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3 results about "Disaccharidase" patented technology
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Disaccharidases are glycoside hydrolases, enzymes that break down certain types of sugars called disaccharides into simpler sugars called monosaccharides. In the human body, disaccharidases are made mostly in an area of the small intestine's wall called the brush border, making them members of the group of "brush border enzymes".
Functionalized disaccharidase compositions
PCT designated stage expiredWO2025008445A1Peptide/protein ingredientsPharmaceutical non-active ingredientsDisaccharidasePolymer science
The present invention relates to a composition comprising a solid carrier, a protein disaccharidase or a fragment thereof immobilized on the surface of the solid carrier, a protective layer to protect the protein disaccharidase or a fragment thereof by embedding the protein disaccharidase or a fragment thereof, and a functional constituent immobilized on the surface of the protective layer, wherein the functional constituent immobilized on the surface of the protective layer is a polymer comprising repeat units wherein each repeat unit comprises at least one amino group and / or at least one thiol group. The present invention also relates to methods of producing said composition.
Owner:PERSEO PHARMA AG
Palatable liquid solutions containing high concentrations of megranrude
PendingCN120390639AMetabolism disorderPharmaceutical delivery mechanismDifficult swallowingDisaccharidase
The present invention relates to a stable and palatable formulation containing a high content of meglustat, which can be used in particular by children or persons with dysphagia. This highly concentrated formulation contains at least 150 mg / mL of megranurite, and as excipients sodium benzoate, tartaric acid, a sweetener, and optionally an acidic flavoring. This formulation can advantageously be administered with a therapeutic bienzyme activator to alleviate the intestinal side effects of Magrude.
Owner:TERRANEX
New application of high active polysaccharide from korla pear in promoting expression of small intestinal disaccharidases
The application discloses a new application of Korla fragrant pear high-activity polysaccharide in promoting expression of small intestinal disaccharidase, and belongs to the technical field of functional food and medicine. In the application, Korla fragrant pear pulp is freeze-dried, ground, sieved, extracted with hot water, alcohol precipitated, decolorized and deproteinized, separated through a membrane filtration system, further purified through DEAE-Fast flow anion exchange column chromatography, and finally, Korla fragrant pear high-activity polysaccharide KPP-2-a is obtained. The application innovatively finds that KPP-2-a can effectively promote expression and activity of disaccharidase (lactase, sucrase and maltase) in the brush border of small intestinal mucosal epithelial cells, significantly improves secondary disaccharidase deficiency and related symptoms, excavates a new use of the Korla fragrant pear high-activity polysaccharide KPP-2-a and widens the application field thereof, provides a new means for intervention of secondary disaccharidase deficiency, and has a broad prospect and market value.
Owner:XINJIANG ACAD OF AGRI SCI (XINJIANG BRANCH OF CHINESE ACAD OF AGRI SCI) +1