasonic stimulation technology, electroencephalogram regulation and control on the experimental subject with the electroencephalogram theta rhythm as the marker are achieved.

Description

technical field [0001] The present application relates to the technical field of neural regulation by ultrasonic stimulation, in particular to a method and system for closed-loop EEG regulation. Background technique [0002] Brain neuromodulation technology is an important method that uses external technical means such as light, magnetism, electricity, ultrasound, etc. to change the transmission of endogenous nerve signals in the brain, thereby causing changes in brain function. Among them, ultrasonic neuromodulation is a new type of brain stimulation technology. Compared with other traditional electrical, magnetic, and optical neurostimulation technologies, it has the advantages of strong directionality, large penetration depth, accurate target control, and non-invasiveness. Ultrasound non-invasive brain nerve regulation technology has attracted much attention from scholars in the field of neuroscience. [0003] As a neuromodulation technology, ultrasound can be widely use...

Claims

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Application Information

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IPC IPC(8): A61B5/369A61B5/374A61B5/377A61B5/00
CPCA61B5/369A61B5/374A61B5/377A61B5/7235A61B5/7203
Inventor 袁毅谢振宇
Owner YANSHAN UNIV
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