63 results about "Sugar derivatives" patented technology

The invention belongs to the technical field of biological medicine, and particularly relates to a chondroitin sulfate oligosaccharide derivative and a preparation method and application thereof.The structure of the chondroitin sulfate oligosaccharide derivative is shown in the formula I # imgabs0 #, in the formula I, R1 is SO3H and R2 is H or R1 is H and R2 is SO3H, and the polymerization degree of the chondroitin sulfate oligosaccharide derivative is equal to 8; the chondroitin sulfate oligosaccharide derivative has good chronic hepatitis repair promotion and anti-inflammatory activity, is clear in structure, and can be orally taken to treat the non-alcoholic fatty liver disease.

The present application belongs to the field of biomedicine technology, and specifically relates to a chondroitin sulfate oligosaccharide derivative and a preparation method and application thereof. The structure of the chondroitin sulfate oligosaccharide derivative is shown in Formula I, #imgabs0#Formula I, where R1 is SO3H, R2 is H or R1 is H, R2 is SO3H, and the polymerization degree of the chondroitin sulfate oligosaccharide derivative is equal to 8; the chondroitin sulfate oligosaccharide derivative has good promotion of chronic hepatitis repair and anti-inflammatory activity, and has a clear structure, and can be used for oral treatment of non-alcoholic fatty liver disease.

The present invention relates to antibody conjugates which are particularly suitable for targeting CEA-expressing cells, in particular tumor cells. An antibody conjugate according to the present invention has the structure (1): AB-[(L6) b-{Z-L-D} x] y (1) wherein AB is an antibody capable of targeting a tumor expressing CEA; l is a joint connecting Z to D; z is a linking group; l6 is-GlcNAc (Fuc) w-(G) j-S-(L7) w-wherein G is a monosaccharide, j is an integer in the range of 0 to 10, S is a sugar or a sugar derivative, GlcNAc is N-acetylglucosamine, and Fuc is fucose, w is 0 or 1, w'is 0, 1 or 2, and L7 is-N (H) C (O) CH2-,-N (H) C (O) CF2-or-CH2-; d is selected from the group consisting of an anthracycline, a camptothecin, a tubulysin, an endiyne, an amanitine, a duocarmycin, a maytansinoid, an aurestatin, eribulin, a BCL-XL inhibitor, a miscanthus hemiphyllum, a KSP inhibitor, a TLR agonist, an indolo-benzodiazepine # imgabs 0 # dimer or a pyrrolo-benzodiazepine # imgabs 1 # dimer (PBD), and analogs or prodrugs thereof; b is 0 or 1; x is 1 or 2; and y is 1, 2, 3 or 4. The invention further relates to a method for preparing said antibody conjugate of structure (1) and to the use of said antibody conjugate of structure (1).

The present invention relates to antibody conjugates which are particularly suitable for targeting cells expressing PTK7, in particular tumor cells. An antibody conjugate according to the present invention has structure (1): AB-[(L6) b-{Z-L-D} x] y (1) wherein AB is an antibody capable of targeting a tumor expressing PTK7; l is a joint connecting Z to D; z is a linking group; l6 is-GlcNAc (Fuc) w-(G) j-S-(L7) w '-wherein G is a monosaccharide, j is an integer in the range of 0 to 10, S is a sugar or a sugar derivative, GlcNAc is N-acetylglucosamine, and Fuc is fucose, w is 0 or 1, w' is 0, 1 or 2, and L7 is-N (H) C (O) CH2-,-N (H) C (O) CF2-or-CH2-; d is selected from the group consisting of an anthracycline, a camptothecin, a tubulysin, an endiyne, an amanitine, a duocarmycin, a maytansinoid, an aurestatin, eribulin, a BCL-XL inhibitor, a miscanthus semiaquilaria, a KSP inhibitor, a TLR agonist, an indolo-benzodiazepine dimer or a pyrrolo-benzodiazepine dimer (PBD), and an analog or prodrug thereof; b is 0 or 1; x is 1 or 2; and y is 1, 2, 3 or 4. The invention further relates to a method for preparing said antibody conjugate of structure (1) and to the use of said antibody conjugate of structure (1).

To provide an aqueous dispersion composition containing solid particles that includes at least one kind selected from a group consisting of resveratrol superior in dispersibility with inhibition of precipitation or an analog thereof; a production method thereof; and a food, cosmetics, and a pharmaceutical using the aqueous dispersion composition.SOLUTION: An aqueous dispersion composition contains solid particles including at least one kind selected from a group consisting of resveratrol and an analog thereof, an aqueous medium, and a dispersion auxiliary agent. The dispersion auxiliary agent includes at least one kind selected from phospholipid, saponin, sucrose fatty acid ester, polyglyceryl fatty acid ester, sorbitan fatty acid ester, polyoxyethylene phytosterol, polysaccharide, sugar derivative, polyvinyl pyrrolidone, polyvinyl alcohol, and enzyme treated matter.SELECTED DRAWING: None

The invention discloses a sugar derivative of hydroxycinnamic acid as well as a preparation method and application thereof in cosmetics. Specifically, the invention provides a sugar derivative of hydroxycinnamic acid. The compound is shown as a formula I in the specification. Compared with original hydroxycinnamic acid, the sugar derivative of hydroxycinnamic acid has better water solubility and stability, and has one or more effects of oxidation resistance, whitening, soothing, moisturizing, ultraviolet absorption and the like; when the composition is applied to cosmetics, light aging damage of skin can be relieved, and skin color can be brightened; .

The invention discloses a biomass sugar solution steam stripping-hydrogenation device and a biomass sugar hydrogenation process, the biomass sugar solution steam stripping-hydrogenation device comprises: a steam stripping reaction kettle, the top of the steam stripping reaction kettle is provided with a feed pipe, and the bottom of the steam stripping reaction kettle is provided with a hydrogen inlet pipe; the fixed bed hydrogenation reactor is communicated with the steam stripping reaction kettle; the cooler is communicated with the fixed bed hydrogenation reactor; and the gas-liquid separator is communicated with the cooler. According to the present invention, the steam stripping-hydrogenation process coupling is adopted to achieve the in-situ conversion of the heat sensitive saccharide derivative, the problems of difficult separation, easy heating coking and the like of the saccharide derivative are solved, and the hydrogen circulation, the heat coupling and the integration of the process process are provided to provide the continuous, high-selectivity and low-energy-efficiency new process for preparing the biomass energy and the chemical product.

This invention provides a naphthopyrimidine-fused-acid sugar derivative, its synthesis method, and its application, belonging to the field of pharmaceutical technology. The naphthopyrimidine-fused-acid sugar derivative has the structures shown in formulas (I) to (IV). These compounds are obtained by one-step cyclization via a condensation reaction with 1,8-diaminonaphthalene in an organic solvent under the catalysis of a trifluoromethanesulfonate catalyst, using a propionyl-protected and p-toluenesulfonated sugar as the starting material. The preparation method is efficient and simple. The compounds of this invention exhibit good anti-proliferative activity against colon cancer tumor cells.

The invention relates to a method for preparing an at least partially acetal-protected sugar, involving the step of reacting a sugar or a sugar derivative selected from the group consisting of valeraldoses, hexanoses, valeraldoglycosides and hexanoglycosides with an aldehyde or a source of aldehyde in the presence of a heterogeneous acidic catalyst, forming an at least partially acetal-protected sugar selected from the group consisting of compounds of formulae (I), (II), (III), (IV), (V), (VI,) (VII), (VIII), (IX), (X), (XI) and (XII), # imgabs0, r1, R1 ', R2, R2', R3, R3 ', R4, R5, R6, R7, R8, R9, R10, R11, R12 and R12' are Y or Z-E, where R1 and R1 ', R2 and R2', R3 and R3 ', R12 and R12' are equal to or different from each other and Y is hydrogen or a linear, branched or cyclic hydrocarbon moiety having 1 to 20 carbon atoms, Z is a linear, branched or cyclic hydrocarbon moiety having 0 to 12 carbon atoms, optionally substituted with 1 to 4 C1 to C4 alkyl groups, 1 to 4 halogen atoms or benzyl groups, e is-COOH,-CH (COOH) 2,-COOR19,-CH (COOR20) (COOR21),-CHO,-CH (CHO) 2,-C2H3, CH (C2H3) 2,-CHCHR22,-CHCR23R24,-C2H,-C2R25,-N3,-NH2,-CH (NH2) 2,-NHR26,-CH (NHR27) (NHR28),-NR29R30,-CH (NR36OH),-OH,-OR35,-CH (R36OH), and R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R32, R33, R34 and R37OH and R13, R14, R15, R16, R17 and R18 are each independently hydrogen or a linear, branched or cyclic hydrocarbon moiety having 1 to 20 carbon atoms.

A composition including (i) a sugar, a sugar derivative or combination thereof; (ii) an optional nutrient salt; and (iii) an optional solvent. A method of treatment comprising contacting an agricultural material with a composition comprising (i) a sugar, a sugar derivative or combination thereof; (ii) an optional nutrient salt; (iii) an optional performance enhancing additive; and (iv) a solvent wherein treatment of the agricultural material results in increased viability of a plant associated with the agricultural material.

The invention relates to the technical field of synthesis of sugar derivatives, in particular to a preparation method of sialic acid galactose disaccharide. The arylboronic acid is used for temporarily protecting hydroxyl groups at positions 4 and 6 of galactose, and after a sialic acid donor and a catalyst are added, sialic acid can be selectively coupled to hydroxyl groups at positions 3. The method can realize 3-site hydroxyl selective reaction under the condition that four hydroxyl groups at 2, 3, 4 and 6 sites of galactose are exposed at the same time, and has good reaction regioselectivity. The steps of selectively feeding and removing protective groups on 2, 4 and 6 sites are reduced, the synthetic route of sialic acid galactose disaccharide is simplified, and the synthetic yield is further improved. In addition, the sialylation reaction of the method provided by the invention has complete alpha selectivity, alpha and beta isomers do not need to be separated, and separation and purification are further simplified.

To provide an aqueous dispersion composition containing a tetrahydrocurcuminoid, which ensures dispersion stability over the long term and suppresses precipitation and a method for producing the same, as well as foods, cosmetics and pharmaceuticals including the aqueous dispersion composition.SOLUTION: The present invention provides an aqueous dispersion composition that comprises solid particles containing a tetrahydrocurcuminoid, an aqueous medium, and a dispersion aid, wherein the dispersion aid contains at least one selected from phospholipids, saponins, sucrose fatty acid esters, polyglyceryl fatty acid esters, sorbitan fatty acid esters, polyoxyethylene phytosterols, polysaccharides, sugar derivatives, polyvinylpyrrolidone, polyvinyl alcohols, and enzyme-treated products, and a method for producing the same, as well as foods, cosmetics and pharmaceuticals including the aqueous dispersion composition.SELECTED DRAWING: None

Provided is an oil-in-water emulsified cosmetic composition having a characteristic fresh feel during use while exhibiting excellent emulsified stability and high covering power. The oil-in-water emulsified cosmetic composition comprises the following components (a) to (d): (a) pigment particles with a mean particle size of 200 to 500 nm and hydrophobically treated on the surface, (b) a water-soluble alkyl-substituted polysaccharide derivative, (c) polyhydroxystearic acid, and (d) an oil containing a polar oil, wherein the pigment particles are dispersed in the oil, the content of the pigment particles is 8.0 mass% to 15 mass%, and the content of nonionic surfactants with an HLB value of 10 or greater is 1.0 mass% or lower.

The present invention relates to a method for preparing oligosaccharides by a glycoside phosphorylase combined with monosaccharide kinase and polyphosphate kinase. The method comprises the steps of using donor monosaccharide, acceptor sugar, polyphosphate, and low equivalent adenosine phosphate as substrates, adding magnesium chloride to the substrate, and then co-catalyzing the reaction for 1.5 to 22 hours at 25 to 40 ° C by polyphosphatase, monosaccharide kinase and glycoside phosphorylase to generate crude oligosaccharide products, and obtaining oligosaccharides after purification. The present invention provides a method for preparing important oligosaccharides by using monosaccharides, acceptor substrates, polyphosphate, and low equivalent adenosine phosphate as substrates, and realizing ATP regeneration by using polyphosphate kinase as substrate, effectively solving the problem that a large amount of expensive sugar nucleotide donors and auxiliary factor ATP need to be added in the process of synthesizing oligosaccharides by bioenzymatic method, resulting in the problem that the cost is too high and cannot be mass-produced. The method of the present invention was successfully used to synthesize lactoyl-N-disaccharide, galactoyl-N-disaccharide, chitosan, and protein N-sugar chain core trisaccharide derivatives.

The invention relates to the technical field of environmental governance and functional materials, in particular to a codonopsis pilosula polysaccharide derivative as well as a preparation method and application thereof. The codonopsis pilosula polysaccharide derivative is mainly prepared from codonopsis pilosula polysaccharide through carboxymethylation or sulfation modification reaction. The codonopsis pilosula polysaccharide derivative is prepared on the basis of natural codonopsis pilosula polysaccharide through simple process steps, and the codonopsis pilosula polysaccharide derivative is especially used for adsorbing and enriching divalent lead ions as a biological adsorbent, so that the problems of high toxicity, high cost, complex adsorption material synthesis process and the like in a lead treatment method in the prior art are solved.

The invention relates to the technical field of veterinary drugs, in particular to povidone-iodine oral liquid and a preparation method thereof. The oral liquid comprises the following components: povidone, a water-soluble anionic polysaccharide derivative, iodine, a metal ion chelating agent, a nonionic surfactant, a water-soluble organic solvent, a pH regulator, a flavoring agent and water. Compared with traditional prevention and treatment preparations with the problems of low bioavailability, poor stability, poor taste and the like, the povidone-iodine oral liquid can effectively prevent and treat the diseases, by optimizing the formula of povidone-iodine and the composite auxiliary materials, adding a proper taste regulator, improving the production process and simplifying the process, the cost is greatly reduced, and the oral liquid is suitable for large-scale popularization and application. The bioavailability is improved, the stability is enhanced, the palatability is improved, the production operation is simpler and more convenient, industrial production can be better adapted, and a practical solution is provided for the breeding industry.

The invention discloses a conjugate containing a trehalose derivative and a carbohydrate antigen as well as a preparation method and application of the conjugate, and belongs to the technical field of anti-tumor carbohydrate vaccines. The conjugate is obtained by taking an immunologic stimulant trehalose derivative of a mincle receptor as an embedded adjuvant to be conjugated with a sugar antigen TF, the trehalose derivative can improve the immunogenicity of the TF sugar antigen, the TF sugar antigen is presented to a corresponding immune cell, and a higher-titer immune response aiming at tumor sugar antigen TF specificity is generated. In addition, the compound also has the advantages of clear structure, simple and convenient synthesis method, stable and controllable product quality and the like, and can overcome the defect of weak immunogenicity of sugar antigens; meanwhile, under the action of an embedded adjuvant trehalose derivative, the vaccine can also generate immune memory.

The present invention relates to a process for preparing an at least partially acetal-protected sugar, comprising the step of reacting a sugar or sugar derivative selected from the group consisting of aldopentoses, aldohexoses, aldopentosides and aldohexosides with an aldehyde or aldehyde source in the presence of a heterogeneous acidic catalyst to form an at least partially acetal-protected sugar selected from the group consisting of compounds of formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI) and (XII): In the formula, R1, R1', R2, R2', R3, R3', R4, R5, R6, R7, R8, R9, R 10 , R 11 , R 12 and R 12 and R and R′, R and R′, R and R′, and R 12 and R 12 are identical or different from one another; and Y is hydrogen or a straight, branched, or cyclic hydrocarbon moiety having 1 to 20 carbon atoms; Z is a linear, branched, or cyclic hydrocarbon moiety having 0 to 12 carbon atoms, optionally substituted with 1 to 4 C1-C4 alkyl groups, or 1 to 4 halogen atoms, or a benzyl group; and E is -COOH, -CH(COOH)2, -COOR 19 , -CH(COOR 20 )(COOR 21 ), -CHO, -CH(CHO)2, -C2H3, -CH(C2H3)2, -CHCHR 22 , -CHCR 23 R 24 , -C2H, -C2R 25 , -N3, -NH2, -CH(NH2)2, -NHR 26 , -CH(NHR 27 )(NHR 28 ), -NR 29 R 30 , -CH(NR 31 R 32 )(NR 33 R 34 ), -OH, -OR35 , or -CH(R 36 OH)(R 37 OH); and R 19 , R 20 , R 21 , R 22 , R 23 , R 24 , R 25 , R 26 , R 27 , R 28 , R 29 , R 30 , R 31 , R 32 , R 33 , R 34 and R 35 are C1 to C 20 is alkyl; and R 20 and R 21 , R 23 and R 24 , R 27 and R 28 , R 29 and R 30 , R 31 and R 32 , and R 33 and R 34 are identical to or different from one another; and R 36 and R 37 are, independently of one another, absent or straight-chain or branched C1-C 12 is a hydrocarbon chain; and R 13 , R 14 , R 15 , R 16 , R 17 and R 18 are each independently hydrogen or a straight-chain, branched-chain, or cyclic hydrocarbon moiety having 1 to 20 carbon atoms. JPEG2025536078000039.jpg83102

The present invention belongs to the technical field of chemical synthesis, and in particular relates to a ruthenium wolfberry oligosaccharide derivative, a preparation method and application thereof. The invention utilizes the remote participation effect of acyl groups, steric hindrance effect, solvent effect and end group effect to achieve efficient construction of 1,2-cis-α-galacturonic acid glycosidic bonds and other glycosidic bonds in the oligosaccharide structure, thereby realizing the first chemical synthesis of ruthenium wolfberry oligosaccharide and its derivatives. The ruthenium wolfberry oligosaccharide fragment provided by the present invention has an inhibitory effect on pancreatic cancer cells, provides a theoretical basis for clarifying the active fragments (active structural domains) of ruthenium wolfberry polysaccharides, conducting more in-depth functional mechanism research and developing new anti-pancreatic cancer drugs based on the active fragments, and has good application prospects in the preparation of new anti-cancer drugs.

The invention relates to an antibacterial chitosan oligosaccharide derivative and a preparation method and application thereof.The main raw materials of the antibacterial chitosan oligosaccharide derivative all belong to green and pure natural raw materials, other synthetic raw materials belong to low-toxicity or non-toxic reagents and are cheap and easy to obtain, the reaction is simple, the reaction condition is mild, the yield is high, the reaction can be quantified, and industrial mass production is easy to achieve; and most of byproducts, such as acetic acid, triethylamine hydrochloride, pivalic acid and the like, involved in the synthesis process can be recycled, so that the preparation cost is greatly saved. According to the scheme, the chitosan oligosaccharide has a relatively strong antibacterial effect, a protective layer similar to a'sugar coating 'chitosan oligosaccharide derivative can be formed on the surface of a feed, and the derivative has antibacterial performance and is small in addition amount, so that the dosage of antibiotics in the feed can be reduced.

The present invention relates to a plant quarantine composition comprising (i) one or more metal sources, (ii) one or more sugars and / or one or more sugar derivatives, and (iii) one or more phosphorous derivatives.

The present invention relates to a novel thalidomide-based compound derivative having significantly improved water solubility due to the introduction of a sugar or sugar derivative into lenalidomide or pomalidomide, which are thalidomide-based compounds, wherein the lenalidomide or pomalidomide derivative according to the present invention has significantly increased water solubility compared to conventional lenalidomide or pomalidomide and can thus be formulated into an injection or eye drop formulation. Therefore, the lenalidomide or pomalidomide derivative can be administered in the form of a high concentration therapeutic agent to a local area, and can be easily administered in combination with a different therapeutic agent developed as an injection or eye drop formulation.

The invention provides the production of sugar-nucleotides and the isolation of sugar-nucleotides. In some embodiments the production or isolation are accomplished under acidic conditions. The production is a cell-free synthesis using enzymes, including immobilized enzymes. They may be accomplished using a one-pot reaction protocol. The synthesis may be used as a highly customizable and highly efficient cell-free manufacturing process. In some embodiments, the sugar-nucleotides are used to prepare UDP-Gal, lactose derivatives, and human milk oligosaccharides (HMOs).

The present invention relates to a phytosanitary composition comprising (i) one or more metal oxide(s), (ii) one or more sugar(s) and / or one or more sugar derivative(s), and (iii) one or more phosphorus derivative(s).

The present invention relates to an antibody comprising a GlcNAc-S(A)x substituent, wherein S(A)x is a sugar derivative comprising x functional groups A wherein A is independently selected from the group consisting of an azido group, a keto group and an alkynyl group and x is 1, 2, 3 or 4, wherein said GlcNAc-S(A)x substituent is bonded to the antibody via C1 of the N-acetylglucosamine of said GlcNAc-S(A)x substituent, and wherein said N-acetylglucosamine is optionally fucosylated.The invention also relates to an antibody-conjugate, in particular to an antibody-conjugate according to the Formula (20) or (20b), wherein AB is an antibody, S is a sugar or a sugar derivative, D is a molecule of interest, and wherein said N-acetylglucosamine is optionally fucosylated (b is 0 or 1).The invention further relates to a process for the preparation of a modified antibody, to a process for the preparation of an antibody-conjugate, and to said antibody-conjugate for use as a medicament.In addition, the invention relates to a kit of parts comprising an azide-modified antibody and a linker-conjugate, wherein said linker-conjugate comprises a (hetero)cycloalkynyl group and one or more molecules of interest.

The invention belongs to the technical field of cosmetic preparation, and particularly relates to a glacier mud skin-cleaning, soothing and repairing mud mask and a preparation method thereof. The skin-cleaning, soothing and repairing mud mask disclosed by the invention is prepared from the following components in parts by weight: 30 to 50 parts of pure water, 20 to 30 parts of modified Canada bentonite, 3 to 6 parts of caprylic / capric triglyceride, 2 to 5 parts of glycerol, 0.5 to 2 parts of sodium hyaluronate, 0.5 to 1 part of ceramide, 0.2 to 0.6 part of lavender extract, 0.1 to 0.5 part of glucosamine derivative, 0.01 to 0.1 part of chamomilla recutita flower extract and 0.5 to 1 part of antibacterial agent. The mud mask prepared by the invention has relatively good moisturizing, oil-controlling, soothing and anti-oxidation effects, and the brightness of facial skin can be remarkably improved after the mud mask is used for a period of time. The modified Canada bentonite is improved in hydrophilic formula and compatibility, and helps the modified Canada bentonite to play a better role, so that by using the mask prepared from the glacier mud, the skin can be better naturally cured and cared, the skin is more balanced and stable, external intervention and influence are reduced, and the healthy and natural beauty of the skin is shown.

The present invention relates to an antibody comprising a GlcNAc-S(A)x substituent, wherein S(A)x is a sugar derivative comprising x functional groups A wherein A is independently selected from the group consisting of an azido group, a keto group and an alkynyl group and x is 1, 2, 3 or 4, wherein said GlcNAc-S(A)x substituent is bonded to the antibody via C1 of the N-acetylglucosamine of said GlcNAc-S(A)x substituent, and wherein said N-acetylglucosamine is optionally fucosylated.The invention also relates to an antibody-conjugate, in particular to an antibody-conjugate according to the Formula (20) or (20b), wherein AB is an antibody, S is a sugar or a sugar derivative, D is a molecule of interest, and wherein said N-acetylglucosamine is optionally fucosylated (b is 0 or 1).The invention further relates to a process for the preparation of a modified antibody, to a process for the preparation of an antibody-conjugate, and to said antibody-conjugate for use as a medicament.In addition, the invention relates to a kit of parts comprising an azide-modified antibody and a linker-conjugate, wherein said linker-conjugate comprises a (hetero)cycloalkynyl group and one or more molecules of interest.

The present invention provides production and isolation of sugar nucleotides. In some embodiments, the production or separation is accomplished under acidic conditions. Production is cell-free synthesis using enzymes, including immobilized enzymes. They may be accomplished using a one-pot reaction protocol. The synthesis can be used as a highly customizable and efficient cell-free manufacturing process. In some embodiments, sugar nucleotides are used to prepare UDP-Gal, lactose derivatives, and human milk oligosaccharides (HMOs).

The invention relates to uridine diphosphate-N-difluoroacetyl galactosamine as well as a preparation method and application thereof. The chemical structure of the UDP-GalNDFA is similar to that of a natural substrate UDP-GalNAc, and the core difference is that N-acetyl at the site 2 of the UDP-GalNDFA is replaced by N-difluoroacetyl. The preparation method comprises the following steps: (1) preparing difluoroacetyl galactosamine; and (2) preparing the UDP-GalNDFA by taking the difluoroacetyl galactosamine as a substrate. As a novel artificial donor sugar, the UDP-GalNDFA has the characteristics of high activity, difficulty in hydrolysis and capability of being artificially synthesized. Compared with the existing donor sugar UDP-GalNTFA, the glucose UDP-GalNTFA has higher catalytic activity on glycosyl transferase, has stronger stability, is not easy to hydrolyze, and can be used as a donor substrate for synthesizing a chondroitin oligosaccharide skeleton, a chondroitin oligosaccharide intermediate and a chondroitin oligosaccharide derivative by a chemical enzyme method.

The invention relates to a hair care and / or scalp care composition comprising rhamnose, trehalose and lactobionic acid. Said composition moisturizes the scalp, protects the scalp from dehydration, promotes the growth of Staphylococcus epidermis and / or Cutibacterium acnes on the scalp and can be used for treating or preventing dandruff.