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Ginseng aconite injection liquid and its preparation method

A Shenfu injection and preparation process technology, applied in the field of Shenfu injection and its preparation, can solve the problems of abnormal time-consuming, cumbersome process, and long heating and extraction time

Inactive Publication Date: 2006-08-30
北京天新园医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, since ginseng is a precious medicinal material, the active ingredients in ginseng can be completely extracted in this patent, and the extraction operation is repeated in the process operation, so the process is very cumbersome and extremely time-consuming; Increased the possibility of degradation of active components of ginseng; on the other hand, since aconite is a highly toxic traditional Chinese medicine, repeated operations and prolonged extraction process will also increase the extraction rate of toxic components, increasing the risk of clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1-preparation of Shenfu Injection

[0027] a. Preparation of effective parts of aconite:

[0028] Take 1 kg of aconite and grind it, add 4 times the amount of water to soak for 24 hours, adjust the pH to 3-4 with hydrochloric acid, add cellulase and amylase, stir, put in a 37°C water bath for 2 hours, filter, and the filtrate is covered with D101 macropores Resin, eluted with water to remove sugars, and then eluted with 3-5 times the volume of 10%, 20%, 30%, 50%, 70% and 95% ethanol gradients, and collected 70% and 95% ethanol eluted fractions, Recover ethanol under reduced pressure until there is no alcohol smell, centrifuge, extract the supernatant with ethyl acetate 5 times, and evaporate the solvent to obtain the effective part of aconite.

[0029] b. Preparation of effective parts of ginseng:

[0030] Take 0.5kg ginseng and grind it, add 12 times the amount of water to soak for 24 hours, adjust the pH to 3-4 with hydrochloric acid, add ce...

Embodiment 2

[0033] Embodiment 2-preparation of Shenfu Injection

[0034] a. Preparation of effective parts of aconite:

[0035] Take 1 kg of aconite and grind it, add 5 times the amount of water to soak for 24 hours, adjust the pH to 3-4 with hydrochloric acid, add cellulase and amylase, stir, put in a water bath at 40°C for 2 hours, filter, and the filtrate is covered with D101 macropores Resin, eluted with water to remove sugars, and then eluted with 3-5 times the volume of 10%, 20%, 30%, 50%, 70% and 95% ethanol gradients, and collected 70% and 95% ethanol eluted fractions, Recover ethanol under reduced pressure until there is no alcohol smell, centrifuge, extract the supernatant with dichloromethane for 3-5 times, and evaporate the solvent to obtain the effective part of aconite.

[0036] b. Preparation of effective parts of ginseng:

[0037] Take 0.5kg ginseng and grind it, add 12 times the amount of water to soak for 24 hours, adjust the pH to 3-4 with hydrochlo...

Embodiment 3

[0040] Embodiment 3-preparation of Shenfu Injection

[0041] a. Preparation of effective parts of aconite:

[0042] Take 1 kg of aconite and grind it, add 4 times the amount of water to soak for 24 hours, adjust the pH to 3-4 with hydrochloric acid, add cellulase and amylase, stir, put in a 37°C water bath for 2 hours, filter, and the filtrate is covered with D101 macropores Resin, eluted with water to remove sugars, and then eluted with 3-5 times the volume of 10%, 20%, 30%, 50%, 70% and 95% ethanol gradients, and collected 70% and 95% ethanol eluted fractions, Recover ethanol under reduced pressure until there is no alcohol smell, centrifuge, extract the supernatant with ethyl acetate 5 times, and evaporate the solvent to obtain the effective part of aconite.

[0043] b. Preparation of effective parts of ginseng:

[0044] Take 0.5kg ginseng and grind it, add 12 times the amount of water to soak for 24 hours, adjust the pH to 3-4 with hydrochloric acid, ...

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Abstract

A Chinese medicine in the form of injection, freeze-dried powder injection, or perfusion is prepared from ginseng and prepared aconite root. It can decrease the toxin of aconite root.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine injections, and in particular relates to a Shenfu injection and a preparation method thereof. Background technique [0002] Ginseng is a kind of precious traditional Chinese medicine, which has high medicinal value. According to "Shen Nong's Materia Medica", ginseng has the effect of "replenishing the five internal organs, calming the spirit, calming the soul, stopping shock, eliminating evil spirits, and making tomorrow happy and intellectually beneficial". Take it lightly and prolong life"; while Fuzi is pungent and hot, nourishes fire and dispels cold, helps the heart yang at the top, warms the spleen yang at the middle, and warms the kidney yang at the bottom. One of the medicines is very hot and also very poisonous. Therefore, the clinical application of aconite should be treated with caution. [0003] Shenfu Decoction, the basic formula of Shenfu Injection, is derived from "Good ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K9/08A61P1/14A61P43/00
Inventor 魏海关
Owner 北京天新园医药科技开发有限公司
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