33 results about "Sugar derivatives" patented technology

The present invention relates to antibody conjugates which are particularly suitable for targeting cells expressing PTK7, in particular tumor cells. An antibody conjugate according to the present invention has structure (1): AB-[(L6) b-{Z-L-D} x] y (1) wherein AB is an antibody capable of targeting a tumor expressing PTK7; l is a joint connecting Z to D; z is a linking group; l6 is-GlcNAc (Fuc) w-(G) j-S-(L7) w '-wherein G is a monosaccharide, j is an integer in the range of 0 to 10, S is a sugar or a sugar derivative, GlcNAc is N-acetylglucosamine, and Fuc is fucose, w is 0 or 1, w' is 0, 1 or 2, and L7 is-N (H) C (O) CH2-,-N (H) C (O) CF2-or-CH2-; d is selected from the group consisting of an anthracycline, a camptothecin, a tubulysin, an endiyne, an amanitine, a duocarmycin, a maytansinoid, an aurestatin, eribulin, a BCL-XL inhibitor, a miscanthus semiaquilaria, a KSP inhibitor, a TLR agonist, an indolo-benzodiazepine dimer or a pyrrolo-benzodiazepine dimer (PBD), and an analog or prodrug thereof; b is 0 or 1; x is 1 or 2; and y is 1, 2, 3 or 4. The invention further relates to a method for preparing said antibody conjugate of structure (1) and to the use of said antibody conjugate of structure (1).

The invention discloses a sugar derivative of hydroxycinnamic acid as well as a preparation method and application thereof in cosmetics. Specifically, the invention provides a sugar derivative of hydroxycinnamic acid. The compound is shown as a formula I in the specification. Compared with original hydroxycinnamic acid, the sugar derivative of hydroxycinnamic acid has better water solubility and stability, and has one or more effects of oxidation resistance, whitening, soothing, moisturizing, ultraviolet absorption and the like; when the composition is applied to cosmetics, light aging damage of skin can be relieved, and skin color can be brightened; .

The invention discloses a biomass sugar solution steam stripping-hydrogenation device and a biomass sugar hydrogenation process, the biomass sugar solution steam stripping-hydrogenation device comprises: a steam stripping reaction kettle, the top of the steam stripping reaction kettle is provided with a feed pipe, and the bottom of the steam stripping reaction kettle is provided with a hydrogen inlet pipe; the fixed bed hydrogenation reactor is communicated with the steam stripping reaction kettle; the cooler is communicated with the fixed bed hydrogenation reactor; and the gas-liquid separator is communicated with the cooler. According to the present invention, the steam stripping-hydrogenation process coupling is adopted to achieve the in-situ conversion of the heat sensitive saccharide derivative, the problems of difficult separation, easy heating coking and the like of the saccharide derivative are solved, and the hydrogen circulation, the heat coupling and the integration of the process process are provided to provide the continuous, high-selectivity and low-energy-efficiency new process for preparing the biomass energy and the chemical product.

This invention provides a naphthopyrimidine-fused-acid sugar derivative, its synthesis method, and its application, belonging to the field of pharmaceutical technology. The naphthopyrimidine-fused-acid sugar derivative has the structures shown in formulas (I) to (IV). These compounds are obtained by one-step cyclization via a condensation reaction with 1,8-diaminonaphthalene in an organic solvent under the catalysis of a trifluoromethanesulfonate catalyst, using a propionyl-protected and p-toluenesulfonated sugar as the starting material. The preparation method is efficient and simple. The compounds of this invention exhibit good anti-proliferative activity against colon cancer tumor cells.

A composition including (i) a sugar, a sugar derivative or combination thereof; (ii) an optional nutrient salt; and (iii) an optional solvent. A method of treatment comprising contacting an agricultural material with a composition comprising (i) a sugar, a sugar derivative or combination thereof; (ii) an optional nutrient salt; (iii) an optional performance enhancing additive; and (iv) a solvent wherein treatment of the agricultural material results in increased viability of a plant associated with the agricultural material.

The invention relates to the technical field of environmental governance and functional materials, in particular to a codonopsis pilosula polysaccharide derivative as well as a preparation method and application thereof. The codonopsis pilosula polysaccharide derivative is mainly prepared from codonopsis pilosula polysaccharide through carboxymethylation or sulfation modification reaction. The codonopsis pilosula polysaccharide derivative is prepared on the basis of natural codonopsis pilosula polysaccharide through simple process steps, and the codonopsis pilosula polysaccharide derivative is especially used for adsorbing and enriching divalent lead ions as a biological adsorbent, so that the problems of high toxicity, high cost, complex adsorption material synthesis process and the like in a lead treatment method in the prior art are solved.

The invention relates to the technical field of veterinary drugs, in particular to povidone-iodine oral liquid and a preparation method thereof. The oral liquid comprises the following components: povidone, a water-soluble anionic polysaccharide derivative, iodine, a metal ion chelating agent, a nonionic surfactant, a water-soluble organic solvent, a pH regulator, a flavoring agent and water. Compared with traditional prevention and treatment preparations with the problems of low bioavailability, poor stability, poor taste and the like, the povidone-iodine oral liquid can effectively prevent and treat the diseases, by optimizing the formula of povidone-iodine and the composite auxiliary materials, adding a proper taste regulator, improving the production process and simplifying the process, the cost is greatly reduced, and the oral liquid is suitable for large-scale popularization and application. The bioavailability is improved, the stability is enhanced, the palatability is improved, the production operation is simpler and more convenient, industrial production can be better adapted, and a practical solution is provided for the breeding industry.

The present invention relates to a process for preparing an at least partially acetal-protected sugar, comprising the step of reacting a sugar or sugar derivative selected from the group consisting of aldopentoses, aldohexoses, aldopentosides and aldohexosides with an aldehyde or aldehyde source in the presence of a heterogeneous acidic catalyst to form an at least partially acetal-protected sugar selected from the group consisting of compounds of formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI) and (XII): In the formula, R1, R1', R2, R2', R3, R3', R4, R5, R6, R7, R8, R9, R 10 , R 11 , R 12 and R 12 and R and R′, R and R′, R and R′, and R 12 and R 12 are identical or different from one another; and Y is hydrogen or a straight, branched, or cyclic hydrocarbon moiety having 1 to 20 carbon atoms; Z is a linear, branched, or cyclic hydrocarbon moiety having 0 to 12 carbon atoms, optionally substituted with 1 to 4 C1-C4 alkyl groups, or 1 to 4 halogen atoms, or a benzyl group; and E is -COOH, -CH(COOH)2, -COOR 19 , -CH(COOR 20 )(COOR 21 ), -CHO, -CH(CHO)2, -C2H3, -CH(C2H3)2, -CHCHR 22 , -CHCR 23 R 24 , -C2H, -C2R 25 , -N3, -NH2, -CH(NH2)2, -NHR 26 , -CH(NHR 27 )(NHR 28 ), -NR 29 R 30 , -CH(NR 31 R 32 )(NR 33 R 34 ), -OH, -OR35 , or -CH(R 36 OH)(R 37 OH); and R 19 , R 20 , R 21 , R 22 , R 23 , R 24 , R 25 , R 26 , R 27 , R 28 , R 29 , R 30 , R 31 , R 32 , R 33 , R 34 and R 35 are C1 to C 20 is alkyl; and R 20 and R 21 , R 23 and R 24 , R 27 and R 28 , R 29 and R 30 , R 31 and R 32 , and R 33 and R 34 are identical to or different from one another; and R 36 and R 37 are, independently of one another, absent or straight-chain or branched C1-C 12 is a hydrocarbon chain; and R 13 , R 14 , R 15 , R 16 , R 17 and R 18 are each independently hydrogen or a straight-chain, branched-chain, or cyclic hydrocarbon moiety having 1 to 20 carbon atoms. JPEG2025536078000039.jpg83102

The present invention belongs to the technical field of chemical synthesis, and in particular relates to a ruthenium wolfberry oligosaccharide derivative, a preparation method and application thereof. The invention utilizes the remote participation effect of acyl groups, steric hindrance effect, solvent effect and end group effect to achieve efficient construction of 1,2-cis-α-galacturonic acid glycosidic bonds and other glycosidic bonds in the oligosaccharide structure, thereby realizing the first chemical synthesis of ruthenium wolfberry oligosaccharide and its derivatives. The ruthenium wolfberry oligosaccharide fragment provided by the present invention has an inhibitory effect on pancreatic cancer cells, provides a theoretical basis for clarifying the active fragments (active structural domains) of ruthenium wolfberry polysaccharides, conducting more in-depth functional mechanism research and developing new anti-pancreatic cancer drugs based on the active fragments, and has good application prospects in the preparation of new anti-cancer drugs.

The present invention relates to a plant quarantine composition comprising (i) one or more metal sources, (ii) one or more sugars and / or one or more sugar derivatives, and (iii) one or more phosphorous derivatives.

The present invention relates to a phytosanitary composition comprising (i) one or more metal oxide(s), (ii) one or more sugar(s) and / or one or more sugar derivative(s), and (iii) one or more phosphorus derivative(s).

The invention relates to uridine diphosphate-N-difluoroacetyl galactosamine as well as a preparation method and application thereof. The chemical structure of the UDP-GalNDFA is similar to that of a natural substrate UDP-GalNAc, and the core difference is that N-acetyl at the site 2 of the UDP-GalNDFA is replaced by N-difluoroacetyl. The preparation method comprises the following steps: (1) preparing difluoroacetyl galactosamine; and (2) preparing the UDP-GalNDFA by taking the difluoroacetyl galactosamine as a substrate. As a novel artificial donor sugar, the UDP-GalNDFA has the characteristics of high activity, difficulty in hydrolysis and capability of being artificially synthesized. Compared with the existing donor sugar UDP-GalNTFA, the glucose UDP-GalNTFA has higher catalytic activity on glycosyl transferase, has stronger stability, is not easy to hydrolyze, and can be used as a donor substrate for synthesizing a chondroitin oligosaccharide skeleton, a chondroitin oligosaccharide intermediate and a chondroitin oligosaccharide derivative by a chemical enzyme method.

The invention relates to a hair care and / or scalp care composition comprising rhamnose, trehalose and lactobionic acid. Said composition moisturizes the scalp, protects the scalp from dehydration, promotes the growth of Staphylococcus epidermis and / or Cutibacterium acnes on the scalp and can be used for treating or preventing dandruff.

The invention provides a drug-loading biodegradable embolism microsphere as well as a preparation method and application thereof, and belongs to the field of biomedical materials. According to the drug-loading biodegradable embolism microsphere prepared by the invention, gelatin molecules with good biocompatibility and low immunogenicity are used as a skeleton, a carboxylated aldosaccharide derivative is used as a cross-linking agent, a large amount of carboxylic acid groups are introduced in the chemical cross-linking process, the microsphere is formed by cross-linking and curing, and the microsphere can be biodegraded and absorbed, so that the drug-loading biodegradable embolism microsphere has the advantages of good biocompatibility, good biocompatibility and good immunogenicity. And the microspheres are endowed with electronegativity through dissociation of carboxylic acid groups, so that carrying of chemotherapeutic drugs with positive charges is realized. By introducing the carboxyl-rich cross-linking reagent, in the process of forming the microspheres through chemical cross-linking, the content of carboxyl in the microspheres is greatly increased, the loading efficiency of the microspheres on antitumor drugs can be effectively improved, and the microspheres are endowed with the capability of realizing drug sustained release at local lesions. The embolism microsphere prepared by the invention has biological absorbability and high-efficiency drug loading property at the same time.

The application discloses a sugar derivative of hydroxycinnamic acid, a preparation method thereof and application of the sugar derivative in cosmetics. Specifically, the application provides a sugar derivative of hydroxycinnamic acid, which is a compound as shown in formula I. The sugar derivative of hydroxycinnamic acid has better water solubility and stability than original hydroxycinnamic acid, and has one or more functions such as antioxidation, whitening, soothing, moisturizing and ultraviolet absorption. The application of the sugar derivative in cosmetics can reduce photoaging damage of skin and brighten skin color.

The present invention provides a method of producing a composition capable of producing a food-like aroma and / or flavour when heated, comprising a) disrupting a Mortierella spp. biomass comprising phospholipids; b) fractionating the disrupted biomass and collecting the supernatant therefrom; and c) combining the supernatant with: (i) one or more sugars, sugar alcohols, sugar acids, or sugar derivatives; and (ii) one or more amino acids or derivatives or salts thereof, or a compound comprising an amino group (e.g. thiamine). The present invention further provides compositions comprising a supernatant of a fractionated, disrupted Mortierella spp. biomass comprising phospholipids and methods of producing food-like aromas and / or flavours.

The present invention concerns antibody-conjugates which are especially suitable for the targeting of PTK7-expressing cells, in particular tumour cells. The antibody-conjugates according to the invention have structure (1):AB-[(L6)b-{Z-L-D}x]y  1Herein, AB is an antibody capable of targeting PTK7-expressing tumours; L is a linker that links Z to D; Z is a connecting group; L6 is -GlcNAc(Fuc)w-(G)j-S-(L7)w′-, wherein G is a monosaccharide, j is an integer in the range of 0-10, S is a sugar or a sugar derivative, GlcNAc is N-acetylglucosamine and Fuc is fucose, w is 0 or 1, w′ is 0, 1 or 2 and L7 is —N(H)C(O)CH2—, —N(H)C(O)CF2— or —CH2—; D is selected from the group consisting of anthracyclines, camptothecins, tubulysins, enediynes, amanitins, duocarmycins, maytansinoids, auristatins, eribulins, BCL-XL inhibitors, hemiasterlins, KSP inhibitors, TLR agonists, indolinobenzodiazepine dimers or pyrrolobenzodiazepine dimers (PBDs), and analogues or prodrugs thereof; b is 0 or 1; x is 1 or 2; and y is 1, 2, 3 or 4. The invention further concerns a method for preparing the antibody-conjugates of structure (1) and application of the antibody-conjugates of structure (1).

The invention discloses an application of a cationic polysaccharide photosensitizer as a blood pathogen inactivation material. The cationic polysaccharide photosensitizer has a repetitive structure unit as shown in a formula I. The invention further discloses a preparation method of the cationic polysaccharide photosensitizer. As an inactivator, the cationic polysaccharide photosensitizer can selectively recognize pathogens, efficiently generate ROS (reactive oxygen species) under illumination and kill the pathogens, and has important practical value.

The present invention relates to the use of at least one phenolically substituted sugar derivative as a stabiliser of organic materials, in particular plastics, against oxidative, thermal and / or actinic degradation. The present invention also relates to a corresponding plastic composition, to a method for stabilising plastics, to a moulding compound or a moulded part as well as a phenolically substituted sugar derivative.

The invention provides a whitening and moisturizing composition, a whitening and moisturizing moisturizer and a preparation method of the whitening and moisturizing moisturizer and belongs to the technical field of skin care products, and the whitening and moisturizing composition is prepared from, by weight, 0.5-1 part of saccharide derivatives, 10-12 parts of ginkgo fruit powder and 0.2-3 parts of dendrobe extracts. The structural formula of the carbohydrate derivative is shown in the specification. By compounding the sugar derivative whitening active ingredients, the ginkgo fruit powder and the dendrobium extract, a triple whitening mechanism of generation inhibition, oxidation resistance and soothing and repairing is formed, and the overall whitening efficiency is remarkably improved through the multi-channel synergistic effect. The whitening and moisturizing moisturizer provided by the invention adopts a powerful moisturizing base to support the whitening effect, adopts a mild and stable emulsification system to ensure that a complex formula containing multiple active components keeps physical and chemical stability in the storage and use processes, and the prepared whitening and moisturizing moisturizer has a remarkable whitening effect.

This document discloses compositions comprising at least one acrylic acid- and / or itaconic acid-polysaccharide derivative. Such derivatives can be produced by contacting acrylic acid and / or itaconic acid with a polysaccharide, wherein the acrylic acid- and / or itaconic acid-polysaccharide derivative has a degree of substitution (DoS) of up to about 3.0 contributed by at least one group formed from acrylic acid and / or itaconic acid. Methods for producing the acrylic acid- and / or itaconic acid-polysaccharide derivative are further disclosed, as well as their use in various applications and products.

The invention provides a vaccine based on an angelica polysaccharide derivative delivery carrier as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention provides a preparation method of the vaccine, and the amphiphilic angelica polysaccharide derivative is used as a delivery carrier to obtain a W / O / W Pickering emulsion, namely the vaccine. According to the vaccine, through delivery of the angelica polysaccharide derivative, the safety of the vaccine is improved, and degradation of an antigen in the digestive tract is reduced. The invention further provides application of the vaccine in preparation of fish culture related products and a fish feed, feed particles contain the vaccine, and the vaccine feed particles stimulate higher innate immunity and adaptive immunity levels of fish bodies and have good application prospects.

This invention relates to a method for modifying a glycoprotein with β-(1,4)-N-acetylgalactosamine transferase or a mutant thereof. The method comprises the following steps: contacting a glycoprotein containing a glycan with a terminal GlcNAc motif with a non-natural sugar derivative nucleotide in the presence of β-(1,4)-N-acetylgalactosamine transferase or a mutant thereof. The non-natural sugar derivative nucleotide is shown in formula (3): wherein A is selected from -N3; ​​-C(O)R 3 ;-C≡C-R 4 ;-SH;-SC(O)R 8 ;-SC(V)OR 8 V is O or S; -X, where X is selected from F, Cl, Br and I; -OS(O)2R 5 ;Optional substitution of C2-C 24 Alkyl; optionally substituted terminal C2-C 24 alkenyl group; and optionally substituted terminal C3-C 24 Allenyl.

The present invention concerns an improved method for the manufacture of 1-phosphate-6-azido sugar derivatives, wherein the formation of a common impurity, wherein an OH group is present instead of an azido group at position 6 of the sugar ring, is completely avoided. A key aspect of the invention is the formation of mono-cyanoethyl compound (2) via: (I) providing compound (1); (II) subjecting compound (1) to a deprotection step with a base to obtain compound (2); (III) crystalizing the product obtained in step (II) to obtain crystalized compound (2).

The present invention concerns antibody-conjugates which are especially suitable for the targeting of PTK7-expressing cells, in particular tumour cells. The antibody-conjugates according to the invention have structure (1):Herein, AB is an antibody capable of targeting PTK7-expressing tumours; L is a linker that links Z to D; Z is a connecting group; L6 is -GlcNAc(Fuc)w-(G)j-S-(L7)w′-, wherein G is a monosaccharide, j is an integer in the range of 0-10, S is a sugar or a sugar derivative, GlcNAc is N-acetylglucosamine and Fuc is fucose, w is 0 or 1, w′ is 0, 1 or 2 and L7 is —N(H)C(O)CH2—, —N(H)C(O)CF2— or —CH2—; D is selected from the group consisting of anthracyclines, camptothecins, tubulysins, enediynes, amanitins, duocarmycins, maytansinoids, auristatins, eribulins, BCL-XL inhibitors, hemiasterlins, KSP inhibitors, TLR agonists, indolinobenzodiazepine dimers or pyrrolobenzodiazepine dimers (PBDs), and analogues or prodrugs thereof; b is 0 or 1; x is 1 or 2; and y is 1, 2, 3 or 4. The invention further concerns a method for preparing the antibody-conjugates of structure (1) and application of the antibody-conjugates of structure (1).

The invention discloses a delivery system with embedding and controlled release effects of astaxanthin and a preparation method of the delivery system. The delivery system comprises an artemisia desertorum polysaccharide derivative and astaxanthin encapsulated in the artemisia desertorum polysaccharide derivative, wherein the artemisia desertorum polysaccharide derivative is obtained by artemisia desertorum polysaccharide which is hydrophobically modified and purified by capryloyl chloride. According to the preparation method of the delivery system with the embedding and controlled release effects of the astaxanthin, disclosed by the invention, capryloyl chloride is grafted to an artemisia desertorum polysaccharide chain through esterification reaction to prepare an amphiphilic artemisia desertorum polysaccharide derivative, and the amphiphilic artemisia desertorum polysaccharide derivative can be used for preparing the amphiphilic artemisia desertorum polysaccharide derivative under electrostatic interaction, hydrophilic / hydrophobic interaction and hydrogen-bond interaction. The amphiphilic artemisia desertorum polysaccharide derivative is self-aggregated to form a stable nano shell structure, the thermal stability of the artemisia desertorum polysaccharide is improved after hydrophobic modification, and the amphiphilic artemisia desertorum polysaccharide derivative has the advantages of efficient embedding and delivery of hydrophobic substances and the like; the artemisia desertorum polysaccharide derivative prepared by the method has nanoscale particle size, larger specific surface area, higher drug loading capacity and acid stability, and has huge application value in the aspects of nutrient transportation of food, functional food design and the like.

The invention relates to an alginate oligosaccharide derivative as well as a preparation method and application thereof. The alginate oligosaccharide derivative provided by the invention is a compound shown as a formula (I) or a pharmaceutically acceptable salt thereof, n is an integer, and n is equal to 1-8, preferably, n is equal to 1-3. The alginate oligosaccharide derivative designed and synthesized by the invention has good treatment effects on acute kidney injury, chronic kidney diseases, gout, liver injury, oral ulcer, rhinitis and other inflammatory diseases, and has good stability under different acid-base conditions. In addition, the invention also provides a compound which is formed by connecting monosaccharide G and / or M through a 1, 4-position glucosidic bond and is shown in a formula (II) or a pharmaceutically acceptable salt thereof, and a compound which is formed by connecting monosaccharide delta and G and / or M through a 1, 4-position glucosidic bond and is shown in a formula (II) or a pharmaceutically acceptable salt thereof. The invention further discloses application of the compound as shown in the formula (III) or pharmaceutically acceptable salt of the compound in preparation of drugs for preventing and / or treating certain inflammatory diseases, wherein the compound is formed by connecting glucosidic bonds at the positions 1, 4 of the compound.

Low-pH, aqueous skin care composition, comprising: a) about 0.1% to about 10% of a hydroxycinnamic acid (HCA); b) about 0.1% to about 10% of a polar emollient; c) from about 1.5% to less than 20% of a co-solvent with a Hansen solubility parameter distance of less than 15 from the—hydroxycinnamic acid (HCA); and d) water, wherein the pH of the composition is about 5.0 or less, and wherein the composition meets at least one of the following conditions (i)-(iii): (i) the composition further contains from about 0.1% to about 10% of a vitamin B3 compound; (ii) the weight ratio between HCA and the polar emollient is from about 1:1 to about 1:10; and (iii) the composition further contains from about 0.1% to about 5% of a sensory improving ingredient selected from the group consisting of: sugar alcohols, sugar-based emulsifiers, modified sugar derivatives, and mixtures thereof.

The present invention relates to a fucoidan oligosaccharide derivative, a preparation method therefor, and a use thereof. The fucoidan oligosaccharide derivative provided by the present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, where n is an integer, and n=1-8, preferably n=1-3. The fucoidan oligosaccharide derivative designed and synthesized in the present invention has good therapeutic effects on inflammatory diseases such as acute kidney injury, chronic kidney disease, gout, liver injury, oral ulcers, and rhinitis, and has good stability under different acidic and basic conditions. In addition, the present invention also provides a compound represented by formula (II) or a pharmaceutically acceptable salt thereof, which is constructed by the connection of monosaccharide G and / or M by means of 1,4-glycosidic bonds, and a compound represented by formula (III) or a pharmaceutically acceptable salt thereof, which is constructed by the connection of monosaccharide Δ and G and / or M by means of 1,4-glycosidic bonds, as well as a use of said compounds or salts in the preparation of a medicament for preventing and / or treating certain inflammatory diseases.