Palatable liquid solutions containing high concentrations of megranrude

The problems of bitter masking, stability and gastrointestinal side effects are addressed by using sodium benzoate, tartaric acid and glycerol/monoammonium glycyrrhizate mixture in Megroot liquid preparations, providing a high concentration, stable and palatable Megroot liquid preparation for use in patients with dysphagia.

CN120390639APending Publication Date: 2025-07-29TERRANEX
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Patent Information

Application Number
CN202380084161.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-10-07
Filing Date
2023-10-09
Publication Date
2025-07-29

AI Technical Summary

Technical Problem

The existing Megrote preparations have problems with difficult to mask bitterness, risk of gastrointestinal side effects, poor stability and large volumes that are not suitable for patients with dysphagia, especially children, especially the concentration of liquid preparations and are not easy to preserve.

Method used

Use sodium benzoate as a preservative, tartaric acid adjusts the pH to 3 to 5, and a mixture of glycerin and monoammonium glycyrrhizate as a sweetener, avoid the use of carbohydrates, combine with acidic flavoring agents, and form a high concentration of Megrote liquid preparation, ensuring stable at room temperature for several months and good palatability.

Benefits of technology

It has achieved a high concentration of Megrote liquid preparation that is stable at room temperature for several months, has good palatability, and is suitable for patients with dysphagia, especially children, avoids gastrointestinal side effects, and is small in size and easy to swallow.

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Abstract

The present invention relates to a stable and palatable formulation containing a high content of meglustat, which can be used in particular by children or persons with dysphagia. This highly concentrated formulation contains at least 150 mg / mL of megranurite, and as excipients sodium benzoate, tartaric acid, a sweetener, and optionally an acidic flavoring. This formulation can advantageously be administered with a therapeutic bienzyme activator to alleviate the intestinal side effects of Magrude.
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