The invention relates to a cable splice closure and a manufacturing method and the use of the same. The cable splice closure consists of a splice closure body, a splice general support bracket, a fiber holding plate and a splice closure upper cover, wherein the whole shape of the splice closure body is a box shape; the box of the splice closure body accommodates the splice general support bracket and the fiber holding plate; the splice closure body is provided with a sealing groove, an general support bracket pillar, a fiber holding plate positioning pillar, a closing and fastening bolt structure, a cable entrance hole, a cable exit hole, a covered wire cable exit hole and a preserved hole; the outer side of the upper bead of the splice closure body is provided with the sealing groove; the sealing groove surrounds the outer side of the upper bead; the shape of the whole section of the sealing groove is a U shape; an annular hollow sealing strip is placed in the sealing groove; and the outside diameter of the hollow sealing strip is matched with the inside diameter of the sealing groove. The cable splice closure is unique in design concept, reasonable in structure, low in cost, excellent in sealing effect and simple in construction operation, saves labor, improves efficiency, can be used as a pipeline, underground straight buried, overhead, wall attached cable splice closure, is wide in application range, and achieves a multifunction effect.