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In-vitro intervention embolism therapy simulation system

A technology of simulation system and treatment system, applied in teaching models, instruments, educational appliances, etc., can solve the problem of inability to evaluate the performance of embolic agents, achieve convenient data accumulation scheme, and inhibit the effect of neovascularization.

Active Publication Date: 2017-09-05
广东广纳安疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] Chinese invention patent, CN202720819U, discloses an intracranial aneurysm embolism simulator, which is designed according to the internal layout of the human body, and can be used as an effective training tool for hospitals to improve doctors' skills, and can improve the proficiency and skill mastery of beginners, further Reduce surgical error rate and improve treatment effect, but as a training tool, it cannot evaluate the performance of embolization agent

Method used

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  • In-vitro intervention embolism therapy simulation system

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preparation example Construction

[0047] Wherein, the preparation method of the microfluidic chip 3 includes the following steps,

[0048] 1) Mix polydimethylsiloxane and curing agent according to the mass ratio of 10:1, put it in a beaker, stir and mix evenly with a glass rod, and pour the mixture on a mold with a chip in place, at 60°C Curing for 2 hours;

[0049] 2) Use a blade to cut off the cured substrate, and use a puncher to make holes at the punching positions;

[0050] 3) Bond the cured upper and lower substrates, and store them in an oven at 50° C. for 30 minutes to complete the bonding.

[0051] The curing agent adopted in the present invention is Dow Corning Sylgard184.

[0052] In the present invention, the simulated blood flow medium 5 is phosphate buffer solution with pH=7.4 or 0.9% physiological saline.

[0053] The simulation system for extracorporeal interventional embolization therapy in the present invention is realized in the following ways:

Embodiment 1

[0055] Step 1: Mix polydimethylsiloxane and curing agent according to the mass ratio of 10:1, put it in a beaker, stir with a glass rod for 30 minutes, stir well, and pour the mixture on the mold (pipeline design in the mold Classified into 9 grades, the pipe widths are 1000 μm, 800 μm, 630 μm, 500 μm, 400 μm, 300 μm, 200 μm, 100 μm, 50 μm, and the pipe height is 20-50 μm), cured at 60 ° C for 2 hours;

[0056] Step 2: Use a blade to cut off the cured substrate, and use a puncher to make a hole at the punching position;

[0057] Step 3: Bond the cured substrate to the glass, and store it in an oven at 50°C for 30 minutes to make the bonding complete, and obtain a microvascular simulation chip;

[0058] Step 4: Repeat the above steps to prepare 2 or more microvascular simulation chips;

[0059] Step Five: Follow the figure 1 After the construction of each component is completed, turn on the thermostat 2, set the system temperature to 37°C, turn on the constant flow pump 7 and...

Embodiment 2

[0061] Step 1: Mix polydimethylsiloxane and curing agent according to the mass ratio of 10:1, put it in a beaker, stir with a glass rod for 30 minutes, stir well, and pour the mixture on the mold (pipeline design in the mold Classified into 9 grades, the pipe widths are 1000 μm, 800 μm, 630 μm, 500 μm, 400 μm, 300 μm, 200 μm, 100 μm, 50 μm, and the pipe height is 50-100 μm), cured at 60 ° C for 2 hours;

[0062] Step 2: Use a blade to cut off the cured substrate, and use a puncher to make a hole at the punching position;

[0063] Step 3: Bond the cured substrate to the glass, and store it in an oven at 50°C for 30 minutes to make the bonding complete, and obtain a microvascular simulation chip;

[0064] Step 4: Repeat the above steps to prepare 2 or more microvascular simulation chips;

[0065] Step Five: Follow the figure 1 After the construction of each component is completed, turn on the thermostat 2, set the system temperature to 37°C, turn on the constant flow pump 7 an...

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Abstract

The invention discloses an in-vitro intervention embolism therapy simulation system which comprises a micro-vessel simulation area, a blood flow simulation area and a pressure monitoring area. The micro-vessel simulation area is placed in a constant temperature device and communicated with the blood flow simulation area through a pipeline, the pressure monitoring area is used for monitoring a pressure value in the pipeline, and the micro-vessel simulation area comprises a micro-fluidic chip. According to the in-vitro intervention embolism therapy simulation system, the difference of terminal embolism performances is quantified by observing pipeline classification in the chip plugged by different embolism agents, so that the terminal embolism performances of the different embolism agents can be more visually evaluated, and a simpler and more convenient data accumulation program is provided for research and development persons. Besides, the performances of the embolism agents are more effectively understood, clinical risk is reduced, blood flow washing resistance effects of the different embolism agents can be accurately analyzed in the pressure monitoring area under different conditions, so that embolism strength is evaluated in vitro, and blood vessel recanalization time can be monitored.

Description

technical field [0001] The invention relates to the technical field of a vascular embolization material evaluation system for medical device intervention and medical operation training, in particular to an embolization treatment simulation system for extracorporeal intervention. Background technique [0002] Interventional therapy is a discipline that integrates imaging diagnosis and clinical treatment. Specifically, under the guidance of digital subtraction angiography, magnetic resonance, ultrasound, CT and other imaging medical equipment, catheters or other interventional equipment are inserted through small wounds. It is a medical technology that introduces the lesion and implements treatment. This technology has the advantages of minimally invasive, quick effect, high accuracy, and less toxic and side effects, which makes it play an increasingly important role in clinical application. A large branch of interventional therapy is interventional therapy for liver cancer. L...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G09B23/28
CPCG09B23/28Y02A50/30
Inventor 李涵赵彦兵刘宏杨祥良刘爽孙海霞曾坚杜青
Owner 广东广纳安疗科技有限公司
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