The invention discloses a 3D pulse electro-therapeutic apparatus circuit which comprises a power supply module and an output module. The output end of the power supply module is sequentially connected with a control module, a constant-current module, an amplifying module and an oscillation module, and the output end of an electro-therapeutic apparatus is a 3D module. The 3D pulse electro-therapeutic apparatus circuit has the advantages of having the 3D function, due to the fact that N sets of independent electrode control terminals are connected to the output of the apparatus, energized time of each set of the electrodes is controlled freely, the controlling mode comprises sequential circulating from left to right or from right to left or from inside to outside or from outside to inside, and multiple types of 3D special effects such as running water or horse running are achieved. Due to the fact that human has sensory illusion, a patient can sense the flowing feeling of current on the human body, the feeling is like real person massage and knocking and the patient feels like being in a dreamlike environment. The 3D pulse electro-therapeutic apparatus circuit overturns the pressing pain and uncomfortable feeling produced by a traditional electro-therapeutic apparatus during human body partial treatment, the multiple sets of electrodes sequentially conduct the 3D therapy, implementation range is wide, he treatment effect is significant, penetration is strong, and the 3D pulse electro-therapeutic apparatus circuit is unique in treatment, protects health of the patient and has the health maintenance effect.