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Extraction method of salvia extract and safflower extract and preparation method of salvia-safflower oral preparation

A safflower extract and extraction method technology, which can be applied to medical preparations, drug combinations, pharmaceutical formulations and other directions containing active ingredients, can solve problems such as unreasonable control indicators of active ingredients, reduce the risk of clinical use, and ensure curative effect. , the effect of improving controllability

Inactive Publication Date: 2012-02-22
哈药集团中药二厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the active ingredient control index of the existing Danhong oral preparation finished product is unreasonable

Method used

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  • Extraction method of salvia extract and safflower extract and preparation method of salvia-safflower oral preparation
  • Extraction method of salvia extract and safflower extract and preparation method of salvia-safflower oral preparation
  • Extraction method of salvia extract and safflower extract and preparation method of salvia-safflower oral preparation

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specific Embodiment approach 1

[0014] Specific embodiment one: the extraction method of the salvia miltiorrhiza extract in this embodiment is carried out according to the following steps: 1. First, add ethanol with 12 to 16 times the mass of the salvia miltiorrhiza root slices and a mass concentration of 40% to 50% in the salvia miltiorrhiza herbal decoction pieces, and then reflux the extraction After 1.5 to 3 hours, filter out the medicinal liquid of Danshen, then add ethanol with a mass concentration of 40% to 50% and 8 to 14 times the mass of the residue to the dregs, reflux and extract for 1 to 2 hours, filter out the medicinal liquid of Danshen, and combine the two The salvia miltiorrhiza medicinal liquid extracted for the first time is then decompressed and concentrated into salvia miltiorrhiza paste with a relative density of 1.12 to 1.24; 2. Add water 3 to 5 times the weight of the salvia miltiorrhiza paste to the salvia miltiorrhiza paste, stir while adding water, and let it stand at room temperatur...

specific Embodiment approach 2

[0017] Specific embodiment two: the difference between this embodiment and specific embodiment one is: in step one, first add the ethanol with 14 times of the mass of the salvia miltiorrhiza to the decoction pieces of the salvia miltiorrhiza medicinal material, and the mass concentration is 45%, then reflux extraction for 2.5 hours, and filter out Salvia miltiorrhiza medicinal liquid, then add ethanol with 12 times the mass of the medicinal residue and 45% mass concentration to the medicinal residue, and reflux for extraction for 1.5 hours. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0018] Specific embodiment 3: The difference between this embodiment and specific embodiment 1 is: in step 1, decompress and condense into Danshenqing paste with a relative density of 1.2. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

An extraction method of a salvia extract and a safflower extract and a preparation method of a salvia-safflower oral preparation relate to an extraction method of salvia and safflower, and a preparation method of a salvia-safflower preparation. The extraction of the salvia extract comprises the following steps: first, refluxing; second, acidification; third, adsorption. The extraction of the safflower extract comprises the following steps: first, decoction; second, acidification; third, adsorption. The preparation of the salvia-safflower oral preparation comprises the following steps: mixing the salvia extract and the safflower extract, adding auxiliary materials to prepare an oral dosage form. According to the invention, the salvia and the safflower are extracted separately; the effective components are extracted fully and completely, which effectively improves the inherent quality of the product, improves and guarantees the controllability of intermediates and the finished product; the control indexes of effective components in the salvia-safflower oral preparation of the invention are very scientific and reasonable; the invention increases the purity of effective components, reduces impurities, reduces risks for clinical application of injections; the preparation process of the invention has simple operations, high efficiency, low cost, and is applicable to industrial production.

Description

technical field [0001] The present invention relates to the extraction method of salvia miltiorrhiza and safflower and the preparation method of danhong preparation. Background technique [0002] Danhong injection is a compound preparation extracted from traditional Chinese medicine Danshen and safflower. The main effect of the traditional Chinese medicine Salvia miltiorrhiza is to promote blood circulation and remove blood stasis, while safflower has the effects of promoting blood circulation, dredging collaterals, removing blood stasis and relieving pain. Both are commonly used medicines for treating chest obstruction. Danhong injection can significantly relieve the symptoms of angina pectoris and improve myocardial ischemia. It is a commonly used clinical drug for the treatment of coronary heart disease, angina pectoris, myocardial infarction, ischemic encephalopathy, and cerebral thrombosis. However, the existing Danhong injection has technical problems such as imperfec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K36/286A61P9/10
Inventor 李殿明任瑞涛吴志军李云涛王英新付饶解黎雯冯文军
Owner 哈药集团中药二厂
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