The invention relates to a nanofiltration membrane blending based high salinity wastewater zero discharge processing method, and a device. The nanofiltration membrane blending based high salinity wastewater zero discharge processing method mainly comprises following steps: high salinity wastewater is delivered through a pretreatment system for impurity removing, salt extraction concentration, andsoftening; softened concentrated water is introduced into a nanofiltration blending system for blending of the concentrations of monovalent and divalent salts, so that the monovalent salt to divalentsalt concentration ratio is controlled to be 0.01 to 0.1; concentrated water discharged from the nanofiltration blending system is introduced into a sodium sulfate crystallization system for processing so as to obtain divalent salt products capable of satisfying industrial salt requirements and a sodium chloride-containing mother liquor; an obtained nanofiltration blending system penetrating fluidis delivered through an extraction concentration system, and is introduced into a sodium chloride crystallization system so as to obtain sodium chloride salt products and a sodium sulfate-containingmother liquor; the sodium chloride crystallization mother liquor is subjected to impurity removing, and is introduced into the sodium sulfate crystallization system; the sodium sulfate crystallizationmother liquor is subjected to impurity removing, and is introduced into the sodium chloride crystallization system. The nanofiltration membrane blending based high salinity wastewater zero dischargeprocessing method is capable of realizing wastewater zero discharge, and stabilizing salinity fluctuation in the crystallization systems.