65 results about "Sugar derivative" patented technology

Technologies to convert biomass to liquid hydrocarbon fuels are currently being developed to decrease our carbon footprint and increase use of renewable fuels. Since sugars/sugar derivatives from biomass have high oxygen content and low hydrogen content, coke becomes an issue during zeolite upgrading to liquid hydrocarbon fuels. A process was designed to reduce the coke by co-feeding sugars/sugar derivatives with a saturated recycle stream containing hydrogenated products.

This invention provides processes to convert biomass into energy-dense biomass for combustion, alone or in combination with another solid fuel. In some variations, biomass is extracted to produce an extract liquor containing hemicellulosic oligomers and cellulose-rich solids; hemicellulosic oligomers are removed; and the cellulose-rich solids are torrefied to produce energy-dense biomass. In some embodiments, hydrotorrefaction is employed to produce hydrophobic, energy-dense biomass in an energy-efficient process that avoids intermediate drying between extraction/hydrolysis and torrefaction. The energy-dense biomass may be pelletized or directly combusted or gasified. The hemicellulosic oligomers may be hydrolyzed to fermentable sugars and then fermented to ethanol or other products, or further reacted to produce furfural or other products.

The invention provides a fabric softening composition comprising; (i) at least one oily sugar derivative which is a liquid or soft solid derivative of a cyclic polyol or of a reduced saccharide, said derivative resulting from 35 to 100% of the hydroxyl groups it said polyol or in said saccharide being esterified or etherified, and wherein, the derivative has two or more ester or ether groups independently attached to alkyl or alkenyl chains derived from a fatty acid mixture comprising at least 50% by weight of a mixture of tallow fatty acid and oleyl fatty acid, and (ii) one or more deposition aid(s). The invention also provides a method of treating fabric by applying thereto the composition of the invention and the use of the aforementioned oily sugar derivatives within a fabric softening composition as a fabric softening aid that does not decrease the absorbency of the fabric. Also provided are the above mentioned oily sugar derivatives.

Glycoproteins comprising a glycan of the formula (102) are disclosed; wherein b is 0 or 1; the GlcNAc residue optionally fucosylated; and Su(A)_x is a sugar derivative comprising x functional groups A, wherein x is 1, 2, 3 or 4 and A is independently selected from the group consisting of an azido group, a keto group, an alkynyl group, a thiol group, a halogen, a sulfonyloxy group, a halogenated acetamido group, a mercaptoacetamido group and a sulfonylated hydroxyacetamido group.

Protein-conjugates having glycoproteins according to the invention conjugated to a molecule of interest (e.g., an active substance) are also disclosed. Examples include modified antibodies, antibody-conjugates, and antibody-drug conjugates (ADCs). Processes for the preparation of the modified glycoproteins according to the invention and methods for the preparation of a protein-conjugate according to the invention are mentioned.

The invention relates to the preparation of monolithic silica under mild conditions from alkoxysilanes derived from sugars, sugar acids, sugar alcohols and polysaccharides including glycerol, sorbitol, mannose and dextran. Unlike the commonly used silica starting material TEOS (Si(OEt)₄), the sol-gel hydrolysis and cure of the sugar derivatives are not very sensitive to pH as similar rates of gelation were observed over a pH range of about 5.5-11. The morphology of the resulting silicas could be varied using specific additives, including multivalent ions and hydrophilic polymers.

The invention provides a quinazoline sugar derivative and a preparation method and application thereof, which can solve the problem of low activity of inhibiting tyrosine kinase in the prior art. The prepared quinazoline sugar derivative has high water solubility and high activity of inhibiting human skin cancer cells A431, and can be used for preparing medicaments for preventing or treating tumors. The quinazoline sugar derivative provided by the invention is a kind of compounds which have novel structures and comprise abundant glycosyl group segments at a 6-bit side chain of a quinazoline parent ring, wherein the raw materials adopted in a method for performing glycosylation on quinazoline rings are readily available; the synthesis method is simple; the purification mode is simple and convenient and quick; and the quinazoline sugar derivative has high water solubility, high biological activity, particularly obvious activity of selectively inhibiting an EGFR, and obvious anti-tumor effect, so the kind of compounds has a wide application prospect in medicaments for preventing or curing tumors. The quinazoline sugar derivative comprises the following structural formula.

The present invention relates to a process for the enzymatic modification of a glycoprotein. The process comprises the step of contacting a glycoprotein comprising a glycan comprising a terminal GlcNAc-moiety, in the presence of glycosyltransferase that is, or is derived from, a β-(1,4)-N-acetylgalactosaminyltransferase, with a non-natural sugar-derivative nucleotide. The non-natural sugar-derivative nucleotide is according to formula (3): wherein A is selected from the group consisting of —N₃, —C(O)R³, —(CH₂)_iC≡C—R⁴, —SH, —SC(O)R⁸, —SC(0)OR8, —SC(S)OR8, —F, —CI, —Br —I, —OS(O)₂R⁵, terminal C₂-C₂₄ alkenyl groups, C₃-C₅ cycloalkenyl groups, C₄-C₈ alkadienyl groups, terminal C₃-C₂₄ allenyl groups and amino groups. The invention further relates to a glycoprotein obtainable by the process according to the invention, to a bioconjugate that can be obtained by conjugating the glycoprotein with a linker-conjugate, and to β-(1,4)-N-acetylgalactosaminyltransferases that can be used in preparing the the glycoprotein according to the invention.

The invention relates to an amphiphilic polysaccharide derivative carrier for targeting tumor new blood vessels. According to the derivative, a polysaccharide skeleton is coupled with functional polypeptide targeting E-selectin by virtue of a disulfide bond to ensure that polysaccharide has amphipathy, and is assembled into nano particles for targeting the tumor new blood vessels after carrying an antitumor drug or a tumor new blood vessel inhibitor in an aqueous medium. The nano particles deliver medicines to the tumor new blood vessels in an active targeting manner by virtue of the high affinity between the functional polypeptide targeting the E-selectin and the E-selectin on the surface of the tumor new blood vessels, then a disulfide bond connecting arm can be specifically degraded by a strong reducing environment in endothelial cells of the tumor new blood vessels to cause that the functional polypeptide targeting the E-selectin is separated from polysaccharide, and the medicines are quickly released to treatment target points, so that the concentration of free medicines at tumor new blood vessel parts can be significantly improved and the antitumor curative effect is enhanced. An auxiliary material can be used as a carrier for water-insoluble, indissolvable or amphiphilic antitumor drugs and the tumor new blood vessel inhibitor, and is administrated by injecting into blood vessels or muscles, or is administrated orally or externally. The amphiphilic polysaccharide derivative carrier provided by the invention is simple in preparation method, mature in process and suitable for large-scale production.

The invention belongs to the technical field of biomass resource utilization, and discloses a method for preparing pesticide by using biomass hydrothermal carbonization liquid phase and preparing organic fertilizers by using solid phase. The method comprises the following steps: uniformly mixing biomass raw materials with water to obtain a biomass aqueous solution; then adding the biomass aqueous solution in a high-pressure reactor; replacing air in the reactor by using inert gas or hydrogen; heating to the temperature of 200-300 DEG C; carrying out constant-temperature hydrothermal carbonization reaction under the condition of stirring; filtering or centrifugally separating a reaction product; extracting the liquid phase with ethyl acetate and then preparing the pesticide; and drying the solid phase and then preparing the organic fertilizers. Compared with the traditional method for preparing pesticide and organic fertilizers by using biological oil water-phase component sugar and sugar derivatives, the method has the advantages of low energy consumption, mild reaction conditions, simple technological process, easiness in separation of the reaction products, environmental friendliness and the like.

In a process for producing a particulate polysaccharide derivative by dry-grinding a moist polysaccharide derivative the median length of the particles after dry-grinding is controlled by controlling the moisture content of the polysaccharide derivative prior to dry-grinding. Advantageously the median length of the particles after dry-grinding is adjusted to a first value by a first moisture content of the polysaccharide derivative prior to dry-grinding and is adjusted to a second value by a second moisture content.

The invention provides a fullerene polysaccharide derivative and its preparation method. The method comprises: adding 2-azidoethyl-2, 3, 4, 6-tetra-O-acetyl-beta-D-glucopyranoside and fullerene in a mole ratio of 1:1, dissolving them with chlorobenzene, conducting shading stirring for 12h at a temperature of 140DEG C and under inert gas protection; carrying out reduced pressure distillation so as to obtain tawny powder; dissolving the obtained tawny powder in a mixed solvent of chloroform and methanol that are in a ratio of 1:1, adding sodium methoxide until the pH reaches 9, and performing stirring for 30min under a temperature of 60DEG C; implementing neutralization with 25% acetic acid, then standing the mixture under refrigeration; and conducting filtration, then carrying out washing with methanol as well as vacuum drying, thus obtain the fullerene polysaccharide derivative. With fullerene and glucose as raw materials, the method of the invention synthesizes the fullerene polysaccharide derivative with nontoxicity to human bodies and good biological compatibility. The unique cancer cell-killing capability of the derivative can substantially improve the medical treatment level of mankind in treating bladder cancers.

To provide a hair styling cosmetic composition which is excellent in hair styling property and hair restyling property, even though having a low viscosity, and is excellent in non-stickiness, smoothness, and light finish of the hair. A hair styling cosmetic composition comprising (a) one or more substances being solid at room temperature (25° C.) selected from among (a₁) a sugar alcohol, (a₂) a sugar, (a₃) a polyalkylene glycol polymer, and (a₄) an inorganic salt, in an amount of from 0.1 to 20 by mass, (b) a sugar derivative and/or a sugar alcohol derivative being liquid at room temperature in an amount of from 0.1 to 25 by mass, (c) one or more film-forming polymers selected from among acrylic and vinylic film-forming polymers (but excepting ampholytic polymers) and urethanic polymers, in an amount of from 0.1 to 12 by mass, and (d) an aqueous solvent, wherein the viscosity of the system is at most 10,000 mPa·s (at 25° C. with B-type viscometer).

The present invention concerns novel and improved antibody-conjugates for targeting CD30. The inventors found that when antibody-conjugates were prepared using a specific mode of conjugation, they exhibit an improved therapeutic index. The mode of conjugation comprises a first step (i) of contacting a glycoprotein comprising 1-4 core N-acetylglucosamine moieties with a compound of the formula S(F¹)_x-P in the presence of a catalyst, wherein S(F¹)_x is a sugar derivative comprising x functional groups F¹ capable of reacting with a functional group Q¹, x is 1 or 2 and P is a nucleoside mono- or diphosphate, and wherein the catalyst is capable of transferring the S(F¹)_x moiety to the core-GlcNAc moiety, to obtain a modified antibody; and a second step (ii) of reacting the modified antibody with a linker-conjugate comprising a functional group Q¹ capable of reacting with functional group F¹ and a target molecule D connected to Q¹ via a linker L² to obtain the antibody-conjugate wherein linker L comprises S—Z³-L² and wherein Z³ is a connecting group resulting from the reaction between Q¹ and F¹. The invention also relates to a use for improving the therapeutic index of an antibody-conjugate and to a method for targeting CD30-expressing cells.

The invention discloses an amphiphilic polysaccharide derivative containing cholesterol and phytolectin group as well as a preparation method and application of the amphiphilic polysaccharide derivative. According to the invention, firstly, an amphiphilic polysaccharide derivative containing cholesterol and a phytolectin group is synthesized; and further an insulin-loaded amphiphilic polysaccharide derivative nanoparticle with glucose responsiveness is synthesized. The capability of combining free glucose molecules in the surrounding environment of the phytolectin group in the nanoparticle ishigher than that of combining glucose groups on polysaccharide chains, so that the chain segments of the amphiphilic polysaccharide derivative become loose, the size of the nanoparticles is increased,insulin is released, and intelligent regulation and control are realized. The preparation conditions of the amphiphilic polysaccharide derivative and the nanoparticle are mild, the used raw materialsare safe, and the activity of specific binding of phytolectin to glucose molecules and the structural stability and biological activity of insulin are maintained. The amphiphilic nanoparticle for intelligently regulating and controlling insulin release prepared by the invention is expected to be used as an insulin delivery carrier, and can intelligently regulate and control insulin release according to the change of the blood glucose level in the body of a diabetes patient, so that the amphiphilic nanoparticle has a certain application prospect in the aspect of diabetes treatment.

The present invention relates to ibuprofen sugar derivative and its preparation process and application. The present invention prepares the target compound through crosslinking unprotected alpha-methyl-D-glucoside and 2-(4'-isobutylphenyl)-propanoic acid with immobilized lipase. The present invention has simplified operation steps, mild reaction condition and high product purity, and may be used in industrial production. The ibuprofen sugar derivative of the present invention may be used in preparing medicine for treating rheumarthritis and rheumatoid arthritis. Its general structural expression is also given.

The invention discloses a method for comprehensive utilization of wood fiber all components. The method comprises the following steps: firstly, separating hemicellulose components by carrying out CO2-assisted hydrothermal liquefaction and mainly hydrolyzing the hemicellulose components into C5 sugar and a C5 sugar derivative; converting lignin into a phenolic product through a catalytic hydrogenation process; finally, dissolving out small amount of hemicellulose and lignin left in the wood fiber residues by carrying out alkaline hydrogen peroxide treatment, thus finally obtaining high-purity cellulose. In situ weak acid carbonic acid is formed by pressurizing carbon dioxide; a reactant is gradually acidized due to the dissociation of the carbonic acid; by use of the pressurization effect of the carbon dioxide, the permeability of a solvent to the wood fiber can be greatly improved. According to the method disclosed by the invention, various products of wood fiber components are obtained by separating and further the comprehensive utilization of the wood fiber all components is realized.

A process for selectively removing isopropylidene from diisopropylidene ketalose derivative includes such steps as immersing nano-TiO2 in the solution of sulfuric acid, filtering, drying calcining to obtain the catalyst SO4/TiO2, dissolving diisopropylidene ktalose derivative in the aqueous solution of methanol or ethanol or acetonitrile, adding said catalyst, reacting at 10-40 deg.C for 10-20 hr, and purifying.

A simple and easy process for preparing pharmacologically useful flavonoid compound having reductase inhibitory effect, active oxygen extinguishing effect, carcinogenesis promotion inhibitory effect, anti-inflammatory effect, and so on. Particularly, a process for preparing the compound of the formula (I): wherein, R2 is a substituted or un-substituted phenyl group; R7 is a hydrogen atom or a hydroxyl group; and n is an integer of 1 to 4; by bonding a sugar derivative to catechins as the starting compound selectively via O-glycoside bond and then oxidizing the 4-position of flavanoid skeleton of the obtained compound.