Application of danshinolic acid C in preparing drug for protecting ischemic brain tissue damage

A technology of brain tissue injury and salvianolic acid, which is applied in the application field of salvianolic acid C in the preparation of drugs for protecting ischemic brain tissue injury, and can solve problems such as the inability to obtain salvianolic acid C application

Inactive Publication Date: 2019-08-09
贵州拜特制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the pharmacodynamic effect of salvianolic acid C on the anti-cerebral ischemic hypoxic injury, and the application of salvianolic acid C in the preparation of drugs for protecting ischemic brain tissue damage cannot be obtained.

Method used

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  • Application of danshinolic acid C in preparing drug for protecting ischemic brain tissue damage
  • Application of danshinolic acid C in preparing drug for protecting ischemic brain tissue damage
  • Application of danshinolic acid C in preparing drug for protecting ischemic brain tissue damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Take salvianolic acid C5g, mannitol 10g, sodium thiosulfate 0.15g into 800ml water for injection, adjust the pH to 4-6 with 0.5% sodium hydroxide; stir evenly with 0.1% activated carbon for injection, keep it at 60 degrees for 30 minutes, Filter and decarbonize while hot, add water for injection to the filtrate to 1000ml, sterilize and filter, fill in 200 10ml vials, half stoppered, send to freeze dryer, pre-freeze at -40°C for 2h, vacuum to 10Pa-20Pa, Incubate at -25°C for 3h, at -10°C for 16h, dry at 30°C for 3h, and plug it out of the box to prepare salvianolic acid C powder injection.

Embodiment 2

[0096] Take the salvianolic acid C ethyl ester and crush it through an 80 mesh sieve. Weigh the sieved salvianolic acid C ethyl ester 650g, spray-dried lactose 750g, cross-linked povidone 50g, and sodium bisulfite 30g, mix well, and then add Mix 30 g of silica gel with a 60 mesh sieve, and finally add 15 g of magnesium stearate to mix, and then mix the 7mm round shallow concave punching tablet. Dissolve the gastric-soluble coating premix in purified water to prepare a coating solution with a solid content of 15%, and use a high-efficiency coating machine to coat the coating with a weight gain of 3% to obtain C ethyl salvianolic acid Coated tablets.

Embodiment 3

[0098] Take the salvianolic acid C sodium salt and vitamin C and crush them through an 80-mesh sieve. Weigh the crushed salvianolic acid C sodium salt, 100g vitamin C, 500g microcrystalline cellulose, and 350g pregelatinized starch after sieving, and mix well. , Add an appropriate amount of absolute ethanol to make soft material, granulate with 20 mesh sieve, dry at 40 ℃, and finish the dry granules with 20 mesh sieve, add 85 g of croscarmellose sodium and 15 g of magnesium stearate and mix uniformly. Total mixed medicine powder: Fill the total mixed medicine powder in 2# hollow capsules, the weight of which is 170mg, to obtain salvianolic acid C sodium salt capsules.

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PUM

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Abstract

The invention provides new application of danshinolic acid C, and particularly, the danshinolic acid C can be used for preparing a drug for protecting the ischemic brain tissue damage. The danshinolicacid C has a good effect of resisting the ischemic brain tissue damage, the effect is obvious, and the danshinolic acid C has development and utilization values.

Description

Technical field [0001] The present invention relates to a new use of salvianolic acid C, in particular to the application of salvianolic acid C in preparing medicines for protecting ischemic brain tissue damage. Background technique [0002] The main cause of ischemic hypoxic encephalopathy is cerebral ischemia and hypoxia caused by various reasons. In the case of brain hypoxia, glycolysis is increased by 3-10 times, a large amount of pyruvate is reduced to lactic acid, and intracellular acidosis develops rapidly and severely. Only a small amount of ATP is produced during glycolysis. Due to insufficient energy sources, brain cells cannot maintain the difference in ion concentration inside and outside the cell membrane. + , Mg 2 + , HPO 4 + Escape from the cell, Na + And Ca 2+ Into the cell, the oxidative metabolism of brain cells is impaired. During hypoxia, the auto-regulatory function of cerebral blood vessels is reduced, and cerebral blood perfusion is easily affected by the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P9/10A61P25/00A61P7/10
CPCA61K31/343A61P7/10A61P9/10A61P25/00
Inventor 范骁辉陆晓燕薛捷张禄权李辉李白玲何容
Owner 贵州拜特制药有限公司
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