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Application of salvianolic acid A and derivatives thereof to prevention and treatment of high-altitude sickness

A technology of salvianolic acid and derivatives, applied in the field of medicine, can solve the problems of low absorption efficiency, high urine output, dehydration, slow onset of action and the like

Inactive Publication Date: 2017-03-08
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, acetazolamide is the most commonly used, but it is easy to cause adverse effects such as excessive urine output and dehydration.
There are also some compound Chinese medicine preparations, mainly Lishukang capsules, etc., but the onset of effect is slow, and the absorption efficiency is low.

Method used

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  • Application of salvianolic acid A and derivatives thereof to prevention and treatment of high-altitude sickness
  • Application of salvianolic acid A and derivatives thereof to prevention and treatment of high-altitude sickness
  • Application of salvianolic acid A and derivatives thereof to prevention and treatment of high-altitude sickness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Salvianolic acid A powder injection:

[0036]

[0037] Add salvianolic acid A, mannitol, and sodium thiosulfate to 800ml of water for injection according to the prescription, adjust the pH to 4-6 with 0.5% sodium hydroxide; stir well with 0.1% activated carbon for injection, keep warm at 60°C for 30 minutes, Filtrate and decarbonize while it is hot, add water for injection to the filtrate to 1000ml, sterilize and fine filter, fill in 200 10ml vials, half stoppered, send to a freeze dryer, pre-freeze at -40°C for 2 hours, and vacuum to 10Pa~20Pa, Incubate at -25°C for 3h, at -10°C for 16h, dry at 30°C for 3h, press the plug out of the box, and obtain salvianolic acid A powder injection.

Embodiment 2

[0039] Salvianolic Acid Ethyl Ester Tablets:

[0040]

[0041] Grind ethyl salvianolic acid A through a 80-mesh sieve, weigh the sieved ethyl salvianolic acid A, spray-dried lactose, crospovidone, and mix evenly with sodium bisulfite, then add the 60-mesh sieved Mix micronized silica gel, and finally add magnesium stearate to mix evenly, and make 7mm round shallow concave punching tablets. Dissolve the gastric-soluble coating premix in purified water to make a coating solution with a solid content of 15%, and use a high-efficiency coating machine for coating, and the weight of the coating will increase by 3%, so as to obtain ethyl salvianolic acid A Coated tablets (based on salvianolic acid A, 60mg / tablet).

Embodiment 3

[0043] Salvianolic acid A sodium salt capsules:

[0044]

[0045] Grind the salvianolic acid A sodium salt and vitamin C, pass through an 80-mesh sieve, weigh the crushed and sieved salvianolic acid A sodium salt, vitamin C, microcrystalline cellulose, and pregelatinized starch, mix them well, and add Appropriate amount of water and ethanol is made into a soft material, granulated with a 20-mesh sieve, dried at 40°C, the dry granules are sorted with a 20-mesh sieve, added with croscarmellose sodium and magnesium stearate and mixed evenly to obtain a total blended medicinal powder. The total mixed medicinal powder is filled in 2# hollow capsules, with a grain weight of 170 mg, to obtain salvianolic acid A sodium salt capsules (calculated as salvianolic acid A, 60 mg / capsule).

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PUM

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Abstract

The invention relates to the field of medicine, in particular to application of salvianolic acid A and derivatives to prevention and / or treatment of high-altitude sickness. The application of the salvianolic acid A involves protection of cardiovascular diseases, cerebrovascular endothelial cells and ischemic brain tissues, prevention and / or treatment of cerebral thrombosis, improvement on neurological function symptoms after cerebral ischemia, prevention and / or treatment of diabetes mellitus and complications, inhibition of brain tissue neuron damage or death, prevention and / or treatment of cerebral thrombosis, drugs for treating ischemic penumbra and multi-drug resistance of tumors, prevention and treatment of HIV encephalopathy and the like. Application of the salvianolic acid A and the derivatives thereof to prevention and / or treatment to the high-altitude sickness has not been reported.

Description

technical field [0001] The invention relates to the application of salvianolic acid A and its derivatives in the prevention and / or treatment of altitude sickness, and belongs to the technical field of medicine. Background technique [0002] Altitude sickness refers to people entering areas above 3000m above sea level (including high mountains and plateaus) for a short period of time, and within a few hours or a day or two, severe headache, dizziness, fatigue, irritability, insomnia, palpitations, shortness of breath, and chest fullness occur. , loss of appetite, nausea and vomiting, abdominal distension and diarrhea, vertigo, tinnitus, epistaxis, numbness of hands and feet or twitching of hands and other symptoms. The severity of the symptoms varies from person to person. Serious events such as high-altitude pulmonary edema, cerebral edema, and heart failure may occur in severe cases. If these diseases are not treated in time, they will lead to death. In light cases, the sym...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P39/00
CPCA61K31/216
Inventor 李东张志伟胡向青李志刚
Owner SHINEWAY PHARMA GRP LTD
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