Indigo carmine colorant as well as preparation method and applications thereof

Abstract

The invention discloses an indigo carmine colorant as well as a preparation method and applications thereof. A mixed solution of indigo carmine and antioxidants contains 0.1%-1%(weight/volume percent concentration, g/100ml) of indigo carmine, the antioxidants are selected from one or combinations of ascorbic acid, tea polyphenols and phytic acid, and the amount of addition is 0.05%-0.5%(weight/volume percent concentration, g/100ml). The indigo carmine colorant has advantages as follows: a product is greatly improved in stability, is easy to use and store, and has a good clinical effect; the safety performance is high, and the clinical risk is low; the operation is simple. A prepared indigo carmine solution can be directly used in clinical treatment, dilution and other additional operations are not required, a clinical operation process is greatly simplified, and defects of a colorant obtained with an immediate preparation and use method in the prior art are solved.

Description

technical field [0001] The invention relates to a digestive tract mucous membrane dye and a preparation method thereof, in particular to an indigo carmine dye capable of long-term storage and a preparation method thereof, and establishes a detection method for the concentration of the indigo carmine dye. Background technique [0002] Gastric cancer is a disease that seriously endangers human health. Its mortality rate is second only to lung cancer and ranks second in the global cancer mortality rate. The number of new patients in the world is about 876,000 every year, and the number of people who die from gastric cancer is about 649,000 every year. According to the third national retrospective sample survey on the cause of death, the standardized death rate of gastric cancer population in my country is 16.2 per 100,000, accounting for 18.2% of the deaths from malignant tumors. 13.8 people / 100,000 people, both higher than the average level of developed and developing countries...

AI Technical Summary

Problems solved by technology

However, this method has the following problems: First, because the indigo carmine dye prepared by the "ready to use" method has not undergone any sterilization, the product has a relatively large clinical risk; secondly, the "ready to use" method to prepare The concentration of the indigo carmine dyeing agent is uncertain, because the solid indigo carmine will also react with oxygen during storage, resulting in partial indigo carmine failure, the concentration of indigo carmine is uncertain, and even affect clinical applications; again, " "Preparation and use now" method is cumbersome to operate, which is not conducive to the promotion of chromoendoscopy technology

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