31results about How to "Effective delivery" patented technology

This invention relates to a method of reducing an irritating or adverse side effect associated with the topical use of an active ophthalmic drug comprising incorporating an effective amount of a cyclodextrin or cyclodextrin derivative into a formulation to complex the active drug such that the concentration of the free active drug is reduced below a tolerable threshold, and incorporating an effective amount of a viscosity increasing agent in said formulation such that the bioavailability of said drug is high enough to be therapeutically effective, wherein the cyclodextrin or cyclodextrin derivative is not required to solubilize the active drug. Another aspect of this invention relates to topical ophthalmic formulations comprising an active drug, a cyclodextrin or cyclodextrin derivative, and a viscosity-enhancing agent, in effective amounts as stated above.

Disclosed herein are conjugates comprising a nanocarrier, a therapeutic agent or imaging agent and a targeting agent. Also disclosed herein are compositions comprising such conjugates and methods for using the conjugates to deliver therapeutic and / or imaging agents to cells. Also disclosed are methods for using the conjugates to treat particular disorders, such as proliferative disorders.

An apparatus and method for transmitting / receiving an urgent packet in a digital broadcast system is provided. A packet transmission apparatus of a digital broadcast transmitter includes a buffer which buffers broadcast packets; an urgent packet generator which generates an urgent packet having an urgent packet header indicating the urgent packet when a packet containing urgent data is detected; and a frame generator which generates a frame with the broadcast packets and inserts the urgent packet into the frame, wherein the urgent packet is substituted for one of broadcast packets in the frame.

Pharmaceutical compositions comprising 4-hydroxy tamoxifen in an amount of 0.105-0.950% by weight effectively deliver the 4-hydroxy tamoxifen. Such compositions, including gels, can treat or prevent benign breast disease, scarring or a keloid, gynecomastia, breast cancer, mastalgia, or a condition involving dense breast tissue.

A method for delivering a melanocortin-4 receptor agonist to a mammalian subject, includes administering the melanocortin-4 receptor agonist to a tissue inside the nasal cavity or sinuses of the mammalian subject. In some instances, the melanocortin-4 receptor agonist includes a guanidine functional group.

The invention relates to immunogenic compositions. In certain embodiments, the invention provides pharmaceutical compositions comprising an antigen, an immunostimulating substance selected from neuroactive compounds, hormones, compounds having a growth hormone activity, and mixtures thereof, and a polycationic polymer.

The invention discloses a raw-liquid-material conveying device. The raw-liquid-material conveying device comprises a main hollow shell. A main hollow structure is arranged on one side inside the main hollow shell, a motor fixing shell is fixed at the portion, located at one end of the main hollow shell, of one end of the main hollow structure through a bolt, a motor is fixed inside the motor fixing shell, a main motor shaft in the motor penetrates through the main hollow shell, a shaft sleeve is fixed at the portion, located on a shaft body inside the main hollow structure, of the main motor shaft, and a sealing ring is fixed between a shaft body of the main motor shaft and the penetrated portion of the main hollow shell. According to the raw-liquid-material conveying device, through the screw conveying principle, raw liquid materials are effectively conveyed; in addition, the device comprises an independent pressurizing mechanism, when liquid with the large density is conveyed, the effective pressurizing effect can be achieved, and the conveying force is improved; meanwhile, the device comprises an anti-deformation mechanism, the anti-deformation mechanism can have the capability capable of preventing a cylinder barrel from being deformed, and the practicability is high.

The invention relates to pharmaceutical dosage units for oral, transmucosal or transdermal administration containing 15- or 16-substituted testosterone analogues, as well as to therapeutic methods that employ these testosterone analogues. More particularly, the invention is concerned with such pharmaceutical dosage units containing at least 10 μg of an androgenic steroid selected from the group consisting of 15-hydroxytestosterones, 16-hydroxytestosterones, precursors thereof and mixtures of these hydroxytestosterones and / or their precursors; and a pharmaceutically acceptable excipient. The term “15-hydroxytestosterones” encompasses both 15β-hydroxytestosterone (15α, 17β-dihydroxy-4-androsten-3-one) and 15β-hydroxytestosterone (15β, 17β-dihydroxy-4-androsten-3-one). Similarly, the term “16-hydroxytestosterones” encompasses both 16α-hydroxytestosterone hydroxytestosterone (16α, 17β-dihydroxy-4-androsten-3-one) and 16α-hydroxytestosterone (16β, 17β-dihydroxy-4-androsten-3-one). The androgenic steroids according to the invention are advantageously employed in e.g. a method of treating or preventing androgen deficiency or a method of hormonal contraception.

A thin-walled capsule of defined permeability is produced by blow-molding an aqueous-based polymer composition.

The invention discloses a pull-up resistance circuit for preventing reverse current filling, which is used for protecting a public signal end from being influenced by drain current of a connected power supply. The pull-up resistance circuit comprises a pull-up resistance module and a control signal generating module, wherein the pull-up resistance module is connected in series between the public signal end and the power supply; the control signal generating module is electrically connected with the pull-up resistance module and the public signal end; when the power supply is in charge, the control signal generating module is used for controlling the pull-up resistance module to be connected with the power supply; and when the power supply is out of charge, the control signal generating module is used for controlling the pull-up resistance module to be disconnected from the power supply. Due to the adoption of the pull-up resistance circuit for preventing reverse current filling, the public signal end is protected from being influenced by the drain current of the connected power supply when a local equipment power supply does not work, and transmission of information with other equipment can be realized effectively when the local equipment power supply works.

The invention relates to a liquid-cooled chassis and a plug-in thereof, wherein the liquid-cooled chassis comprises a chassis; a plug-in is installed on the inner wall of the chassis, the plug-in comprises a heat conduction seat plate, a groove is arranged on the heat conduction seat plate, and a heat conduction part for conducting heat is arranged inside the groove. The groove on the plug in is provided with the heat conduction part for conducting heat, which can quickly transmit the heat dissipated by the integrated element to a liquid cooling pipeline on the side wall of the chassis, thereby realizing the rapid and effective heat transfer, largely avoiding the negative influence caused by the accumulation of heat and the excessive temperature inside the elements, and effectively prolonging the service life of the element.

The invention discloses a flexible heat pipe and a machining method thereof. The flexible heat pipe comprises a flexible main body, a first metal sheet and a second metal sheet, wherein the flexible main body can be bent, the flexible main body is made of a flexible material, the flexible main body is internally provided with an evaporation cavity, a condensation cavity, and a liquid channel and agas channel for connecting the evaporation cavity and the condensation cavity, and the evaporation cavity and the condensation cavity are both of a cavity structure with the bottom surface or the side surface open. According to the flexible heat pipe, working liquid is injected into the flexible main body, and the working liquid is arranged between the evaporation cavity and the condensation cavity, and flows through the gas channel and the liquid channel to achieve heat transfer. Due to the fact that the flexible main body is made of the flexible material and capable of being bent along withan electronic device, the heat dissipation requirement of the electronic device which is narrow in space and foldable under complex working conditions can be met, effective heat transfer is achievedby arranging the first metal sheet and the second metal sheet, the adverse effect of poor heat conduction performance of a flexible material is avoided, and the flexible heat pipe is applied to the technical field of heat pipes.

The invention relates to an aerosol distribution device which comprises an aerosol generator. The aerosol generator is communicated with a gas inlet system, an aerosol inlet system and an aerosol gas output system separately. The gas inlet system is used for providing gas of certain pressure and flow for the aerosol generator. The aerosol inlet system is used for providing a certain amount of powdery and granular aerosol for the aerosol generator. The aerosol generator is used for mixing received gas and the aerosol into aerosol gas of the certain concentration, and then, the aerosol gas is conveyed to an experimental loop main pipeline through the aerosol gas output system. According to the aerosol distribution device, gas is used as an aerosol carrier, an aerosol material is uniformly, stably and efficiently conveyed into the experimental loop main pipeline within a long period of time, and it is ensured that aerosol distribution can simulate actual possible working conditions; and the aerosol distribution device is simple and compact in structure and convenient to install and has the high adjustability.

The invention provides an advertisement putting method and platform. The method comprises the steps that acquiring text information of a webpage; analyzing the text information of the webpage, and adding a main scene tag to the webpage according to an analysis result; and after determining that the application scene label of the advertisement in the database is matched with the main scene label ofthe webpage, associating the main scene label of the webpage with the application scene label of the advertisement, and putting the advertisement to the webpage for display. According to the advertisement putting method provided by the invention, the main scene label of the webpage is extracted, the application scene label of the advertisement is matched with the main scene label of the webpage,and then the advertisement is put to the webpage, so that the effective putting of the advertisement is realized.

A fuel cell comprising an anode and cathode, fuel delivery means comprising a superabsorbent nonwoven absorbent media in fluid contact with a wicking material, gas-liquid separation means, and water management means. In one embodiment, the fuel cell also uses a microporous membrane, a wicking material, and an absorbent material to provide for gas-liquid separation, and a wicking material and absorbent material to provide for liquid management means at the cathode. In some embodiments, the combination of materials provides the advantage of passive operation and orientation independence for the fuel cell.

The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.

The invention provides a multi-functional stirring machine. The multi-functional stirring machine comprises motors and a stirring box; reduction gearboxes are connected with output shafts of the motors; couplers are connected with output shafts of the reduction gearboxes and connected with stirring shafts; the stirring shafts are arranged in the stirring box; the motors, the reduction gearboxes, the couplers and the stirring shafts are symmetrically arranged around the center line of the stirring box correspondingly; electric heating tapes are arranged around the surface of the stirring box; and an air circulation plate is arranged in the center of the upper surface of the stirring box. The multi-functional stirring machine is simple in structure connection, convenient to operate, and capable of stably achieving the continuous stirring function, achieving drying at the same time in the stirring process and performing dewatering and dust removal after stirring is finished, the abrasionresistance of the stirring shafts is good, the stirring and flow guide effects are good, the service life is long, and the multi-functional stirring machine is suitable for being applied and popularized.

In a heater system for a microwave oven including an air tunnel having an suction portion and a discharge portion, formed at an upper surface of a cooking chamber, a fan assembly installed inside the air tunnel and having a circulation fan forming air flow by sucking air inside the cooking chamber through the suction portion and discharge the sucked air through the air tunnel and the discharge portion, a first heater chamber having a first heater installed inside the air tunnel and heating air discharged into the discharge portion from the air tunnel, and a second heater chamber having a second heater installed inside the air tunnel and emitting radiation heat into the cooking chamber, wherein the suction portion and the discharge portion are respectively formed at each end portions of the upper surface of the cooking chamber, said end portions facing each other and positioned toward the side walls of the cooking chamber.

The present invention provides, among other things, methods of formulating nucleic acid-containing nanoparticles with an enzyme to afford efficient delivery of payload to a cell or tissue of interest via subcutaneous administration. In some embodiments, the present invention provides a process in which mRNA-loaded lipid nanoparticles are co-mixed with various amounts of hyaluronidase and administered via subcutaneous administration. The resulting payload can be efficiently delivered to the liver and other organs or tissues of a treated subject.

The invention relates to complete equipment for transverse large-diameter hole forming in a soft coal seam coal pillar area and a hole forming technology. The complete equipment comprises a high-torque drilling machine, a holing drilling tool and a reaming drilling tool, wherein the high-torque drilling machine comprises a guide rail assembly, a stable drilling support assembly and a drilling androtating device; the stable drilling support assembly is installed on a large rotation plate of the high-torque drilling machine to provide support for a drilling machine in the drilling process; thedrilling and rotating device is installed on the guide rail assembly, and drives the holing drilling tool to rotate according to the drilling process to achieve high-speed drilling or driving the reaming drilling tool to rotate to achieve low-speed high-torque back reaming; the guide rail assembly is installed on the stable drilling support assembly, can adjust the drilling position and directionof the drilling and rotating device and provide required pulling force for back reaming of the drilling and rotating device. The hole forming technology comprises a holing process and a back reaming process. The problems of difficult operation, low efficiency, low hole forming rate, high labor intensity and the like in transverse large-diameter hole forming in the soft coal seam coal pillar can beeffectively solved.

The invention discloses an efficient energy-saving single-screw extruder. The efficient energy-saving single-screw extruder is characterized by comprising a conventional device, a hopper, a machine barrel, a screw rod arranged in the machine barrel, a heating and cooling device, a lathe bed and an electrical control device, wherein the conventional device comprises a main motor and a reduction gearbox, the screw rod adopts equal-width separation-type threads, and the end, back on to the conventional device, of the screw rod is provided with a barrier head. The efficient energy-saving single-screw extruder has beneficial effects that as the screw rod adopts a mode of combining the equal-width separation-type threads and the barrier head, and the design of shallow slot threads is also added, added materials are rapidly and effectively conveyed, the retention time is shortened, efficient low-temperature plasticizing of the materials is accelerated, and the increase of production capacity is guaranteed; as the electrical control device has the function of interlocking control on all main systems of the whole set of the extruder, overloading running of equipment is effectively avoided, and the safety and the stability of the whole production process are ensured.

The invention discloses a hollowed-out star wheel guardrail which comprises a baseplate, supporting columns and protecting assemblies, wherein the baseplate is detachably mounted on the supporting columns; the protecting assemblies are detachably mounted on the baseplate; and mounting spaces used for the entry of star wheels are formed between the protecting assemblies and the baseplate. The invention further discloses a light inspection machine which comprises a rack, the guardrail and the star wheels, wherein the guardrail is detachably mounted on the rack; the star wheels are rotatably mounted on the rack; the supporting columns are detachably mounted on the rack; the protecting assemblies are arranged around the outer circumferential directions of the star wheels; upper protecting plates, lower protecting plates and guiding plates are all arranged around the outer circumferential directions of the star wheels; and feeding areas used for the passing of bottles are formed between theupper protecting plates and the star wheels. By adoption of the hollowed-out star wheel guardrail disclosed by the invention, the bottles can be protected against collision and explosion; the effective transmission can be achieved; and the hollowed-out star wheel guardrail is convenient and rapid to dismount, so that the cleanliness and the sanitation can be facilitated.

Disclosed is a power bus apparatus for improving power mass ratio of a power supply controller. The power bus apparatus is characterized in that the apparatus comprises at least one power conversion circuit board, at least one input power positive interface (4), at least one output power positive interface (5), at least one power negative interface (6), a fastening assembly (3) and a power transmission assembly, wherein the at least one power conversion circuit board is mounted on one power supply controller; the at least one input power positive interface (4), at least one output power positive interface (5), and at least one power negative interface (6) are mounted on the first power conversion circuit board (11) through the fastening assembly (3); and the power transmission assembly isfixed with the input power positive interface (4) and / or the output power positive interface (5) and / or the power negative interface (6), and mounted on the power conversion circuit board.

The invention relates to the technical field of dismounting tools, in particular to an equal-distance thread progressive type small bolt dismounting tool and a using method. The tool is matched with ahexagonal open wrench for converting a screwdriver or wrench dismounting fastening way which is difficult to implement in a narrow space into a hexagonal open wrench fastening way which is convenientto operate in a wide space, so that the problems such as screwdriver or wrench partial screwing or inclined screwing as a common screwdriver or wrench cannot be normally used if there is no enough operation space in a dismounting process in the prior art are solved; through engagement of a planetary wheel, a first gear and an inner gear, equal-thread advance and retract effect between a performing head and a bolt is realized based on gear variable-speed transmission principle when a drive sleeve rotates, so that the performing head is always tightly combined with a bolt head for synchronous advance and retract, and thus, bolt head damages caused by slip or inclination under force are avoided, and normal and effective transmission of torsion force moment is guaranteed.

The invention discloses a sand suction and mud suction circulation launching device, and relates to the technical field of sand suction and mud suction devices. The sand suction and mud suction circulation launching device comprises a chassis, a suction mechanism, an auxiliary mechanism, a water jet scalpel mechanism and mud discharge mechanisms, wherein telescopic rods are fixed to the edge of the upper surface of the chassis at equal intervals, the suction mechanism is arranged in the center between the chassis and a supporting disc, the auxiliary mechanism is installed on the edge of the upper portion of the supporting disc and composed of a unit ladder block, a through pipe, a through net, a ring pipe and an injection pipe, the water jet scalpel mechanism is arranged in the center of the upper portion of the supporting disc, and the mud discharge mechanisms penetrate through positioning sleeves. According to the sand suction and mud suction circulation launching device, the water jet scalpel mechanism is assisted through the auxiliary mechanism, so that mud and sand can be quickly scattered after passing through a mud passing net, on one hand, the operation pressure of the water jet scalpel mechanism is reduced, and on the other hand, a large amount of mud and sand cannot be left at dead corners around the water jet scalpel mechanism, complete output of the mud and sand canbe guaranteed, and the mud and sand conveying efficiency is improved.

Provided is a method for easily preventing adhesion and clogging of wet mineral raw material, such as coal, iron ore, dust, coke, or limestone, in transportation equipment, such as piping. This methodcomprises a step for obtaining a raw material mixture with superabsorbent resin in contact with the wet mineral raw material by spraying superabsorbent resin on the wet mineral raw material before orduring the transportation thereof using a belt conveyor. Thus, the material mixture is transported using the transportation equipment and the adhesion and clogging of the mineral material in the transportation equipment is prevented.

The present invention relates to a corrugated smoke tube structure for a boiler, which improves the heat exchange efficiency of a smoke tube, and comprises: a plurality of first recessed portions formed by being recessed along a first side portion in the length direction of a main body; a plurality of second recessed portions formed so as to be recessed along a second side portion in the longitudinal direction of the body disposed so as to face the first side portion, the plurality of second recessed portions being positioned so as to face each other between the pair of first recessed portions; and a plurality of blocking grooves formed in a pair of side wall portions provided between the first side portion and the second side portion.

The invention relates to a special-purpose truck key structure for container transportation, in particular to a transverse beam bearing structure for a loading container well-hole wagon, which comprises an upper cover plate and a slot-type beam, and further comprises an angle-shaped bearing seat, wherein the upper cover plate is folded and pressed to be a wide U shape, the upper cover plate comprises a left vertical plane, a right vertical plane and a bottom surface, the bottom surface and the slot-type beam are fastened, installed and welded, the angle-shaped bearing seat is a break angle-shaped hollow section steel casting, the angle-shaped bearing seat comprises a vertical end and a horizontal end, and the vertical end is provided with an embedded mouth. The transverse beam bearing structure for the loading container well-hole wagon has the beneficial effects that the transverse beam bearing structure for the loading container well-hole wagon achieves to directly weld the two ends of a transverse beam structure and a side wall plate and a side column of a wagon depressed center underframe side wall structure with extremely strong vertical stiffness, enables wagon body stress distribution to tend to be uniform, and prevents stress concentration.

In order to realize more rapid and more efficient transfer of information between trucks of motorcades, the invention discloses a method for interacting road condition information between the trucks of the motorcades. The method for interacting road condition information mainly comprises two manners, wherein the first manner is information transfer (wide area) between a traffic command center andvehicle nodes, the traffic command center releases traffic service information such as weather, road conditions and the like to the vehicle nodes in an effective communication range of the traffic command center, the nodes forward the information after receiving the information, and moreover, traffic information perceived by the vehicle nodes are also released to the command center; and the secondmanner is information transfer (local area) between the vehicle nodes. Before a freight motorcade sends cargoes, trucks are pairwise coupled (numbered as 1 and 2), the truck 2 is only controlled according to the local area information, and the truck 1 not only interacts with the local area information of the truck 2, but also interacts with an ITS wide area, so that the operation throughput is greatly reduced. The local areas of the two trucks are interacted without transferring all the road information, so that the transferred information amount is small and then the information is transferred more rapidly and efficiently. In the wide area, half of the ITS information interaction amount is reduced.