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Transcriptomic biomarkers for individual risk assessment in new onset heart failure

a transcriptional biomarker and individual risk assessment technology, applied in the field of transcriptional biomarkers of heart disease, can solve the problems of limited accuracy of prediction tools based on standard criteria, and achieve the effect of accurate prognostic assessment and substantial financial savings

Inactive Publication Date: 2010-05-06
UNIV OF MIAMI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes a method for predicting the outcome of cardiovascular diseases and disorders by analyzing the expression of certain genes in a patient's biological sample. This can help to identify patients at risk of developing these conditions and allow for early intervention with appropriate treatment. The method is based on the use of transcriptomic biomarkers, which are gene sequences that can predict the likelihood of a negative outcome or the development of cardiovascular diseases. The detection of these biomarkers can provide a prognosis for heart failure or the diagnosis of other cardiovascular diseases.

Problems solved by technology

Prediction tools based on standard criteria have had limited accuracy.

Method used

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  • Transcriptomic biomarkers for individual risk assessment in new onset heart failure
  • Transcriptomic biomarkers for individual risk assessment in new onset heart failure
  • Transcriptomic biomarkers for individual risk assessment in new onset heart failure

Examples

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example 1

Transcriptomic Biomarkers for Individual Risk Assessment in New Onset Heart Failure

[0179]Accurate risk assessment and prediction of prognosis at first presentation are crucial for appropriate allocation of therapy, monitoring and patient management. In this study, a transcriptomic based biomarker (TBB) is presented which has been derived from a single endomyocardial biopsy (EMB) and which predicts the long term clinical outcome of patients with idiopathic dilated cardiomyopathy (IDCM) with very high accuracy.

[0180]Materials and Methods

[0181]Abbreviations: NYHA, New York Heart Association classification; LV EF, left ventricular ejection fraction, LVIDD, left ventricular internal diastolic dimension; PAP, pulmonary artery pressure; PCWP, pulmonary capillary wedge pressure. Patients: EMBs were collected from patients that were referred to Johns Hopkins Hospital between 1997 and 2006 for evaluation of cardiomyopathy (n=35012). A clinical data base of patient outcome was maintained concu...

example 2

Transcriptomic Biomarker for Predicting Clinical Outcome and Prognosis in Heart Failure Using a Transcriptomic Biomarker

[0199]To identify this biomarker (gene signature) heart samples were collected from patients undergoing heart biopsy early in their clinical course. Following this the samples were stored in a biorepository for 5-10 years during which time the outcome of patients were determined.

[0200]Endomyocardial biopsy samples from patients with idiopathic cardiomyopathy have been collected at the Johns Hopkins Hospital between 1997-2004 and stored in liquid nitrogen. Biopsy samples from patients with idiopathic cardiomyopathy were chosen from this biorepsitory—18 patients with good prognosis and 12 patients with bad prognosis. Bad prognosis was defined as occurrence of death or an intervention, namely left-ventricular assist device placement or cardiac transplant, in the first 2 years after diagnosis, while good prognosis was defined as event free survival for greater than 5 y...

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Abstract

A novel transcriptomic biomarker for prognosis in heart failure has a direct clinical application in prediction of prognosis in new onset heart failure, heart disease, heart disorders and associated heart conditions. This approach should improve individualization of cardiac care and help identify patients at highest risk for circulatory collapse within the first years of presentation with heart failure.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation in part of International Application No. PCT / US2008 / 62281, international filing date May 1, 2008, which in turn claims priority to U.S. provisional application No. 61 / 019,749 filed Jan. 8, 2008 and U.S. provisional patent application No. 60 / 915,224 filed May 1, 2007 which are incorporated herein by reference in their entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH[0002]This invention was made with U.S. government support under grant numbers M400-217-2954 and RO-1 HL-65455 both awarded by the National Institutes of Health. The U.S. government may have certain rights in the invention.FIELD OF THE INVENTION[0003]This invention relates to biomarkers of heart disease novel drug therapeutic targets, compositions and methods of predicting, diagnosing and treating heart diseases and related disorders thereof. More specifically, the invention concerns methods and compositions based on unique mole...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68C12N5/00C12N15/63C40B40/06C07K16/00C07H21/00
CPCC12Q1/6883G01N33/6893G01N2800/325C12Q2600/16C12Q2600/118C12Q2600/136C12Q2600/158G01N2800/50C12N15/11C12N15/115C12Q1/6837C40B40/08
Inventor HARE, JOSHUA M.HEIDECKER, BETTINA
Owner UNIV OF MIAMI
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