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Fullerene polysaccharide derivative and its preparation method

A technology of fullerene polysaccharides and fullerene sugars, which is applied in the field of novel fullerene polysaccharide derivatives and preparation, and the preparation of organic polymer materials, and can solve the problems affecting the promotion of fullerene-derived drugs and poor biocompatibility. problem, to achieve the effect of improving medical level and good selectivity

Inactive Publication Date: 2012-08-08
HARBIN ENG UNIV
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Problems solved by technology

According to the principle that fullerene has good selectivity to the bladder and can generate singlet oxygen under laser irradiation conditions, researchers have also prepared fullerene derivatives for the treatment of bladder cancer (such as: fullerene poly Oxyethylene derivatives, Polyethylenglycol), but most of them have not achieved the desired effect due to poor biocompatibility or some other side effects, which has affected the promotion of fullerene-derived drugs

Method used

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  • Fullerene polysaccharide derivative and its preparation method
  • Fullerene polysaccharide derivative and its preparation method
  • Fullerene polysaccharide derivative and its preparation method

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Embodiment Construction

[0019] The following examples describe the present invention in more detail:

[0020] Synthesis of 1,2,3,4,6-penta-O-acetyl-β-D-glucose

[0021] Add 350ml of anhydrous acetic acid to anhydrous sodium acetate (25.2g, 0.307mol), heat to 140°C, and slowly add 50.0g of D-glucose while the system is boiling. After the addition is complete, continue heating to boiling until the reaction is complete, and place it at room temperature to cool. The reaction solution was poured onto 1 liter of ice cubes, and a brown precipitate was formed after stirring for 4 hours. After suction filtration, rinse with water until there is no smell of acetic acid, and dry under reduced pressure. The obtained substance was added to 400 mL of ethanol, and stirred while heating to dissolve it. After adding activated carbon and stirring thoroughly, suction filter while hot to remove activated carbon. The obtained solution was continued to be heated, the solvent was evaporated to a normal amount, cooled n...

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Abstract

The invention provides a fullerene polysaccharide derivative and its preparation method. The method comprises: adding 2-azidoethyl-2, 3, 4, 6-tetra-O-acetyl-beta-D-glucopyranoside and fullerene in a mole ratio of 1:1, dissolving them with chlorobenzene, conducting shading stirring for 12h at a temperature of 140DEG C and under inert gas protection; carrying out reduced pressure distillation so as to obtain tawny powder; dissolving the obtained tawny powder in a mixed solvent of chloroform and methanol that are in a ratio of 1:1, adding sodium methoxide until the pH reaches 9, and performing stirring for 30min under a temperature of 60DEG C; implementing neutralization with 25% acetic acid, then standing the mixture under refrigeration; and conducting filtration, then carrying out washing with methanol as well as vacuum drying, thus obtain the fullerene polysaccharide derivative. With fullerene and glucose as raw materials, the method of the invention synthesizes the fullerene polysaccharide derivative with nontoxicity to human bodies and good biological compatibility. The unique cancer cell-killing capability of the derivative can substantially improve the medical treatment level of mankind in treating bladder cancers.

Description

technical field [0001] The invention relates to an organic polymer material. The invention also relates to a preparation method of the organic polymer material. Specifically, it is a novel fullerene polysaccharide derivative and a preparation method thereof. Background technique [0002] Fullerene is the fourth crystalline form of carbon discovered in 1985 after diamond, graphite and linear carbon (carbyne). It has excellent mechanical, optical, electrical, and chemical properties, and is one of the new materials that has attracted much attention. Its properties have been widely used in aviation, aerospace, electronic devices, and chemical industries. In addition, researchers have found that it also has some functions of drugs. For example, R.F. Schinazi, a virologist at the Emory University School of Medicine in Atlanta, USA, and his colleagues found that fullerene spheres have some functions on drugs. A key HIV (AIDS) viral enzyme kills without harming host cells. Alth...

Claims

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Application Information

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IPC IPC(8): C01B31/00A61K41/00A61P35/00C01B32/156
Inventor 沈贤德矢野重信觉知丰次赤司治夫鸣海敦
Owner HARBIN ENG UNIV
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