296 results about "Breast disease" patented technology

The present invention provides a method for diagnosing and detecting diseases associated with breast. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in breast diseases (BCAT) and antibodies binds to BCAT. The present invention provides that BCAT is used as targets for screening agents that modulates the BCAT activities. Further the present invention provides methods for treating diseases associated with breast.

A differential temperature sensor device is provided for detecting differential temperatures in a human breast. A pad having a contoured design is covered with an adhesive layer having differing release forces on its two sides to insure sustained contact between the breast and temperature sensors and to ease removal after use. Temperature sensors are arranged in a useful pattern and covered with a silicon lidding which is removed prior to use. The device is especially useful for the detection of breast cancer and breast disease.

The invention discloses a Chinese medicinal preparation for treating breast diseases and uterine fibroid and a preparation method thereof. The Chinese medicinal preparation is prepared by extracting and mixing the following raw materials in percentage by weight: 8 to 15 percent of Chinese thorowax root, 4 to 6 percent of turmeric root-tuber, 3 to 6 percent of pangolin, 4 to 6 percent of nutgrass galingale rhizome, 3 to 5 percent of thunbery fritillary bulb, 3 to 5 percent of snake gourd fruit, 3 to 4 percent of hemlock parsley, 3 to 5 percent of suberect spatholobus stem, 2 to 4 percent of red-rooted salvia root, 2 to 3 percent of common burreed rhizome, 2 to 3 percent of curcuma zedoary, 2 to 3 percent of frankincense, 2 to 3 percent of myrrh, 3 to 5 percent of rhizoma corydalis, 3 to 5 percent of turtle shell, 2 to 4 percent of spina gleditsiae, 2 to 3 percent of semen litchi, 5 to 6 percent of selfheal, 3 to 6 percent of Astragalus root, 2 to 4 percent of angelica, 2 to 3 percent of Atractylis ovate, 2 to 3 percent of white peony root, 2 to 3 percent of poria, and 2 to 3 percent liquorice. The Chinese medicinal preparation can be used for treating patients with hyperplasia of mammary glands, mamstitis or hysteromyoma, and has high clinical cure rate and good healing effect.

Disclosed is a method and apparatus for accomplishing a noninvasive screen for breast disease markers, including breast cancer markers and cytologically abnormal cells. Intraductal fluid is noninvasively aspirated using compression, heating and suction cycles. The removed sample is thereafter assayed for the presence of cytologically abnormal cells and / or one or more breast disease markers. In addition to the diagnostic applications of the disclosed method and apparatus, a therapeutic application is also contemplated wherein intraductal fluids are noninvasively aspirated using compression, heating and suction cycles to remove toxic buildups within the fluid.

The invention provides a mammary gland auxiliary diagnosis system and method based on fusion depth characteristics, and relates to the technical field of medical image post-processing. The system comprises a preprocessing unit, a lump detection unit, a fusion depth feature extraction unit and a lump diagnosis unit, and is characterized in that an original mammary gland image is preprocessed, and amammary gland region is divided into a plurality of non-overlapped sub-regions; Mammary gland sub-region depth features are extracted by using a convolutional neural network CNN, and US- ELM is usedto cluster the depth characteristics of each sub-region to obtain mammary gland lumps and non-lump regions; a convolutional neural network CNN is used to extract lump depth features, lump morphology and texture features are extracted, and the lump depth, morphology and texture features are fused into a fused depth feature; And the fusion depth features are learned by using an extreme learning machine (ELM) to finally obtain benign and malignant diagnosis results of the lumps. The method is applied to breast auxiliary diagnosis, and accurate diagnosis of breast diseases can be effectively assisted.

Disclosed is a method and apparatus for accomplishing a noninvasive screen for breast disease markers, including breast cancer markers and cytologically abnormal cells. Intraductal fluid is noninvasively aspirated using compression, heating and suction cycles. The removed sample is thereafter assayed for the presence of cytologically abnormal cells and / or one or more breast disease markers. Sample size and intraductal mobility of breast disease markers may be enhanced by retrograde introduction of a carrier. Devices and assays are also disclosed.

The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast diseases and diseases susceptible to endoxifen. In particular, the compositions of the present invention include liposomes, complexes, vesicles, emulsions, micelles and mixed micelles of endoxifen in which the compositions further contain any of a variety of neutral or charged lipids and desirably, cholesterol and cholesterol derivatives, sterols, Z- and E-guggulsterones, phospholipids, fatty acids, vitamin D, and vitamin E. The present invention also provides methods of preparing endoxifen. The present invention provides methods for treating and preventing breast cancer and other breast related diseases by administrating novel formulations or compositions comprising a therapeutically effective amount of endoxifen.

The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast diseases and diseases susceptible to endoxifen. In particular, the compositions of the present invention include liposomes, complexes, vesicles, emulsions, micelles and mixed micelles of endoxifen in which the compositions further contain any of a variety of neutral or charged lipids and desirably, cholesterol and cholesterol derivatives, sterols, Z- and E-guggulsterones, phospholipids, fatty acids, vitamin D, and vitamin E. The present invention also provides methods of preparing endoxifen. The present invention provides methods for treating and preventing breast cancer and other breast related diseases by administrating novel formulations or compositions comprising a therapeutically effective amount of endoxifen.

The invention discloses a time intensity characteristic-based computer aided method for diagnosing benign and malignant breast lesions, comprising the following steps of: selecting an image sequence layer with suspicious lesions from a DCE(Dynamic Contrast-Enhanced)-MRI (Magnetic Resonance Imaging) image sequence set; carrying out denoising and filtering treatment on each image layer and acquiring a photographic subtraction sequence of the layer; determining a time intensity curve according to the photographic subtraction sequence of the layer; analyzing the characteristic of the time intensity curve and giving out a diagnosis result of the layer, namely a preliminary diagnosis result of the lesion; and fusing diagnosis results of the time intensity curves for different layers to give out a final lesion diagnosis result. According to the time intensity characteristic-based computer aided method disclosed by the invention, by comprehensively analyzing the characteristic of the time intensity curve on each layer, the accuracy of benign and malignant diagnosis of the lesions can be greatly improved for assisting clinical diagnosis for breast diseases and further the misdiagnosis rate is reduced.

The invention provides a medicament for treating adenofibroma of breast and cyclomastopathy. The medicament is prepared by the following raw materials in portion by weight: 30 to 50 portions of Chinese thorowax, 50 to 70 portions of rhizoma cyperi, 10 to 30 portions of trigone, 50 to 70 portions of tulip, 30 to 50 portions of rhizoma arisaematis, 20 to 40 portions of seaweed, 20 to 40 portions of sea-tangle, 20 to 40 portions of radix codonopsitis, 20 to 40 portions of radix astragali, 20 to 40 portions of fritillary bulb, 30 to 50 portions of green tangerine orange peel, 20 to 40 portions of radix linderae, 50 to 70 portions of oyster, 10 to 30 portions of woodlouse, 10 to 30 portions of spina gleditsiae, 20 to 40 portions of rhizoma zedoariae, and 20 to 40 portions of radix curcumae. In the medicament, the Chinese medicines are compatible with each other, compact but not complex, and play the efficacies of promoting qi circulation and removing obstruction in the collateral, promoting blood circulation and removing obstruction in channels, resolving phlegm and softening hard masses, and can treat breast diseases perfectly. The medicament is mainly used for treating adenofibroma of breast and cyclomastopathy, and has good treatment effect and short treatment period.

The invention discloses a system and method for three-dimensional breast X-ray and three-dimensional color Doppler ultrasound fusion imaging. The system for fusion imaging comprises a breast X-ray machine for collecting three-dimensional X-ray images of the breast, an ultrasonic machine for collecting three-dimensional ultrasound images of the breast and a collecting terminal for performing fusion treatment on the three-dimensional X-ray images and the three-dimensional ultrasound images of the breast so as to obtain a two-dimensional image group. The two-dimensional image group comprises two or more fused two-dimensional images. The collecting terminal is in communication connection with the breast X-ray machine and the ultrasonic machine. According to the system, the advantages of the X-ray technology and the color Doppler ultrasound technology are combined, so that the breast two-dimensional image group fusing X-ray and color Doppler ultrasound imaging information is obtained, and thus clinical doctors can make a diagnosis on breast diseases more accurately and more conveniently.

The invention discloses a breast massaging instrument. The air outlet end of an air supply device is connected with 4-8 main air pipes, wherein each main air pipe is respectively communicated with two branch air pipes; an inner cavity is arranged between an outer layer and a liner; a plurality of airbag arrays are arranged in the inner cavity; the airbags are adhered with the outer layer; a cup is equally divided into 4-8 approximate sector-shaped areas; the airbags in various areas are mutually communicated; one airbag positioned at the outmost side in each area is communicated with one branch air pipe; and two branch air pipes connected with the same main air pipe are respectively communicated with the airbags in the same area in two cups. According to the breast massaging instrument disclosed by the invention, the airbags are adopted as parts for generating displacement and massaging; the air supply device is used for inflating the airbags to enable the airbags to be deformed; and massage manipulations such as extruding, pushing and kneading, lifting and the like are realized by controlling the inflating time and intervals in different areas, thus breast diseases are prevented and breasts are stimulated to grow.

The invention discloses a superconducting magnetic resonance imaging machine, and a construction method and a use thereof. The superconducting magnetic resonance imaging machine of the invention comprises imaging areas, at least one vacuum insulation cover, a main magnet and a low-temperature cooling system, wherein the main magnet generates magnetic fields in the imaging areas; the low-temperature cooling system is connected with the vacuum insulation cover; a low vacuum space is formed and a lower-temperature heat conducting plate and at least one high vacuum inner cover and high vacuum outer cover are arranged inside the vacuum insulation cover; the vacuum insulation cover at least provides one imaging area; at least one superconducting radio frequency coil is arranged inside the low vacuum space and connected with the low-temperature heat conducting plate; and the low-temperature heat conducting plate is connected with the low-temperature cooling system through a heat pipe to realize and maintain the lower temperature condition of the superconducting radio frequency coil. The construction of the vacuum insulation cover is suitable for the imaging of the following body parts: breasts, knees, wrists, feet, a neck and a head. The invention can improve the magnetic resonance imaging quality and achieve a high signal-to-noise ratio in the imaging areas.

The invention provides a medicine for treating hyperplasia of mammary glands, mastodynia and general mammary diseases and a preparation method thereof, relating to the field of traditional Chinese medicine. At present, hormone replacement therapy is commonly used in western medicine, but the side effects are large, and the curative effects are dubious, however, traditional Chinese medicine has a good development prospect. The medicine comprises the following ingredients: 10-15 g of Chinese angelica, 9-15 g of rhizoma corydalis, 9-15 g of thunberg fritillary bulb, 9-15 g of cowherb seed, 9-15 g of Cyperus rotundus, 9-15 g of curcuma aromatica, 9-15 g of radix bupleuri, 10-15 g of turtle shell, 9-15 g of bighead atractylodes rhizome, 9-15 g of banksia rose, 9-15 g of Poria cocos, 6-9 g of gleditsia sinensis, and 9-15 g of motherwort. Experiments of pharmacodynamics,toxicology and clinical experiment prove that the medicine provided by the invention has the advantages of substantial curative effect, little toxic and side effect, convenient usage, low cost and the like.

This invention relates to the use of two or more breast specific markers for the detection of breast cancer in a patient.

Disclosed are compositions and corresponding methods for treating fibrocystic breast disease or other breast-related disease or condition. The compositions comprise, per serving or dose, from zero to about 400 μg selenium, from about 100 mg to about 6000 mg gamma linolenic acid, and about 0.15 mg to about 5 mg iodine, with nutritional embodiments further comprising one or more of protein, fat, carbohydrate, vitamins, and minerals and providing from about 50 to about 1000 kcal of energy per severing or dose. Also disclosed are in-vitro studies showing that certain combinations of gamma linolenic acid, iodine, and / or selenium may 1) inhibit breast cancer or fibrocystic cell proliferation, 2) reinforce the function of tight junctions of endothelial cells and of mammary epithelial cells in estrogen-sensitive conditions, and 3) reduce the risk of vascular invasion by breast cancer cells.

A dual-waveband infrared instrument for diagnosing mastopathy is composed of a hand-held laser source consisting of single-source laser probe and multi-source laser probe with multiple laser heads and their positions regulator, an infrared detecting system consisting of optical splitting system, near infrared camera head and far infrared camera head, and a data processing and computer control system.

The invention provides a bra for preventing and treating breast diseases, which includes a bra body with left and right cups, an intelligent control device, a battery integration component, a human body sign data acquisition processor and functional components are installed on the bra body, the The intelligent control device is electrically connected to the battery integration component and the functional component respectively; the functional component includes a massage device, a far-infrared heat compress device, and a bioelectric physiotherapy device, and the human body sign data acquisition processor is used to measure the signs of human breasts , and transmit the measurement results to the mobile communication terminal wirelessly. The invention has a monitoring function, can track and monitor the health condition of the breast in real time, provides a basis for the proposal of the next treatment plan, and reduces the risk of disease. The invention combines a massage device, a far-infrared heat compress device and a bioelectric physiotherapy device, and the three cooperate to effectively perform physiotherapy and health care on breasts, so as to reduce and prevent mammary gland diseases.

The invention discloses a taxus chinensis-containing bra, which is made from taxus chinensis serving as a raw material. The taxus chinensis-containing bra selectively contains one or more of dandelion having effects of clearing heat and releasing toxin, removing swelling and masses and treating mastitis, nutgrass galingale rhizome having effects of regulating qi and relieving depression, regulation menstruation and relieving pain, and treating mammary swelling, orange leaf having an effect of treating hypochondriac pain and acute mastitis, rose having an effect of treating swollen breasts, and corydalis having effects of activating blood circulation to dissipate blood stasis and promoting circulation of qi and relieving pain. The invention has the advantages that: the taxus chinensis-containing bra has obvious effects of regulating qi and relieving pain, activating blood circulation to dissipate blood stasis, softening hardness to dissipate stagnation and preventing and treating breast diseases such as swollen breasts, mammary gland hyperplasia, breast fibroadenoma and the like, and can prevent and inhibit breast cancer.

The invention provides an external preparation for treating breast diseases. The external preparation comprises the following crude drugs in parts by weight: 19-20 parts of safflower, 5-9 parts of daemonorops draco, 10-20 parts of szechuan lovage rhizome, 8-12 parts of common burreed rhizome, 20-30 parts of glechoma longituba, 20-30 parts of myrrh, 8-12 parts of agrimonia pilosa, 15-25 parts of zedoary, 1-3 parts of propolis, 10-20 parts of peach flower, 8-12 parts of rhizoma acori graminei, 15-25 parts of dandelion and 1-5 parts of borneol. The traditional Chinese medicine preparation is strict in components and scientific in compatibility, has the functions of invigorating blood circulation and softening hard mass and dredging collaterals and removing toxicity, is capable of treating the breast diseases, such as hyperplasia of mammary glands, acute and chronic mastitis, galactocele and the like, and is short in treatment course, quick in effectiveness, easy for consolidation, safe for use and free of toxic or side effects.

The invention relates to a Chinese medicinal herb adhering corsage for preventing and treating the mammary diseases, comprising a corsage which can cover the chest and the back of a female and is madeof soft cotton cloth materials. Parts of the inner surface of the corsage corresponding to chest breast acupuncture point and thoracic lymph are respectively provided with a medical physical therapypatch dipped and treated by the Chinese medicinal herb solution, and the Chinese medicinal herb solution is prepared from medicine raw materials f saffron, pseudo-ginseng, rhubarb, leech, asarum, ground beeltle, camptotheca acuminata nuts and the like and water according to a certain proportion. The whole prescription has the functions of dispersing stagnated hepatoqi, activating blood and dissolving stasis, reducing swelling and easing pain and diminishing inflammation, has excellent effect of treating the female mammary diseases and can remarkably reduce or eliminate the threat and the harmfulness of the diseases to women health.

The invention relates to a mammary gland electronic medical record entity recognition system based on multi-standard active learning, and the system is characterized in that the system comprises a preprocessing module; an entity identification module; and an active learning module. According to the invention, the active learning selection strategy for text sequence annotation is designed by considering three aspects of annotation data volume, sentence annotation cost and data sampling balance, so the total annotation workload is reduced. On the one hand, the system can be used for constructingsystems such as breast disease risk patient identification marks, disease medicine recommendation and auxiliary decision diagnosis, doctors are helped to improve the execution efficiency of breast disease standardized diagnosis and treatment, and scientific bases and suggested schemes are provided; on the other hand, doctors can be assisted in finding out potential abnormal conditions in the diagnosis and treatment process, the misdiagnosis and missed diagnosis rate is reduced, the curing probability of breast disease patients is increased, and important value is achieved for intelligent development of breast disease research.

The invention belongs to the field of an intelligent wearing technology, and specifically an intelligent corsage for detecting breast diseases. The intelligent corsage for detecting the breast diseases is provided with a signal acquisition module, a wireless communication module and a control module which are sequentially connected; the signal acquisition module comprises an infrared transmitter, an infrared receiver and a signal processor which are sequentially connected, wherein the signal processor is connected with the wireless communication module; the control module comprises a microprocessor, a memory and a buzzer, wherein the microprocessor is respectively connected with the memory and the buzzer, and the microprocessor is connected with the wireless communication module. Mammary abnormity is judged by acquiring the near infrared ray grey scale signals of mammary tissues through the intelligent corsage; by adopting the wireless communication module, an electronic circuit in the corsage can be reduced, the comfort of the corsage can be improved, and the life of washing and prolonging the corsage can be conveniently prolonged; and compared with the self-check of females through specific skills and annual periodic physical examination, the intelligent corsage is high in reliability and is capable of discovering the mammary abnormity.

The present invention relates to a Chinese medicine for curing mamary aggregation. It is a compound Chinese medicine preparation made up by using 11 Chinese medicinal materials of prunella spike, ligusticum root, silkworm, turtle shell, bupleurum root, red peony root and others.

An elongate probe, with a suction channel extending longitudinally along the probe, is inserted into a patient so that a distal tip of the probe is in contact with a fibroid mass inside the patient. Thereafter the probe is ultrasonically vibrated so that the distal tip has an excursion amplitude or distance greater than 275 microns. During probe vibration, suction is applied to the channel at a vacuum level greater than 24″ Hg to thereby maintain the target tissue mass in engagement with the distal tip during the vibrating of the probe and enable ablation of at least a selectable portion of the target tissue mass.

The invention discloses a method for efficiently separating and purifying mammary epithelial cells. The method is suitable for a plurality of mammals. The mammary tissues of adult mammals, which are in the middle and later periods of gestation or in the lactation period, are collected through aseptic operation. According to the provided method, the separation and purification can be achieved in one step, the whole experiment is simple and efficient; the purification, which comprises repeated differential digestion and differential attachment, in the conventional method is eliminated, the purity of mammary epithelial cells obtained by the provided method can reach 98% or more, the obtained mammary epithelial cells can be continuously cultured in-vitro and passed down for 40 generations, and the lactating function of mammary epithelial cells is not affected. The obtained mammary epithelial cells can be applied to the researches on growth of mammary gland, lactating mechanism, mammary bioreactor, transgenic animals, mammary diseases, and the like.

The invention discloses a Chinese medicine combination for treating breast disease through external administration, which includes the following dried raw medicines by weight: 30-60 parts of radix pseudoginseng, 30-50 parts of hemlock parsley, 35-50 parts of motherwort, 30-60 parts of cowherb seed, 20-40 parts of asarum, 30-60 parts of citron, 30-60 parts of rhizoma pleionis, 30-60 parts of airpotato yam, 30-60 parts of seaweed, 30-60 parts of sea-tangle, 35-50 parts of cinnamon, 30-60 parts of angelica dahurica, 40-50 parts of borneol and 30-50 parts of camphor. The Chinese medicine of the invention can treat a plurality of breast diseases and has the functions of softening hardness, dissipating stagnation, promoting lactation, activating collaterals, removing swelling, stopping pain, activating blood circulation, and removing blood stasis. When in use, the invention can be prepared into medicine bags and directly and externally applied on affected parts, so as to exert direct drug effect. Proved by practice, the medicine has the advantages of short treatment course and difficult recurrence after healing and can cure both symptoms and root causes; the curative effect is stable, the cure rate reaches 81.8 percent and the total effective rate reaches 86.7 percent.

The present invention discloses a signal processing system and method of a mobile data terminal. The system comprises an intelligent hardware terminal, the mobile data terminal and a cloud database server, the intelligent hardware terminal comprises a plurality of sensors, the mobile data terminal comprises a receiving unit, a communication unit and an output display unit, and the cloud database server comprises a plurality of data storage units, a data analysis unit and an ideal data unit. The method comprises the steps of using the sensors to acquire the photo-thermal electromagnetic radiation information data of different areas of the skin surface, and transmitting to an information data detection module; using the information data detection module to detect and verify the information data, retaining the effective data, and sending the effective data to a mobile terminal; using the mobile terminal to transmit the effective data to the cloud database server; using the data analysis unit to compare and analyze the effective data, and using the output display unit to display the analysis results. According to the technical scheme disclosed by the present invention, the early signs of a breast disease can be discovered in advance, and the cure rate is improved.

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS322 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS322-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS322 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases