39 results about "Ductus arteriosus" patented technology

A medicament injection kit, for use in occluding a renal artery and a renal vein in a kidney and injecting a therapeutic medicament into the kidney so as to pressurize the kidney, includes: an artery catheter which includes a first balloon capable of occluding the renal artery; a vein catheter which includes a second balloon capable of occluding the renal vein; a syringe for injecting the therapeutic medicament, the syringe being capable of being connected to at least one of the artery catheter and the vein catheter; and a syringe for pressurizing the inside of the kidney by injecting a liquid, the syringe being capable of being connected to at least one of the artery catheter and the vein catheter.

Provided is a catheter suitable for catheterization of a right coronary artery using a right transradial approach. The catheter presents improved directionality, thereby requiring minimized external torque to be applied during insertion and diagnostic procedures. A catheter according to the disclosed design includes a tip near its distal end, a primary curve, a secondary curve, a tertiary curve and a proximal end accessible external a catheterized body. When properly inserted, the secondary curve may rest near the junction of the bracheocephalic trunk and the right subclavian artery, and the tertiary curve may rest in the superior curve of the right subclavian artery. In addition to improved directionality, the secondary and/or tertiary curve offers additional resistance against cephalic, or upward, back-up force by providing caudal, or downward, torque to more distal portions of the catheter body.

The invention relates to a method for establishing a rat external carotid artery catheter-indwelled cerebral ischemia reperfusion model. The method includes the following steps that: the direction of an external carotid artery blood vessel of a rat is drifted, the direction of the external carotid artery blood vessel of the rat is drifted to a position which is consistent with or parallel to the direction of an internal carotid artery blood vessel of the rat; the external carotid artery blood vessel is cut, a suture is inserted into an incision, so that cerebral ischemia can be formed in the neck of the rat; and 1 to 2 hours after the suture is inserted into the incision, and cerebral ischemia is formed, the suture is pulled out, and a catheter injection bag through which medicine can be injected repeatedly is arranged into the external carotid artery blood vessel. According to the method, an external carotid artery suture method is adopted to manufacture the rat ischemia reperfusion model, and therefore, the normal structures of an operation-side common carotid artery and an internal carotid artery can be protected; the catheter injection bag through which medicine can be injected repeatedly is indwelled in the external carotid artery, medicine can be injected into the internal carotid artery through the artery catheter repeatedly at different time points; nerve functional assessment after the model is established can be realized, and qualified animals could be accepted and subjected to experimental intervention, and therefore, the scientific nature of experiments can be greatly improved.

The invention provides a novel degradable stopper implanted through a guide pipe. The novel degradable stopper comprises a ball bag, a supporting rod and degrading liquid. The supporting rod is fixedly connected with the ball bag, the periphery of the supporting rod is wrapped by the ball bag, and the degrading liquid is a biological material which can be degraded and absorbed and is arranged in the ball bag in a filling mode to play a supporting effect. The invention further provides a conveying system of the novel degradable stopper implanted through the guide pipe. The conveying system comprises a long sheath, an inner core, a loader, a pushing rod and an infusion pipe. The stopper is made of degradable materials, foreign objects are not left in vivo, and a long-term effect is obvious. In addition, the stopper is of a ball bag type structure, and the inner filler of the stopper is temperature-sensitive hydrogel. When an abnormal defect is blocked, the stopper can be attached to the periphery of the defect completely, and especially a better blocking effect is achieved on irregular defects. The stopper can be suitable for blocking of the patent ductus arteriosus and can be made into a stopper suitable for atrial septal defects and a stopper suitable for ventricular septal defects through changing of the shape of the ball bag.

Antagonistic peptides of prostaglandin E2 receptor subtype EP4 and their use in the treatment or prevention of medical conditions associated with oligouric nephropathy, bone resorption, abnormal intestinal crypt cell proliferation or patency of the ductus arteriosus and the like are provided herein. The antagonistic peptides of the present invention can include the following formula:

X-AR_nY_m

wherein “X” is a hydrogen atom or an amine protecting group producing a carbamate or an amide when reacting with the amine; “A” is L-(4,4′)-biphenylalanine or D-(4,4′)-biphenylalanine; “R” is an amino acid selected from the group consisting of threonine, serine, tyrosine, glutamic acid, alanine, leucine and glycine; “Y” is lysine; “n” is an integer ranging from 5 to 7; and “m” is an integer ranging from 0 to 2.

The invention discloses a blood collection device used during invasive artery monitoring. The blood collection device comprises an arterial duct, a pressure connection tube, a pressure sensor, a continuous washing system and an electronic monitor, wherein the pressure connection tube is filled with liquid and provided with a switch. The blood collection device is characterized in that the pressure connection tube is provided with a blood collection plug, a three-way plug valve and an injection syringe, the blood collection plug is arranged on the part, on the root of a palm of a patient, of the pressure connection tube, the three-way plug valve is arranged between the blood collection plug and the injection syringe, and the injection syringe and the pressure connection tube are formed at a time. During blood collection, the injection syringe sucks the liquid in the pressure connection tube, blood is sucked to the position of the blood collection plug, a blood taking needle punctures the blood collection plug and the blood is collected; after blood collection is finished, the liquid sucked out by the injection syringe is injected into the pressure connection tube, waste of the blood of the human body of avoided, and pulsating pressure produced during injection of the injection syringe can reduce the blood vessel blocking probability; meanwhile, no bloodstain is formed on the blood collection position, and therefore the blood infection probability of the patient is reduced; in addition, blood collection steps are simplified and the quantity of consumables is reduced.

The invention relates to a stent. The stent includes at least one degradable section zone and at least one non-degradable section zone which are connected to each other. The axial length of the at least one degradable section zone is not less than 3 mm. At least one end of the stent is provided with the non-degradable section zone the axial length of which is not less than 3 mm. The stent enablessubsequent arterial duct closing after implantation of the stent into an arterial duct without the need of taking out the stent, thus reducing the probability of harm to child patients and other complications. The invention also provides a stent system.

The invention discloses an ibuprofen and lysine medicament compound as well as a preparation method and the application thereof. The medicament compound contains ibuprofen and lysine in the mole ratio of 1:0.5-1:2. An aqueous solution preparation of the medicament compound can be prepared by firstly dissolving lysine into water to form a lysine solution, and then dissolving ibuprofen into the lysine solution to form the aqueous solution of ibuprofen and lysine. The medicament compound is used for refrigerating, easing pain, resisting inflammation, resisting rheumatism and treating unclosed ductus arteriosus, and the like.

The invention discloses an application of a multi-protein composition and a congenital heart disease screening kit. The detection and functions of a platelet factor 4, a vascular hemophilia factor, fibrinogen, collagen, protein-associated serine protease 2 and fibronectin are researched by utilizing a modern biological technology and bioinformatics analysis, and it is discovered that the combinedapplication has the purpose of predicting patent ductus arteriosus of a congenital heart disease; the multi-protein composition can be applied to the preparation of a targeted drug for early intervention of related diseases, and also can be applied to the preparation of the congenital heart disease screening kit; and the kit has a potential huge application value for preventing the disease, namely, the patent ductus arteriosus.

The invention discloses a tissue project arterial duct unclosed plugging device, which is characterized by the following: knitting T shape mount with degradable biological material with elasticity; un-filling plugging material in the mount to stop blood flow; painting cell hyperplasia medicine on the surface of the plugging device; accelerating quick grow of plugging device metallic mount surface fiber cell and under bark cell; reaching the goal of with self cell to plug abnormal channel; possessing degradability; realizing self-repairing effect of unclosed arterial duct.

The present invention designs and synthesizes the ascorbyl ester derivatives of the aryl (ethanoic) propanoic acid non-steroidal anti-inflammatory medicaments, such as ibuprofen, ketoprofen and naproxen, and addition salt of the derivatives with pharmaceutical acid or pharmaceutical alkaline. The non-steroidal anti-inflammatory medicament which takes the ibuprofen as the representative is a common antipyretic analgesic medicament. The invention has remarkable antipyretic and analgesic effects and good safety except for anti-inflammatory effect, thus being not only suitable for adults, but also suitable for the elderly people, infants and children. The aryl (ethanoic) propanoic acid ascorbyl ester can be converted into ascorbyl ester derivatives and the addition salts of the derivatives with pharmaceutical acid or pharmaceutical alkaline, which can improve the water solubility thereof, facilitate intravenously administration, reduce the onset time, improve the bioavailability, reduce the stimulation effect to gastrointestinal tract, and enhance the penetrating capacity to hemato encephalic barrier, and can be used as a novel medicament to be applied for antiphlogistic, antipyresis, analgesia, treatment of arthritis, dysmenorrheal, multiple sclerosis, pneumonia cystic fibrosis and patent ductus arteriosus of premature infants, and prevention and treatment of cerebral apoplexy, hypoxic-ischemic brain damage, senile dementia and certain cancers.

The invention discloses a patent ductus arteriosus plugging device. A fabric body is sequentially provided with a right disc, a first reducing neck, a first cylinder, a second reducing neck, a second cylinder and a left disc from a right heat system to a left heart system; the two cylinders are in hollow cylinder shapes with the diameter from 4 mm to 20 mm; the diameter of the two reducing necks is obviously smaller than that of the two cylinders; the thickness of the two reducing necks is smaller than or equal to 1 mm; the right disc is in a round shape with the external edge to be 1 mm larger than the first cylinder; the left disc is in a round shape with the external edge to be 3.5 mm larger than the second cylinder; closing positions of the fabric body are arranged at centers of the two discs; a threaded column is fixed at the closing position on the right disc; two expanding thin films are arranged in an empty chamber inside the second cylinder. According to the patent ductus arteriosus plugging device, diameter of the reducing neck portion and the cylinder portion has significant difference, micro-deformation in the length direction can be achieved, and the plugging device can be firmly fixed inside an arterial duct to form into a riveting force.

Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.

The invention discloses a smart transportation device used for minimally invasive closure of patent ductus arteriosus, and belongs to the technical field of medical apparatuses. A handle is threaded to the tail end of an outer sheath tube, a pushing piece is mounted at the front ends in the handle, a pushing rod is mounted at the rear end of the pushing piece, the rear end of the pushing rod is connected with an input end of a sensor, and an output end of the sensor is connected with a control unit. A loading sheath is mounted at the front end of the outer sheath tube, the loading sheath is provided with a video device, and the video device is wirelessly controlled with the control unit. A closing device can be transported through ultrasonic guiding, no radioactive wound affects people during an operation, radiography is needless, and no medical damage occurs. The transportation of the closing device can be intelligentized through the sensor and the control unit, a transportation system is short and small and can be held by hands, so the transportation system can be close to a defect portion to the nearest, only one doctor can puncture, adjust the direction, establish a track, and release the closing device, and the safety of a patient can be furthest ensured.

The present invention relates to a composition of matter comprising novel prostaglandin E2 receptor antagonists, and their use in treatments for regulating the fluid filtration in the kidney, preventing bone mineral loss in osteoporosis and dental disease and additionally, closure of ductus arteriosus (DA) in premature infants or fetal animals. Additionally, the compositions include linear peptides, peptide analogs, and peptidomimetics.

The present invention discloses a method for diagnosing a cardiac complication in a patient due to coronary catheterization, comprising the steps of (a) obtaining at least one baseline sample from the patient during or after coronary catheterization, and then (b) obtaining at least one test sample from the patient after coronary catheterization, (c) determining a change of the level of an ANP-type peptide between the baseline sample and the test sample, wherein a significant decrease in the level of the ANP-type peptide according to step c) indicates a cardiac complication.

The invention discloses a plugging device for an unclosed hole of a patent ductus arteriosus. The perforated plugging device for the unclosed hole of the patent ductus arteriosus comprises a front disk for plugging a gap, a cylindrical barrier part for blocking an unclosed ductus, and a through hole penetrating through the front disk and the cylindrical barrier part; one end of the cylindrical barrier part is connected with the front disk; the other end of the cylindrical barrier part is a closed end; the diameter of the front disk is greater than that of the cylindrical barrier part; the front disk, the cylindrical barrier part and the through hole are all formed by weaving a plurality of memory alloy wires; the memory alloy wires penetrate through the through hole to form the hole wall of the through hole and are wound to form the front disk and the cylindrical barrier part; the two ends of the memory alloy wires are fixed to the same fixing clamp for restricting the memory alloy wires; the memory alloy wires are interwoven to form an elastic mesh; a sealing film is arranged in the elastic mesh. According to the perforated plugging device for the patent ductus arteriosus, the shunt of aorta-pulmonary artery is limited, and the blood flow of the aorta of a high-pressure chamber is also prevented from flowing to the pulmonary artery; the volume overload and the pressure transfer of pulmonary vessels are lightened; serious consequences caused by sudden rise of the pulmonary artery pressure can also be prevented, so that the high pressure of a right heart system has release space.