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Polymer mixtures of anionic and cationic polysaccharides anduse thereof

A technology for anionic polysaccharides and mixtures, which is applied in the fields of drug combination, medical science, bone diseases, etc., can solve the problems of no mixture, no coexistence of anionic and cationic polymers, loss and other problems

Inactive Publication Date: 2009-06-10
UNIV DEGLI STUDI DI TRIESTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, such mixtures did not form and there were no known problems with the coexistence of anionic and cationic polymers mentioned
The conditions required for the mixture thus do not form coagulation or possible layer separation and irreversibly lose the conditions for molecular dispersion of the mixture solution and the modification of the rheological properties of the composition disappears

Method used

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  • Polymer mixtures of anionic and cationic polysaccharides anduse thereof
  • Polymer mixtures of anionic and cationic polysaccharides anduse thereof
  • Polymer mixtures of anionic and cationic polysaccharides anduse thereof

Examples

Experimental program
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Effect test

example 1

[0047] example 1: Synthetic Chitosan Lactose Derivatives (known as Kitrak)

[0048] Chitosan (1.5 g, degree of acetylation 11%) was dissolved in 110 mL of methanol (55 mL) and 1% acetic acid buffer (pH 4.5 (55 mL)) solution. 60 mL of a solution of lactose (2.2 g) and sodium cyanoborohydride (900 mg) in methanol (30 mL) and 1% acetic acid buffer (pH 4.5 (30 mL)) was added. The mixture was stirred for 24 hours, transferred to a dialysis tube (cutoff: 12000 Da) and dialyzed against 0.1 M NaCl (2 times) and deionized water until the conductivity was 4 μS (4° C.). Finally the solution was filtered through a microporous (0.45 μm) filter and lyophilized.

example 2

[0049] Example 2: Synthesis of Chitosan Cellobiose Derivatives (hereinafter referred to as Kissel)

[0050] Chitosan (1.5 g, degree of acetylation 11%) was dissolved in 110 mL of methanol (55 mL) and 1% acetic acid buffer (pH 4.5 (55 mL)). 60 mL of methanol (30 mL), 1% acetate buffer (pH 4.5 (30 mL)) solution containing cellobiose (2.2 g) and sodium cyanoborohydride (900 mg) was added. The mixture was stirred for 24 hours, transferred to a dialysis tube (cutoff: 12000 Da) and dialyzed against NaCl 0.1M (2 times) and deionized water until the conductivity was 4 μS (4°C). Finally the solution was filtered through a millipore filter (0.45 μm) and freeze-dried.

example 3

[0051] Example 3: Synthesis of Chitosan Maltotriose Derivatives (hereinafter referred to as Kimmel 3)

[0052] Chitosan (300 mg, degree of acetylation 11%) was dissolved in 22 mL of methanol (11 mL) and 1% acetic acid buffer (pH 4.5 (11 mL)). 12 mL of methanol (6 mL), 1% acetate buffer (pH 4.5 (6 mL)) containing maltotriose (650 mg) and sodium cyanoborohydride (180 mg) was added. The mixture was stirred for 24 hours, transferred to a dialysis tube (cutoff: 12000 Da) and dialyzed against NaCl 0.1M (2 times) and deionized water until the conductivity was 4 μS (4°C). Finally the solution was filtered through a millipore filter (0.45 μm) and freeze-dried.

[0053] The following examples of polysaccharide mixtures are obtained from the aforementioned chitosan derivatives and commercially available polyanionic polysaccharides with different average molecular weights.

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Abstract

Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behaviour with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behaviour renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery.

Description

Technical field: [0001] The invention relates to a composition comprising a polysaccharide mixture composed of anionic and polycationic polysaccharides, and the polysaccharide has suitable physical and chemical properties, especially high viscosity and viscoelasticity, and its biomedical application. Background technique: [0002] It is known that polysaccharides are considered to be biopolymers with application value due to their high biocompatibility and their special physicochemical properties, especially the viscosity properties of their aqueous solutions. It is also known that the so-called rheological properties are mainly related to their molecular weight relevant. From the application point of view, among these biopolymers, hyaluronic acid is a particularly useful bio-applicable polymer, so it is widely used in the field of biomedicine. Its aqueous solution has unique rheological properties, showing interesting properties. Viscous and viscoelastic properties. Polys...

Claims

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Application Information

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IPC IPC(8): C08L5/00C08L5/08
CPCA61L27/52C08L1/286C08L5/08C08L5/00C08L5/10C08L5/06A61L27/20C08L5/04C08L5/12A61P19/00A61P19/02A61P19/04A61P27/02A61P29/00C08L2666/26
Inventor 塞乔·保莱蒂伊万·多纳蒂伊莲诺·马斯奇
Owner UNIV DEGLI STUDI DI TRIESTE
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